1,673 research outputs found
A brief measure of peer affiliation and social acceptance (PASA): Validity in an ethnically diverse sample of early adolescents
Objective
Conduct a multiagent–multimethod analysis of the validity of a brief measure of deviant peer affiliations and social acceptance (PASA) in young adolescents. Peer relationships are critical to child and adolescent social and emotional development, but currently available measures are tedious and time consuming. The PASA consists of a youth, parent, and teacher report that can be collected longitudinally to study development and intervention effectiveness.
Method
This longitudinal study included 998 middle school students and their families. We collected the PASA and peer sociometrics data in Grade 7 and a multiagent–multimethod construct of deviant peer clustering in Grade 8.
Results
Confirmatory factor analyses of the multiagent–multimethod data revealed that the constructs of deviant peer affiliations and social acceptance and rejection were distinguishable as unique but correlated constructs within the PASA. Convergent, discriminant, concurrent, and predictive validity of the PASA was satisfactory, although the acceptance and rejection constructs were highly correlated and showed similar patterns of concurrent validity. Factor invariance was established for mother and for father reports.
Conclusions
Results suggest that the PASA is a valid and reliable measure of peer affiliation and of social acceptance among peers during the middle school years and provides a comprehensive yet brief assessment of peer affiliations and social acceptance
Projecting productivity losses for cancer-related mortality 2011 - 2030
© 2016 The Author(s). Background: When individuals stop working due to cancer this represents a loss to society - the loss of productivity. The aim of this analysis was to estimate productivity losses associated with premature mortality from all adult cancers and from the 20 highest mortality adult cancers in Ireland in 2011, and project these losses until 2030. Methods: An incidence-based method was used to estimate the cost of cancer deaths between 2011 and 2030 using the Human Capital Approach. National data were used for cancer, population and economic inputs. Both paid work and unpaid household activities were included. Sensitivity analyses estimated the impact of assumptions around future cancer mortality rates, retirement ages, value of unpaid work, wage growth and discounting. Results: The 233,000 projected deaths from all invasive cancers in Ireland between 2011 and 2030 will result in lost productivity valued at €73 billion; €13 billion in paid work and €60 billion in household activities. These losses represent approximately 1.4 % of Ireland's GDP annually. The most costly cancers are lung (€14.4 billion), colorectal and breast cancer (€8.3 billion each). However, when viewed as productivity losses per cancer death, testis (€364,000 per death), cervix (€155,000 per death) and brain cancer (€136,000 per death) are most costly because they affect working age individuals. An annual 1 % reduction in mortality reduces productivity losses due to all invasive cancers by €8.5 billion over 20 years. Conclusions: Society incurs substantial losses in productivity as a result of cancer-related mortality, particularly when household production is included. These estimates provide valuable evidence to inform resource allocation decisions in cancer prevention and control
A scalar invariant and the local geometry of a class of static spacetimes
The scalar invariant, I, constructed from the "square" of the first covariant
derivative of the curvature tensor is used to probe the local geometry of
static spacetimes which are also Einstein spaces. We obtain an explicit form of
this invariant, exploiting the local warp-product structure of a 4-dimensional
static spacetime, , where is
the Riemannian hypersurface orthogonal to a timelike Killing vector field with
norm given by a positive function, on . For a static
spacetime which is an Einstein space, it is shown that the locally measurable
scalar, I, contains a term which vanishes if and only if is
conformally flat; also, the vanishing of this term implies (a)
is locally foliated by level surfaces of , , which are totally
umbilic spaces of constant curvature, and (b) is locally a
warp-product space. Futhermore, if is conformally flat it
follows that every non-trivial static solution of the vacuum Einstein equation
with a cosmological constant, is either Nariai-type or Kottler-type - the
classes of spacetimes relevant to quantum aspects of gravity.Comment: LaTeX, 13 pages, JHEP3.cls; The paper is completely rewritten with a
new title and introduction as well as additional results and reference
Risk homeostasis theory - A study of intrinsic compensation
