Measurement of horizontal air showers with the Auger Engineering Radio Array

The Auger Engineering Radio Array (AERA), at the Pierre Auger Observatory in Argentina, measures the radio emission of extensive air showers in the 30-80 MHz frequency range. AERA consists of more than 150 antenna stations distributed over 17 km$^2$. Together with the Auger surface detector, the fluorescence detector and the under-ground muon detector (AMIGA), AERA is able to measure cosmic rays with energies above 10$^{17}$ eV in a hybrid detection mode. AERA is optimized for the detection of air showers up to 60$^{\circ}$ zenith angle, however, using the reconstruction of horizontal air showers with the Auger surface array, very inclined showers can also be measured. In this contribution an analysis of the AERA data in the zenith angle range from 62$^{\circ}$ to 80$^{\circ}$ will be presented. CoREAS simulations predict radio emission footprints of several km$^2$ for horizontal air showers, which are now confirmed by AERA measurements. This can lead to radio-based composition measurements and energy determination of horizontal showers in the future and the radio detection of neutrino induced showers is possible.Comment: To be published in the Proceedings of the ARENA2016 conference, Groningen, The Netherland

One Hundred Years of Observations of the Be Star HDE 245770 (the X-ray Binary A0535+26/V725 Tau): The End of an Active Phase

UBV observations of the X-ray binary system A0535+26/V725 Tau at the Crimean Station of the Sternberg Astronomical Institute in 1980-1998 are presented. Based on our and published data, we analyze the photometric history of the star from 1898.Comment: Translated from Pis'ma Astronomicheskii Zhurnal, Vol. 26, No. 1, 2000, pp. 13-2

High-dispersion spectroscopic monitoring of the Be/X-ray binary A0535+26/V725 Tau I: The long-term profile variability

We report on optical high-dispersion spectroscopic monitoring observations of the Be/X-ray binary A0535+26/V725 Tau, carried out from November 2005 to March 2009. The main aim of these monitoring observations is to study spectral variabilities in the Be disc, on both the short (a week or so) and long (more than hundreds of days) timescales, by taking long-term frequent observations. Our four-year spectroscopic observations indicate that the V/R ratio, i.e., the relative intensity of the violet (V) peak to the red (R) one, of the double-peaked H-alpha line profile varies with a period of 500 days. The H-beta line profile also varies in phase with the H-alpha profile. With these observations covering two full cycles of the V/R variability, we reconstruct the 2-D structure of the Be disc by applying the Doppler tomography method to the H-alpha and H-beta emission line profiles, using a rigidly rotating frame with the V/R variability period. The resulting disc structure reveals non-axisymmetric features, which can be explained by a one-armed perturbation in the Be disc. It is the first time that an eccentric disc structure is directly detected by using a method other than the interferometric one.Comment: (10 pages, 9 figures, accepted to MNRAS

Subarachnoid haemorrhage with negative initial neurovascular imaging: a systematic review and meta-analysis

Abstract: Background: In patients with spontaneous subarachnoid haemorrhage (SAH), a vascular cause for the bleed is not always found on initial investigations. This study aimed to systematically evaluate the delayed investigation strategies and clinical outcomes in these cases, often described as “non-aneurysmal” SAH (naSAH). Methods: A systematic review was performed in concordance with the PRISMA checklist. Pooled proportions of primary outcome measures were estimated using a random-effects model. Results: Fifty-eight studies were included (4473 patients). The cohort was split into perimesencephalic naSAH (PnaSAH) (49.9%), non-PnaSAH (44.7%) and radiologically negative SAH identified on lumbar puncture (5.4%). The commonest initial vascular imaging modality was digital subtraction angiography. A vascular abnormality was identified during delayed investigation in 3.9% [95% CI 1.9–6.6]. There was no uniform strategy for the timing or modality of delayed investigations. The pooled proportion of a favourable modified Rankin scale outcome (0–2) at 3–6 months following diagnosis was 92.0% [95% CI 86.0–96.5]. Complications included re-bleeding (3.1% [95% CI 1.5–5.2]), hydrocephalus (16.0% [95% CI 11.2–21.4]), vasospasm (9.6% [95% CI 6.5–13.3]) and seizure (3.5% [95% CI 1.7–5.8]). Stratified by bleeding pattern, we demonstrate a higher rate of delayed diagnoses (13.6% [95% CI 7.4–21.3]), lower proportion of favourable functional outcome (87.2% [95% CI 80.1–92.9]) and higher risk of complications for non-PnaSAH patients. Conclusion: This study highlights the heterogeneity in delayed investigations and outcomes for patients with naSAH, which may be influenced by the initial pattern of bleeding. Further multi-centre prospective studies are required to clarify optimal tailored management strategies for this heterogeneous group of patients

