Crystal structure of methyl N-ferrocenylcarbamate

The asymmetric unit of the title compound, [Fe(C5H5)(C7H8NO2)], contains two independent molecules consisting of a ferrocenyl moiety and a nitrogen-bound methyl carbamate. These units are almost perpendicular to each other, making dihedral angles of 87.74 (9) and 87.32 (8)°. In each independent molecule, the cyclopentadienyl rings deviate slightly from an eclipsed conformation and lie virtually parallel [dihedral angles = 1.42 (15) and 0.49 (13)°]. In the crystal, molecules are linked by N—H...O hydrogen bonds into chains along the a-axis direction

Estimating the burden of malaria in Senegal : Bayesian zero-inflated binomial geostatistical modeling of the MIS 2008 data

The Research Center for Human Development in Dakar (CRDH) with the technical assistance of ICF Macro and the National Malaria Control Programme (NMCP) conducted in 2008/2009 the Senegal Malaria Indicator Survey (SMIS), the first nationally representative household survey collecting parasitological data and malaria-related indicators. In this paper, we present spatially explicit parasitaemia risk estimates and number of infected children below 5 years. Geostatistical Zero-Inflated Binomial models (ZIB) were developed to take into account the large number of zero-prevalence survey locations (70%) in the data. Bayesian variable selection methods were incorporated within a geostatistical framework in order to choose the best set of environmental and climatic covariates associated with the parasitaemia risk. Model validation confirmed that the ZIB model had a better predictive ability than the standard Binomial analogue. Markov chain Monte Carlo (MCMC) methods were used for inference. Several insecticide treated nets (ITN) coverage indicators were calculated to assess the effectiveness of interventions. After adjusting for climatic and socio-economic factors, the presence of at least one ITN per every two household members and living in urban areas reduced the odds of parasitaemia by 86% and 81% respectively. Posterior estimates of the ORs related to the wealth index show a decreasing trend with the quintiles. Infection odds appear to be increasing with age. The population-adjusted prevalence ranges from 0.12% in Thille-Boubacar to 13.1% in Dabo. Tambacounda has the highest population-adjusted predicted prevalence (8.08%) whereas the region with the highest estimated number of infected children under the age of 5 years is Kolda (13940). The contemporary map and estimates of malaria burden identify the priority areas for future control interventions and provide baseline information for monitoring and evaluation. Zero-Inflated formulations are more appropriate in modeling sparse geostatistical survey data, expected to arise more frequently as malaria research is focused on eliminatio

Pour une agriculture intelligente face au changement climatique au Sénégal: Recueil de bonnes pratiques d'adaptation et d'atténuation

Climate change is at the present time a new threat which leads to increased frequency and intensity of floods, droughts and cyclones with rising sea levels; thus placing additional demands on a situation already critical in rural areas. In Senegal, as in many countries of the Sahel, those natural phenomena result in a significant drop in harvests, water shortages and worsening health crisis which leads to consequences such as growing food insecurity of the population; thus threatening the progress achieved in regards with the fight against poverty during the last century. Indeed, many farmers live in rural areas which are characterized as low rainfall, saline soils, fragile or degraded soils and limited market access areas. The poverty in which they live, especially those of women, is often worsened by social exclusion. Such farmers are vulnerable because they depend directly on rainfall and seasons. They have little savings while supports from the government or their local authorities remain inadequate. It is essential to strengthen the adaptive capacity of vulnerable countries and communities to cope with the impacts of climate change on agriculture and food security. This document is the result of a multi-criteria analysis of experiences of tackling climate variability, drought and desertification, and land degradation on one hand, and Adaptation to Climate Change in Senegal on the other. It is carried out on the initiative of the national platform for science-policy dialogue on adaptation of agriculture and food security to climate change (C-CASA) for capacity building and informed decision making for adaptation to climate change. This work has received technical and financial support from CCAFS Program (www.ccafs.cgiar.org). It is intended for the use of field workers in the area of adaptation to climate change. It also serves as technologies and tools guide to adapt to climate change impacts in the area of agriculture and food security. The manual is based primarily on (1) both the institutional and peasant experiences of the actors; (2) the recommendations of the reports of the Inter-governmental Panel on Climate Change (IPCC); (3) the procedures manual for assessing climate change impacts and adaptation strategies; (4) the results of development projects and applied research. This is a collection that comes as a complement to other initiatives in the country and ongoing operations which provide practical examples of using the technological options for successful implementation of projects and programs and for the definition of agricultural policies in the Sahel

Epidemiology of snakebites in Kedougou region (eastern Senegal) : comparison of various methods for assessment of incidence and mortality

