Intake and Growth of Steers Offered Different Allowances of Autumn Grass and Concentrates

The aim of this experiment was to quantify the relationship between autumn grass supply and concentrate supplementation level on grass intake and animal performance. One hundred and ten continental steers (567kg) were assigned to ten treatments in a three grass allowances: (6, 12 and 18kg dry matter (DM) per head daily) by three concentrate levels: (0, 2.5 and 5kg/head/daily) factorial design with a positive control group offered concentrates ad-libitum. Grass allowance was offered daily and concentrates were fed individually. The experiment began on August 22 and all animals were slaughtered after a mean experimental period of 95 days. Grass allowance increased (P\u3c 0.001) complete diet digestibility only in the absence of concentrates and supplementary concentrates increased (P\u3c 0.001) complete diet digestibility only at the low grass allowance. Both offering animals supplementary concentrates (P\u3c 0.001) and increasing daily grass allowance (P\u3c 0.001) increased their carcass growth rate. Grazed grass supported only one third the carcass growth rate of supplementary concentrates per kg of DM eaten. As a strategy for increasing the performance of cattle grazing autumn grass, offering supplementary concentrates offers more scope than altering grass allowance

Networked Geotechnical Near Real-Time Monitoring for Large Urban Excavation Using Multiple Wireless Sensors

A massive urban excavation is required to construct the below-grade rail platforms for the Transbay Transit Center. A performance-based approach was used to design the minimum stiffness of the shoring system to limit excavation-induced ground movements to appropriate magnitudes and minimize impact to adjacent infrastructure. During construction, a fully-automated near real-time digital geotechnical monitoring system that integrates wireless sensor data streams into an integrated database and decision support system called the Global Analyzer is used to track the performance of this excavation. Instrumentation used for monitoring includes inclinometers, deep settlement markers, extensometers, piezometers, and an automated total station network. Some of the advantages of the Global Analyzer system include (a) integration of all project monitoring data and construction history information in a centralized database, (b) the ability to compare measured and estimated or target performance, (c) the use of early indicators to understand problems areas prior to excavation reaching critical stages, (d) the distribution of geotechnical monitoring data to adjacent building owners and other stakeholders through a web-based portal, and (e) the generation of computer generated email alerts when threshold values are exceeded by a given instrument. The Global Analyzer is a key tool in supporting an efficient decision process informed by more complete and timely performance data. It represents a component of the decision support process needed in the observational approach and deformation control. This application is relatively new to such a large scale project in the US and provides an example of a large complex data collection and distribution system. The monitoring process used for this project takes advantage of the latest communications technologies in the monitoring of the construction of the Transbay Transit Center excavation in its complex urban environment

A Multicriteria Assessment of Forage or Concentrate-Based Finishing Diets for Temperate Pasture-Based Suckler Beef Production Systems

This study evaluated the effect of contrasting ‘finishing’ diets on animal performance, meat nutritional value, land use, food-feed competition, farm economics and greenhouse gas (GHG) emissions in temperate pasture-based suckler weanling-to-steer beef systems. Post-weaning, eight-month-old, spring-born, late-maturing breed steers (333 kg) were assigned to one of three systems: (1) Grass silage + 1.2 kg concentrate DM (148 days), followed by pasture (123 days) and finished on ad libitum concentrates (120 days) - slaughter age, 21 months (GRAIN); (2) as per (1) but pasture (196 days) and finished on grass silage ad libitum + 3.5 kg concentrate DM (124 days) - slaughter age, 24 months (SIL+GRAIN); and (3) grass silage-only (148 days), pasture (196 days), silage-only (140 days) and finished on pasture (97 days) - slaughter age, 28 months (FORAGE). The mean target carcass weight was 390 kg for each system. Data generated was used to parameterise a farm-level beef systems model. Measured concentrate DM intake was 1187, 606 and 0 kg/head, and average daily gain was 0.83, 0.72 and 0.62 kg for GRAIN, SIL+GRAIN and FORAGE, respectively. Direct (pasture) land use was lowest for GRAIN. FORAGE was more profitable and was the only net producer of human edible protein and energy/ha. GRAIN produced the lowest GHG emissions per animal and meat essential amino acid concentration. FORAGE was more favourable for GHG emissions per kg of net (produced vs. consumed) production of human edible protein. Muscle amino acid and saturated fatty acid concentrations did not differ between the production systems, but FORAGE had the highest muscle concentration of omega-3 poly-unsaturated fatty acids. Differences in muscle mineral concentration were small. In conclusion, there are inverse relationships between food-feed competition, land-use, economics and GHG emissions per unit of product among different systems