Human rhinoviruses enter and induce proliferation of B lymphocytes

Background: Human rhinoviruses (HRVs) are one of the main causes of virus-induced asthma exacerbations. Infiltration of B lymphocytes into the subepithelial tissue of the lungs has been demonstrated during rhinovirus infection in allergic individuals. However, the mechanisms through which HRVs modulate the immune responses of monocytes and lymphocytes are not yet well described. Objective: To study the dynamics of virus uptake by monocytes and lymphocytes, and the ability of HRVs to induce the activation of in vitro-cultured human peripheral blood mononuclear cells. Methods: Flow cytometry was used for the enumeration and characterization of lymphocytes. Proliferation was estimated using 3H-thymidine or CFSE labeling and ICAM-1 blocking. We used bead-based multiplex assays and quantitative PCR for cytokine quantification. HRV accumulation and replication inside the B lymphocytes was detected by a combination of in situ hybridization (ISH), immunofluorescence, and PCR for positive-strand and negative-strand viral RNA. Cell images were acquired with imaging flow cytometry. Results: By means of imaging flow cytometry, we demonstrate a strong and quick binding of HRV types 16 and 1B to monocytes, and slower interaction of these HRVs with CD4+ T cells, CD8+ T cells, and CD19+ B cells. Importantly, we show that HRVs induce the proliferation of B cells, while the addition of anti-ICAM-1 antibody partially reduces this proliferation for HRV16. We prove with ISH that HRVs can enter B cells, form their viral replication centers, and the newly formed virions are able to infect HeLa cells. In addition, we demonstrate that similar to epithelial cells, HRVs induce the production of pro-inflammatory cytokines in PBMCs. Conclusion: Our results demonstrate for the first time that HRVs enter and form viral replication centers in B lymphocytes and induce the proliferation of B cells. Newly formed virions have the capacity to infect other cells (HeLa). These findings indicate that the regulation of human rhinovirus-induced B-cell responses could be a novel approach to develop therapeutics to treat the virus-induced exacerbation of asthma.</p

Clonal diversity and conservation genetics of the medicinal plant Carapichea ipecacuanha (Rubiaceae)

The roots of the understorey shrub Carapichea ipecacuanha (ipecac) have medicinal properties, and the uprooting of wild plants has supplied most of the world demand for this species. Although under severe population decline, C. ipecacuanha lacks legal protection. In the wild, the aerial stems of ipecac clump together to form clusters with well-defined borders. Cluster size may range from several to hundreds of aerial stems. To investigate the extent of clonality among aerial stems in ipecac clusters, we sampled 50 wild clusters (a total of 291 aerial stems) and screened them with 89 inter-simple sequence repeat (ISSR) markers. The 291 aerial stems were grouped into 42 putative clones. The clonal groups generally consisted of aerial stems from the same cluster, and there was little or no genetic differentiation among aerial stems at the cluster level. These findings suggest that strategies designed to conserve ipecac in situ should not rely upon census data, which are based on the number of aerial stems per cluster and the number of clusters per population, because such data greatly underestimate the species effective population size and genetic diversity. Our results also indicate that this species needs protection at a federal level

Environmental Costs of Government-Sponsored Agrarian Settlements in Brazilian Amazonia

