Video advertisement as a tool for promotion of goods and services on the Internet

The article includes the researching of a video advertisement as a tool for promoting goods and services on the Internet. The focus is on video advertisement, which is placed on YouTube and Instagram. The study clarified the features of video advertisement as the main element of communication between consumers and the company. Moreover, the features, advantages and disadvantages of video advertisement have been studied. The guaranties of success of the using of video advertisement for promoting in the internet were analysed, as well as the advantages of its placement on YouTube and Instagram platforms were identified. Aspects of the impact of video advertisement from bloggers and their impact on subscribers in general have been studied

Order-Revealing Encryption: File-Injection Attack and Forward Security

Order-preserving encryption (OPE) and order-revealing encryption (ORE) are among the core ingredients for encrypted database (EDB) systems as secure cloud storage. In this work, we study the leakage of OPE and ORE and their forward security. We propose generic yet powerful file-injection attacks (FIAs) on OPE/ORE, aimed at the situations of possessing order by and range queries. The FIA schemes only exploit the ideal leakage of OPE/ORE (in particular, no need of data denseness or frequency). We also improve its efficiency with the frequency statistics using a hierarchical idea such that the high-frequency values will be recovered more quickly. Compared with other attacks against OPE/ORE proposed in recent years, our FIA attacks rely upon less demanding conditions and are more effective for attacking the systems with the function of data sharing or transferring like encrypted email system. We executed some experiments on real datasets to test the performance, and the results show that our FIA attacks can cause an extreme hazard on most of the existing OPE and ORE schemes with high efficiency and 100% recovery rate. In order to resist the perniciousness of FIA, we propose a practical compilation framework for achieving forward secure ORE. The compilation framework only uses some simple cryptographical tools like pseudo-random function, hash function and trapdoor permutation. It can transform most of the existing OPE/ORE schemes into forward secure ORE schemes, with the goal of minimizing the extra burden incurred on computation and storage. We also present its security proof and execute some experiments to analyze its performance

As peculiaridades do mercado de serviços turísticos e hoteleiros na moderna rússia

The purpose of this article is to determine the role of tourism in socio-economic development of the economy at all levels of its development, as well as the identification of the functioning of the market of tourist and hotel services in the current economic conditions. Main research methods are: analysis and synthesis, classification and comparison. Based on the results of the analysis of the market of hotel services of Russia, we can conclude that the infrastructure of the hotel industry is not sufficiently developed.Our research highlighted a number of factors determining the growth of technical and material base of Russia in the sphere of tourism and hotel services: the development of existing cities and the increase in the number of new cities, the growth of industry, culture and art, science, improvement of the material welfare of the population, domestic tourism.These factors should be the conditions for the development of domestic tourism, exchange, increase in the number of business travelers and vacationers.El propósito de este artículo es determinar el papel del turismo en el desarrollo socioeconómico de la economía en todos los niveles de su desarrollo, así como la identificación del funcionamiento del mercado de servicios turísticos y hoteleros en las condiciones económicas actuales. Los principales métodos de investigación son: análisis y síntesis, clasificación y comparación. Sobre la base de los resultados del análisis del mercado de servicios hoteleros de Rusia, podemos concluir que la infraestructura de la industria hotelera no está suficientemente desarrollada.Nuestra investigación destacó una serie de factores que determinan el crecimiento de la base técnica y material de Rusia en el ámbito del turismo y los servicios hoteleros: el desarrollo de las ciudades existentes y el aumento del número de nuevas ciudades, el crecimiento de la industria, la cultura y el arte. Ciencia, mejora del bienestar material de la población, turismo interno. Estos factores deben ser las condiciones para el desarrollo del turismo interno, el intercambio, el aumento en el número de viajeros de negocios y vacacionistas.O objetivo deste artigo é determinar o papel do turismo no desenvolvimento socioeconômico da economia em todos os níveis de seu desenvolvimento, bem como a identificação do funcionamento do mercado de turismo e serviços hoteleiros nas condições econômicas atuais. Os principais métodos de pesquisa são: análise e síntese, classificação e comparação. Com base nos resultados da análise do mercado russo de serviços hoteleiros, podemos concluir que a infraestrutura da indústria hoteleira não está suficientemente desenvolvida.Nossa pesquisa destacou uma série de fatores que determinam o crescimento da base técnica e material da Rússia no campo do turismo e serviços de hotelaria: o desenvolvimento das cidades existentes e o aumento do número de novas cidades, o crescimento da indústria, Cultura e arte Ciência, melhoria do bem-estar material da população, turismo interno. Esses fatores devem ser as condições para o desenvolvimento do turismo doméstico, o intercâmbio, o aumento do número de viajantes de negócios e turistas

