Long-term survival for a cohort of adults with cerebral palsy

The aim of this study was to investigate long-term survival and examine causes of death in adult patients with cerebral palsy (CP). A 1940–1950 birth cohort based on paediatric case referral allows for long-term survival follow-up. Survival is analyzed by birth characteristics and severity of disability from age 20 years (and age 2y for a subset of the data). Survival outcome compared with that expected in the general population based on English life tables. The main cohort consisted of 341 individuals, with 193 males and 148 females. Conditional on surviving to age 20 years, almost 85% of the cohort survived to age 50 years (a comparable estimate for the general population is 96%). Very few deaths were attributed to CP for those people dying over 20 years of age. Females survived better than males. However, females faced a greater increase in risk relative to the general population than did males. We conclude that survival outlook is good though lower than in the general population. The relative risk of death compared with the UK population decreases with age, although it shows some indication of rising again after age 50 years. Many more deaths were caused by diseases of the respiratory system among those dying in their 20s and 30s than would be expected in the general population. Many fewer deaths than expected in this age group are caused by injuries and accidents. For those people who die in their 40s and 50s, an increase in deaths due to diseases of the circulatory system and neoplasms is observed. More deaths than expected in this age group are due to diseases of the nervous system

Measuring pH variability using an experimental sensor on an underwater glider

Autonomous underwater gliders offer the capability of measuring oceanic parameters continuously at high resolution in both vertical and horizontal planes, with timescales that can extend to many months. An experimental ion sensitive field effect transistor (ISFET) sensor measuring pH on the total scale was attached to a glider during the REP14 – MED experiment in June 2014 in the northwestern Mediterranean Sea. During the deployment, pH was sampled at depths of up to 1000 m, along an 80 km transect over a period of 12 days. Water samples were collected from a nearby ship and analysed for dissolved inorganic carbon concentration and total alkalinity to derive pH for validating the ISFET measurements. The vertical resolution of the pH sensor was good (1 to 2 m), but stability was poor, and the sensor drifted in a non-monotonous fashion. In order to remove the sensor drift, a time-dependent, depth-invariant offset was applied throughout the water column for each dive, reducing the spread of the data by approximately two thirds. Furthermore, the ISFET sensor required temperature and pressure-based corrections, which were achieved using linear regression. Correcting for this decreased the apparent sensor pH variability by a further 13 to 31 %. Sunlight caused an apparent sensor pH decrease of up to 0.1 in surface waters around local noon, highlighting the importance of shielding the sensor away from light in future deployments. The corrected pH from the ISFET sensor is presented along with potential temperature, salinity, potential density anomalies (σθ), and dissolved oxygen concentrations (c(O2)) measured by the glider, providing insights into physical and biogeochemical variability in this region. pH maxima were identified at the depth of the summer chlorophyll maximum, where high c(O2) values were also found. Longitudinal pH variations at depth (σθ > 28.8 kg m−3) highlighted variability of water masses in this region. Higher pH was observed where salinity was > 38.65, and lower pH was found where salinity ranged between 38.3 and 38.65. It seemed that the higher pH was associated with saltier Levantine Intermediate Water. Furthermore, shoaling isopycnals closer to shore coinciding with low pH, high salinity, low c(O2) waters may be indicative of upwelling

Hawking Radiation from AdS Black Holes

We investigate Hawking radiation from black holes in (d+1)-dimensional anti-de Sitter space. We focus on s-waves, make use of the geometrical optics approximation, and follow three approaches to analyze the radiation. First, we compute a Bogoliubov transformation between Kruskal and asymptotic coordinates and compare the different vacua. Second, following a method due to Kraus, Parikh, and Wilczek, we view Hawking radiation as a tunneling process across the horizon and compute the tunneling probablility. This approach uses an anti-de Sitter version of a metric originally introduced by Painleve for Schwarzschild black holes. From the tunneling probability one also finds a leading correction to the semi-classical emission rate arising from the backreaction to the background geometry. Finally, we consider a spherically symmetric collapse geometry and the Bogoliubov transformation between the initial vacuum state and the vacuum of an asymptotic observer.Comment: 13 pages, latex2e, v2: some clarifications and references adde

A Multi-Boundary AdS Orbifold and DLCQ Holography: A universal holographic description of extremal black hole horizons

We examine a stationary but non-static asymptotically AdS_3 spacetime with two causally connected conformal boundaries, each of which is a ``null cylinder'', namely a cylinder with a null direction identified. This spacetime arises from three different perspectives: (i) as a non-singular, causally regular orbifold of global AdS_3 by boosts, (ii) as a Penrose-like limit focusing on the horizon of extremal BTZ black holes, and (iii) as an S^1 fibration over AdS_2. Each of these perspectives sheds an interesting light on holography. Examination of the conformal boundary of the spacetime shows that the dual to the space should involve DLCQ limits of the D1-D5 conformal field theory. The Penrose-like limit approach leads to a similar conclusion, by isolating a sector of the complete D1-D5 CFT that describes the physics in the vicinity of the horizon of an extremal black hole. As such this is a holographic description of the universal horizon dynamics of the extremal black holes in AdS_3 and also of the four and five dimensional stringy black holes whose states were counted in string theory. The AdS_2 perspective draws a connection to a 0+1d quantum mechanical theory. Various dualities lead to a Matrix model description of the spacetime. Many interesting issues that are related to both de Sitter physics and attempts to ``see behind a horizon'' using AdS/CFT arise from (a) the presence of two disconnected components to the boundary, and (b) the analytic structure of bulk physics in the complex coordinate plane.Comment: 48 pages. 3 EPS figures. If you use mpage to print multiple postscript pages on the same sheet of paper you may have difficulties with the figures. The PDF version will print fine, as will postscript if you stick to one page per sheet. v3: minor edits and references adde