Brazil has presided over the most comprehensive agrarian reform frontier colonization program on Earth, in which ~1.2 million settlers have been translocated by successive governments since the 1970's, mostly into forested hinterlands of Brazilian Amazonia. These settlements encompass 5.3% of this ~5 million km2 region, but have contributed with 13.5% of all land conversion into agropastoral land uses. The Brazilian Federal Agrarian Agency (INCRA) has repeatedly claimed that deforestation in these areas largely predates the sanctioned arrival of new settlers. Here, we quantify rates of natural vegetation conversion across 1911 agrarian settlements allocated to 568 Amazonian counties and compare fire incidence and deforestation rates before and after the official occupation of settlements by migrant farmers. The timing and spatial distribution of deforestation and fires in our analysis provides irrefutable chronological and spatially explicit evidence of agropastoral conversion both inside and immediately outside agrarian settlements over the last decade. Deforestation rates are strongly related to local human population density and road access to regional markets. Agrarian settlements consistently accelerated rates of deforestation and fires, compared to neighboring areas outside settlements, but within the same counties. Relocated smallholders allocated to forest areas undoubtedly operate as pivotal agents of deforestation, and most of the forest clearance occurs in the aftermath of government-induced migration

Методичні рекомендації

Тактика самозахисту та особистої безпеки працівників Національної поліції України : метод. рек. / [уклад.: Бортник С. М., Моргунов О. А., Артем'єв В. О., Хомко І. Г.] ; МВС України, Харків. нац. ун-т внутр. справ, Каф. спец. фіз. підготовки ф-ту № 2; за заг. ред. В. В. Сокуренка. Харків : ХНУВС, 2017. 136 с. : іл.Методичні рекомендації мають практично-прикладний характер, якій відображено в чіткій послідовності викладеного матеріалу, з урахуванням сучасної нормативної бази. Представлено модель застосування сили, яка є допомогою у розумінні принципів застосування заходів поліцейського примусу та співвідношення обраного заходу загрозі тощо. Рекомендації будуть корисними для викладачів та інструкторів з особистої безпеки, при плануванні та підготовці до проведення практичних занять та занять у системі службової підготовки особового складу співробітників Національної поліції України.Methodological recommendations are of a practical-applied nature, which is reflected in a clear sequence of the material presented, taking into account the modern regulatory framework. A model of the use of force is presented, which is an aid in understanding the principles of the use of police coercion measures and the ratio of the chosen means of threat, etc. The recommendations will be useful for teachers and instructors on personal safety, when planning and preparing for practical classes and classes in the service system. training of personnel of the National Police of Ukraine.Методические рекомендации имеют практически-прикладной характер, который отражен в четкой последовательности изложенного материала, с учетом современной нормативной базы. Представлена модель применения силы, которая является помощью в понимании принципов применения мер полицейского принуждения и соотношения избранного средства угрозы и т. п. Рекомендации будут полезны для преподавателей и инструкторов по личной безопасности, при планировании и подготовке к проведению практических занятий и занятий в системе служебной подготовки личного состава сотрудников Национальной полиции Украины

An Indication of Anisotropy in Arrival Directions of Ultra-high-energy Cosmic Rays through Comparison to the Flux Pattern of Extragalactic Gamma-Ray Sources

A new analysis of the data set from the Pierre Auger Observatory provides evidence for anisotropy in the arrival directions of ultra-high-energy cosmic rays on an intermediate angular scale, which is indicative of excess arrivals from strong, nearby sources. The data consist of 5514 events above 20 EeV with zenith angles up to 80 degrees. recorded before 2017 April 30. Sky models have been created for two distinct populations of extragalactic gamma-ray emitters: active galactic nuclei from the second catalog of hard Fermi-LAT sources (2FHL) and starburst galaxies from a sample that was examined with Fermi-LAT. Flux-limited samples, which include all types of galaxies from the Swift-BAT and 2MASS surveys, have been investigated for comparison. The sky model of cosmic-ray density constructed using each catalog has two free parameters, the fraction of events correlating with astrophysical objects, and an angular scale characterizing the clustering of cosmic rays around extragalactic sources. A maximum-likelihood ratio test is used to evaluate the best values of these parameters and to quantify the strength of each model by contrast with isotropy. It is found that the starburst model fits the data better than the hypothesis of isotropy with a statistical significance of 4.0 sigma, the highest value of the test statistic being for energies above 39 EeV. The three alternative models are favored against isotropy with 2.7 sigma-3.2 sigma significance. The origin of the indicated deviation from isotropy is examined and prospects for more sensitive future studies are discussed