4,563 research outputs found
Aplikasi Game Mewarnai dengan Macromedia Flash 8
Scientific writing is about the making of Game edutaintment.yang intended forchildren age play group, kindergarten and elementary school children in grade 1,many included images that allows users colored objects in coloredgambar.Game consists of two core components. The first component is thechoice of colors, usually displayed with the color blocks and objects whichbecome targets coloring and added sound notification on every color. Incompleting this writing, the author approached by reading books, articles andbrowse the Internet to get as much information so it can be used to solve theproblem in this writing
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Achieving selectivity in space and time with DNA double-strand-break response and repair: molecular stages and scaffolds come with strings attached
When double-strand breaks (DSBs) in DNA remain unrepaired, catastrophic loss of genes occurs, leading to translocations, mutations and carcinogenesis. If a sister chromatid is not available at the DNA DSB, nonhomologous end joining (NHEJ) is used to join broken ends. The NHEJ pathway comprises synapsis, end processing and ligation. Here, we ask how DSBs in DNA are repaired efficiently. We suggest that colocation of proteins is achieved over time by the following components: stages, where the main actors are assembled, scaffolds that are erected quickly around broken parts to give access, and strings that tether proteins together. In NHEJ, a is provided by the Ku heterodimer interacting with DSBs and several other proteins including DNA-PKcs, APLF, BRCA1 and PAXX. A further , DNA-PKcs, links the kinase with DNA, Ku, PARP1, BRCA1 and Artemis. A temporary facilitates repair and is constructed from XRCC4/XLF filaments that bridge Ku bound at DSB ends. LigIV bound to XRCC4 C-termini likely terminates the scaffold, bringing LigIV close to the DNA broken ends. A , provided by the Artemis C-terminal region, is intrinsically disordered but includes short linear ‘‘epitopes’’ that recognise DNA-PKcs, LigIV and PTIP, so keeping these components nearby. We show that these stages, scaffolds and strings facilitate colocation and efficient DSB repair. Understanding these processes provides insight into the biology of DNA repair and possible therapeutic intervention in cancer and other diseases.Wellcome Trust (Programme Grant ID: 093167/Z/ 10/Z), National Health and Medical Research Council of Australia (C. J. Martin Research Fellowship, Grant ID: APP1072476), Gates Cambridge ScholarshipThis is the final version of the article. It first appeared from Springer via http://dx.doi.org/10.1007/s11224-016-0841-
Double bundle arthroscopic Anterior Cruciate Ligament reconstruction with remnant preserving technique using a hamstring autograft
<p>Abstract</p> <p>Background</p> <p>Preservation of the Anterior Cruciate Ligament (ACL) remnant is important from the biological point of view as it enhances revascularization, and preserves the proprioceptive function of the graft construct. Additionally, it may have a useful biomechanical function. Double bundle ACL reconstruction has been shown to better replicate the native ACL anatomy and results in better restoration of the rotational stability than single bundle reconstruction.</p> <p>Methods</p> <p>We used the far anteromedial (FAM) portal for creation of the femoral tunnels, with a special technique for its preoperative localization using three dimensional (3D) CT. The central anteromedial (AM) portal was used to make a longitudinal slit in the ACL remnant to allow visualization of the tips of the guide pins during anatomical creation of the tibial tunnels within the native ACL tibial foot print. The use of curved hemostat allow retrieval of the wire loop from the apertures of the femoral tunnels through the longitudinal slit in the ACL remnant thereby, guarding against impingement of the reconstruction graft against the ACL remnant as well as the roof of the intercondylar notch.</p> <p>Conclusion</p> <p>Our technique allows for anatomical double bundle reconstruction of the ACL while maximally preserving the ACL remnant without the use of intra-operative image intensifier.</p
Pulmonary injury after cardiopulmonary bypass: Beneficial effects of low-frequency mechanical ventilation