Mesenchymal stromal cells of bone marrow and azathioprine in Crohn's disease therapy

Crohn's disease (CD) is a chronic, recurring disease of the gastrointestinal tract of unclear etiology. One of the new approaches to CD therapy is the use of the possibilities of stem cells, in particular, mesenchymal stromal cells (MSCs). Currently, the use of MSC in clinical practice for the treatment of chronic inflammatory and autoimmune diseases is being studied in patients who receive concomitant therapy with other immunomodulatory medications. Aim. To evaluate the effectiveness of MSCs therapy in patients with CD receiving azathioprine (AZA). Materials and methods. The study included 34 patients with inflammatory (luminal) form of CD. The 1st group of patients (n=15) received anti-inflammatory therapy using MSCs culture in combination with AZA. The 2nd group (n=19) received MSCs without AZA. The severity of the attack was assessed in points in accordance with the of Crohn's disease activity index (CDAI). Immunoglobulins (IgA, IgG, IgM), interleukins (IL) 1β, 4, 10, tumor necrosis factor-α (TNF-α), interferon-γ (INF-γ), transforming growth factor-1β (TGF-1β), C-reactive protein (CRP), platelets and erythrocyte sedimentation rate (ESR) at 2, 6 and 12 months from the beginning of MSCs therapy. Results. The initial mean CDAI in the 1st group was 337.6±17.1 points, in the 2nd group - 332.7±11.0 points (p=0.3). In both groups of patients there was a significant decrease in CDAI after 2 months. From the beginning of therapy MSCs: in the 1st group to 118.9±12.4 points, in the 2nd - 120.3±14.1 points (p=0.7), after 6 months - 110.3±11.1 and 114.3±11.8 points (p=0.8), respectively. After 12 months CDAI in the 1st group was 99.9±10.8 points, in the 2nd group it was 100.6±12.1 points (p=0.8). The level of IgA, IgG, IgM was significantly lower in the group of patients with a longer history of the disease and long-term ASA. After the introduction of MSC in both groups of patients with BC, there was a tendency for the growth of pro - and anti-inflammatory cytokines, with a significantly lower level of pro-inflammatory cytokines - INF-γ, TNF-α, IL-1β - in the 1st group, indicating potentiation of the immunosuppressive effect of MSCs and AZA, which provides a more pronounced anti-inflammatory effect. Conclusion. Transplantation of MSCs promotes an increase in the serum of patients with CD initially reduced concentration of IG, cytokines and restoring their balance as the onset of clinical remission. The combination with AZA has a more pronounced anti-inflammatory effect

Parameter-Hiding Order Revealing Encryption

Order-revealing encryption (ORE) is a popular primitive for outsourcing encrypted databases, as it allows for efficiently performing range queries over encrypted data. Unfortunately, a series of works, starting with Naveed et al. (CCS 2015), have shown that when the adversary has a good estimate of the distribution of the data, ORE provides little protection. In this work, we consider the case that the database entries are drawn identically and independently from a distribution of known shape, but for which the mean and variance are not (and thus the attacks of Naveed et al. do not apply). We define a new notion of security for ORE, called parameter-hiding ORE, which maintains the secrecy of these parameters. We give a construction of ORE satisfying our new definition from bilinear maps

