Influence of initial fixation position in scene viewing

During scene perception our eyes generate complex sequences of fixations. Predictors of fixation locations are bottom-up factors like luminance contrast, top-down factors like viewing instruction, and systematic biases like the tendency to place fixations near the center of an image. However, comparatively little is known about the dynamics of scanpaths after experimental manipulation of specific fixation locations. Here we investigate the influence of initial fixation position on subsequent eye-movement behavior on an image. We presented 64 colored photographs to participants who started their scanpaths from one of two experimentally controlled positions in the right or left part of an image. Additionally, we computed the images' saliency maps and classified them as balanced images or images with high saliency values on either the left or right side of a picture. As a result of the starting point manipulation, we found long transients of mean fixation position and a tendency to overshoot to the image side opposite to the starting position. Possible mechanisms for the generation of this overshoot were investigated using numerical simulations of statistical and dynamical models. We conclude that inhibitory tagging is a viable mechanism for dynamical planning of scanpaths.Comment: 34 pages with 10 figures submitted to Vision Research. Reviews Received on June 8th, 2016 (Minor Revision). Updated Version will be uploaded within the year 201

Construction and application of a questionnaire for the social scientific investigation of environmental noise effects

A social psychological questionnair has been developed to study the effects of environmental noise and was applied to 636 people living in 19 different areas of Hamburg. The theoretical foundations and the statistical means employed in its development are described. Four main reactions to noise are isolated statistically, and it is determined that these are moderated by several intervening variables, chief of which are coping capacity for noise, the perceived dangerousness of the noise souce, other daily loads and the individual's liability

Near-Infrared Studies of V1280 Sco (Nova Scorpii 2007)

We present spectroscopic and photometric results of Nova V1280 Sco which was discovered in outburst in early 2007 February. The large number of spectra obtained of the object leads to one of the most extensive, near-infrared spectral studies of a classical nova. The spectra evolve from a P-Cygni phase to an emission-line phase and at a later stage is dominated by emission from the dust that formed in this nova. A detailed model is computed to identify and study characteristics of the spectral lines. Inferences from the model address the vexing question of which novae have the ability to form dust. It is demonstrated, and strikingly corroborated with observations, that the presence of lines in the early spectra of low-ionization species like Na and Mg - indicative of low temperature conditions - appear to be reliable indicators that dust will form in the ejecta. It is theoretically expected that mass loss during a nova outburst is a sustained process. Spectroscopic evidence for such a sustained mass loss, obtained by tracing the evolution of a P-Cygni feature in the Brackett gamma line, is presented here allowing a lower limit of 25-27 days to be set for the mass-loss duration. Photometric data recording the nova's extended 12 day climb to peak brightness after discovery is used to establish an early fireball expansion and also show that the ejection began well before maximum brightness. The JHK light curves indicate the nova had a fairly strong second outburst around 100 days after the first.Comment: Accepted in MNRAS. The paper contains 8 figures and 4 tables. Few typographical errors were correcte

Eclipsing Binaries in the OGLE Variable Star Catalog. IV. The Pre-Contact, Equal-Mass Systems

We used the database of eclipsing binaries detected by the OGLE microlensing project in the pencil-beam search volume toward Baade's Window to define a sample of 74 detached, equal-mass, main-sequence binary stars with short orbital periods in the range 0.19<P<8 days. The logarithmic slope of the period distribution, logN propto (-0.8 pm 0.2) logP, was used to infer the angular-momentum-loss (AML) efficiency for the late, rapidly-rotating members of close binaries. It is very likely that the main cause of the negative slope is a discovery selection bias that progressively increases with the orbital period length. Assuming a power-law dependence for the correction for the bias: bias propto -C logP (with C ge 0), the AML braking-efficiency exponent alpha in dH/dt = P^-alpha can take any value alpha = (-1.1 pm 0.2) + C. Very simple considerations of discovery biases suggest C simeq 4/3, which would give an AML braking law very close to the "saturated" one, with no dependence on the period. However, except for plausibility arguments, we have no firm data to support this estimate of C, so that alpha remains poorly constrained. The results signal the utmost importance of the detection bias evaluation for variable star databases used in analyses similar to the one presented in this study.Comment: accepted by AJ, October 1999. AASTEX-4. 9 PS figures and 3 table

Significant association of a M129V independent polymorphism in the 5\prime UTR of the PRNP gene with sporadic Creutzfeldt-Jakob disease in a large German case-control study

