Molecular diversification and preliminary evaluations of some satsuma selections’ performance under mediterranean conditions

Satsuma (Citrus unshiu Marc.) has been cultivated for a long time in Turkey, and therefore variations for agronomical traits are likely among cultivated satsumas due to bud mutations. The objectives of this study were to determine variations for some selected agronomical traits and genetic markers among 21 new satsumas derived from selections. Fruit yield, fruit quality and molecular diversification of these clones were determined. The clones of 62 Adana, 4/2 Izmir and 11/1 Izmir indicated the highest yield. The fruits obtained from all clones were heavier than the control (Owari Satsuma). Molecular analysis, as assessed with 9 random amplification of polymorphic DNA (RAPD) and 14 simple sequence repeats (SSR) primers, indicated that satsuma clones showed a narrow genetic base suggesting that the observed morphological polymorphism within the group must be associated with  somatic mutations which were not detected by these molecular markers.Key words: Mandarins, clonal selection, citrus

Targeting IRE1 with small molecules counteracts progression of atherosclerosis

Metaflammation, an atypical, metabolically induced, chronic lowgrade inflammation, plays an important role in the development of obesity, diabetes, and atherosclerosis. An important primer for metaflammation is the persistent metabolic overloading of the endoplasmic reticulum (ER), leading to its functional impairment. Activation of the unfolded protein response (UPR), a homeostatic regulatory network that responds to ER stress, is a hallmark of all stages of atherosclerotic plaque formation. The most conserved ERresident UPR regulator, the kinase/endoribonuclease inositol-requiring enzyme 1 (IRE1), is activated in lipid-laden macrophages that infiltrate the atherosclerotic lesions. Using RNA sequencing in macrophages, we discovered that IRE1 regulates the expression of many proatherogenic genes, including several important cytokines and chemokines. We show that IRE1 inhibitors uncouple lipid-induced ER stress from inflammasome activation in both mouse and human macrophages. In vivo, these IRE1 inhibitors led to a significant decrease in hyperlipidemia-induced IL-1β and IL-18 production, lowered T-helper type-1 immune responses, and reduced atherosclerotic plaque size without altering the plasma lipid profiles in apolipoprotein E-deficient mice. These results show that pharmacologic modulation of IRE1 counteracts metaflammation and alleviates atherosclerosis

Revisiting the depositional age and provenance characteristics of metasedimentary rocks from the basement units in the Central Pontides (N Turkey): New constraints for tectonic evolution of the southern Black Sea region

This dataset includes the whole rock geochemistry, detrital zircon U-Pb, trace element and Lu-Hf and mica Ar-Ar data from a study on the basement units (Devrekani Massif, the Geme Complex and the Serveçay Unit) in the Central Pontides (N Turkey) to constrain the depositional age, provenance characteristics and tectonic evolution of metasedimentary rocks.THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV

Studies on UV-vis and fluorescence changements in Co 2+ and Cu 2+ recognition by a new benzimidazole-benzothiadiazole derivative

A novel fluorescent sensor (BI-T) was synthesized by the coupling reaction of 2-(2-hydroxyphenyl)-7-phenyl-1H-benzimidazole-4-boronic acid with 4,7-dibromo-2,1,3-benzothiadiazole via Pd-catalysed Suzuki reaction. Its photophysical properties were investigated systematically in different solvents to analyze its potential usage in the fluorescence detection for transition metal ions such as Co 2+ and Cu 2+ in solutions. In benzonitrile solution, new absorption bands for complex structure of BI-T at 470 nm and 580 nm were appeared in the presence of Co 2+ ions with respect to the uncomplexed form of the sensor absorption. BI-T sensor is usable for both Co 2+ and Cu 2+ sensation through "on-off" fluorescence change in benzonitrile. In ethanol solution, BI-T shows similar optical performances to detect Co 2+ and Cu 2+ ions. BI-T detects trace amount of transition metals in ethanol with estimated limit of detection around 4.1 × 10 -7 M and 5.5 × 10 -7 M for Co 2+ and Cu 2+ ions, respectively. Possible formation of metal-to-ligand charge transfer (MLCT) state during the titration with Co 2+ ion is supported by the detection of long-lived species in the excited state. © 2014 Elsevier B.V. All rights reserved.Celal Bayar ÜniversitesiFinancial support for this work was provided by the Research Council of Celal Bayar, Manisa, Turkey with the project number of 2011-056 . Oğuzhan Çimen was born in 1986 in Muğla, Turkey, and received his B.Sc. from the Chemistry Department of Faculty of Arts and Science, Celal Bayar University, Turkey in 2010. He received his M.Sc. degree from the same University in 2012 under the supervision of Associate Professor Dr. Haluk Dinçalp, on a thesis entitled “ Synthesis of New Benzimidazole Derivatives Designed for the Production of White Organic Light Emitting Diode” . He is currently working in DYO dye company as a researcher in R&D department. Haluk Dinçalp is an Associate Professor of Chemistry Department of Faculty of Arts and Science, Celal Bayar University, Manisa, Turkey. He received his Ph.D. degree from the Chemistry Department of Institute of Natural Science, Ege University, Izmir in 2003 under the direction of Professor Sıddık İçli, on a thesis entitled “ Solar Photooxidation Reactions ”. His current interests involve synthesis and characterization of photosensitizers, bulk heterojunction solar cells, dye sensitized solar cells and photosensitizer/DNA G-Quadruplex interactions. Canan Varlıklı is an Associate Professor of Solar Energy Institute, Ege University, Izmir, Turkey. She received her Ph.D. degree from the Chemistry Department of Institute of Natural Science, Ege University in 2003 under the direction of Professor Sıddık İçli. Her current interests involve organic and inorganic coatings, optoelectronic devices, semiconductors, photodetectors and organic light emitting diodes. -

