6,024 research outputs found
Domains of invasion organelle proteins from apicomplexan parasites are homologous with the Apple domains of blood coagulation factor XI and plasma pre-kallikrein and are members of the PAN module superfamily
AbstractMicronemes are specialised organelles, found in all apicomplexan parasites, which secrete molecules that are essential for parasite attachment to and invasion of host cells. Regions of several microneme proteins have sequence similarity to the Apple domains (A-domains) of blood coagulation factor XI (FXI) and plasma pre-kallikrein (PK). We have used mass spectrometry on a recombinant-expressed, putative A-domain from the microneme protein EtMIC5 from Eimeria tenella, to demonstrate that three intramolecular disulphide bridges are formed. These bridges are analogous to those that stabilise A-domains in FXI and PK. The data confirm that the apicomplexan domains are structural homologues of A-domains and are therefore novel members of the PAN module superfamily, which also includes the N-terminal domains of members of the plasminogen/hepatocyte growth factor family. The role of A-domains/PAN modules in apicomplexan parasites is not known, but their presence in the microneme suggests that they may be important for mediating proteinâprotein or proteinâcarbohydrate interactions during parasite attachment and host cell invasion
Diversity of Decline-Rate-Corrected Type Ia Supernova Rise Times: One Mode or Two?
B-band light-curve rise times for eight unusually well-observed nearby Type
Ia supernovae (SNe) are fitted by a newly developed template-building
algorithm, using light-curve functions that are smooth, flexible, and free of
potential bias from externally derived templates and other prior assumptions.
From the available literature, photometric BVRI data collected over many
months, including the earliest points, are reconciled, combined, and fitted to
a unique time of explosion for each SN. On average, after they are corrected
for light-curve decline rate, three SNe rise in 18.81 +- 0.36 days, while five
SNe rise in 16.64 +- 0.21 days. If all eight SNe are sampled from a single
parent population (a hypothesis not favored by statistical tests), the rms
intrinsic scatter of the decline-rate-corrected SN rise time is 0.96 +0.52
-0.25 days -- a first measurement of this dispersion. The corresponding global
mean rise time is 17.44 +- 0.39 days, where the uncertainty is dominated by
intrinsic variance. This value is ~2 days shorter than two published averages
that nominally are twice as precise, though also based on small samples. When
comparing high-z to low-z SN luminosities for determining cosmological
parameters, bias can be introduced by use of a light-curve template with an
unrealistic rise time. If the period over which light curves are sampled
depends on z in a manner typical of current search and measurement strategies,
a two-day discrepancy in template rise time can bias the luminosity comparison
by ~0.03 magnitudes.Comment: As accepted by The Astrophysical Journal; 15 pages, 6 figures, 2
tables. Explanatory material rearranged and enhanced; Fig. 4 reformatte
Why 0.02%? A review of the basis for current broadscale control of rabbits in New Zealand
Nugent, G., Warburton, B., Fisher, P., Twigg, L., Cowan, P
The Risetime of Nearby Type Ia Supernovae
We present calibrated photometric measurements of the earliest detections of
nearby type Ia supernovae (SNe Ia). The set of ~30 new, unfiltered CCD
observations delineate the early rise behavior of SNe Ia > 18 to 10 days before
maximum. Using simple empirical models, we demonstrate the strong correlation
between the risetime (i.e., the time between explosion and maximum), the
post-rise light-curve shape, and the peak luminosity. Using a variety of
light-curve shape methods, we find the risetime to B maximum for a SN Ia with
Delta m15(B)=1.1 mag and peak M_V=-19.45 mag to be 19.5+/-0.2 days. We find
that the peak brightness of SNe Ia is correlated with their risetime; SNe Ia
which are 0.10 mag brighter at peak in the B-band require 0.80+/-0.05 days
longer to reach maximum light.
We determine the effects of several possible sources of systematic errors,
but none of these significantly impacts the inferred risetime. Constraints on
SN Ia progenitor systems and explosion models are derived from a comparison
between the observed and theoretical predictions of the risetime.Comment: Submitted to the Astronomical Journal, 24 pages, 7 figure
The Rise Times of High and Low Redshift Type Ia Supernovae are Consistent
We present a self-consistent comparison of the rise times for low- and
high-redshift Type Ia supernovae. Following previous studies, the early light
curve is modeled using a t-squared law, which is then mated with a modified
Leibundgut template light curve. The best-fit t-squared law is determined for
ensemble samples of low- and high-redshift supernovae by fitting simultaneously
for all light curve parameters for all supernovae in each sample. Our method
fully accounts for the non-negligible covariance amongst the light curve
fitting parameters, which previous analyses have neglected. Contrary to Riess
et al. (1999), we find fair to good agreement between the rise times of the
low- and high-redshift Type Ia supernovae. The uncertainty in the rise time of
the high-redshift Type Ia supernovae is presently quite large (roughly +/- 1.2
days statistical), making any search for evidence of evolution based on a
comparison of rise times premature. Furthermore, systematic effects on rise
time determinations from the high-redshift observations, due to the form of the
late-time light curve and the manner in which the light curves of these
supernovae were sampled, can bias the high-redshift rise time determinations by
up to +3.6/-1.9 days under extreme situations. The peak brightnesses - used for
cosmology - do not suffer any significant bias, nor any significant increase in
uncertainty.Comment: 18 pages, 4 figures, Accepted for publication in the Astronomical
Journal. Also available at http://www.lbl.gov/~nugent/papers.html Typos were
corrected and a few sentences were added for improved clarit
The Impact of Strong Gravitational Lensing on Observed Lyman-Break Galaxy Numbers at 4<z<8 in the GOODS and the XDF Blank Fields
Detection of Lyman-Break Galaxies (LBGs) at high-redshift can be affected by
gravitational lensing induced by foreground deflectors not only in galaxy
clusters, but also in blank fields. We quantify the impact of strong
magnification in the samples of , , , LBGs () observed in the XDF and GOODS/CANDELS fields, by investigating the
proximity of dropouts to foreground objects. We find that of bright
LBGs () by
foreground objects. This fraction decreases from at to
at . Since the observed fraction of strongly lensed
galaxies is a function of the shape of the luminosity function (LF), it can be
used to derive Schechter parameters, and , independently
from galaxy number counts. Our magnification bias analysis yields
Schechter-function parameters in close agreement with those determined from
galaxy counts albeit with larger uncertainties. Extrapolation of our analysis
to suggests that future surveys with JSWT, WFIRST and EUCLID
should find excess LBGs at the bright-end, even if there is an intrinsic
exponential cutoff of number counts. Finally, we highlight how the
magnification bias measurement near the detection limit can be used as probe of
the population of galaxies too faint to be detected. Preliminary results using
this novel idea suggest that the magnification bias at is not
as strong as expected if extends well below the current
detection limits in the XDF. At face value this implies a flattening of the LF
at . However, selection effects and completeness estimates
are difficult to quantify precisely. Thus, we do not rule out a steep LF
extending to .Comment: Submitted to ApJ on 18/12/201
A Geospatial Semantic Enrichment and Query Service for Geotagged Photographs
With the increasing abundance of technologies and smart devices, equipped with a multitude of sensors for sensing the environment around them, information creation and consumption has now become effortless. This, in particular, is the case for photographs with vast amounts being created and shared every day. For example, at the time of this writing, Instagram users upload 70 million photographs a day. Nevertheless, it still remains a challenge to discover the ârightâ information for the appropriate purpose. This paper describes an approach to create semantic geospatial metadata for photographs, which can facilitate photograph search and discovery. To achieve this we have developed and implemented a semantic geospatial data model by which a photograph can be enrich with geospatial metadata extracted from several geospatial data sources based on the raw low-level geo-metadata from a smartphone photograph. We present the details of our method and implementation for searching and querying the semantic geospatial metadata repository to enable a user or third party system to find the information they are looking for
Initial Hubble Diagram Results from the Nearby Supernova Factory
The use of Type Ia supernovae as distance indicators led to the discovery of
the accelerating expansion of the universe a decade ago. Now that large second
generation surveys have significantly increased the size and quality of the
high-redshift sample, the cosmological constraints are limited by the currently
available sample of ~50 cosmologically useful nearby supernovae. The Nearby
Supernova Factory addresses this problem by discovering nearby supernovae and
observing their spectrophotometric time development. Our data sample includes
over 2400 spectra from spectral timeseries of 185 supernovae. This talk
presents results from a portion of this sample including a Hubble diagram
(relative distance vs. redshift) and a description of some analyses using this
rich dataset.Comment: Short version of proceedings for ICHEP08, Philadelphia PA, July 2008;
see v1 for full-length versio
The Nearby Supernova Factory
The Nearby Supernova Factory (SNfactory) is an ambitious project to find and
study in detail approximately 300 nearby Type Ia supernovae (SNe~Ia) at
redshifts 0.03<z<0.08. This program will provide an exceptional data set of
well-studied SNe in the nearby smooth Hubble flow that can be used as
calibration for the current and future programs designed to use SNe to measure
the cosmological parameters. The first key ingredient for this program is a
reliable supply of Hubble-flow SNe systematically discovered in unprecedented
numbers using the same techniques as those used in distant SNe searches. In
2002, 35 SNe were found using our test-bed pipeline for automated SN search and
discovery. The pipeline uses images from the asteroid search conducted by the
Near Earth Asteroid Tracking group at JPL. Improvements in our subtraction
techniques and analysis have allowed us to increase our effective SN discovery
rate to ~12 SNe/month in 2003.Comment: 7 pages, 3 figures to be published in New Astronomy Review
- âŠ