Ab Initio Calculations of the Walls Shear Strength of Carbon Nanotubes

The dependence of the energy of interwall interaction in double-walled carbon nanotubes (DWNT) on the relative position of walls has been calculated using the density functional method. This dependence is used to evaluate forces that are necessary for the relative telescopic motion of walls and to calculate the shear strength of DWNT for the relative sliding of walls along the nanotube axis and for their relative rotation about this axis. The possibility of experimental verification of the obtained results is discussed.Comment: 4 pages, 1 figur

Coulomb excitation of exotic nuclei at the R3B-LAND setup

Exotic Ni isotopes have been measured at the R3B-LAND setup at GSI in Darmstadt, using Coulomb excitation in inverse kinematics at beam energies around 500 MeV/u. As the experimental setup allows kinematically complete measurements, the excitation energy was reconstructed using the invariant mass method. The GDR and additional low-lying strength have been observed in 68Ni, the latter exhausting 4.1(1.9)% of the E1 energy-weighted sum rule. Also, the branching ratio for the non-statistical decay of the excited 68Ni nuclei was measured and amounts to 24(4)%.Comment: 11 pages, 7 figures. Invited Talk given at the 11th International Conference on Nucleus-Nucleus Collisions (NN2012), San Antonio, Texas, USA, May 27-June 1, 2012. To appear in the NN2012 Proceedings in Journal of Physics: Conference Series (JPCS

Аnalysis of clinical and morphological manifestations of septo-optical Dysplasia

The article presents data on the analysis of clinical and functional manifestations of septo-optical dysplasia in both the perinatal and postnatal periods, as well as the determination of factors affecting the occurrence of a congenital developmental disorder of the CNS both in isolation and in combination with other congenital malformations diagnosed in the Sverdlovsk region. The study includes 29 cases of septo-optical dysplasia, both in isolated form and in combination with other defects of the central nervous system, as well as in combination with defects of other internal organs. The diagnosis is based on the presence of a burdened obstetric and gynecological history, prenatal diagnosis, neuroimaging data - brain MRI, neurosonography. The article shows the clinical course and diagnostic symptoms, prenatal diagnosis of pregnant women, MRI and NSG-picture of the brain.В статье изложены данные анализа клинико-функциональных проявлений септо-оптической дисплазии, определение сроков выявления и факторов, влияющих на возникновение данного врожденного порока развития ЦНС. Исследование включает 29 случаев септо-оптической дисплазии диагностированных у пробандов в Свердловской области. диагноз основывается на результатах, полученных в ходе пренатальной эхографии и методов нейровизуализации, применяемых после рождения ребенка – МРТ головного мозга, нейросонографии. В статье показаны особенности клинического течения и диагностические симптомы, данные пренатальной диагностики беременных женщин, МРТ и ультразвуковая картина головного мозга

Результаты клинического исследования препаратов Траумель® С и Цель® Т у пациентов с остеоартритом коленного сустава, имеющих сопутствующие сердечно-сосудистые заболевания

