11 research outputs found
Intraperitoneal drain placement and outcomes after elective colorectal surgery: international matched, prospective, cohort study
- Author
- Aba M
- Abdellatif M
- Abdelmahmoud S
- Abu Hassan F
- Acil C
- Adarkwah P
- Adarraga J
- Adderley O
- Adefolaju A
- Afzal A
- Afzal Z
- Agarwal H
- Agnes A
- Agostinelli L
- Ahari D
- Ahmad H
- Ahmad R
- Ahmad S
- Ahmed N
- Ahmed N
- Ahmed WUR
- Ahmed WUR
- Akhbari M
- Akintunde A
- Akkaya YM
- Akram J
- Aktas MK
- Aktas MK
- Aktas MK
- AktaĆ A
- Akula Y
- Al Nassrallah M
- Al-Habsi R
- Alam F
- Albino V
- Alfadhel S
- Ali T
- Alicata F
- AljiÄ A
- Allison W
- Almeida T
- Alonso Batanero E
- Alonso Batanero E
- Alsaif A
- Alsusa H
- Altaf R
- Altay L
- Altinel Y
- Altiner S
- Altomare DF
- Altomare DF
- Altunsu S
- Alvarez-Gallego M
- Amendola A
- Amjad T
- Amjad T
- Anabitarte Bautista O
- Anastasi A
- Anderson K
- Andolfi E
- Andolfi E
- Andrejevic P
- Andrejevic P
- Angarano E
- Angelini E
- Angelini M
- Angrisani M
- Anoldo P
- Anthony A
- Antropoli C
- Antypas A
- Antypas A
- Appleton B
- Argyriou A
- Arnold A
- Arnold A
- Arslan ER
- Asero S
- Ashaye A
- Ashdown T
- Asim K
- Aslam A
- Atar C
- Ates J
- Atıcı N
- Atiyah Z
- Attaallah W
- Atzeni J
- Augestad KM
- Aulicino M
- Aung MT
- Auterson L
- Aversano A
- Axmarker T
- Aydin R
- Azizan N
- Azmi A
- Badessi G
- Bagaglini G
- Bagaglini G
- Bagheri K
- Bailey E
- Bailey S
- Baili E
- Bakar B
- Baker D
- Baker E
- Baki BE
- Baki BE
- Balak B
- Balalis D
- Balalis D
- Balasubramanya S
- Balasubramanya S
- Baldemor S
- Banaz T
- Banerjee D
- Banerjee I
- Banerjee M
- Banji-Kelan A
- Bao QR
- Bapty J
- Bardon A
- Bargellini T
- Barter R
- Barton H
- Bassi R
- Bastiaenen V
- Bawa JH
- Beckett RG
- Begum S
- Belev N
- Belia F
- Belia F
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- Bellato V
- Belli A
- BeltrĂĄn de Heredia J
- Ben Sassi A
- Benuzzi L
- Berry A
- Beuca A
- Beuca A
- Beuca A
- Bezede C
- Bhatia S
- Bhojwani D
- Bhojwani D
- Biancafarina A
- Biancafarina A
- Bianco F
- Bianco F
- Bickley-Morris E
- Bilbao J
- Bini S
- Bini S
- Bini S
- Bintintan V
- Biondi A
- Bircan R
- Bisheet G
- Bissett IP
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- Blaga SN
- Blanco-Colino R
- Blas Laina JL
- Blas Laina JL
- Bompetsi G
- Borghi F
- Borrello A
- Borumand M
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- Botelho P
- Botelho P
- Bourhill J
- Bowen J
- Boyd M
- Boyle E
- Bozbiyik O
- Bozhkova L
- Bozonelou I
- BoÄa A
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- Brachini G
- Bradbury M
- Bradbury M
- Bragaglia L
- Bragaglia L
- Braniste A
- Brankin-Frisby T
- Bray J
- Brazkiewicz M
- Brazukas A
- Bridges I
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- Browne D
- Brozzetti S
- Bryden M
- Buchwald P
- Buchwald P
- Burchi-Khairy T
- Burdekin E
- Burgher T
- Bylapudi SK
- Bylapudi SK
- Calikoglu F
- Calikoglu F
- CalĂČ PG
- Camarero RodrĂguez E
- Camassa M
- Cambridge W
- Cameron F
- Cammarata F
- Campagnaro T
- Campanelli M
- Campanelli M
- Campbell I
- Campus F
- Canali G
- Caneparo A
- Cannavera A
- Canonico G
- Canu GL
- Capasso G
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- Capelli G
- Capezzuoli L
- Cappellacci F
- Cappiello A
- Cappiello A
- Capuzzolo S
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- Carmichael A
- Carnevali P
- Cassaro F
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- Chapman SJ
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- Cheema H
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- Chevallay M