ObjectivePulmonary dysfunction is a frequent postoperative complication after cardiac surgery with cardiopulmonary bypass, and atelectasis is thought to be one of the main causes. The aim of this study was to evaluate whether low-frequency ventilation and continuous positive airway pressure during cardiopulmonary bypass reduce postcardiopulmonary bypass lung injury.MethodsEighteen Yorkshire pigs were subjected to 120 minutes of cardiopulmonary bypass (1 hour of cardioplegic arrest) followed by 90 minutes of recovery before being sacrificed. Six animals served as control with the endotracheal tube open to atmosphere during cardiopulmonary bypass. The remaining animals were divided into 2 groups of 6: One group received continuous positive airway pressure of 5 cm H2O, and one group received low-frequency ventilation (5/minutes) during cardiopulmonary bypass. Lung tissue biopsy and bronchoalveolar lavage samples were obtained before and 90 minutes after discontinuation of cardiopulmonary bypass for measurement of adenine nucleotide (adenosine-5′-triphosphate, adenosine diphosphate, adenosine monophosphate), lactate dehydrogenase, DNA levels, and histology. Hemodynamic data and arterial blood gases were also collected through the study.ResultsThe hemodynamic parameters were similar in the 3 groups. After cardiopulmonary bypass, the low-frequency ventilation group showed significantly better oxygen tension and alveolar arterial oxygen gradient, higher adenine nucleotide, lower lactate dehydrogenase levels, and reduced histologic damage in lung biopsy, as well as lower DNA levels in bronchoalveolar lavage compared with the control group. The continuous positive airway pressure group showed only significantly reduced lactate dehydrogenase levels compared with control.ConclusionLow-frequency ventilation during cardiopulmonary bypass in a pig experimental model reduces tissue metabolic and histologic damage in the lungs and is associated with improved postoperative gas exchange
Study of the Gauge Mediation Signal with Non-pointing Photons at the CERN LHC
In this paper we study the gauge mediation signal with the ATLAS detector at
the CERN LHC. We focus on the case where the NLSP is the long-lived lightest
neutralino () which decays dominantly into a photon
() and a gravitino (). A non-pointing photon from the
neutralino decay can be detected with good position and time resolutions by the
electormagnetic calorimeter (ECAL), while the photon momentum would be
precisely measured if the photon is converted inside the inner tracking
detector before reaching the ECAL. A new technique is developed to determine
the masses of the slepton () and the neutralino from events with
a lepton and a converted non-pointing photon arising from the cascade decay
. A Monte Carlo
simulation at a sample point shows that the masses would be measured with an
error of 3% for (100) selected pairs. Once the sparticle
masses are determined by this method, the decay time and momentum of the
neutralino are solved using the ECAL data and the lepton momentum only, for all
pairs without the photon conversion. We estimate the sensitivity
to the neutralino lifetime for cm to (10) m.Comment: 19 page, 7 figures, revte
NN coupling and two-pion photoproduction on the nucleon
Effects of non-resonant photoproductions arising from two different
couplings are investigated in the reaction. We find that
the pseudoscalar (PS) coupling is generally preferable to the
pseudovector (PV) coupling and particularly the total cross sections
are successfully described by the model with the PS coupling. In order
to see the difference between the two couplings, we also show the results of
invariant mass spectra and helicity-dependent cross sections in various isospin
channels calculated with the PS and PV couplings.Comment: 35 pages, 11 figures, minor changes and version to be published in
Phys.Rev.
On the background in the reaction and mixed event simulation
In this paper we evaluate sources of background for the , with the detected through its decay channel, to
compare with the experiment carried out at ELSA. We find background from
followed by decay of a into two ,
recombining one and one , and from the reaction with subsequent decay of the into two photons. This
background accounts for the data at invariant masses beyond 700
MeV, but strength is missing at lower invariant masses which was attributed to
photon misidentification events, which we simulate to get a good reproduction
of the experimental background. Once this is done, we perform an event mixing
simulation to reproduce the calculated background and we find that the method
provides a good description of the background at low invariant
masses but fakes the background at high invariant masses, making background
events at low invariant masses, which are due to misidentification
events, responsible for the background at high invariant masses which is due to
the and reactions.Comment: 10 pages, 5 figure
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