High-Speed CMOS-Free Purely Spintronic Asynchronous Recurrent Neural Network

Neuromorphic computing systems overcome the limitations of traditional von Neumann computing architectures. These computing systems can be further improved upon by using emerging technologies that are more efficient than CMOS for neural computation. Recent research has demonstrated memristors and spintronic devices in various neural network designs boost efficiency and speed. This paper presents a biologically inspired fully spintronic neuron used in a fully spintronic Hopfield RNN. The network is used to solve tasks, and the results are compared against those of current Hopfield neuromorphic architectures which use emerging technologies

Medical Therapies for Uterine Fibroids - A Systematic Review and Network Meta-Analysis of Randomised Controlled Trials

BACKGROUND: Uterine fibroids are common, often symptomatic and a third of women need repeated time off work. Consequently 25% to 50% of women with fibroids receive surgical treatment, namely myomectomy or hysterectomy. Hysterectomy is the definitive treatment as fibroids are hormone dependent and frequently recurrent. Medical treatment aims to control symptoms in order to replace or delay surgery. This may improve the outcome of surgery and prevent recurrence. PURPOSE: To determine whether any medical treatment can be recommended in the treatment of women with fibroids about to undergo surgery and in those for whom surgery is not planned based on currently available evidence. STUDY SELECTION: Two authors independently identified randomised controlled trials (RCT) of all pharmacological treatments aimed at the treatment of fibroids from a list of references obtained by formal search of MEDLINE, EMBASE, Cochrane library, Science Citation Index, and ClinicalTrials.gov until December 2013. DATA EXTRACTION: Two authors independently extracted data from identified studies. DATA SYNTHESIS: A Bayesian network meta-analysis was performed following the National Institute for Health and Care Excellence-Decision Support Unit guidelines. Odds ratios, rate ratios, or mean differences with 95% credible intervals (CrI) were calculated. RESULTS AND LIMITATIONS: A total of 75 RCT met the inclusion criteria, 47 of which were included in the network meta-analysis. The overall quality of evidence was very low. The network meta-analysis showed differing results for different outcomes. CONCLUSIONS: There is currently insufficient evidence to recommend any medical treatment in the management of fibroids. Certain treatments have future promise however further, well designed RCTs are needed

Bias associated with delayed verification in test accuracy studies: accuracy of tests for endometrial hyperplasia may be much higher than we think!

BACKGROUND: To empirically evaluate bias in estimation of accuracy associated with delay in verification of diagnosis among studies evaluating tests for predicting endometrial hyperplasia. METHODS: Systematic reviews of all published research on accuracy of miniature endometrial biopsy and endometr ial ultrasonography for diagnosing endometrial hyperplasia identified 27 test accuracy studies (2,982 subjects). Of these, 16 had immediate histological verification of diagnosis while 11 had verification delayed > 24 hrs after testing. The effect of delay in verification of diagnosis on estimates of accuracy was evaluated using meta-regression with diagnostic odds ratio (dOR) as the accuracy measure. This analysis was adjusted for study quality and type of test (miniature endometrial biopsy or endometrial ultrasound). RESULTS: Compared to studies with immediate verification of diagnosis (dOR 67.2, 95% CI 21.7–208.8), those with delayed verification (dOR 16.2, 95% CI 8.6–30.5) underestimated the diagnostic accuracy by 74% (95% CI 7%–99%; P value = 0.048). CONCLUSION: Among studies of miniature endometrial biopsy and endometrial ultrasound, diagnostic accuracy is considerably underestimated if there is a delay in histological verification of diagnosis

Measurement properties of the Minimal Insomnia Symptom Scale (MISS) in an elderly population in Sweden

<p>Abstract</p> <p>Background</p> <p>Insomnia is common among elderly people and associated with poor health. The Minimal Insomnia Symptom Scale (MISS) is a three item screening instrument that has been found to be psychometrically sound and capable of identifying insomnia in the general population (20-64 years). However, its measurement properties have not been studied in an elderly population. Our aim was to test the measurement properties of the MISS among people aged 65 + in Sweden, by replicating the original study in an elderly sample.</p> <p>Methods</p> <p>Data from a cross-sectional survey of 548 elderly individuals were analysed in terms of assumptions of summation of items, floor/ceiling effects, reliability and optimal cut-off score by means of ROC-curve analysis and compared with self-reported insomnia criteria.</p> <p>Results</p> <p>Corrected item-total correlations ranged between 0.64-0.70, floor/ceiling effects were 6.6/0.6% and reliability was 0.81. ROC analysis identified the optimal cut-off score as ≥7 (sensitivity, 0.93; specificity, 0.84; positive/negative predictive values, 0.256/0.995). Using this cut-off score, the prevalence of insomnia in the study sample was 21.7% and most frequent among women and the oldest old.</p> <p>Conclusions</p> <p>Data support the measurement properties of the MISS as a possible insomnia screening instrument for elderly persons. This study make evident that the MISS is useful for identifying elderly people with insomnia-like sleep problems. Further studies are needed to assess its usefulness in identifying clinically defined insomnia.</p