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- Chung W
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- Cigognini M
- Cillara N
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- Ciofic E
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- Clancy N
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- Colella M
- Coletta D
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- Colombo F
- Colsa P
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- Conway-Jones R
- Cornett L
- Couto J
- Crescentini G
- Crippa J
- Crone L
- Crone L
- Cros B
- Croyle JA
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- D Sa S
- D'Amico S
- D'Amico S
- D'Amore A
- Daler HK
- Dalton H
- Damasio Cotovio M
- Damoli I
- Danna R
- Dare M
- Darrah N
- Daudu D
- Davakis S
- David A
- Davies A
- Davoudi K
- De Andrés-Asenjo B
- De Lucia C
- de Manzoni Garberini A
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- de Manzoni Garberini A
- De Marco G
- De Marco G
- De Palma GD
- De Paola G
- De Peppo V
- De Prizio M
- De Santiago Alvarez I
- de Stadler K
- Deader N
- Deeny D
- Delibegovic S
- Deliyannis E
- Delogu D
- Delorme M
- Delorme M
- Delrio P
- Demirbas I
- Demirel MT
- Desai R
- Detering R
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- Devine A
- Dhavala P
- Dhillon S
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- Di Martino C
- di Mola FF
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- Douthwaite J
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- Duff S
- Duku A
- Duman E
- Dumitrascu F
- Dundas L
- Durmaz AG
- DuĆĄek T
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- DâAlterio C
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- Edwards A
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- Egoroff N
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- El Kasmy El Kasmy Y
- El-Dalil D
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- Elias S
- Ellacott M
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- Elsamani K
- Elsayeh K
- Elsayeh K
- Elsworth C
- Elter C
- Eltilib I
- Emanet O
- Emms L
- Eray IC
- Erdas E
- Erkul O
- Erotocritou M
- Erotocritou M
- Erotocritou M
- ErtĂŒrk MS
- Eskici AB
- Esposito E
- Esposito G
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- Evans N
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- Fagarasan V
- Falconer K
- Fancellu A
- Farag K
- Farnan R
- Farnesi F
- Farren A
- Farrugia M
- Farrugia M
- Farrugia M
- Fassari A
- Fatimah Hussain Q
- Feo CF
- Ferancikova N
- Ferarrio I
- Fernandes M
- Ferrara F
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- Ferrario L
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- Filippone E
- Fitzpatrick A
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- GarcĂa FlĂłrez LJ
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- Garoufalia Z
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- Gecchele G
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- Gelarda E
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- Georgiou T
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- Giudiceandrea I
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- Glasbey JC
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- Gordon D
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- Gouvas N
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- Hadley E
- Hadzhiev D
- Hadzhieva E
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- Hamidovic A
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- Haque M
- Hargest R
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- Henriques S