Risk homeostasis theory (RHT) suggests that changes made to the intrinsic risk of environments are negated in one of three ways: behavioural adjustments within the environment, mode migration, and avoidance of the physical risk. To date, this three-way model of RHT has little empirical support, whilst research findings on RHT have at times been diametrically opposed. A reconciliation of apparently opposing findings might be possible by suggesting that extrinsic compensation fails to restore previously existing levels of actual risk in cases where behavioural adjustments within the environment are incapable of negating intrinsic risk changes. This paper reports a study in which behavioural adjustments within the physical risk-taking environment are capable of reconciling target with actual risk. The results provide positive support for RHT in the form of overcompensation for the intrinsic risk change on specific driver behaviours
The determination of the electron-phonon interaction from tunneling data in the two-band superconductor MgB2
We calculate the tunneling density of states (DOS) of MgB2 for different
tunneling directions, by directly solving the real-axis, two-band Eliashberg
equations (EE). Then we show that the numeric inversion of the standard
single-band EE, if applied to the DOS of the two-band superconductor MgB2, may
lead to wrong estimates of the strength of certain phonon branches (e.g. the
E_2g) in the extracted electron-phonon spectral function alpha^(2)F(omega). The
fine structures produced by the two-band interaction turn out to be clearly
observable only for tunneling along the ab planes in high-quality single
crystals. The results are compared to recent experimental data.Comment: 2 pages, 2 figures, proceedings of M2S-HTSC-VII conference, Rio de
Janeiro (May 2003
Both TLR2 and TRIF Contribute to Interferon-β Production during Listeria Infection
Synthesis of interferon-β (IFN-β) is an innate response to cytoplasmic infection with bacterial pathogens. Our recent studies showed that Listeria monocytogenes limits immune detection and IFN-β synthesis via deacetylation of its peptidoglycan, which renders the bacterium resistant to lysozyme degradation. Here, we examined signaling requirements for the massive IFN-β production resulting from the infection of murine macrophages with a mutant strain of L. monocytogenes, ΔpgdA, which is unable to modify its peptidoglycan. We report the identification of unconventional signaling pathways to the IFN-β gene, requiring TLR2 and bacterial internalization. Induction of IFN-β was independent of the Mal/TIRAP adaptor protein but required TRIF and the transcription factors IRF3 and IRF7. These pathways were stimulated to a lesser degree by wild-type L. monocytogenes. They operated in both resident and inflammatory macrophages derived from the peritoneal cavity, but not in bone marrow-derived macrophages. The novelty of our findings thus lies in the first description of TLR2 and TRIF as two critical components leading to the induction of the IFN-β gene and in uncovering that individual macrophage populations adopt different strategies to link pathogen recognition signals to IFN-β gene expression
Soil Moisture Retrieval with Airborne PALS Instrument over Agricultural Areas in SMAPVEX16
NASA's SMAP (Soil Moisture Active Passive) calibration and validation program revealed that the soil moisture products are experiencing difficulties in meeting the mission requirements in certain agricultural areas. Therefore, the mission organized airborne field experiments at two core validation sites to investigate these anomalies. The SMAP Validation Experiment 2016 included airborne observations with the PALS (Passive Active L-band Sensor) instrument and intensive ground sampling. The goal of the PALS measurements are to investigate the soil moisture retrieval algorithm formulation and parameterization under the varying (spatially and temporally) conditions of the agricultural domains and to obtain high resolution soil moisture maps within the SMAP pixels. In this paper the soil moisture retrieval using the PALS brightness temperature observations in SMAPVEX16 is presented
Risk factors associated with exposure to bovine respiratory disease pathogens during the peri-weaning period in dairy bull calves
peer-reviewedBackground
Bovine respiratory disease (BRD) remains among the leading causes of death of cattle internationally. The objective of this study was to identify risk factors associated with exposure to BRD pathogens during the peri-weaning period (day (d)-14 to d 14 relative to weaning at 0) in dairy bull calves using serological responses to these pathogens as surrogate markers of exposure.
Clinically normal Holstein-Friesian and Jersey breed bull calves (n = 72) were group housed in 4 pens using a factorial design with calves of different breeds and planes of nutrition in each pen. Intrinsic, management and clinical data were collected during the pre-weaning (d − 56 to d − 14) period. Calves were gradually weaned over 14 days (d − 14 to d 0). Serological analysis for antibodies against key BRD pathogens (BRSV, BPI3V, BHV-1, BHV-4, BCoV, BVDV and H. somni) was undertaken at d − 14 and d 14. Linear regression models (for BVDV, BPI3V, BHV-1, BHV-4, BCoV and H. somni) and a single mixed effect random variable model (for BRSV) were used to identify risk factors for changes in antibody levels to these pathogens.
