44 research outputs found
Dopant-dependent impact of Mn-site doping on the critical-state manganites: R0.6Sr0.4MnO3 (R=La, Nd, Sm, and Gd)
Versatile features of impurity doping effects on perovskite manganites,
SrMnO, have been investigated with varying the doing
species as well as the -dependent one-electron bandwidth. In
ferromagnetic-metallic manganites (=La, Nd, and Sm), a few percent of Fe
substitution dramatically decreases the ferromagnetic transition temperature,
leading to a spin glass insulating state with short-range charge-orbital
correlation. For each species, the phase diagram as a function of Fe
concentration is closely similar to that for SrMnO
obtained by decreasing the ionic radius of site, indicating that Fe doping
in the phase-competing region weakens the ferromagnetic double-exchange
interaction, relatively to the charge-orbital ordering instability. We have
also found a contrastive impact of Cr (or Ru) doping on a spin-glass insulating
manganite (=Gd). There, the impurity-induced ferromagnetic magnetization is
observed at low temperatures as a consequence of the collapse of the inherent
short-range charge-orbital ordering, while Fe doping plays only a minor role.
The observed opposite nature of impurity doping may be attributed to the
difference in magnitude of the antiferromagnetic interaction between the doped
ions.Comment: 7 pages, 6 figure
Local Ferromagnetism in Microporous Carbon with the Structural Regularity of Zeolite Y
Magnetization M(H,T) measurements have been performed on microporous carbon
(MC) with a three-dimensional nano-array structure corresponding to that of a
zeolite Y supercage. The obtained results unambiguously demonstrate the
occurrence of high-temperature ferromagnetism in MC, probably originating from
a topological disorder associated with curved graphene sheets. The results
provide evidence that the ferromagnetic behavior of MC is governed by isolated
clusters in a broad temperature range, and suggest the occurrence of
percolative-type transition with the temperature lowering. A comparative
analysis of the results obtained on MC and related materials is given.Comment: To be published in Physical Review B (2003
Proximity induced metal/insulator transition in superlattices
The far-infrared dielectric response of superlattices (SL) composed of
superconducting YBaCuO (YBCO) and ferromagnetic La%
CaMnO (LCMO) has been investigated by ellipsometry. A drastic
decrease of the free carrier response is observed which involves an unusually
large length scale of d20 nm in YBCO and d10
nm in LCMO. A corresponding suppression of metallicity is not observed in SLs
where LCMO is replaced by the paramagnetic metal LaNiO. Our data suggest
that either a long range charge transfer from the YBCO to the LCMO layers or
alternatively a strong coupling of the charge carriers to the different and
competitive kind of magnetic correlations in the LCMO and YBCO layers are at
the heart of the observed metal/insulator transition. The low free carrier
response observed in the far-infrared dielectric response of the magnetic
superconductor RuSrGdCuO is possibly related to this effect
Long range electronic phase separation in CaFe3O5
Electronic phase separation is an important feature of many correlated perovskite compounds but hasn’t been seen in other complex oxides with similar physical behaviour such as magnetite. Hong et al. find phase separation between a magnetite-like charge ordered phase and a charge averaged phase in CaFe3O5
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly
Cell-specific expression of runt-related transcription factor 2 contributes to pulmonary fibrosis.
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with limited therapeutic options and unknown etiology. IPF is characterized by epithelial cell injury, impaired cellular crosstalk between epithelial cells and fibroblasts, and the formation of fibroblast foci with increased extracellular matrix deposition (ECM). We investigated the role of runt-related transcription factor 2 (RUNX2), a master regulator of bone development that has been linked to profibrotic signaling. RUNX2 expression was up-regulated in lung homogenates from patients with IPF and in experimental bleomycin-induced lung fibrosis. The RUNX2 level correlated with disease severity as measured by decreased diffusing capacity and increased levels of the IPF biomarker, matrix metalloproteinase 7. Nuclear RUNX2 was observed in prosurfactant protein C-positive hyperplastic epithelial cells and was rarely found in myofibroblasts. We discovered an up-regulation of RUNX2 in fibrotic alveolar epithelial type II (ATII) cells as well as an increase of RUNX2-negative fibroblasts in experimental and human pulmonary fibrosis. Functionally, small interfering RNA-mediated RUNX2 knockdown decreased profibrotic ATII cell function, such as proliferation and migration, whereas fibroblasts displayed activation markers and increased ECM expression after RUNX2 knockdown. This study reveals that RUNX2 is differentially expressed in ATII cells vs. fibroblasts in lung fibrosis, which contributes to profibrotic cell function. Cell-specific targeting of RUNX2 pathways may represent a therapeutic approach for IPF
Cell‐specific expression of runt‐related transcription factor 2 contributes to pulmonary fibrosis
Energies of the delayed neutrons from U²³⁵ fission products /
Manhattan District Declassified CodeIncludes bibliographical references.Mode of access: Internet