Antidepressant medication and ocular factors in association with the need for anti-VEGF retreatment in neovascular age-related macular degeneration.

Vascular endothelial growth factor (VEGF) is a key player in the pathogenesis of neovascular age-related macular degeneration (nAMD) and is also involved in the final common pathway of antidepressant medication. This study investigated the relationship between the need for anti-VEGF retreatment in patients with nAMD and antidepressant medication, and the potential impact of ocular structural factors. Data from two identical prospective 2-year treatment protocols using ranibizumab or aflibercept in a variable-dosing regimen ('Observe-and-Plan') were analysed. Retreatment requirement was compared with antidepressant medication intake (primary outcome) and a variety of ocular factors from baseline and from month 3 response (secondary outcomes), using univariate and multivariate analyses. Of the 206 included patients (227 eyes), 19 were on antidepressant medication. Their nAMD eyes significantly more often had pigment epithelium detachment (PED, p=0.04). Multivariate analysis revealed a significant association between anti-VEGF retreatment requirement and antidepressant medication use (p=0.027), as well as thicker central retinal thickness at month 3 (p<0.0001) and month 3 PED height (p=0.001). This study provides evidence that treatment with antidepressant medication increases the anti-VEGF retreatment requirement in patients with nAMD, possibly through the interplay of antidepressant medication, depression status and VEGF levels

First experimental results of very high accuracy centroiding measurements for the neat astrometric mission

NEAT is an astrometric mission proposed to ESA with the objectives of detecting Earth-like exoplanets in the habitable zone of nearby solar-type stars. NEAT requires the capability to measure stellar centroids at the precision of 5e-6 pixel. Current state-of-the-art methods for centroid estimation have reached a precision of about 2e-5 pixel at two times Nyquist sampling, this was shown at the JPL by the VESTA experiment. A metrology system was used to calibrate intra and inter pixel quantum efficiency variations in order to correct pixelation errors. The European part of the NEAT consortium is building a testbed in vacuum in order to achieve 5e-6 pixel precision for the centroid estimation. The goal is to provide a proof of concept for the precision requirement of the NEAT spacecraft. In this paper we present the metrology and the pseudo stellar sources sub-systems, we present a performance model and an error budget of the experiment and we report the present status of the demonstration. Finally we also present our first results: the experiment had its first light in July 2013 and a first set of data was taken in air. The analysis of this first set of data showed that we can already measure the pixel positions with an accuracy of about 1e-4 pixel.Comment: SPIE conference proceeding

Апроксимація згортки розподілів Вейбулла за допомогою сплайн-експоненційних розподілів

Calculable technology of spline-exponential approximation to Weibull renewal has proposed. The comparative analysis of results of methods of approximation is conducted with the results of construction of analytical renewal function for the Weibull distribution.Предложена вычислительная технология аппроксимации свёртки распределений Вейбулла с помощью сплайн-экспоненциальных распределений. Проведён сравнительный анализ результатов методов аппроксимации с результатами построения аналитической функции распределения свёртки.Запропоновано обчислювальну технологiю апроксимацiї згортки розподiлів Вейбулла за допомогою сплайн-експоненцiйних розподілів. Проведено порівняльний аналіз результатів апроксимаційних методів з результатами побудови аналітичної функції розподілу згортки.

A detector interferometric calibration experiment for high precision astrometry

Context: Exoplanet science has made staggering progress in the last two decades, due to the relentless exploration of new detection methods and refinement of existing ones. Yet astrometry offers a unique and untapped potential of discovery of habitable-zone low-mass planets around all the solar-like stars of the solar neighborhood. To fulfill this goal, astrometry must be paired with high precision calibration of the detector. Aims: We present a way to calibrate a detector for high accuracy astrometry. An experimental testbed combining an astrometric simulator and an interferometric calibration system is used to validate both the hardware needed for the calibration and the signal processing methods. The objective is an accuracy of 5e-6 pixel on the location of a Nyquist sampled polychromatic point spread function. Methods: The interferometric calibration system produced modulated Young fringes on the detector. The Young fringes were parametrized as products of time and space dependent functions, based on various pixel parameters. The minimization of func- tion parameters was done iteratively, until convergence was obtained, revealing the pixel information needed for the calibration of astrometric measurements. Results: The calibration system yielded the pixel positions to an accuracy estimated at 4e-4 pixel. After including the pixel position information, an astrometric accuracy of 6e-5 pixel was obtained, for a PSF motion over more than five pixels. In the static mode (small jitter motion of less than 1e-3 pixel), a photon noise limited precision of 3e-5 pixel was reached

Multiwavelength campaign on Mrk 509. XIII. Testing ionized-reflection models on Mrk 509

Active Galactic Nuclei (AGN) are the most luminous persistent objects in the universe. An excess of X-ray emission below about 2 keV, called soft-excess, is very common in Type 1 AGN spectra. The origin of this feature remains debated. Originally modeled with a blackbody, there are now several possibilities to model the soft-excess, including warm Comptonization and blurred ionized reflection. In this paper, we test ionized-reflection models on Mrk 509, a bright Seyfert 1 galaxy for which we have a unique data set, in order to determine whether it can be responsible for the strong soft-excess. We use ten simultaneous XMM-Newton and INTEGRAL observations performed every four days. We present here the results of the spectral analysis, the evolution of the parameters and the variability properties of the X-ray emission. The application of blurred ionized-reflection models leads to a very strong reflection and an extreme geometry, but fails to reproduce the broad-band spectrum of Mrk 509. Two different scenarios for blurred ionized reflection are discussed: stable geometry and lamp-post configuration. In both cases we find that the model parameters do not follow the expected relations, indicating that the model is fine-tuned to fit the data without physical justification. A large, slow variation of the soft-excess without counterpart in the hard X-rays could be explained by a change in ionization of the reflector. However, such a change does not naturally follow from the assumed geometrical configuration. Warm Comptonization remains the most probable origin of the soft-excess in this object. Nevertheless, it is possible that both ionized reflection and warm Comptonization mechanisms can explain the soft-excess in all objects, one dominating the other one, depending on the physical conditions of the disk and the corona.Comment: 12 pages, A&A accepte