The NANOGrav Nine-year Data Set:Astrometric Measurements of 37 Millisecond Pulsars

Using the nine-year radio-pulsar timing data set from the North American Nanohertz Observatory for Gravitational Waves (NANOGrav), collected at Arecibo Observatory and the Green Bank Telescope, we have measured the positions, proper motions, and parallaxes for 37 millisecond pulsars. We report twelve significant parallax measurements and distance measurements, and eighteen lower limits on distance. We compare these measurements to distances predicted by the NE2001 interstellar electron density model and find them to be in general agreement. We use measured orbital-decay rates and spin-down rates to confirm two of the parallax distances and to place distance upper limits on other sources; these distance limits agree with the parallax distances with one exception, PSR. J1024-0719, which we discuss at length. Using the proper motions of the 37 NANOGrav pulsars in combination with other published measurements, we calculate the velocity dispersion of the millisecond pulsar population in Galactocentric coordinates. We find the radial, azimuthal, and perpendicular dispersions to be 46, 40, and 24 km s(-1), respectively, in a model that allows for high-velocity outliers; or 81, 58, and 62 km s(-1) for the full population. These velocity dispersions are far smaller than those of the canonical pulsar population, and are similar to older Galactic disk populations. This suggests that millisecond pulsar velocities are largely attributable to their being an old population rather than being artifacts of their birth and evolution as neutron star binary systems. The components of these velocity dispersions follow similar proportions to other Galactic populations, suggesting that our results are not biased by selection effects

Einstein@Home discovery of a Double-Neutron Star Binary in the PALFA Survey

We report here the Einstein@Home discovery of PSR J1913+1102, a 27.3 ms pulsar found in data from the ongoing Arecibo PALFA pulsar survey. The pulsar is in a 4.95 hr double neutron star (DNS) system with an eccentricity of 0.089. From radio timing with the Arecibo 305 m telescope, we measure the rate of advance of periastron to be $\dot{\omega }=5.632(18)$° yr−1. Assuming general relativity accurately models the orbital motion, this corresponds to a total system mass of M tot =  2.875(14) ${M}_{\odot }$, similar to the mass of the most massive DNS known to date, B1913+16, but with a much smaller eccentricity. The small eccentricity indicates that the second-formed neutron star (NS) (the companion of PSR J1913+1102) was born in a supernova with a very small associated kick and mass loss. In that case, this companion is likely, by analogy with other systems, to be a light (~1.2 ${M}_{\odot }$) NS; the system would then be highly asymmetric. A search for radio pulsations from the companion yielded no plausible detections, so we cannot yet confirm this mass asymmetry. By the end of 2016, timing observations should permit the detection of two additional post-Keplerian parameters: the Einstein delay (γ), which will enable precise mass measurements and a verification of the possible mass asymmetry of the system, and the orbital decay due to the emission of gravitational waves (${\dot{P}}_{b}$), which will allow another test of the radiative properties of gravity. The latter effect will cause the system to coalesce in ~0.5 Gyr

Timing of 29 Pulsars Discovered in the PALFA Survey

We report on the discovery and timing observations of 29 distant long-period pulsars found in the ongoing Arecibo L-band Feed Array pulsar survey. Following discovery with the Arecibo Telescope, confirmation and timing observations of these pulsars over several years at Jodrell Bank Observatory have yielded high-precision positions and measurements of rotation and radiation properties. We have used multi-frequency data to measure the interstellar scattering properties of some of these pulsars. Most of the pulsars have properties that mirror those of the previously known pulsar population, although four show some notable characteristics. PSRs J1907+0631 and J1925+1720 are young and are associated with supernova remnants or plerionic nebulae: J1907+0631 lies close to the center of SNR G40.5−0.5, while J1925+1720 is coincident with a high-energy Fermi γ-ray source. One pulsar, J1932+1500, is in a surprisingly eccentric, 199 day binary orbit with a companion having a minimum mass of 0.33 M⊙. Several of the sources exhibit timing noise, and two, PSRs J0611+1436 and J1907+0631, have both suffered large glitches, but with very different post-glitch rotation properties. In particular, the rotational period of PSR J0611+1436 will not recover to its pre-glitch value for about 12 years, a far greater recovery timescale than seen following any other large glitches

PSR J1024-0719:A Millisecond Pulsar in an Unusual Long-Period Orbit

PSR J1024-0719 is a millisecond pulsar that was long thought to be isolated. However, puzzling results concerning its velocity, distance, and low rotational period derivative have led to a reexamination of its properties. We present updated radio timing observations along with new and archival optical data which show that PSR J1024-0719 is most likely in a long-period (2-20 kyr) binary system with a low-mass (approximate to 0.4 M-circle dot), low-metallicity (Z approximate to -0.9 dex) main-sequence star. Such a system can explain most of the anomalous properties of this pulsar. We suggest that this system formed through a dynamical exchange in a globular cluster that ejected it into a halo orbit, which is consistent with the low observed metallicity for the stellar companion. Further astrometric and radio timing observations such as measurement of the third period derivative could strongly constrain the range of orbital parameters