7,245 research outputs found
Patenting Living Matter in the European Community: Diriment of the Draft Directive
This article attempts to disentangle the mire of European patent authority and provide some picture of how the ultimate resolution of the proposed EC Directive will appear. Part I contains introductory and background materials on the biotech industry and the importance of patent protection to the future proliferation of technological innovation. Part I exposes current issues in the scientific and political realms of biotech patent law as well as the standard justifications for recognizing inventors rights, considerations that are presently shaping the debate in Europe. Part II attempts to ground the reader in the fundamentals of biotechnology patent laws as developed in the United States in order to provide a basic conceptual foundation for comparing and evaluating the bodies of European law. This section begins by introducing the basic statutory terminology before turning to a discussion of the landmark United States Supreme Court opinion in Diamond v. Chakrabarty, where the Court held that genetically altered living matter may be patented.8 The remainder of the section traces the legal developments spawned by the Chakrabarty decision. Part III begins with an introduction of the various bodies purporting to govern patent rights in Europe and attempts to resolve the supremacy issues among them. Attention then shifts to the proposed Council Directive on biotech patents: the procedures for its adoption, the political forces shaping the debate of life patents in Europe, and the important proposals for amending the original draft. Finally, this article will speculate on the ultimate resolution of the Draft Directive as a united system of patent laws for the European Community Member States
The epidemiology of Mycobacterium bovis in wild deer and feral pigs and their roles in the establishment and spread of bovine tuberculosis in New Zealand wildlife
In New Zealand, wild deer and feral pigs are assumed to be spillover hosts for Mycobacterium bovis, and so are not targeted in efforts aimed at locally eradicating bovine tuberculosis (TB) from possums (Trichosurus vulpecula), the main wildlife host. Here we review the epidemiology of TB in deer and pigs, and assess whether New Zealand's TB management programme could be undermined if these species sometimes achieve maintenance host status. In New Zealand, TB prevalences of up to 47% have been recorded in wild deer sympatric with tuberculous possums. Patterns of lesion distribution, age-specific prevalences and behavioural observations suggest that deer become infected mainly through exposure to dead or moribund possums. TB can progress rapidly in some deer (<10%), but generalised disease is uncommon in wild deer; conversely some infected animals can survive for many years. Deer-to-deer transmission of M. bovis is rare, but transmission from tuberculous deer carcasses to scavengers, including possums, is likely. That creates a small spillback risk that could persist for a decade after transmission of new infection to wild deer has been halted. Tuberculosis prevalence in New Zealand feral pigs can reach 100%. Infections in lymph nodes of the head and alimentary tract predominate, indicating that TB is mostly acquired through scavenging tuberculous carrion, particularly possums. Infection is usually well contained, and transmission between pigs is rare. Large reductions in local possum density result in gradual declines (over 10 years) in TB prevalence among sympatric wild deer, and faster declines in feral pigs. Elimination of TB from possums (and livestock) therefore results in eventual disappearance of TB from feral pigs and wild deer. However, the risk of spillback infection from deer to possums substantially extends the time needed to locally eradicate TB from all wildlife (compared to that which would be required to eradicate disease from possums alone), while dispersal or translocation of pigs (e.g. by hunters) creates a risk of long-distance spread of disease. The high rate at which pigs acquire M. bovis infection from dead possums makes them useful as sentinels for detecting TB in wildlife. It is unlikely that wild deer and feral pigs act as maintenance hosts anywhere in New Zealand, because unrestricted year-round hunting keeps densities low, with far less aggregation than on New Zealand farms. We conclude that active management of wild deer or feral pigs is not required for local TB eradication in New Zealand.Funding to support the drafting of this review was provided by TBfree New Zealand (Project R10735-01), with co-funding from the Ministry of Business, Innovation and Employment (Contact C09X0803); Christian Gortazar additionally acknowledges
support from Plan Nacional I+D+i AGL2011-30041 (MINECO, Spain) for his contribution to this review.Peer Reviewe
Diversity of Decline-Rate-Corrected Type Ia Supernova Rise Times: One Mode or Two?
B-band light-curve rise times for eight unusually well-observed nearby Type
Ia supernovae (SNe) are fitted by a newly developed template-building
algorithm, using light-curve functions that are smooth, flexible, and free of
potential bias from externally derived templates and other prior assumptions.