Masking Fuzzy-Searchable Public Databases

We introduce and study the notion of keyless fuzzy search (KlFS) which allows to mask a publicly available database in such a way that any third party can retrieve content if and only if it possesses some data that is “close to” the encrypted data – no cryptographic keys are involved. We devise a formal security model that asks a scheme not to leak any information about the data and the queries except for some well-defined leakage function if attackers cannot guess the right query to make. In particular, our definition implies that recovering high entropy data protected with a KlFS scheme is costly. We propose two KlFS schemes: both use locality-sensitive hashes (LSH), cryptographic hashes and symmetric encryption as building blocks. The first scheme is generic and works for abstract plaintext domains. The second scheme is specifically suited for databases of images. To demonstrate the feasibility of our KlFS for images, we implemented and evaluated a prototype system that supports image search by object similarity on a masked database

The first combined russian experience of using perampanel in children and adolescents with epilepsy in everyday clinical practice

Background. Real world data help to provide more information on the effects and tolerability of therapy. However, data on the use of perampanel in Russian population of children remain limited. aim. To conduct a retrospective analysis of perampanel efficacy and tolerability in children and adolescents with epilepsy in real clinical practice. Materials and methods. A total of 106 children aged 4–18 years receiving perampanel as part of combination therapy for epilepsy were observed at 18 centers. Seizure frequency at 1–3, after 6 and 12 months of treatment, presence and type of adverse events (AEs) were analyzed. The main assessed efficacy parameters were seizure control, significant (≥50 %) decrease in seizure frequency. All other outcomes (<50 % decrease, no change or increased seizure frequency) were considered to be no effect. The assessed safety parameters were the percentage of patients with or without AEs and the percentage of perampanel withdrawals due to AEs. results. We defined 3 age groups for comparison: children 4–6, 7–11 and 12–17 years old. Perampanel efficacy was 69 % (seizure control – 23.6 %, ≥50 % decrease in seizure frequency – 45.3 %). The mean duration of the effect was 7.3 ± 4.1 months. No significant difference in efficacy between age groups was found. However, some greater efficacy of perampanel was noted in adolescents: absence of effect in the form of remission or significant decrease in seizures frequency was noted only in 25.5 %, with 40 % in children 4–11 years old. Among those with inefficacy, 3.8 % reported seizure aggravation. AEs occurred in only 23 % of patients, with the least frequent occurrence in adolescents (11.8 %) and the most frequent in children aged 7–11 years (40 %). The most frequent AEs was sluggishness and/or drowsiness. Discontinuation of perampanel due to AEs was required in 7.6 %. Conclusion. Perampanel has demonstrated high efficacy and good tolerability in real clinical practice among children from 4 years of age and adolescents with partial (focal) and secondary generalized seizures. The AEs that developed were not serious and very rarely led to withdrawal of the therapy. The results are comparable to those of phase III studies and previous real-world data. The usage of perampanel in children with primary generalized seizures should be further investigated. © 2022 ABV-Press Publishing House. All rights reserved.EisaiО.А. Рахманина / O.A. Rakhmanina: https://orcid.org/0000-0001-9218-2531 И.В. Волков / I.V. Volkov: https://orcid.org/0000-0002-7816-7535 О.К. Волкова / O.K. Volkova: https://orcid.org/0000-0003-3314-3895 Ю.А. Александров / Yu.A. Aleksandrov: https://orcid.org/0000-0003-3887-5219 М.В. Бархатов / M.V. Barkhatov: https://orcid.org/0000-0002-6372-4677 И.С. Бахтин / I.S. Bakhtin: https://orcid.org/0000-0003-3600-687X Г.М. Бережная / G.M. Berezhnaya: https://orcid.org/0000-0003-3917-422X А.Ю. Карась / A.Yu. Karas: https://orcid.org/0000-0001-9089-9627 Д.В. Морозов / D.V. Morozov: https://orcid.org/0000-0003-4389-9143 И.С. Бахтин / I.S. Bakhtin: https://orcid.org/0000-0003-3600-687X Т.Р. Томенко / T.R. Tomenko: https://orcid.org/0000-0002-0652-1996 Ж.М. Цоцонава / Zh.M. Tsotsonava: https://orcid.org/0000-0003-3275-5099 Конфликт интересов и финансирование. Публикация подготовлена при финансовой поддержке компании «Эйсай». Авторы несут полную ответственность за содержание статьи и редакционные решения. Conflict of interest and funding. This publication was funded by Eisai. The authors are fully responsible for the content of the article and editorial decisions