Background: A single nucleotide polymorphism (SNP) in the coding region of the prion protein gene (PRNP) at codon 129 has been repeatedly shown to be an associated factor to sporadic Creutzfeldt-Jakob disease (sCJD), but additional major predisposing DNA variants for sCJD are still unknown. Several previous studies focused on the characterisation of polymorphisms in PRNP and the prion-like doppel gene (PRND), generating contradictory results on relatively small sample sets. Thus, extensive studies are required for validation of the polymorphisms in PRNP and PRND.Methods: We evaluated a set of nine SNPs of PRNP and one SNP of PRND in 593 German sCJD patients and 748 German healthy controls. Genotyping was performed using MALDI-TOF mass spectrometry.Results: In addition to PRNP 129, we detected a significant association between sCJD and allele frequencies of six further PRNP SNPs. No significant association of PRND T174M with sCJD was shown. We observed strong linkage disequilibrium within eight adjacent PRNP SNPs, including PRNP 129. However, the association of sCJD with PRNP 1368 and PRNP 34296 appeared to be independent on the genotype of PRNP 129. We additionally identified the most common haplotypes of PRNP to be over-represented or under-represented in our cohort of patients with sCJD.Conclusion: Our study evaluated previous findings of the association of SNPs in the PRNP and PRND genes in the largest cohorts for association study in sCJD to date, and extends previous findings by defining for the first time the haplotypes associated with sCJD in a large population of the German CJD surveillance study

Epidemiological and clinical features of travel-associated cryptosporidiosis

ABSTRACTData concerning the clinical and epidemiological features of travel-associated cryptosporidiosis are lacking. In order to investigate the impact of this disease on travellers' health, a retrospective study was conducted at the Institute of Tropical Medicine, Berlin. In total, 57 cryptosporidial infections were identified between 2000 and 2004, resulting in a prevalence of 2.9% in patients with travel-associated diarrhoea. Travel to south-central Asia, especially India, was associated with a higher prevalence of infection than was travel to other destinations. Clinically, the disease resembled giardiasis, but fever and arthralgias seemed to occur more frequently

Perspectives Pathways to clean hands: highlights of successful hand hygiene implementation

infections and estimates of vaccine effectiveness i

The impact of the demographic transition on dengue in Thailand: Insights from a statistical analysis and mathematical modeling

Background: An increase in the average age of dengue hemorrhagic fever (DHF) cases has been reported in Thailand. The cause of this increase is not known. Possible explanations include a reduction in transmission due to declining mosquito populations, declining contact between human and mosquito, and changes in reporting. We propose that a demographic shift toward lower birth and death rates has reduced dengue transmission and lengthened the interval between large epidemics. Methods and Findings: Using data from each of the 72 provinces of Thailand, we looked for associations between force of infection (a measure of hazard, defined as the rate per capita at which susceptible individuals become infected) and demographic and climactic variables. We estimated the force of infection from the age distribution of cases from 1985 to 2005. We find that the force of infection has declined by 2% each year since a peak in the late 1970s and early 1980s. Contrary to recent findings suggesting that the incidence of DHF has increased in Thailand, we find a small but statistically significant decline in DHF incidence since 1985 in a majority of provinces. The strongest predictor of the change in force of infection and the mean force of infection is the median age of the population. Using mathematical simulations of dengue transmission we show that a reduced birth rate and a shift in the population's age structure can explain the shift in the age distribution of cases, reduction of the force of infection, and increase in the periodicity of multiannual oscillations of DHF incidence in the absence of other changes. Conclusions: Lower birth and death rates decrease the flow of susceptible individuals into the population and increase the longevity of immune individuals. The increase in the proportion of the population that is immune increases the likelihood that an infectious mosquito will feed on an immune individual, reducing the force of infection. Though the force of infection has decreased by half, we find that the critical vaccination fraction has not changed significantly, declining from an average of 85% to 80%. Clinical guidelines should consider the impact of continued increases in the age of dengue cases in Thailand. Countries in the region lagging behind Thailand in the demographic transition may experience the same increase as their population ages. The impact of demographic changes on the force of infection has been hypothesized for other diseases, but, to our knowledge, this is the first observation of this phenomenon

Continuity of the Maximum-Entropy Inference

We study the inverse problem of inferring the state of a finite-level quantum system from expected values of a fixed set of observables, by maximizing a continuous ranking function. We have proved earlier that the maximum-entropy inference can be a discontinuous map from the convex set of expected values to the convex set of states because the image contains states of reduced support, while this map restricts to a smooth parametrization of a Gibbsian family of fully supported states. Here we prove for arbitrary ranking functions that the inference is continuous up to boundary points. This follows from a continuity condition in terms of the openness of the restricted linear map from states to their expected values. The openness condition shows also that ranking functions with a discontinuous inference are typical. Moreover it shows that the inference is continuous in the restriction to any polytope which implies that a discontinuity belongs to the quantum domain of non-commutative observables and that a geodesic closure of a Gibbsian family equals the set of maximum-entropy states. We discuss eight descriptions of the set of maximum-entropy states with proofs of accuracy and an analysis of deviations.Comment: 34 pages, 1 figur