Hem{thorn}irelerin Bak?{thorn} Aç?s?yla T?bbi Hatalar?n De{eth}erlendirilmesi

This study was conducted as a descriptive study in order to determine the medical errors in hospital services and preventive measures that could be taken to reduce these errors, from the perspective of nurses. The population of the study is composed of nurses working in 2 public hospitals in center of the province of Sakarya. We haven't selected sample and it was aimed to reach as many nurses as possible in the study. A total of 441 questionnaires were send and 324 were returned. A questionnaire as a means of data collection was prepared and used by the authors. Structural Equation Modeling, confirmatory factor analysis, descriptive statistical methods, the significance control test between compared means and ANOVA test were used in statistical analysis. Physicians, nurses, work environment and lack of communication are stated as possible causes of medical error. According to nurses, the major causes of medical errors, in order of their frequency, were inadequate number of health personnel, excessive work stress, high number of patients per nurse, the weariness due to the behavior and attitudes of superiors and the pressure to care so many patients in a very short period of time, and long time of study. Compensation of medical error is very difficult in health care. A great amount of health care is provided in hospitals and medical errors in hospital services must be prevented. In order to prevent these errors which directly affect human life, it is thought that adequate number of staff should be employed in hospitals and the attitude of superiors towards the employees should be motivating

Astım hastalarının sağlık i?nanç modeline dayalı algı ve tutumları ile tedavi başarısına yönelik düşüncelerinin belirlenmesi

AIM: This study is a descriptive study which aims to determine the attitude and perceptions of asthma patients about their health and their opinion regarding the success of treatment. METHOD: The study is carried out without any sampling. The participants are 74 patients who were admitted in a public pulmonary disease clinic between April and June 2010. A revised version of Health Belief Model scale for asthma treatment and another scale, which was developed to determine the opinion and observations of patients regarding the success of treatment, are used for data collection. RESULTS: The mean score of attitudes and perceptions of asthma patients, which is defined with the Health Belief Model and which can affect their responsiveness to treatment, is found out 3,37(±0,38) and the attitude and perceptions of patients are positive. The mean value for success treatment is 2,35(±0,49). Since the treatment is deemed to be more successful as it gets closer to 1 hence it can be said that the opinion of asthma patients regarding the success of treatment is positive. In the study, it is found out that the participants have a high admission rate to hospitals and that there is no significant difference for socio-demographic characteristics in the positive attitude development and in their belief in the efficiency of the treatment that they are receiving, of which both are components of health belief model concept. The findings from regression analysis indicate that the duration of the asthma sickness and the number of people living in the household not only affect the perceptions and attitudes of patients that are investigated by health belief model, but also the effectiveness of the treatment and the number of admissions to the Emergency Room in the last 6 months. CONCLUSION: In order to prevent long-term complications, the behavior and attitudes of asthma patients, especially the young ones, regarding asthma should be determined and detailed programs should be organized to educate and inform them. Treatment models, which would enable to receive treatment whilst not to cause any problem in their social and professional life's, should be investigated

Fruit yield and quality of santa teresa lemon on seven rootstocks in Adana (Turkey)

The effects of various rootstocks on yield, yield efficiency, vegetative growth and fruit quality of Santa Teresa lemon variety were evaluated under Adana ecological conditions during 2004 and 2005. Canopy volume was the lowest for trees on Carrizo citrange, followed by Troyer citrange and Citrus ampullacea. Total cumulative yield over two years of production was highest on C. obovoidea, followed by that on Citrus sulcata. On the other hand, the trees on C. citrange were the most efficient in yield per cubic meter of canopy volume (CV) and trunk cross-sectional area (TCSA) due to its small TCSA and CV. The largest fruit size was obtained from the trees on C. sulcata, Taiwanica, C. ampullacea, followed by sour orange and Citrus obovoidea. The highest total acid content of fruits was found with sour orange and T. citrange, followed by C. obovoidea. When all the results are considered, it can be concluded that C. obovoidea was more promising rootstock for Santa Teresa lemon in Çukurova Region. © 2010 Academic Journals