Background: Although considered a public health issue in Senegal, the actual incidence and mortality from snakebite are not known. In the present study, an epidemiological survey was carried out in Kedougou region, southeastern Senegal, where envenomations, particularly by Echisocellatus, are frequent and severe. Methods: Three sources of data were used: records from health centers and reports by health professionals; traditional healers; and household surveys. Results: The annual incidence and mortality provided by health centers were 24.4 envenomations and 0.24 deaths per 100,000 population, respectively. The annual incidence recorded by traditional healers was 250 bites per 100,000 inhabitants, but the number of deaths was unknown. Finally, the household surveys reported an annual incidence of 92.8 bites per 100,000 inhabitants and an annual mortality rate of 2.2 deaths per 100,000 inhabitants. The differences in incidence and mortality between the different methods were explained by significant bias, resulting in particular from the complex patient's healthcare-seeking behavior. The incidence provided by health records should be used to specify the immediate quantitative requirements of antivenoms and places where they should be available first. Conclusion: Mandatory reporting of cases would improve the management of envenomation by simplifying epidemiological surveys. Patients' preference for traditional medicine should prompt health authorities to urge traditional healers to refer patients to health centers according to defined clinical criteria (mainly edema and bleeding or neurotoxic symptoms). Finally, household surveys were likely to reflect the actual epidemiological situation. Poison Control Center of Senegal should continue its work to sensitize stakeholders and train health staff

Segregation Distortions in an Interspecific Cotton Population issued from the [(Gossypium hirsutum x G. raimondii)² x G. sturtianum] Hybrid

The segregation ratio of 10 Gossypium sturtianum specific SSR markers belonging to linkage groups c2-c14, c3-c17, and c6-c25 was analysed in the BC2S6 progeny of the [G. hirsutum x G. raimondii)² x G. sturtianum] (HRS) hybrid; based on chi-square test. All the marker loci tested were associated with skewed allele frequencies (P<0.001) showing a strong SD with a zygotic selection. The possible causes and consequences of this massive segregation distortion are discussed

Candidate genes that may be responsible for the unusual resistances exhibited by Bacillus pumilus SAFR-032 spores

The spores of several Bacillus species, including Bacillus pumilus SAFR-032 and B. safensis FO-36b, which were isolated from the spacecraft assembly facility at NASA's Jet Propulsion Laboratory, are unusually resistant to UV radiation and hydrogen peroxide. In order to identify candidate genes that might be associated with these resistances, the whole genome of B. pumilus SAFR-032, and the draft genome of B. safensis FO-36b were compared in detail with the very closely related type strain B. pumilus ATCC7061(T). 170 genes are considered characteristic of SAFR-032, because they are absent from both FO-36b and ATCC7061(T). Forty of these SAFR-032 characteristic genes are entirely unique open reading frames. In addition, four genes are unique to the genomes of the resistant SAFR-032 and FO-36b. Fifty three genes involved in spore coat formation, regulation and germination, DNA repair, and peroxide resistance, are missing from all three genomes. The vast majority of these are cleanly deleted from their usual genomic context without any obvious replacement. Several DNA repair and peroxide resistance genes earlier reported to be unique to SAFR-032 are in fact shared with ATCC7061(T) and no longer considered to be promising candidates for association with the elevated resistances. Instead, several SAFR-032 characteristic genes were identified, which along with one or more of the unique SAFR-032 genes may be responsible for the elevated resistances. These new candidates include five genes associated with DNA repair, namely, BPUM_0608 a helicase, BPUM_0652 an ATP binding protein, BPUM_0653 an endonuclease, BPUM_0656 a DNA cytosine-5- methyltransferase, and BPUM_3674 a DNA helicase. Three of these candidate genes are in immediate proximity of two conserved hypothetical proteins, BPUM_0654 and BPUM_0655 that are also absent from both FO-36b and ATCC7061(T). This cluster of five genes is considered to be an especially promising target for future experimental work

Water stress induces overexpression of superoxide dismutases that contribute to the protection of cowpea plants against oxidative stress

Water stress is known to induce active oxygen species in plants. The accumulation of these harmful species must be prevented by plants as rapidly as possible to maintain growth and productivity. The aim of this study was to determine the effect of water stress on superoxide dismutase isozymes (SOD, EC 1.15.1.1.) in two cowpea cultivars [Vigna unguiculata L. Walp., cv. Bambey 21 (B21) and cv. TN88-63]. Plants were submitted to water stress by withholding water supply and the expression of SOD was characterized during stress induction. In the same time, photosynthesis characteristics were determinedthrough the measurement of the quantum yield of PS II photochemistry and the energy absorption rate per reaction centre. Results show how water stress regulates the synthesis and the activity of superoxide dismutase isoforms and how these enzymes contribute to protect photosynthesis against the damageable effects of superoxide radicals in cowpea. Increased MnSOD and FeSOD activity and concentration were shown to be induced by water stress and associated with protection of photosystem II photochemistry and whole plant growth against oxidative stress in these plants. On the contrary, plants unable to express high MnSOD and/or FeSOD isoforms showed more sensitivity to water stress