Sensors for the monitoring of analytes in the sweat

In the last decade, can be found an exceptional growth in research activity relating to the development of wearable devices, capable of continuously monitoring the health conditions of the wearer by analyzing body fluids such as blood, urine, saliva, tears and sweat. Among the body fluids available, sweat is a biofluid of particular interest, as it allows a non-invasive, continuous and comfortable collection. Human sweat contains useful information on the health of an individual and therefore is an excellent biofluid for the detection of specific analytes. The most abundant ions in the sweat are Na+ and Cl- (10 - 100 mM), and their monitoring is useful in patients with cystic fibrosis. Other constituents are Ca2+, K+, ascorbic acid, glucose (0.1-10 µM) related to osteoporosis, hypoaldosteronism, scurvy and diabetes disease. The sweat pH is in the range 3 to 8 [1] [2] and indicates the level of metabolism and homeostasis of the body. Wearable sensor needs to be flexible, compact and easily applicable. It must also offer a stable response, with high sensitivity and selectivity towards specific analytes [3]. Over the years, many wearable sensors for sweat monitoring have been developed, combining different form factors, substrates and sensing mechanism. In this work, electrochemical sensors based on polyaniline (PANi), which is pH sensitive, were studied. First, the best conditions of electrochemical deposition of PANi were studied [4], using as flexible substrate polyethylene terephthalate coated with indium-tin oxide (ITO-PET). In order to improve the sensor performance electrodes were also modified by electrochemical deposition of reduced graphene oxide (rGO). All samples were characterized by XRD, SEM and EDS analysis in order to study morphology and evaluate the crystalline phases of the deposited PANi. The electrodes were tested as pH sensors using different buffer solutions, from 2 to 8, by Open Circuit Potential (OCP) technique. The ITO-PET/rGO/PANi electrodes show good behavior in terms of sensitivity (62.3 mV/pH), very close to Nernstian response of 59 mV/pH and reproducibility of 3.8%. Flexibility and mechanical stability tests were carried out on the sensor to evaluate both the wearability and mechanical resistance. In addition, interference tests, in the presence of competing ions such as Na+, Cl-, K+, NH4+, aimed to verify the selectivity were also performed

Antimicrobial drug usage from birth to 180 days of age in Irish dairy calves and in suckler beef calves

peer-reviewedConcern about the use of antimicrobials in food producing animals is increasing. The study objective was to quantify antimicrobial drug usage in calves using antimicrobial treatment records from Irish suckler beef and dairy farms. Antimicrobial treatment records for calves born between 1 July 2014 and 30 June 2015 on 79 suckler beef and 44 dairy farms were analyzed. Calves were followed from birth (day 0) until 6 months of age. According to standard farm protocol, calves exhibiting clinical signs of any disease were identified and antimicrobial treatment was administered. Farmers recorded the following information for each treatment administered: calf identification, age at treatment, disease event, drug name, number of treatment days, and amount of drug administered. In total, 3,204 suckler beef calves and 5,358 dairy calves, representing 540,953 and 579,997 calf-days at risk, respectively, were included in the study. A total of 1,770 antimicrobial treatments were administered to suckler beef (n = 841) and dairy calves (n = 929) between birth and 6 months of age. There was large variation in TIDDDvet and TIDCDvet by farm. This study provides new insights into the time periods and indications for which specific antimicrobial substances are used in Irish dairy and beef suckler calves

Skill-mix change in general practice : a qualitative comparison of three ‘new’ non-medical roles in English primary care

Background: General practice is currently facing a significant workforce challenge. Changing the general practice skill mix by introducing new non-medical roles is recommended as one solution; the literature highlights that organisational and/or operational difficulties are associated with skill-mix changes. Aim: To compare how three non-medical roles were being established in general practice, understand common implementation barriers, and identify measurable impacts or unintended consequences. Design and setting: In-depth qualitative comparison of three role initiatives in general practices in one area of Greater Manchester, England; that is, advanced practitioner and physician associate training schemes, and a locally commissioned practice pharmacist service. Method: Semi-structured interviews and focus groups with a purposive sample of stakeholders involved in the implementation of each role initiative were conducted. Template analysis enabled the production of pre-determined and researcher-generated codes, categories, and themes. Results: The final sample contained 38 stakeholders comprising training/service leads, role holders, and host practice staff. Three key themes captured participants’ perspectives: purpose and place of new roles in general practice, involving unclear role definition and tension at professional boundaries; transition of new roles into general practice, involving risk management, closing training–practice gaps and managing expectations; and future of new roles in general practice, involving demonstrating impact and questions about sustainability. Conclusion: This in-depth, in-context comparative study highlights that introducing new roles to general practice is not a simple process. Recognition of factors affecting the assimilation of roles may help to better align them with the goals of general practice and harness the commitment of individual practices to enable role sustainability