Branes in Time-Dependent Backgrounds and AdS/CFT Correspondence

We study supergravity solutions of Dp-branes in the time-dependent orbifold background. We show that worldvolume theories decouple from the bulk gravity for p less than six. Along AdS/CFT correspondence, these solutions could provide the gravity description of noncommutative field theory with time-dependent noncommutative parameter. Type II NS5-brane (M5-brane) in the presence of RR n-form for n=0,..., 4 (C field) in this time-dependent background have also been studied.Comment: 15 pages, latex file, v2: typos corrected, ref added, v3: references added, minor change

Exact Solutions for Domain Walls in Coupled Complex Ginzburg - Landau Equations

The complex Ginzburg Landau equation (CGLE) is a ubiquitous model for the evolution of slowly varying wave packets in nonlinear dissipative media. A front (shock) is a transient layer between a plane-wave state and a zero background. We report exact solutions for domain walls, i.e., pairs of fronts with opposite polarities, in a system of two coupled CGLEs, which describe transient layers between semi-infinite domains occupied by each component in the absence of the other one. For this purpose, a modified Hirota bilinear operator, first proposed by Bekki and Nozaki, is employed. A novel factorization procedure is applied to reduce the intermediate calculations considerably. The ensuing system of equations for the amplitudes and frequencies is solved by means of computer-assisted algebra. Exact solutions for mutually-locked front pairs of opposite polarities, with one or several free parameters, are thus generated. The signs of the cubic gain/loss, linear amplification/attenuation, and velocity of the coupled-front complex can be adjusted in a variety of configurations. Numerical simulations are performed to study the stability properties of such fronts.Comment: Journal of the Physical Society of Japan, in pres

On classical super-radiance in Kerr-Newman-anti-de Sitter black holes

We study in detail the modes of a classical scalar field on a Kerr-Newman-anti-de Sitter (KN-AdS) black hole. We construct sets of basis modes appropriate to the two possible boundary conditions (``reflective'' and ``transparent'') at time-like infinity, and consider whether super-radiance is possible. If we employ ``reflective'' boundary conditions, all modes are non-super-radiant. On the other hand, for ``transparent'' boundary conditions, the presence of super-radiance depends on our definition of positive frequency. For those KN-AdS black holes having a globally time-like Killing vector, the natural choice of positive frequency leads to no super-radiance. For other KN-AdS black holes, there is a choice of positive frequency which gives no super-radiance, but for other choices there will, in general, be super-radiance.Comment: 23 pages, 3 figures, v2: minor changes, references adde

String Theory on Warped AdS_3 and Virasoro Resonances

We investigate aspects of holographic duals to time-like warped AdS_3 space-times--which include G\"odel's universe--in string theory. Using worldsheet techniques similar to those that have been applied to AdS_3 backgrounds, we are able to identify space-time symmetry algebras that act on the dual boundary theory. In particular, we always find at least one Virasoro algebra with computable central charge. Interestingly, there exists a dense set of points in the moduli space of these models in which there is actually a second commuting Virasoro algebra, typically with different central charge than the first. We analyze the supersymmetry of the backgrounds, finding related enhancements, and comment on possible interpretations of these results. We also perform an asymptotic symmetry analysis at the level of supergravity, providing additional support for the worldsheet analysis.Comment: 24 pages + appendice

Massless black holes and black rings as effective geometries of the D1-D5 system

We compute correlation functions in the AdS/CFT correspondence to study the emergence of effective spacetime geometries describing complex underlying microstates. The basic argument is that almost all microstates of fixed charges lie close to certain "typical" configurations. These give a universal response to generic probes, which is captured by an emergent geometry. The details of the microstates can only be observed by atypical probes. We compute two point functions in typical ground states of the Ramond sector of the D1-D5 CFT, and compare with bulk two-point functions computed in asymptotically AdS_3 geometries. For large central charge (which leads to a good semiclassical limit), and sufficiently small time separation, a typical Ramond ground state of vanishing R-charge has the M=0 BTZ black hole as its effective description. At large time separation this effective description breaks down. The CFT correlators we compute take over, and give a response whose details depend on the microstate. We also discuss typical states with nonzero R-charge, and argue that the effective geometry should be a singular black ring. Our results support the argument that a black hole geometry should be understood as an effective coarse-grained description that accurately describes the results of certain typical measurements, but breaks down in general.Comment: 47 pages, 4 figures. v2: references added. v3: minor corrections to Appendix A, references adde

Charged BTZ-like Black Holes in Higher Dimensions

Motivated by many worthwhile paper about (2 + 1)-dimensional BTZ black holes, we generalize them to to (n + 1)-dimensional solutions, so called BTZ-like solutions. We show that the electric field of BTZ-like solutions is the same as (2 + 1)-dimensional BTZ black holes, and also their lapse functions are approximately the same, too. By these similarities, it is also interesting to investigate the geometric and thermodynamics properties of the BTZ-like solutions. We find that, depending on the metric parameters, the BTZ-like solutions may be interpreted as black hole solutions with inner (Cauchy) and outer (event) horizons, an extreme black hole or naked singularity. Then, we calculate thermodynamics quantities and conserved quantities, and show that they satisfy the first law of thermodynamics. Finally, we perform a stability analysis in the canonical ensemble and show that the BTZ-like solutions are stable in the whole phase space.Comment: 5 pages, two column format, one figur