Art and Identity in the Forbidden City: Paradox in One Day in 2004 No. 6

By representing and manipulating locations that hold widespread cultural significance, artists mediate the relationship between individuals and city spaces. The photographic work of Cui Xiuwen explores the complexity of identity formation in the Forbidden City, the political center of China. Studying the nuances of her piece One Day in 2004 No. 6 reveals the tension of the relationship between the body and the spaces it inhabits. Though Cui has emphasized the dominating presence of Tiananmen Gate looming over her youthful female figure, the image also supports the agency of this young girl. Rather than defining the piece as a representation of either subordination to the weight of cultural history or the assertion of individual identity, this paper recognizes the paradox inherent in the work. In my analysis of the photographic image, I embrace contradictory readings of its meaning to emphasize the importance of visual culture in how individuals define themselves in city spaces. The paper draws on the shifting cultural meaning of Tiananmen Gate and contextualizes Cui’s work with pieces by other contemporary Chinese artists, including Hu Ming and Lin Xin, engaging in similar themes. Analyzing specific elements of Cui’s piece, such as the Young Pioneer’s Uniform and the young girl’s cyborg hand, reveals the significance of gender when considering identity formation in the Forbidden City. This paper outlines the subtleties of Cui’s artwork to place it in conversation with academic and artistic representations of the Forbidden City, as the historical significance of this space continues to influence self-conception

Reflections on three neophyte sport and exercise psychologists’ developing philosophies for practice

In response to the recent literature regarding the development of applied sport psychologists’ service philosophies (Lindsay, Breckon, Thomas, & Maynard, 2007), three neophyte psychologists take an autoethnographical approach to detailing how they developed their current philosophies. Using vignettes and personal accounts of their experiences they describe how reflection on their beliefs and values about people, behavior, sport, and change has underpinned their development as practitioners. The three authors detail how their delivery has developed from an approach that initially relied heavily on one framework into a more client-led approach that is more congruent with their beliefs and how this has in turn enhanced their effectiveness as practitioners. The implications of this reflective process for other neophytes is explored in relation to the experiences of the three authors

Zika virus preferentially replicates in the female reproductive tract after vaginal inoculation of rhesus macaques.

Zika virus (ZIKV) is a mosquito-transmitted virus that can cause severe defects in an infected fetus. ZIKV is also transmitted by sexual contact, although the relative importance of sexual transmission is unclear. To better understand the role of sexual transmission in ZIKV pathogenesis, a nonhuman primate (NHP) model of vaginal transmission was developed. ZIKV was readily transmitted to mature cycling female rhesus macaque (RM) by vaginal inoculation with 104-106 plaque-forming units (PFU). However, there was variability in susceptibility between the individual RM with 1->8 vaginal inoculations required to establish infection. After treatment with Depoprovera, a widely used contraceptive progestin, two RM that initially resisted 8 vaginal ZIKV inoculations became infected after one ZIKV inoculation. Thus, Depoprovera seemed to enhance susceptibility to vaginal ZIKV transmission. Unexpectedly, the kinetics of virus replication and dissemination after intravaginal ZIKV inoculation were markedly different from RM infected with ZIKV by subcutaneous (SQ) virus inoculation. Several groups have reported that after SQ ZIKV inoculation vRNA is rapidly detected in blood plasma with vRNA less common in urine and saliva and only rarely detected in female reproductive tract (FRT) secretions. In contrast, in vaginally inoculated RM, plasma vRNA is delayed for several days and ZIKV replication in, and vRNA shedding from, the FRT was found in all 6 animals. Further, after intravaginal transmission ZIKV RNA shedding from FRT secretions was detected before or simultaneously with plasma vRNA, and persisted for at least as long. Thus, ZIKV replication in the FRT was independent of, and often preceded virus replication in the tissues contributing to plasma vRNA. These results support the conclusion that ZIKV preferentially replicates in the FRT after vaginal transmission, but not after SQ transmission, and raise the possibility that there is enhanced fetal infection and pathology after vaginal ZIKV transmission compared to a mosquito transmitted ZIKV

A structural test of the Integrated Motivational-Volitional model of suicidal behaviour.

Suicidal behaviours are highly complex, multi-determined phenomena. Despite this, historically research has tended to focus on bivariate associations between atheoretical demographic and/or psychiatric factors and suicidal behaviour. The aim of this study was to empirically test the Integrated Motivational-Volitional model of suicidal behaviour using structural equation modeling. Healthy adults (N = 1, 809) completed anonymous self-report surveys. The fit of the proposed model was good, and explained 79% of variance in defeat, 83% of variance in entrapment, 61% of variance in suicidal ideation, and 27% of variance in suicide attempts. All proposed paths were significant except for those between goal re-engagement and two factors of suicide resilience (Internal Protective and External Protective) and suicidal ideation; and impulsivity and discomfort intolerance and suicide attempts. These findings represent a preliminary step towards greater clarification of the mechanisms driving suicidal behaviour, and support the utility of basing future research on the Integrated Motivational–Volitional model of suicidal behaviour

The antimicrobial peptide cathelicidin drives development of experimental autoimmune encephalomyelitis in mice by affecting Th17 differentiation

Multiple sclerosis (MS) is a highly prevalent demyelinating autoimmune condition; the mechanisms regulating its severity and progression are unclear. The IL-17-producing Th17 subset of T cells has been widely implicated in MS and in the mouse model, experimental autoimmune encephalomyelitis (EAE). However, the differentiation and regulation of Th17 cells during EAE remain incompletely understood. Although evidence is mounting that the antimicrobial peptide cathelicidin profoundly affects early T cell differentiation, no studies have looked at its role in longer-term T cell responses. Now, we report that cathelicidin drives severe EAE disease. It is released from neutrophils, microglia, and endothelial cells throughout disease; its interaction with T cells potentiates Th17 differentiation in lymph nodes and Th17 to exTh17 plasticity and IFN-γ production in the spinal cord. As a consequence, mice lacking cathelicidin are protected from severe EAE. In addition, we show that cathelicidin is produced by the same cell types in the active brain lesions in human MS disease. We propose that cathelicidin exposure results in highly activated, cytokine-producing T cells, which drive autoimmunity; this is a mechanism through which neutrophils amplify inflammation in the central nervous system