Electrochemical sensors for worker safety in manufacturing industries

The National Institute for Occupational Safety and Health has attributed most occupational diseases of industrial workers to excessive exposure to dangerous substances. In particular, occupational lung diseases are caused by the inhalation of harmful substances such as dust particles and gases [1]. The use of DPI and periodic health checks for industrial workers certainly reduces risks, but a more effective prevention strategy should include real-time monitoring of physiological parameters [2]. In this context, recent academic and industrial research has focused on the development of smart wearable systems for continuous health monitoring. This has been possible mainly due to significant progress in micro- and nanotechnology and the miniaturization of devices [3]. In such regard, electrochemical sensors represent a promising alternative due to their speed of response, simplicity of operation, and lower cost than traditional methods of diagnosis [4]. This research activity involves the development of a smart mask based on an electrochemical sensor for the non-invasive detection of hydrogen peroxide in exhaled breath. In particular, a higher concentration of this biomarker indicates the onset of oxidative stress, a pathological condition that can lead to more serious diseases, such as asthma and COPD (Chronic Obstructive Pulmonary Disease) [5]. This sensor was fabricated through a sustainable production process, from the CDs at the end of life because their silver layer can be used for its good electrochemical properties. In particular, this layer was peeled off the CD and a three electrodes configuration was given using a laser cutter

Assessing the combined effect of surface topography and substrate rigidity in human bone marrow stem cell cultures

The combined effect of surface topography and substrate rigidity in stem cell cultures is still under-investigated, especially when biodegradable polymers are used. Herein, we assessed human bone marrow stem cell response on aliphatic polyester substrates as a function of anisotropic grooved topography and rigidity (7 and 12 kPa). Planar tissue culture plastic (TCP, 3 GPa) and aliphatic polyester substrates were used as controls. Cell morphology analysis revealed that grooved substrates caused nuclei orientation/alignment in the direction of the grooves. After 21 days in osteogenic and chondrogenic media, the 3 GPa TCP and the grooved 12 kPa substrate induced significantly higher calcium deposition and alkaline phosphatase (ALP) activity and glycosaminoglycan (GAG) deposition, respectively, than the other groups. After 14 days in tenogenic media, the 3 GPa TCP upregulated four and downregulated four genes; the planar 7 kPa substrate upregulated seven genes and downregulated one gene; and the grooved 12 kPa substrate upregulated seven genes and downregulated one gene. After 21 days in adipogenic media, the softest (7 kPa) substrates induced significantly higher oil droplet deposition than the other substrates and the grooved substrate induced significantly higher droplet deposition than the planar. Our data pave the way for more rational design of bioinspired constructs.This work has also received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie, grant agreement No. 676338, the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme, grant agreement No. 866126 and the European Union’s Horizon 2020 research and innova tion Widespread: Twinning programme, grant agreement No. 810850. This publication has emanated from research supported in part by grants from Science Foundation Ireland (SFI) under Grant numbers 15/CDA/3629 and 19/FFP/6982 and Science Foundation Ireland (SFI) and European Regional Development Fund (ERDF) under grant number 13/RC/2073_2. E.M.F. acknowledges to the project TERM RES Hub – Infraestrutura Científica para a Engenharia de Tecidos e Medicina Regenerativa, Ref Num ber NORTE-01-0145-FEDER-02219015. The authors would like to acknowledge the significant contribution of Dr Oonagh Dwane in the writing and management of all grants. Open access funding provided by IReL

The first bite: Imaginaries, promotional publics and the laboratory grown burger

In this paper we analyse a 2013 press conference hosting the world’s first tasting of a laboratory grown hamburger. We explore this as a media event: an exceptional performative moment in which common meanings are mobilised and a connection to a shared centre of reality is offered. We develop our own theoretical contribution – the promotional public – to characterise the affirmative and partial patchwork of carefully selected actors invoked during the burger tasting. Our account draws upon three areas of analysis: interview data with the scientists who developed the burger, media analysis of the streamed press conference itself, and media analysis of the social media tail during and following the event. We argue that the call to witness an experiment is a form of promotion but that such promotional material also offers an address that invokes a public with its attendant tensions.The research leading to this publication has received funding from the European Community’s Seventh Framework Programme (FP7/2007–2013) under grant agreement number 288971 (EPINET). Neil Stephens’ involvement has also received the support of the Economic and Social Research Council (ESRC). His work is part of the Research Programme of the ESRC Genomics Network at Cesagen (ESRC Centre for Economic and Social Aspects of Genomics). Neil Stephens’ work was also supported by the Wellcome Trust (WT096541MA) and a visiting scholarship to CGS Centre for Society and Genomics in The Netherlands, May to July 2011. This support is gratefully acknowledge