Holocaust tourism: education or exploitation?

The purpose of this research study is to investigate the ethics of holocaust tourism as a niche market which is becoming very commercialised due to the growing demand for such activities at certain locations and to examine the motivating factors for tourists visiting these destinations. Holocaust sites, a number of which were commissioned for memorial after the liberation during World War II to memorialise those lost and act as an educational resource. The main aim of this research is to explore whether holocaust tourism can be seen as education or exploitation. This will be investigated through a site visit to a holocaust tourism destination in Germany (Memorial to the Murdered Jews of Europe, Berlin) and a survey to identify those who engage in holocaust tourism, their motivations for doing so, and the outcome of their visits. Finally, this research study will provide results on the ethics of holocaust tourism and its educational value through a review of the academic research as well as the opinions of those who have or will engage in holocaust tourism. One of the main conclusions is that both primary participants and secondary authors spoke of how when visiting these sites, you create a connection to the destination and the sense of what occurred at the location is undeniable

Humor development in children

Studying children's humor development can be a window into children's social and cognitive development. According to McGhee (1974, 1976), both children and adults find jokes maximally funny when they are cognitively demanding and present an "incongruency" - that is, a violation of your expectations about how the world works. In order for an incongruency to be perceived as funny, you must have a sophisticated enough grasp of the concepts that the joke is about so that you perceive the incongruency, but at the same time, the joke must be "cognitively demanding" - that is, it can't be too obvious. This "Cognitive Congruency Principle" (McGhee, 1974, 1976; Zigler et al., 1966) has been demonstrated by showing that children in elementary school find jokes most funny when they are about concepts that children have recently mastered. Humor also contains a social component, requiring the ability to read and produce social cues to indicate that you are joking (McGhee, 1974, Hoicka & Akhtar, 2012). Hoicka and Akhtar (2012) suggested that humor was a socio-cognitive phenomenon and were curious to know if toddlers could produce novel humor, or if it all consists of copied humor patterns from their parents. They found that even children under 12 months of age "produce" humor through hide-and-seek and peekaboo games, and that many children begin to produce novel verbal and conceptual jokes around 2 years of age. Questions remain regarding the development of humor, more specifically the types of jokes/humor young children/babies use and how they differ across developmental stages. By evaluating children’s use of humor in the context of the "jokes" they engage in, we can more deeply understand why and how they use humor to communicate at their given age. (Author abstract)Hardiman, N., O'Connor, M., Carlson, J., & Magee, N. (2021). Humor development in children. Retrieved from http://academicarchive.snhu.ed

BCMA Is Essential for the Survival of Long-lived Bone Marrow Plasma Cells

Long-lived humoral immunity is manifested by the ability of bone marrow plasma cells (PCs) to survive for extended periods of time. Recent studies have underscored the importance of BLyS and APRIL as factors that can support the survival of B lineage lymphocytes. We show that BLyS can sustain PC survival in vitro, and this survival can be further enhanced by interleukin 6. Selective up-regulation of Mcl-1 in PCs by BLyS suggests that this α-apoptotic gene product may play an important role in PC survival. Blockade of BLyS, via transmembrane activator and cyclophilin ligand interactor–immunoglobulin treatment, inhibited PC survival in vitro and in vivo. Heightened expression of B cell maturation antigen (BCMA), and lowered expression of transmembrane activator and cyclophilin ligand interactor and BAFF receptor in PCs relative to resting B cells suggests a vital role of BCMA in PC survival. Affirmation of the importance of BCMA in PC survival was provided by studies in BCMA−/− mice in which the survival of long-lived bone marrow PCs was impaired compared with wild-type controls. These findings offer new insights into the molecular basis for the long-term survival of PCs

Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1

Background: There have been a number of candidate gene association studies of cancer cachexia-related traits, but no genome-wide association study (GWAS) has been published to date. Cachexia presents in patients with a number of complex traits, including both cancer and COPD. The objective of the current investigation was to search for a shared genetic aetiology for change in body mass index (ΔBMI) among cancer and COPD by using GWAS data in the Framingham Heart Study. Methods: A linear mixed effects model accounting for age, sex, and change in smoking status was used to calculate ΔBMI in participants over 40 years of age with three consecutive BMI time points (n = 4162). Four GWAS of ΔBMI using generalized estimating equations were performed among 1085 participants with a cancer diagnosis, 204 with gastrointestinal (GI) cancer, 112 with lung cancer, and 237 with COPD to test for association with 418 365 single-nucleotide polymorphisms (SNPs). Results: Two SNPs reached a level of genome-wide significance (P < 5 × 10−8) with ΔBMI: (i) rs41526344 within the CNTN4 gene, among COPD cases (β = 0.13, P = 4.3 × 10−8); and (ii) rs4751240 in the gene Dedicator of Cytokinesis 1 (DOCK1) among GI cancer cases (β = 0.10, P = 1.9 × 10−8). The DOCK1 SNP association replicated in the ΔBMI GWAS among COPD cases (βmeta-analyis = 0.10, Pmeta-analyis = 9.3 × 10−10). The DOCK1 gene codes for the dedicator of cytokinesis 1 protein, which has a role in myoblast fusion. Conclusions: In sum, one statistically significant common variant in the DOCK1 gene was associated with ΔBMI in GI cancer and COPD cases providing support for at least partially shared aetiology of ΔBMI in complex diseases

A Genetic Lesion that Arrests Plasma Cell Homing to the Bone Marrow

The coordinated regulation of chemokine responsiveness plays a critical role in the development of humoral immunity. After antigen challenge and B cell activation, the emerging plasma cells (PCs) undergo CXCL12-induced chemotaxis to the bone marrow, where they produce Ab and persist. Here we show that PCs, but not B cells or T cells from lupus-prone NZM mice, are deficient in CXCL12-induced migration. PC unresponsiveness to CXCL12 results in a marked accumulation of PCs in the spleen of mice, and a concordant decrease in bone marrow PCs. Unlike normal mice, in NZM mice, a majority of the splenic PCs are long-lived. This deficiency is a consequence of the genetic interactions of multiple systemic lupus erythematosus susceptibility loci

Constructing the Screen-tourist Experience: A Popular Television Drama Production Perspective

Melbourne, VI

STOPP/START criteria for potentially inappropriate prescribing in older people: version 2

Purpose: screening tool of older people’s prescriptions (STOPP) and screening tool to alert to right treatment (START) criteria were first published in 2008. Due to an expanding therapeutics evidence base, updating of the criteria was required. Methods: we reviewed the 2008 STOPP/START criteria to add new evidence-based criteria and remove any obsolete criteria. A thorough literature review was performed to reassess the evidence base of the 2008 criteria and the proposed new criteria. Nineteen experts from 13 European countries reviewed a new draft of STOPP & START criteria including proposed new criteria. These experts were also asked to propose additional criteria they considered important to include in the revised STOPP & START criteria and to highlight any criteria from the 2008 list they considered less important or lacking an evidence base. The revised list of criteria was then validated using the Delphi consensus methodology. Results: the expert panel agreed a final list of 114 criteria after two Delphi validation rounds, i.e. 80 STOPP criteria and 34 START criteria. This represents an overall 31% increase in STOPP/START criteria compared with version 1. Several new STOPP categories were created in version 2, namely antiplatelet/anticoagulant drugs, drugs affecting, or affected by, renal function and drugs that increase anticholinergic burden; new START categories include urogenital system drugs, analgesics and vaccines. Conclusion: STOPP/START version 2 criteria have been expanded and updated for the purpose of minimizing inappropriate prescribing in older people. These criteria are based on an up-to-date literature review and consensus validation among a European panel of experts