QUANTIFYING AXIAL ROTATION OF UPPER EXTREMITY SEGMENTS

The calibrated anatomical systems technique (CAST) (Cappozzo et al, 1995) is an established method in gait and lower limb analyses. Its application to 6-degrees-of-freedom kinematic analyses and reduction of soft tissue artefact could make it particularly useful in quantifying axial rotation of the upper extremity. Such rotations have been established as being important in generating racket-head velocity in a variety of racket skills (Marshall and Elliott, 2000). The present study assesses the accuracy of CAST in quantifying the rotation of the forearm

MEMS 411: T-Shirt Strip Dispenser

For this design project, we worked with Dr. Mary Ruppert-Stroescu from the Sam Fox School of Design and Visual Arts to create a device that dispenses t-shirt strips. Dr. Ruppert-Stroescu has a patented process where strips of cloth are laid down on a sticky backing paper and sewn together to be made into new clothing. Our goal was to streamline the strip-laying process, making it less tedious and time consuming

Spirituality and attitudes towards nature in the Pacific Islands: insights for enabling climate - change adaptation

A sample of 1226 students at the University of the South Pacific, the premier tertiary institution in the Pacific Islands, answered a range of questions intended to understand future island decision-makers’ attitudes towards Nature and concern about climate change. Questions asking about church attendance show that the vast majority of participants have spiritual values that explain their feelings of connectedness to Nature which in turn may account for high levels of pessimism about the current state of the global/Pacific environment. Concern about climate change as a future livelihood stressor in the Pacific region is ubiquitous at both societal and personal levels. While participants exhibited a degree of understanding matching objective rankings about the vulnerability of their home islands/countries, a spatial optimism bias was evident in which ‘other places’ were invariably regarded as ‘worse’. Through their views on climate change concern, respondents also favoured a psychological distancing of environmental risk in which ‘other places’ were perceived as more exposed than familiar ones. Influence from spirituality is implicated in both findings. Most interventions intended to reduce exposure to environmental risk and to enable effective and sustainable adaptation to climate change in the Pacific Islands region have failed to acknowledge influences on decision making of spirituality and connectedness to Nature. Messages that stress environmental conservation and stewardship, particularly if communicated within familiar and respected religious contexts, are likely to be more successful than secular ones

Institutional Traps and Economic Growth

This paper's point of departure is that low-quality institutions, concentration of political power, and underdevelopment are persistent over time. Its analytical model views an equal distribution of political power as a commitment device to enhance institutional quality thereby promoting growth. The politically powerful coalition contemplates relinquishing of its power, weighing this advantageous consequence against the limit on own appropriative ability that it entails. The possibility of two developmental paths is exhibited: with concentration of political and economic power, low-quality institutions, and slow growth; and a more equal distribution of political and economic resources, high-quality institutions, and faster growth

Development of the ACTIVE framework to describe stakeholder involvement in systematic reviews

Objectives Involvement of patients, health professionals, and the wider public (‘stakeholders’) is seen to be beneficial to the quality, relevance and impact of research and may enhance the usefulness and uptake of systematic reviews. However, there is a lack of evidence and resources to guide researchers in how to actively involve stakeholders in systematic reviews. In this paper we report the development of the ACTIVE framework to describe how stakeholders are involved in systematic reviews. Methods We developed a framework using methods previously described in the development of conceptual frameworks relating to other areas of public involvement, including: literature searching, data extraction, analysis, and categorisation. A draft ACTIVE framework was developed and then refined after presentation at a conference workshop, before being applied to a series of example systematic reviews. Data extracted from 32 systematic reviews, identified in a systematic scoping review, were categorised against pre-defined constructs, including: who was involved, how stakeholder were recruited, the mode of involvement, at what stage there was involvement and the level of control or influence. Results The final ACTIVE framework described whether patients, carers and/or families, and/or other stakeholders (including health professionals, health decision makers and funders) were involved. We defined: recruitment as either open or closed; the approach to involvement as either onetime, continuous or combined; and the method of involvement as either direct or indirect. The stage of involvement in reviews was defined using the Cochrane Ecosystem stages of a review. The level of control or influence was defined according to the roles and activities of stakeholders in the review process, and described as the ACTIVE continuum of involvement. Conclusions The ACTIVE framework provides a structure with which to describe key components of stakeholder involvement within a systematic review, and we have used this to summarise how stakeholders have been involved in a subset of varied systematic reviews. The ACTIVE continuum of involvement provides a new model that uses tasks and roles to detail the level of stakeholder involvement. This work has contributed to the development of learning resources aimed at supporting systematic review authors and editors to involve stakeholders in their systematic reviews. This framework may support the decision-making of systematic review authors in planning how to involve stakeholders in future review

Redistribution of Aluminum Ions During Processing of Sialon Ceramics

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65916/1/j.1151-2916.1986.tb04820.x.pd

Prolonged and tunable residence time using reversible covalent kinase inhibitors.

Drugs with prolonged on-target residence times often show superior efficacy, yet general strategies for optimizing drug-target residence time are lacking. Here we made progress toward this elusive goal by targeting a noncatalytic cysteine in Bruton's tyrosine kinase (BTK) with reversible covalent inhibitors. Using an inverted orientation of the cysteine-reactive cyanoacrylamide electrophile, we identified potent and selective BTK inhibitors that demonstrated biochemical residence times spanning from minutes to 7 d. An inverted cyanoacrylamide with prolonged residence time in vivo remained bound to BTK for more than 18 h after clearance from the circulation. The inverted cyanoacrylamide strategy was further used to discover fibroblast growth factor receptor (FGFR) kinase inhibitors with residence times of several days, demonstrating the generalizability of the approach. Targeting of noncatalytic cysteines with inverted cyanoacrylamides may serve as a broadly applicable platform that facilitates 'residence time by design', the ability to modulate and improve the duration of target engagement in vivo

The National Awareness and Early Diagnosis Initiative in England: assembling the evidence

A National Awareness and Early Diagnosis Initiative (NAEDI) has been established in England as part of the Government's strategy to improve cancer outcomes. One of the early priorities for this initiative has been to assemble the diverse evidence linking late diagnosis with poor survival and avoidable deaths. This supplement brings together new perspectives on existing research in this area together with findings from recently commissioned research. This paper describes a provisional model, the ‘NAEDI pathway', for testing hypotheses relating to late diagnosis and its impact. Key findings from other papers in this supplement are also highlighted