   Objective: to evaluate the efficacy and safety of simultaneous intramuscular administration of Traumeel® S and Zeel® T followed by therapy with the tablet medication Zeel® T in patients with knee osteoarthritis (OA) and concomitant cardiovascular diseases.   Material and methods. The analysis included 119 patients aged 45–79 years (78.2 % women and 21.8 % men) with confirmed diagnosis of knee OA according to Altman criteria, stage II–III according to Kellgren–Lawrence and confirmed cardiovascular disease. The main indicator of efficacy was the change in pain intensity in the target knee joint according to the “Pain” subscale of the WOMAC questionnaire (A) at the final examination compared to the baseline. Other criteria were the dynamics of each symptom of knee OA according to the WOMAC questionnaire (pain, stiffness, and functional impairment, total score) on each visit, pain intensity in the target joint on a visual analogue scale (VAS), time it takes to travel 15 m, and the patient's overall disease assessment on the VAS. In addition, duration of use and dose of paracetamol (if used) were assessed, as well as quality of life by EuroQol and adverse events (AEs). Treatment safety was also analyzed in patients who had received at least one dose of the study drug.   Results and discussion. WOMAC pain intensity decreased by on average of 3.8 points: from 7.6 to 3.8 points (95 % confidence interval, CI from -4.3 to -3.3). Data on changes in knee OA symptoms (pain, stiffness, and functional impairment) for each WOMAC subscale and the total score showed significant improvement at each follow-up visit (p < 0.0001). The VAS pain level decreased by 52%. An improvement in joint function was noted: the time it takes to travel 15 m fell from 19.5 to 16.4 s (p < 0.0001). The EuroQol quality of life score also improved from 57.1 ± 16.2 points at baseline to 71.1 ± 14.8 points on the 84<sup>th</sup> day of therapy. Thirty (25.2 %) patients had AEs, mainly neurological: headache (7.6 %) and hypoesthesia (1.7 %). No serious AEs were recorded. An association between AEs and study drug use was noted in 4 patients (headache, hypoesthesia, muscle cramps, and injection site pain).   Conclusion. The results of the study confirm the efficacy and safety of the use of Traumeel® S and Zeel® T in patients with knee OA who have concomitant cardiovascular disease. During therapy, a significant decrease in pain and other clinical signs of OA (stiffness, limitation of physical activity) was observed, which allows us to recommend this treatment regimen for patients with comorbid pathology, as well as with the risk of developing of AEs during non-steroidal anti-inflammatory drugs therapy.   Цель исследования – оценить эффективность и безопасность совместного внутримышечного введения Траумель® С и Цель® Т с последующей терапией таблетированным препаратом Цель® Т у пациентов с остеоартритом (ОА) коленного сустава (КС), имеющих сопутствующие сердечно-сосудистые заболевания.   Материал и методы. В анализ включено 119 пациентов 45–79 лет (78,2 % женщин и 21,8 % мужчин) с подтвержденным диагнозом ОА КС по критериям Альтмана, II–III стадией по Kellgren–Lawrence и подтвержденным заболеванием сердечно-сосудистой системы. Основным критерием эффективности было изменение интенсивности боли в целевом КС по субшкале «Боль» опросника WOMAC (A) на завершающем визите по сравнению с исходным уровнем, а дополнительными – динамика отдельных симптомов ОА КС по опроснику WOMAC (боль, скованность и функциональная недостаточность, суммарный индекс) при каждом визите, интенсивность боли в целевом КС по визуальной аналоговой шкале (ВАШ), время прохождения 15 м и общая оценка заболевания пациентом по ВАШ. Кроме того, оценивались продолжительность приема и доза парацетамола (если он использовался), а также качество жизни по EuroQol и нежелательные явления (НЯ). Проведен также анализ безопасности терапии у пациентов, получивших хотя бы одну дозу исследуемого препарата.   Результаты и обсуждение. Интенсивность боли по WOMAC снизилась в среднем на 3,8 балла: с 7,6 до 3,8 балла (95 % доверительный интервал, ДИ от -4,3 до -3,3). Данные об изменении симптомов ОА КС (боль, скованность и функциональная недостаточность) по каждой подшкале WOMAC и суммарный индекс свидетельствовали о значимом улучшении (p < 0,0001) при каждом последующем визите. Уровень боли по ВАШ уменьшился на 52 %. Отмечено улучшение функциональной способности суставов: изменение времени прохождения 15 м (p < 0,0001) с 19,5 до 16,4 с. Оценка качества жизни по EuroQol также улучшилась с 57,1 ± 16,2 балла исходно до 71,1 ± 14,8 балла на 84-й день терапии. У 30 (25,2 %) пациентов возникли НЯ, в основном со стороны нервной системы: головная боль (7,6 %) и гипестезия (1,7 %). Серьезных НЯ не зарегистрировано. Связь НЯ с приемом исследуемого препарата выявлена у 4 пациентов (головная боль, гипестезия, мышечные спазмы и боль в месте инъекции).   Заключение. Результаты исследования подтвердили эффективность и безопасность применения препаратов Траумель® С и Цель® Т у пациентов с ОА КС, имеющих сопутствующие сердечно-сосудистые заболевания. На фоне терапии отмечено значимое уменьшение боли и других клинических признаков ОА (скованности, ограничения физической активности), что позволяет рекомендовать данную схему лечения для пациентов с коморбидной патологией, а также с риском развития НЯ при приеме нестероидных противовоспалительных препаратов

Coulomb breakup of neutron-rich 29,30^{29,30}Na isotopes near the island of inversion

First results are reported on the ground state configurations of the neutron-rich $^{29,30}$Na isotopes, obtained via Coulomb dissociation (CD) measurements as a method of the direct probe. The invariant mass spectra of those nuclei have been obtained through measurement of the four-momentum of all decay products after Coulomb excitation on a $^{208}Pb$ target at energies of 400-430 MeV/nucleon using FRS-ALADIN-LAND setup at GSI, Darmstadt. Integrated Coulomb-dissociation cross-sections (CD) of 89 $(7)$ mb and 167 $(13)$ mb up to excitation energy of 10 MeV for one neutron removal from $^{29}$Na and $^{30}$Na respectively, have been extracted. The major part of one neutron removal, CD cross-sections of those nuclei populate core, in its' ground state. A comparison with the direct breakup model, suggests the predominant occupation of the valence neutron in the ground state of $^{29}$Na${(3/2^+)}$ and $^{30}$Na${(2^+)}$ is the $d$ orbital with small contribution in the $s$-orbital which are coupled with ground state of the core. The ground state configurations of these nuclei are as $^{28}$Na_{gs (1^+)\otimes\nu_{s,d} and $^{29}$Na$_{gs}(3/2^+)\otimes\nu_{ s,d}$, respectively. The ground state spin and parity of these nuclei, obtained from this experiment are in agreement with earlier reported values. The spectroscopic factors for the valence neutron occupying the $s$ and $d$ orbitals for these nuclei in the ground state have been extracted and reported for the first time. A comparison of the experimental findings with the shell model calculation using MCSM suggests a lower limit of around 4.3 MeV of the sd-pf shell gap in $^{30}$Na.Comment: Modified version of the manuscript is accepted for publication in Journal of Physics G, Jan., 201