Structural study of alpha-Bi2O3 under pressure

An experimental and theoretical study of the structural properties of monoclinic bismuth oxide (alpha-(BiO3)-O-2) under high pressures is here reported. Both synthetic and mineral bismite powder samples have been compressed up to 45 GPa and their equations of state have been determined with angle-dispersive x-ray diffraction measurements. Experimental results have been also compared with theoretical calculations which suggest the possibility of several phase transitions below 10 GPa. However, experiments reveal only a pressure-induced amorphization between 15 and 25 GPa, depending on sample quality and deviatoric stresses. The amorphous phase has been followed up to 45 GPa and its nature discussed.Financial support from the Spanish Consolider Ingenio 2010 Program (MALTA Project No. CSD2007-00045) is acknowledged. This work was also supported by Brazilian Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) under project 201050/2012-9, Spanish MICINN under projects MAT2010-21270-C04-01/03/04, Spanish MINECO under project CTQ2012-36253-C03-02, by Generalitat Valenciana through project GVA-ACOMP2013- 012 and from Vicerrectorado de Investigaci on dePereira, ALJ.; Errandonea, D.; Beltrán, A.; Gracia, L.; Gomis Hilario, O.; Sans, JA.; García-Domene, B.... (2013). Structural study of alpha-Bi2O3 under pressure. Journal of Physics: Condensed Matter. 25(47):475402-1-475402-12. https://doi.org/10.1088/0953-8984/25/47/475402S475402-1475402-12254

Low-Temperature Polymorphic Phase Transition in a Crystalline Tripeptide L-Ala-L-Pro-Gly·H2O Revealed by Adiabatic Calorimetry

We demonstrate application of precise adiabatic vacuum calorimetry to observation of phase transition in the tripeptide l-alanyl-l-prolyl-glycine monohydrate (APG) from 6 to 320 K and report the standard thermodynamic properties of the tripeptide in the entire range. Thus, the heat capacity of APG was measured by adiabatic vacuum calorimetry in the above temperature range. The tripeptide exhibits a reversible first-order solid-to-solid phase transition characterized by strong thermal hysteresis. We report the standard thermodynamic characteristics of this transition and show that differential scanning calorimetry can reliably characterize the observed phase transition with <5 mg of the sample. Additionally, the standard entropy of formation from the elemental substances and the standard entropy of hypothetical reaction of synthesis from the amino acids at 298.15 K were calculated for the studied tripeptide.National Institute of Biomedical Imaging and Bioengineering (U.S.) (EB-003151)National Institute of Biomedical Imaging and Bioengineering (U.S.) (EB-001960)National Institute of Biomedical Imaging and Bioengineering (U.S.) (EB-002026

Dual-Mode NIZKs from Obfuscation

Two standard security properties of a non-interactive zero-knowledge (NIZK) scheme are soundness and zero-knowledge. But while standard NIZK systems can only provide one of those properties against unbounded adversaries, dual-mode NIZK systems allow to choose dynamically and adaptively which of these properties holds unconditionally. The only known dual-mode NIZK systems are Groth-Sahai proofs (which have proved extremely useful in a variety of applications), and the FHE-based NIZK constructions of Canetti et al. and Peikert et al, which are concurrent and independent to this work. However, all these constructions rely on specific algebraic settings. Here, we provide a generic construction of dual-mode NIZK systems for all of NP. The public parameters of our scheme can be set up in one of two indistinguishable ways. One way provides unconditional soundness, while the other provides unconditional zero-knowledge. Our scheme relies on subexponentially secure indistinguishability obfuscation and subexponentially secure one-way functions, but otherwise only on comparatively mild and generic computational assumptions. These generic assumptions can be instantiated under any one of the DDH, k-LIN, DCR, or QR assumptions. As an application, we reduce the required assumptions necessary for several recent obfuscation-based constructions of multilinear maps. Combined with previous work, our scheme can be used to construct multilinear maps from obfuscation and a group in which the strong Diffie-Hellman assumption holds. We also believe that our work adds to the understanding of the construction of NIZK systems, as it provides a conceptually new way to achieve dual-mode properties