From the available literature, photometric BVRI data collected over many
months, including the earliest points, are reconciled, combined, and fitted to
a unique time of explosion for each SN. On average, after they are corrected
for light-curve decline rate, three SNe rise in 18.81 +- 0.36 days, while five
SNe rise in 16.64 +- 0.21 days. If all eight SNe are sampled from a single
parent population (a hypothesis not favored by statistical tests), the rms
intrinsic scatter of the decline-rate-corrected SN rise time is 0.96 +0.52
-0.25 days -- a first measurement of this dispersion. The corresponding global
mean rise time is 17.44 +- 0.39 days, where the uncertainty is dominated by
intrinsic variance. This value is ~2 days shorter than two published averages
that nominally are twice as precise, though also based on small samples. When
comparing high-z to low-z SN luminosities for determining cosmological
parameters, bias can be introduced by use of a light-curve template with an
unrealistic rise time. If the period over which light curves are sampled
depends on z in a manner typical of current search and measurement strategies,
a two-day discrepancy in template rise time can bias the luminosity comparison
by ~0.03 magnitudes.Comment: As accepted by The Astrophysical Journal; 15 pages, 6 figures, 2
tables. Explanatory material rearranged and enhanced; Fig. 4 reformatte
Domains of invasion organelle proteins from apicomplexan parasites are homologous with the Apple domains of blood coagulation factor XI and plasma pre-kallikrein and are members of the PAN module superfamily
AbstractMicronemes are specialised organelles, found in all apicomplexan parasites, which secrete molecules that are essential for parasite attachment to and invasion of host cells. Regions of several microneme proteins have sequence similarity to the Apple domains (A-domains) of blood coagulation factor XI (FXI) and plasma pre-kallikrein (PK). We have used mass spectrometry on a recombinant-expressed, putative A-domain from the microneme protein EtMIC5 from Eimeria tenella, to demonstrate that three intramolecular disulphide bridges are formed. These bridges are analogous to those that stabilise A-domains in FXI and PK. The data confirm that the apicomplexan domains are structural homologues of A-domains and are therefore novel members of the PAN module superfamily, which also includes the N-terminal domains of members of the plasminogen/hepatocyte growth factor family. The role of A-domains/PAN modules in apicomplexan parasites is not known, but their presence in the microneme suggests that they may be important for mediating protein–protein or protein–carbohydrate interactions during parasite attachment and host cell invasion
Measuring Type Ia Supernova Distances and Redshifts From Their Multi-band Light Curves
The distance and redshift of a type Ia supernova can be determined
simultaneously through its multi-band light curves. This fact may be used for
imaging surveys that discover and obtain photometry for large numbers of
supernovae; so many that it would be difficult to obtain a spectroscopic
redshift for each. Using available supernova-analysis tools we find that there
are several conditions in which a viable distance-redshift can be determined.
Uncertainties in the effective distance at z~0.3 are dominated by redshift
uncertainties coupled with the steepness of the Hubble law. By z~0.5 the Hubble
law flattens out and distance-modulus uncertainties dominate. Observations that
give S/N=50 at peak brightness and a four-day observer cadence in each of
griz-bands are necessary to match the intrinsic supernova magnitude dispersion
out to z=1.0. Lower S/N can be tolerated with the addition of redshift priors
(e.g. from a host-galaxy photometric redshift), observations in an additional
redder band, or by focusing on supernova redshifts that have particular
leverage for this measurement. More stringent S/N requirements are anticipated
as improved systematics control over intrinsic color, metallicity, and dust is
attempted to be drawn from light curves.Comment: 16 pages, 4 figures, Astroparticle Physics, accepte
Why 0.02%? A review of the basis for current broadscale control of rabbits in New Zealand
Nugent, G., Warburton, B., Fisher, P., Twigg, L., Cowan, P
The Rise Times of High and Low Redshift Type Ia Supernovae are Consistent
We present a self-consistent comparison of the rise times for low- and
high-redshift Type Ia supernovae. Following previous studies, the early light
curve is modeled using a t-squared law, which is then mated with a modified
Leibundgut template light curve. The best-fit t-squared law is determined for
ensemble samples of low- and high-redshift supernovae by fitting simultaneously
for all light curve parameters for all supernovae in each sample. Our method
fully accounts for the non-negligible covariance amongst the light curve
fitting parameters, which previous analyses have neglected. Contrary to Riess
et al. (1999), we find fair to good agreement between the rise times of the
low- and high-redshift Type Ia supernovae. The uncertainty in the rise time of
the high-redshift Type Ia supernovae is presently quite large (roughly +/- 1.2
days statistical), making any search for evidence of evolution based on a
comparison of rise times premature. Furthermore, systematic effects on rise
time determinations from the high-redshift observations, due to the form of the
late-time light curve and the manner in which the light curves of these
supernovae were sampled, can bias the high-redshift rise time determinations by
up to +3.6/-1.9 days under extreme situations. The peak brightnesses - used for
cosmology - do not suffer any significant bias, nor any significant increase in
uncertainty.Comment: 18 pages, 4 figures, Accepted for publication in the Astronomical
Journal. Also available at http://www.lbl.gov/~nugent/papers.html Typos were
corrected and a few sentences were added for improved clarit
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