A density functional theory based analysis of photoinduced electron transfer in a triazacryptand based K+ sensor

The electronic structure and photoinduced electron transfer processes in a K+ fluorescent sensor that comprises a 4-amino-naphthalimide derived fluorophore with a triazacryptand lig- and is investigated using density functional theory (DFT) and time-dependent density functional theory (TDDFT) in order to rationalise the function of the sensor. The absorption and emission energies of the intense electronic excitation localised on the fluorophore are accurately described using a ∆SCF Kohn-Sham DFT approach, which gives excitation energies closer to experiment than TDDFT. Analysis of the molecular orbital diagram arising from DFT calculations for the isolated molecule or with implicit solvent cannot account for the function of the sensor and it is necessary to consider the relative energies of the electronic states formed from the local excitation on the fluorophore and the lowest fluorophore→chelator charge transfer state. The inclusion of solvent in these calculations is critical since the strong interaction of the charge transfer state with the solvent lowers it energy below the local fluorophore excited state making a reductive photoinduced electron transfer possible in the absence of K+, while no such process is possible when the sensor is bound to K+. The rate of electron transfer is quantified using Marcus theory, which gives a rate of electron transfer of k_ET=5.98 x 10^6 s−1

Measurement of the 92,93,94,100Mo(γ,n) reactions by Coulomb Dissociation

The Coulomb Dissociation (CD) cross sections of the stable isotopes 92,94,100Mo and of the unstable isotope 93Mo were measured at the LAND/R3B setup at GSI Helmholtzzentrum für Schwerionenforschung in Darmstadt, Germany. Experimental data on these isotopes may help to explain the problem of the underproduction of 92,94Mo and 96,98Ru in the models of p-process nucleosynthesis. The CD cross sections obtained for the stable Mo isotopes are in good agreement with experiments performed with real photons, thus validating the method of Coulomb Dissociation. The result for the reaction 93Mo(γ,n) is especially important since the corresponding cross section has not been measured before. A preliminary integral Coulomb Dissociation cross section of the 94Mo(γ,n) reaction is presented. Further analysis will complete the experimental database for the (γ,n) production chain of the p-isotopes of molybdenum

Humoral regulation of the immune answer at tuberculosis of lungs

The main task of immunological researches at tuberculosis - an assessment of a condition of the patient, definition of changes in immune system, studying of patogenesis of diseases. Concentration studying cytokines at the patients infected with M. tuberculosis, definition of regulation of the immune answer became the purpose of work. Research is conducted with participation of 39 people. They were united in three groups: 10 healthy people, 15 patients with lung tuberculosis, tuberculoma, 14 patients with infiltrative tuberculosis. Determined concentration cytokines by IL-1p, IL-4, IL-6, TNF-a, structure of leukocytes and lymphocytes, and also phagocyte activity of monocytes, neutrophils. It is established that balance change between cytokines is strategy of a survival for M. tuberculosis. One of main cytokines, defining resistance of immune system to tuberculosis, is TNF-a. Concentration of IL-ip in blood correlates with weight of infectious process at tuberculosis of lungs.Основная задача иммунологических исследований при туберкулезе - оценка состояния больного и выявление изменений в иммунной системе для выявления патогенеза заболевания. Целью работы стало изучение цитокинового профиля у больных, инфицированных М. tuberculosis для оценки гуморальной регуляции иммунного ответа. Исследование проведено с участием 39 человек, составивших три группы: 10 здоровых людей, 15 больных с диагнозом туберкулез легкого, туберкулома, 14 пациентов с инфильтративным туберкулезом. Определяли концентрацию цитокинов IL-1p, IL-4, IL-6, TNF-a, популяционный состав лейкоцитов и лимфоцитов, а также фагоцитарную активность моноцитов, нейтрофилов. Установлено, что изменение баланса между цитокинами является стратегией выживания для М. tuberculosis. Одним из основных цитокинов, определяющим устойчивость иммунной системы к туберкулезу является TNF-a. Концентрация IL-1p в крови коррелирует с тяжестью инфекционного процесса при туберкулезе легких