Results
BRSV was the only pathogen which demonstrated clustering by pen. Jersey calves experienced significantly lower changes in BVDV S/P than Holstein-Friesian calves. Animals with a high maximum respiratory score (≥8) recorded significant increases in H. somni S/P during the peri-weaning period when compared to those with respiratory scores of ≤3.
Haptoglobin levels of between 1.32 and 1.60 mg/ml at d − 14 were significantly associated with decreases in BHV-1 S/N during the peri-weaning period. Higher BVDV S/P ratios at d − 14 were significantly correlated with increased changes in serological responses to BHV-4 over the peri-weaning period.
Conclusions
Haptoglobin may have potential as a predictor of exposure to BHV-1. BRSV would appear to play a more significant role at the ‘group’ rather than ‘individual animal’ level. The significant associations between the pre-weaning levels of antibodies to certain BRD pathogens and changes in the levels of antibodies to the various pathogens during the peri-weaning period may reflect a cohort of possibly genetically linked ‘better responders’ among the study population
NADH Shuttling Couples Cytosolic Reductive Carboxylation of Glutamine with Glycolysis in Cells with Mitochondrial Dysfunction.
The bioenergetics and molecular determinants of the metabolic response to mitochondrial dysfunction are incompletely understood, in part due to a lack of appropriate isogenic cellular models of primary mitochondrial defects. Here, we capitalize on a recently developed cell model with defined levels of m.8993T>G mutation heteroplasmy, mTUNE, to investigate the metabolic underpinnings of mitochondrial dysfunction. We found that impaired utilization of reduced nicotinamide adenine dinucleotide (NADH) by the mitochondrial respiratory chain leads to cytosolic reductive carboxylation of glutamine as a new mechanism for cytosol-confined NADH recycling supported by malate dehydrogenase 1 (MDH1). We also observed that increased glycolysis in cells with mitochondrial dysfunction is associated with increased cell migration in an MDH1-dependent fashion. Our results describe a novel link between glycolysis and mitochondrial dysfunction mediated by reductive carboxylation of glutamine
Prophylactic Anticonvulsants in Intracerebral Hemorrhage
Background and Purpose
Prophylactic anticonvulsants are routinely prescribed in the acute setting for intracerebral hemorrhage (ICH) patients, but some studies have reported an association with worse outcomes. We sought to characterize the prevalence and predictors of prophylactic anticonvulsant administration after ICH as well as guideline adherence. We also sought to determine whether prophylactic anticonvulsants were independently associated with poor outcome.
Methods
We performed a retrospective study of primary ICH in our two academic centers. We used a propensity matching approach to make treated and non-treated groups comparable. We conducted multiple logistic regression analysis to identify independent predictors of prophylactic anticonvulsant initiation and its association with poor outcome as measured by modified Rankin score.
Results
We identified 610 patients with primary ICH, of whom 98 were started on prophylactic anticonvulsants. Levetiracetam (97%) was most commonly prescribed. Age (OR 0.97, 95% CI 0.95–0.99, p < .001), lobar location (OR 2.94, 95% CI 1.76–4.91, p < .001), higher initial National Institutes of Health Stroke Scale (NIHSS) score (OR 2.31, 95% CI 1.40–3.79, p = .001), craniotomy (OR 3.06, 95% CI 1.51–6.20, p = .002), and prior ICH (OR 2.36, 95% CI 1.10–5.07, p = .028) were independently associated with prophylactic anticonvulsant initiation. Prophylactic anticonvulsant use was not associated with worse functional outcome [modified Rankin score (mRS) 4–6] at hospital discharge or with increased case-fatality. There was no difference in prescribing patterns after 2010 guideline publication.
Discussion
Levetiracetam was routinely prescribed following ICH and was not associated with worse outcomes. Future investigations should examine the effect of prophylactic levetiracetam on cost and neuropsychological outcomes as well as the role of continuous EEG in identifying subclinical seizures
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