Ground Heave Due to Jet Grouting Near an Existing Structure

Renovations of the MBTA Copley Station in Boston included construction of a new elevator shaft to improve disabled access to the existing Green Line station. The site is immediately adjacent to the Eastern façade of the historic Old South Church. The construction work required excavation support including a perimeter secant pile wall and a jet-grouted base plug. Significant ground and structural movements were observed during jet grouting, mainly associated with soil displacements during grout injection. A three dimensional numerical model was developed, using the Plaxis 3D Foundation™ program, in order to test the hypothesis that the observed movements of the structure could be associated with the installation of the jet grout piles. The amount of volume expansion associated with installation of jet grout piles is estimated based by calibrating the model to measured ground movements. The finite element model results give a consistent explanation for the observed pattern of movements, including the heave of the church wall and lateral displacements at inclinometers located within the vicinity of the structure, measured at the time when damage occurred. The model assumes there is a vertical line of weakness in the masonry, representative of a pre-existing structural crack, as observed by structural investigations; and hence, confirms the underlying mechanical hypothesis for the source of ground movements

Adaptability of irrigated spring canola oil production to the US High Plains

Canola oil is high in oleic acid which is commonly used for food and industrial purposes. To determine adaptability of spring canola (Brassica napus L.) to the High Plains for industrial oil production, 26 irrigated trials were conducted from 2005 to 2008. Trials were divided into five regions—1: 36–37◦N 108◦W; 2: 39–40◦N 101–103◦W; 3: 41–42◦N 102–103◦W; 4: 41–42◦N 104◦W; 5: 43–44◦N 106–108◦W. Cultural practices were based on site-specific protocols. Four cultivars, Hyola 401, Hyola 357 Magnum, SW Marksman, and SW Patriot, were planted in replicated plots in April or May under standard irrigation and harvested in July to October depending on region. Seed yield Hyola 401 and Hyola 357 Magnum were higher than SW Marksman and SW Patriot across the five regions and within Regions 1, 2, 3, and 5. Regions 1, 2 and 3 yielded significantly greater than did Regions 4 and 5. Samples from 18 trials were examined for their oil content and fatty acid distribution. The four cultivars had greater than 38% oil content; SW Marksman and SW Patriot had higher oil content than Hyola 401 and Hyola 357 Mag. Higher oil content was achieved in Regions 1, 4 and 5. Across and within regions, the percent of oleic acid did not differ for the four cultivars. The mean content of oleic acid decreased going north from Region 2 to Region 5, as did seed yield in the High Plains. Linoleic acid increased going north from Region 1. Linolenic acids showed little variation across regions. Considering yield and total oil content together, growing spring canola would be excellent in the High Plains

Adaptability of irrigated spring canola oil production to the US High Plains

Canola oil is high in oleic acid which is commonly used for food and industrial purposes. To determine adaptability of spring canola (Brassica napus L.) to the High Plains for industrial oil production, 26 irrigated trials were conducted from 2005 to 2008. Trials were divided into five regions—1: 36–37◦N 108◦W; 2: 39–40◦N 101–103◦W; 3: 41–42◦N 102–103◦W; 4: 41–42◦N 104◦W; 5: 43–44◦N 106–108◦W. Cultural practices were based on site-specific protocols. Four cultivars, Hyola 401, Hyola 357 Magnum, SW Marksman, and SW Patriot, were planted in replicated plots in April or May under standard irrigation and harvested in July to October depending on region. Seed yield Hyola 401 and Hyola 357 Magnum were higher than SW Marksman and SW Patriot across the five regions and within Regions 1, 2, 3, and 5. Regions 1, 2 and 3 yielded significantly greater than did Regions 4 and 5. Samples from 18 trials were examined for their oil content and fatty acid distribution. The four cultivars had greater than 38% oil content; SW Marksman and SW Patriot had higher oil content than Hyola 401 and Hyola 357 Mag. Higher oil content was achieved in Regions 1, 4 and 5. Across and within regions, the percent of oleic acid did not differ for the four cultivars. The mean content of oleic acid decreased going north from Region 2 to Region 5, as did seed yield in the High Plains. Linoleic acid increased going north from Region 1. Linolenic acids showed little variation across regions. Considering yield and total oil content together, growing spring canola would be excellent in the High Plains

2019 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations

The International Liaison Committee on Resuscitation has initiated a continuous review of new, peer-reviewed, published cardiopulmonary resuscitation science. This is the third annual summary of the International Liaison Committee on Resuscitation International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. It addresses the most recent published resuscitation evidence reviewed by International Liaison Committee on Resuscitation Task Force science experts. This summary addresses the role of cardiac arrest centers and dispatcher-assisted cardiopulmonary resuscitation, the role of extracorporeal cardiopulmonary resuscitation in adults and children, vasopressors in adults, advanced airway interventions in adults and children, targeted temperature management in children after cardiac arrest, initial oxygen concentration during resuscitation of newborns, and interventions for presyncope by first aid providers. Members from 6 International Liaison Committee on Resuscitation task forces have assessed, discussed, and debated the certainty of the evidence on the basis of the Grading of Recommendations, Assessment, Development, and Evaluation criteria, and their statements include consensus treatment recommendations. Insights into the deliberations of the task forces are provided in the Justification and Evidence to Decision Framework Highlights sections. The task forces also listed priority knowledge gaps for further research

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Digging Deep for New Compounds from the Compass Plant, Silphium laciniatum

The compass plant, Silphium laciniatum, is an iconic perennial plant of the North American tallgrass prairie. The plants of the tallgrass prairie historically have been subjected to a number of biological and environmental stresses. Among the adaptations developed by <i>S. laciniatum</i> is a large deep taproot. An investigation of the secondary metabolites found in the root of a <i>S. laciniatum</i> specimen has led to the identification of 15 new terpenoids (<b>3</b>–<b>8</b>, <b>10</b>–<b>17</b>, and <b>22</b>), which were screened for cytotoxic activity in the NCI-H460 human large-cell lung carcinoma cell line

A Total Synthesis of Bifidenone

The first total synthesis of bifidenone, a novel natural tubulin polymerization inhibitor, has been achieved in 12 steps starting from commercially available 1,4-dioxaspiro[4.5]­decan-8-one. The synthesis includes a newly developed method to generate the dihydro­benzo­dioxolone core by palladium-catalyzed aerobic dehydrogenation. The three stereocenters were installed with an AD-mix-β dihydroxylation step followed by a late-stage palladium-catalyzed decarboxylation–​allylation procedure. The absolute stereochemistry of <b>3</b> was determined via <b>13a</b> by single-crystal X-ray analysis

Acetylated Dammarane-Type Bisdesmosides from <i>Combretum inflatum</i>

The first study of the chemical constituents of <i>Combretum inflatum</i> has resulted in the isolation of seven new acetylated dammarane-type bisdesmosides (<b>1</b>–<b>7</b>). Their structures were determined from microgram quantities on hand using Bruker BioSpin TCI 1.7 mm MicroCryoProbe technology, ESIMS, and comparison to data found in the literature. Compounds <b>1</b>–<b>7</b> were screened for inhibition of an <i>Escherichia coli</i> strain UTI89 biofilm, MRSA inhibition, and cytotoxicity in NCI-H460 human lung cancer cells. Compounds <b>3</b>–<b>7</b> reduced the growth of MRSA at 16 μg/mL by 71–45%, and compound <b>7</b> had an IC₅₀ value of 3.9 μM in NCI-H460