Anatomy of the AGN in NGC 5548: V. A clear view of the X-ray narrow emission lines

Context. Our consortium performed an extensive multi-wavelength campaign of the nearby Seyfert 1 galaxy NGC 5548 in 2013-14. The source appeared unusually heavily absorbed in the soft X-rays, and signatures of outflowing absorption were also present in the UV. He-like triplets of neon, oxygen and nitrogen, and radiative recombination continuum (RRC) features were found to dominate the soft X-ray spectrum due to the low continuum flux. Aims. Here we focus on characterising these narrow emission features using data obtained from the XMM-Newton RGS (770 ks stacked spectrum). Methods. We use SPEX for our initial analysis of these features. Self-consistent photoionisation models from Cloudy are then compared with the data to characterise the physical conditions of the emitting region. Results. Outflow velocity discrepancies within the O VII triplet lines can be explained if the X-ray narrow-line region (NLR) in NGC 5548 is absorbed by at least one of the six warm absorber components found by previous analyses. The RRCs allow us to directly calculate a temperature of the emitting gas of a few eV ($\sim10^{4}$ K), favouring photoionised conditions. We fit the data with a Cloudy model of log $\xi = 1.45 \pm 0.05$ erg cm s$^{-1}$, log $N_H = 22.9 \pm 0.4$ cm$^{-2}$ and log v$_{turb} = 2.25 \pm 0.5$ km s$^{-1}$ for the emitting gas; this is the first time the X-ray NLR gas in this source has been modelled so comprehensively. This allows us to estimate the distance from the central source to the illuminated face of the emitting clouds as $13.9 \pm 0.6$ pc, consistent with previous work.Comment: Accepted by A&A, 15 pages, 6 figure

High resolution X-ray spectroscopy of the Seyfert 1 Mrk841: insights into the warm absorber and warm emitter

The Seyfert 1 galaxy Mrk841 was observed five times between 2001 and 2005 by the XMM-Newton X-ray observatory. The source is well known for showing spectral complexity in the variable iron line and in the soft X-ray excess. This paper reports on the first study of Mrk841 soft X-ray spectrum at high spectral resolution. The availability of multiple exposures obtained by the Reflection Grating Spectrometer (RGS) cameras allows a thorough study of the complex absorption and emission spectral features in the soft X-ray band.The three combined exposures obtained in January 2001 and the two obtained in January and July 2005 were analysed using the SPEX software. We detect a two-phase warm absorber: a medium ionisation component (logxi~1.5-2.2 ergs s cm^{-1}) is responsible for a deep absorption feature in the Unresolved Transition Array of the Fe M-shell and for several absorption lines in the OVI-VIII band; a higher ionisation phase with logxi~3 ergs s cm^{-1} is required to fit absorption in the NeIX-X band. The ionisation state and the column density of the gas present moderate variation from 2001 to 2005 for both phases. The high ionisation component of the warm absorber has no effect in the Fe K band. No significant velocity shift of the absorption lines is measured in the RGS data. Remarkably, the 2005 spectra show emission features consistent with photoionisation in a high density (n_e>10^{11} cm^{-3}) gas: a prominent OVII line triplet is clearly observed in January 2005 and narrow Radiative Recombination Continua (RRC) of OVII and CVI are observed in both 2005 data sets. A broad Gaussian line around 21.7 Angstrom is also required to fit all the data sets. The derived radial distance for the emission lines seems to suggest that the photoionisation takes place within the optical Broad Line Region of the source.Comment: In press on A&A, replaced version includes language editing and typo on velocities corrected in Table

Multiwavelength campaign on Mrk 509 XIV. Chandra HETGS spectra

We present in this paper the results of a 270 ks Chandra HETGS observation in the context of a large multiwavelength campaign on the Seyfert galaxy Mrk 509. The HETGS spectrum allows us to study the high ionisation warm absorber and the Fe-K complex in Mrk 509. We search for variability in the spectral properties of the source with respect to previous observations in this campaign, as well as for evidence of ultra-fast outflow signatures. The Chandra HETGS X-ray spectrum of Mrk 509 was analysed using the SPEX fitting package. We confirm the basic structure of the warm absorber found in the 600 ks XMM-Newton RGS observation observed three years earlier, consisting of five distinct ionisation components in a multikinematic regime. We find little or no variability in the physical properties of the different warm absorber phases with respect to previous observations in this campaign, except for component D2 which has a higher column density at the expense of component C2 at the same outflow velocity (-240 km/s). Contrary to prior reports we find no -700 km/s outflow component. The O VIII absorption line profiles show an average covering factor of 0.81 +/- 0.08 for outflow velocities faster than -100 km/s, similar to those measured in the UV. This supports the idea of a patchy wind. The relative metal abundances in the outflow are close to proto-solar. The narrow component of the Fe Kalpha emission line shows no changes with respect to previous observations which confirms its origin in distant matter. The narrow line has a red wing that can be interpreted to be a weak relativistic emission line. We find no significant evidence of ultra-fast outflows in our new spectrum down to the sensitivity limit of our data.Comment: 12 pages, 9 figures, accepted for publication in Astronomy & Astrophysic