A young man with acute dilated cardiomyopathy associated with methylphenidate

An 18-year-old obese man with a body mass index of 40, diagnosed with attention-deficit hyperactivity disorder and treated with methylphenidate (Concerta®) was acutely admitted to hospital with hypoxia and dyspnoea. On investigation signs of liver-, renal-, and heart-failure were found. Noradrenalin infusion was started. Echocardiography showed dilated left ventricle and an ejection fraction (EF) of 25%. Liver function improved, noradrenalin and dobutamine were tapered, but three days after admission a new echocardiography showed an EF of 10%. The patient was transferred to the National Hospital (Rikshospitalet, Oslo), where intensified treatment including intra aortic balloon pump (IABP) was instituted. Cardiac function improved, and 3 weeks later the IABP was disconnected. EF at this point was 15%. The patient was denied heart transplantation due to various cofactors. The investigation concluded with a probable relationship between his cardiomyopathy and the use of methylphenidate (Concerta)

Shanidar Cave and the Baradostian, a Zagros Aurignacian industry

Whilst there has been significant interest in the origins and spread of the Aurignacian industry, usually linked with the physical dispersal of anatomically modern humans into Europe, comparatively little attention has been paid to possible origins or movements further east. Recent work at Shanidar Cave, a site better known for the Neanderthal evidence discovered by Ralph Solecki in his 1951–1960 excavations, has recovered new information on the “Baradostian” Upper Palaeolithic in Iraq. This paper reviews the regional evidence for the Baradostian as an example of the Zagros Aurignacian and discusses its place in debates about Neanderthal/Modern Human relations.The financial support of the Leverhulme Trust (Research Grant RPG-2013-105), the Rust Family Foundation, and Natural Environment Research Council's Oxford Radiocarbon Dating Facility (grant NF/2016/2/14) is also gratefully acknowledged

DNA copy number loss and allelic imbalance at 2p16 in lung cancer associated with asbestos exposure

Five to seven percent of lung tumours are estimated to occur because of occupational asbestos exposure. Using cDNA microarrays, we have earlier detected asbestos exposure-related genomic regions in lung cancer. The region at 2p was one of those that differed most between asbestos-exposed and non-exposed patients. Now, we evaluated genomic alterations at 2p22.1-p16.1 as a possible marker for asbestos exposure. Lung tumours from 205 patients with pulmonary asbestos fibre counts from 0 to 570 million fibres per gram of dry lung, were studied by fluorescence in situ hybridisation (FISH) for DNA copy number alterations (CNA). The prevalence of loss at 2p16, shown by three different FISH probes, was significantly increased in lung tumours of asbestos-exposed patients compared with non-exposed (P=0.05). In addition, a low copy number loss at 2p16 associated significantly with high-level asbestos exposure (P=0.02). Furthermore, 27 of the tumours were studied for allelic imbalances (AI) at 2p22.1–p16.1 using 14 microsatellite markers and also AI at 2p16 was related to asbestos exposure (P=0.003). Our results suggest that alterations at 2p16 combined with other markers could be useful in diagnosing asbestos-related lung cancer

Radio emission of SN1993J. The complete picture: II. Simultaneous fit of expansion and radio light curves

We report on a simultaneous modelling of the expansion and radio light curves of SN1993J. We have developed a simulation code capable of generating synthetic expansion and radio light curves of supernovae by taking into consideration the evolution of the expanding shock, magnetic fields, and relativistic electrons, as well as the finite sensitivity of the interferometric arrays used in the observations. Our software successfully fits all the available radio data of SN 1993J with an standard emission model for supernovae extended with some physical considerations, as an evolution in the opacity of the ejecta material, a radial drop of the magnetic fields inside the radiating region, and a changing radial density profile of the circumstellar medium beyond day 3100 after explosion.Comment: 12 pages, 12 figures, accepted for publication in A&

Light responses and light adaptation in rat retinal rods at different temperatures

Rod responses to brief pulses of light were recorded as electroretinogram (ERG) mass potentials across isolated, aspartate-superfused rat retinas at different temperatures and intensities of steady background light. The objective was to clarify to what extent differences in sensitivity, response kineticsandlight adaptationbetweenmammalianandamphibianrods can be explained by temperature and outer-segment size without assuming functional differences in the phototransduction molecules. Corresponding information for amphibian rods from the literature was supplemented by new recordings from toad retina. All light intensities were expressed as photoisomerizations per rod (Rh∗). In the rat retina, an estimated34%of incident photons at the wavelength of peak sensitivity caused isomerizations in rods, as the (hexagonally packed) outer segments measured 1.7 μm×22 μm and had specific absorbance of 0.016 μm−1 on average. Fractional sensitivity (S) in darkness increased with cooling in a similar manner in rat and toad rods, but the rat function as a whole was displaced to a ca 0.7 log unit higher sensitivity level. This difference can be fully explained by the smaller dimensions of rat rod outer segments, since the same rate of phosphodiesterase (PDE) activation by activated rhodopsin will produce a faster drop in cGMP concentration, hence a larger response in rat than in toad. In the range 15–25◦C, the waveformand absolute time scale of dark-adapted dim-flash photoresponses at any given temperature were similar in rat and toad, although the overall temperature dependence of the time to peak (tp) was somewhat steeper in rat (Q10 ≈ 4 versus 2–3). Light adaptation was similar in rat and amphibian rods when measured at the same temperature. The mean background intensity that depressed S by 1 log unit at 12◦C was in the range 20–50 Rh∗ s−1 in both, compared with ca 4500 Rh∗ s−1 in rat rods at 36◦C. We conclude that it is not necessary to assume major differences in the functional properties of the phototransduction molecules to account for the differences in response properties of mammalian and amphibian rods

Non-spherical core collapse supernovae III. Evolution towards homology and dependence on the numerical resolution

(abridged) We study the hydrodynamic evolution of a non-spherical core-collapse supernova in two spatial dimensions. We find that our model displays a strong tendency to expand toward the pole. We demonstrate that this expansion is a physical property of the low-mode, SASI instability. The SASI leaves behind a large lateral velocity gradient in the post shock layer which affects the evolution for minutes and hours later. This results in a prolate deformation of the ejecta and a fast advection of Ni-rich material from moderate latitudes to the polar regions. This effect might actually be responsible for the global asymmetry of the nickel lines in SN 1987A. The simulations demonstrate that significant radial and lateral motions in the post-shock region, produced by convective overturn and the SASI during the early explosion phase, contribute to the evolution for minutes and hours after shock revival. They lead to both later clump formation, and a significant prolate deformation of the ejecta which are observed even as late as one week after the explosion. As pointed out recently by Kjaer et al., such an ejecta morphology is in good agreement with the observational data of SN 1987A. Systematic future studies are needed to investigate how the SASI-induced late-time lateral expansion depends on the dominant mode of the SASI, and to which extent it is affected by the dimensionality of the simulations. The impact on and importance of the SASI for the distribution of iron group nuclei and the morphology of the young SNR argues for future three-dimensional explosion and post-explosion studies on singularity-free grids that cover the entire sphere. Given the results of our 2D resolution study, present 3D simulations must be regarded as underresolved, and their conclusions must be verified by a proper numerical convergence analysis in three dimensions.Comment: 16 pages, 20 figures, accepted for publication in Astronomy & Astrophysic