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- Hipolito M
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- Hysejni X
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- Schack K
- Schembri R
- Schena CA
- Schizas D
- Sciaudone G
- Scricciolo M
- Scriven J
- Seehra JK
- Segura-Sampedro JJ
- Sel EK
- Selvaggi F
- Selvaggi L
- Sensi B
- Seow W
- Sethi R
- Sethi S
- Sever AE
- Seymour Z
- SgrĂČ A
- Shafi S
- Shafiq U
- Shafiq Y
- Shah H
- Shah M
- Shah P
- Shah S
- Shaikh I
- Shaikh M
- Sharma P
- Sharma P
- Sharma P
- Shaw J
- Sheefat S
- Sheikh F
- Shimato M
- Sica G
- Sica G
- Sidiropoulos T
- Silva A
- Silva A
- Silva C
- Simonelli L
- Simpson C
- Sinan LOH
- Sinan LOH
- Sinclair R
- Singh B
- Sinibaldi G
- Sinibaldi G
- Sinibaldi G
- Sisto G
- Sivanu K
- Skene E
- Slavchev M
- Slavchev M
- Slim N
- Slim N
- Smart N
- Smith I
- Smithers R
- Smolarek S
- Smyth S
- Soare C
- Soares AS
- Soares AS
- Soddu C
- Soh VWY
- Soldevila Verdeguer C
- Soldevila Verdeguer C
- Solinas L
- Sotiropoulos GC
- Sotiropoulos GC
- Spagni G
- Speake D
- Spencer G
- Spilsbury C
- Spilsbury C
- Spoletini D
- Spolverato G
- Sreenivasan S
- St F
- Stamopoulos P
- Stanley A
- Stark D
- Stark D
- Stavrinidou O
- Steinholt I
- Stewart EG
- Stokell C
- Stolcers K
- Stuart LM
- Suarez A
- Sundaralingam SS
- Sundaram Venkatesan G
- Suresh A
- Syllaios A
- Szal A
- SĂĄnchez GarcĂa C
- Tachezy M
- Tailor B
- Takar S
- Talal El-Abur I
- Talal El-Abur I
- Talal El-Abur I
- Tamini N
- Tamini N
- Tamini N
- Tan E
- Tan HWN
- Tan JY
- Tancredi M
- Tanis P
- Tanis P
- Tanna V
- Tansey M
- Tansey M
- Taser M
- Tatar OC
- Tatar OC
- Taubwurcel J
- Temperley H
- Tepe MD
- Testa V
- Thaker A
- Theodoropoulos C
- Theodorou D
- Theodorou D
- Thomas C
- Thomas T
- Thompson B
- Tiesi V
- Tijare C
- Ting A
- Tirimanna R
- Tirloni L
- Toh S
- Toh WH
- Tomara N
- Tomlin J
- Tonchev P
- Tone JF
- Tong KS
- Tonini V
- Top C
- Trapani R
- Tremlett A
- Triantafyllou A
- Triantafyllou T
- Triantafyllou T
- Trigiante G
- Trivedi R
- Troller R
- Troller R
- Troller R
- Trout I
- Trovato C
- Trujillo DĂaz J
- Truskovs A
- Tsaparas P
- Tsimplis V
- Tsourouflis G
- Tulina I
- Tulina I
- Tuminello F
- Tuminello F
- Turhan AB
- Turner B
- Turner B
- Turri G
- Turri G
- Tutino R
- Tutino R
- Tzoumas N
- Tzoumas N
- Ugur M
- Ugur M
- Uhanowita Marage R
- Ular B
- Uprak TK
- Urbani A
- Urbieta A
- Usta MA
- Utkan NZ
- Utrilla Fornals A
- Utukuri M
- Uyar B
- V Vadiveloo T
- Vagios I
- Valiyeva S
- Valnarov-Boulter A
- van Dalen AS
- van de Ven A
- van de Ven A
- Van Straten S
- Vanalia P
- Varcada M
- Varghese C
- Vaselli NM
- Velez C
- Venturelli P
- Venturelli P
- Venturelli P
- Verlingieri V
- Vertaldi S
- Vetsa K
- Vicario Bravo M
- Vician M
- Vieira BN
- Vigna SA
- Vignotto C
- Villalonga B
- Virgilio E
- Viscosi F
- Vitish-Sharma P
- Vitish-Sharma P
- Vittori L
- Vladova P
- Vo UG
- Votava J
- Wagstaff A
- Walker B
- Walmsley A
- Walsh J
- Walter L
- Walters B
- Wang B
- Wang J
- WeiĂ C
- Wells CI
- Wenban C
- White C
- Whitehurst O
- Wilkins L
- Williams CY
- Williams G
- Williams J
- Willis L
- Wilson A
- Wise H
- Wong C
- Wong J Y
- Wong KHF
- Wright F
- Xu D
- Xu W
- Yalcinkaya A
- Yalcinkaya A
- Yang HW
- Yao L
- Yap SHK
- Yasin I
- Yates C
- Yates C
- Yek WY
- Yeo JY
- Yick C
- Yick C
- Yıldırım A
- Yogarajah T
- Yoldas T
- Yotsov T
- Yousaf H
- Yousuff M
- YĂĄnez C
- YĂŒksel E
- Zabiyaka M
- Zafer F
- Zafer F
- Zaffaroni G
- ZagibovĂĄ D
- Zagorac Z
- Zaheer M
- Zahid A
- Zahid M
- Zaidi M
- Zambon M
- Zammit-Maempel M
- