42 research outputs found
Preventive effect of hydrogen water on the development of bladder dysfunction in a rat model of bladder outlet obstruction
博士(医学)福島県立医科大
Subaru Hyper Suprime-Cam Survey for An Optical Counterpart of GW170817
We perform a -band survey for an optical counterpart of a binary neutron
star coalescence GW170817 with Subaru/Hyper Suprime-Cam. Our untargeted
transient search covers deg corresponding to the credible
region of GW170817 and reaches the completeness magnitude of mag
on average. As a result, we find 60 candidates of extragalactic transients,
including J-GEM17btc (a.k.a. SSS17a/DLT17ck). While J-GEM17btc is associated
with NGC 4993 that is firmly located inside the 3D skymap of GW170817, the
other 59 candidates do not have distance information in the GLADE v2 catalog or
NASA/IPAC Extragalactic Database (NED). Among 59 candidates, 58 are located at
the center of extended objects in the Pan-STARRS1 catalog, while one candidate
has an offset. We present location, -band apparent magnitude, and time
variability of the candidates and evaluate the probabilities that they are
located inside of the 3D skymap of GW170817. The probability for J-GEM17btc is
being much higher than those for the other 59 candidates
(). Furthermore, the possibility, that at
least one of the other 59 candidates is located within the 3D skymap, is only
. Therefore, we conclude that J-GEM17btc is the most-likely and
distinguished candidate as the optical counterpart of GW170817.Comment: 14 pages, 9 figures. Accepted for publication in PASJ (Publications
of the Astronomical Society of Japan
Light Curve Modeling of Superluminous Supernova 2006gy: Collision between Supernova Ejecta and Dense Circumstellar Medium
We show model light curves of superluminous supernova 2006gy on the
assumption that the supernova is powered by the collision of supernova ejecta
and its dense circumstellar medium. The initial conditions are constructed
based on the shock breakout condition, assuming that the circumstellar medium
is dense enough to cause the shock breakout within it. We perform a set of
numerical light curve calculations by using a one-dimensional multigroup
radiation hydrodynamics code STELLA. We succeeded in reproducing the overall
features of the early light curve of SN 2006gy with the circumstellar medium
whose mass is about 15 Msun (the average mass-loss rate ~ 0.1 Msun/yr). Thus,
the progenitor of SN 2006gy is likely a very massive star. The density profile
of the circumstellar medium is not well constrained by the light curve modeling
only, but our modeling disfavors the circumstellar medium formed by steady mass
loss. The ejecta mass is estimated to be comparable to or less than 15 Msun and
the explosion energy is expected to be more than 4e51 erg. No 56Ni is required
to explain the early light curve. We find that the multidimensional effect,
e.g., the Rayleigh-Taylor instability, which is expected to take place in the
cool dense shell between the supernova ejecta and the dense circumstellar
medium, is important in understanding supernovae powered by the shock
interaction. We also show the evolution of the optical and near-infrared model
light curves of high-redshift superluminous supernovae. They can be potentially
used to identify SN 2006gy-like superluminous supernovae in the future optical
and near-infrared transient surveys.Comment: 18 pages, 19 figures, 2 tables, accepted by Monthly Notices of the
Royal Astronomical Societ
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force
「コロナ制圧タスクフォース」COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 --重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する--. 京都大学プレスリリース. 2022-08-23.Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection
DOCK2 is involved in the host genetics and biology of severe COVID-19
「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target
The Hyper Suprime-Cam SSP survey: Overview and survey design
Hyper Suprime-Cam (HSC) is a wide-field imaging camera on the prime focus of the 8.2-m Subaru telescope on the summit of Mauna Kea in Hawaii. A team of scientists from Japan, Taiwan, and Princeton University is using HSC to carry out a 300-night multi-band imaging survey of the high-latitude sky. The survey includes three layers: the Wide layer will cover 1400 deg2 in five broad bands (grizy), with a 5 σ point-source depth of r ≈ 26. The Deep layer covers a total of 26 deg2 in four fields, going roughly a magnitude fainter, while the UltraDeep layer goes almost a magnitude fainter still in two pointings of HSC (a total of 3.5 deg2). Here we describe the instrument, the science goals of the survey, and the survey strategy and data processing. This paper serves as an introduction to a special issue of the Publications of the Astronomical Society of Japan, which includes a large number of technical and scientific papers describing results from the early phases of this survey
Blueberry Prevents the Bladder Dysfunction in Bladder Outlet Obstruction Rats by Attenuating Oxidative Stress and Suppressing Bladder Remodeling
Various berries demonstrate antioxidant activity, and this effect is expected to prevent chronic diseases. We examined whether a diet containing blueberry powder could prevent the development of bladder dysfunction secondary to bladder outlet obstruction (BOO). Eighteen 8-week-old male Sprague-Dawley rats were randomly divided into three groups: Sham (sham operated + normal diet), N-BOO (BOO operated + normal diet) and B-BOO (BOO operated + blueberry diet). Four weeks after BOO surgery, the N-BOO group developed bladder dysfunction with detrusor overactivity. The B-BOO group showed significantly improved micturition volume and micturition interval. The urinary levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG) and malondialdehyde (MDA) were measured as oxidative stress markers. In the N-BOO group, 8-OHdG increased 1.6-fold and MDA increased 1.3-fold at 4 weeks after surgery, whereas the increase in 8-OHdG was significantly reduced by 1.1-fold, despite a similar increase in MDA, in the B-BOO group. Bladder remodeling was confirmed due to bladder hypertrophy, fibrosis and increased connexin43 expression in the N-BOO group, but these histological changes were reduced in the B-BOO group. The intake of blueberries prevented the development of bladder dysfunction secondary to BOO. This effect seems to be related to antioxidation and the inhibition of bladder remodeling