5,244 research outputs found
Strong-field tidal distortions of rotating black holes: Formalism and results for circular, equatorial orbits
Tidal coupling between members of a compact binary system can have an
interesting and important influence on that binary's dynamical inspiral. Tidal
coupling also distorts the binary's members, changing them (at lowest order)
from spheres to ellipsoids. At least in the limit of fluid bodies and Newtonian
gravity, there are simple connections between the geometry of the distorted
ellipsoid and the impact of tides on the orbit's evolution. In this paper, we
develop tools for investigating tidal distortions of rapidly rotating black
holes using techniques that are good for strong-field, fast-motion binary
orbits. We use black hole perturbation theory, so our results assume extreme
mass ratios. We develop tools to compute the distortion to a black hole's
curvature for any spin parameter, and for tidal fields arising from any bound
orbit, in the frequency domain. We also develop tools to visualize the
horizon's distortion for black hole spin (leaving the more
complicated case to a future analysis). We then study how a
Kerr black hole's event horizon is distorted by a small body in a circular,
equatorial orbit. We find that the connection between the geometry of tidal
distortion and the orbit's evolution is not as simple as in the Newtonian
limit.Comment: 37 pages, 8 figures. Accepted for publication to Physical Review D.
This version corrects a number of typographical errors found when reviewing
the page proof
Systematic Errors in Cosmic Microwave Background Interferometry
Cosmic microwave background (CMB) polarization observations will require
superb control of systematic errors in order to achieve their full scientific
potential, particularly in the case of attempts to detect the B modes that may
provide a window on inflation. Interferometry may be a promising way to achieve
these goals. This paper presents a formalism for characterizing the effects of
a variety of systematic errors on interferometric CMB polarization
observations, with particular emphasis on estimates of the B-mode power
spectrum. The most severe errors are those that couple the temperature
anisotropy signal to polarization; such errors include cross-talk within
detectors, misalignment of polarizers, and cross-polarization. In a B mode
experiment, the next most serious category of errors are those that mix E and B
modes, such as gain fluctuations, pointing errors, and beam shape errors. The
paper also indicates which sources of error may cause circular polarization
(e.g., from foregrounds) to contaminate the cosmologically interesting linear
polarization channels, and conversely whether monitoring of the circular
polarization channels may yield useful information about the errors themselves.
For all the sources of error considered, estimates of the level of control that
will be required for both E and B mode experiments are provided. Both
experiments that interfere linear polarizations and those that interfere
circular polarizations are considered. The fact that circular experiments
simultaneously measure both linear polarization Stokes parameters in each
baseline mitigates some sources of error.Comment: 19 pages, 9 figures, submitted to Phys. Rev.
Self-field effects upon the critical current density of flat superconducting strips
We develop a general theory to account self-consistently for self-field
effects upon the average transport critical current density Jc of a flat
type-II superconducting strip in the mixed state when the bulk pinning is
characterized by a field-dependent depinning critical current density Jp(B),
where B is the local magnetic flux density. We first consider the possibility
of both bulk and edge-pinning contributions but conclude that bulk pinning
dominates over geometrical edge-barrier effects in state-of-the-art YBCO films
and prototype second-generation coated conductors. We apply our theory using
the Kim model, JpK(B) = JpK(0)/(1+|B|/B0), as an example. We calculate Jc(Ba)
as a function of a perpendicular applied magnetic induction Ba and show how
Jc(Ba) is related to JpK(B). We find that Jc(Ba) is very nearly equal to
JpK(Ba) when Ba > Ba*, where Ba* is the value of Ba that makes the net flux
density zero at the strip's edge. However, Jc(Ba) is suppressed relative to
JpK(Ba) at low fields when Ba < Ba*, with the largest suppression occurring
when Ba*/B0 is of order unity or larger.Comment: 9 pages, 4 figures, minor revisions to add four reference
Mosaicking with cosmic microwave background interferometers
Measurements of cosmic microwave background (CMB) anisotropies by
interferometers offer several advantages over single-dish observations. The
formalism for analyzing interferometer CMB data is well developed in the
flat-sky approximation, valid for small fields of view. As the area of sky is
increased to obtain finer spectral resolution, this approximation needs to be
relaxed. We extend the formalism for CMB interferometry, including both
temperature and polarization, to mosaics of observations covering arbitrarily
large areas of the sky, with each individual pointing lying within the flat-sky
approximation. We present a method for computing the correlation between
visibilities with arbitrary pointing centers and baselines and illustrate the
effects of sky curvature on the l-space resolution that can be obtained from a
mosaic.Comment: 9 pages; submitted to Ap
