Розвиток системи кадрового забезпечення видавничої справи в Україні в 20-ті роки ХХ століття

(uk) У статті автором проаналізовано основні тенденції у розвитку системи підготовки та перепідготовки кадрів для української поліграфічної промисловості, висвітлено проблему кадрового забезпечення книготорговельної мережі республіки в 20-ті роки ХХ століття.(en) In this article an author is analyses basic tendencies in development of the system of preparation and retraining of shots for Ukrainian polygraph industry, the problem of the skilled providing of network the trade of books of republic is reflected in 20th of ХХ age

Preclinical activity of melflufen (J1) in ovarian cancer

Ovarian cancer carries a significant mortality. Since symptoms tend to be minimal, the disease is often diagnosed when peritoneal metastases are already present. The standard of care in advanced ovarian cancer consists of platinum-based chemotherapy combined with cytoreductive surgery. Unfortunately, even after optimal cytoreduction and adjuvant chemotherapy, most patients with stage III disease will develop a recurrence. Intraperitoneal administration of chemotherapy is an alternative treatment for patients with localized disease. The pharmacological and physiochemical properties of melflufen, a peptidase potentiated alkylator, raised the hypothesis that this drug could be useful in ovarian cancer and particularily against peritoneal carcinomatosis. In this study the preclinical effects of melflufen were investigated in different ovarian cancer models. Melflufen was active against ovarian cancer cell lines, primary cultures of patient-derived ovarian cancer cells, and inhibited the growth of subcutaneous A2780 ovarian cancer xenografts alone and when combined with gemcitabine or liposomal doxorubicin when administered intravenously. In addition, an intra- and subperitoneal xenograft model showed activity of intraperitoneal administered melflufen for peritoneal carcinomatosis, with minimal side effects and modest systemic exposure. In conclusion, results from this study support further investigations of melflufen for the treatment of peritoneal carcinomatosis from ovarian cancer, both for intravenous and intraperitoneal administration

Fast Multigrid Solution Method for Nested Edge-Based Finite Element Meshes

In this paper a fast multigrid solution method for edge-based finite element magnetostatic field computation with nested meshes in introduced and its efficiency is investigated. Special prolongation and restriction matrices were constructed according to the nature of the edge based field approximation

Novel Biochemical Markers of Psychosocial Stress in Women

Background: Prolonged psychosocial stress is a condition assessed through self-reports. Here we aimed to identify biochemical markers for screening and early intervention in women