Decreased NADPH oxidase expression and antioxidant activity in cachectic skeletal muscle
Background - Cancer cachexia is the progressive loss of skeletal muscle protein that contributes significantly to cancer morbidity and mortality. Evidence of antioxidant attenuation and the presence of oxidised proteins in patients with cancer cachexia indicate a role for oxidative stress. The level of oxidative stress in tissues is determined by an imbalance between reactive oxygen species production and antioxidant activity. This study aimed to investigate the superoxide generating NADPH oxidase (NOX) enzyme and antioxidant enzyme systems in murine adenocarcinoma tumour-bearing cachectic mice. Methods - Superoxide levels, mRNA levels of NOX enzyme subunits and the antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidise (GPx) and catalase was measured in the skeletal muscle of mice with cancer and cancer cachexia. Protein expression levels of NOX enzyme subunits and antioxidant enzyme activity was also measured in the same muscle samples. Results - Superoxide levels increased 1.4-fold in the muscle of mice with cancer cachexia, and this was associated with a decrease in mRNA of NOX enzyme subunits, NOX2, p40phox and p67phox along with the antioxidant enzymes SOD1, SOD2 and GPx. Cancer cachexia was also associated with a 1.3-fold decrease in SOD1 and 2.0-fold decrease in GPx enzyme activity. Conclusion - Despite increased superoxide levels in cachectic skeletal muscle, NOX enzyme subunits, NOX2, p40phox and p67phox, were downregulated along with the expression and activity of the antioxidant enzymes. Therefore, the increased superoxide levels in cachectic skeletal muscle may be attributed to the reduction in the activity of endogenous antioxidant enzymes
Ticarcillin hypersusceptibility in pseudomonas aeruginosa in cystic fibrosis
Background: A subpopulation of Pseudomonas aeruginosa (PsA) exists in cysticfibrosis (CF) patients that is hypersusceptible to ticarcillin, a carboxypenicillin, in vitro (Tichs strain) defined as a minimum inhibitory concentration (MIC) ≤4μg/ml. Methods: In a retrospective cohort study, isolates of PsA from CF (23), non-cystic fibrosis bronchiectasis (NCFB) (17) and control (18) patients were analysed. MICs for each isolate were determined using agar dilution against six antibiotics and interpreted using EUCAST breakpoints. Prevalence of Tichs in each cohort was calculated. A point prevalence survey was conducted in CF to review the patients’ clinical progress following PsA isolation. Results: Prevalence of the Tichs strain in PsA was 48%, 76% and 0% in the CF, NCFB and control cohorts respectively. A statistically significant difference in geometric mean MIC was seen between the Tichs and non-Tichs cohorts in CF for ticarcillin (as expected) and temocillin (p=0.041and p=0.036 respectively). A similar trend was observed in NCFB for ticarcillin (p=0.038) and temocillin (p=0.067), although statistical significance was not reached for the latter.In CF, the Tichs strain demonstrated lower MICs to all antibiotics tested apart from gentamicin compared to their non-Tichs counterparts. Those who had the Tichs strain in CF had fewer antibiotics (13.9 days versus 23.5 days, Tichs and non-Tichs respectively) although this result was not statistically significant p=0.202. Conclusion: Our data supports the existence of a Tichs strain of PsA in our CF and NCFB patient populations. This strain correlated with reduced MICs to temocillin in CF, to which PsA would normally be resistant, which may be of clinical relevance.</p
Relationship between dietary intake and erythrocyte PUFA in adolescents from a Western Australian cohort
Background: Population-based studies show that the intake of omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFA) are associated with a range of health conditions. Therefore, the reliability of food frequency questionnaires (FFQ) as rapid and easily accessible screening tools for PUFA intake deserve investigation. Objective: We aimed to assess the relationship between erythrocyte fatty acids and fatty acid intake collected using the Commonwealth Scientific and Industrial Research Organisation (CSIRO) food frequency questionnaire in an adolescent cohort. Design: A cross-sectional study using data from 1155 young adolescents participating in the 14-year follow-up of the Raine Study. Bland–Altman plots were used to determine the agreement between dietary intake and erythrocyte levels of each fatty acid. Results: The main dietary source of n-3 long-chain (LC) PUFA was ‘fresh fish’ (53% of total n-3 LC-PUFA). Docosahexaenoic acid (DHA) showed the strongest correlation between erythrocyte and diet assessment (r = 0.274; p \u3c 0.001), whilst linoleic acid (LA) (r = 0.103; p \u3c 0.001) and arachidonic acid (AA) (r = − 0.06; p = 0.042) showed weaker correlations, with limits of agreement relatively narrow. Bland–Altman plots showed a dose-dependent bias between the FFQ fatty acid data and corresponding erythrocyte data. Conclusions: For the major n-3 and n-6 PUFA, dietary intakes derived from the FFQ showed weaker correlations and poorer agreement with erythrocyte levels, and the deviation between the two increased with higher intake levels
Unsettling sustainability: the poetics of discomfort
peerreview_statement: The publishing and review policy for this title is described in its Aims & Scope. aims_and_scope_url: http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=rgrl2
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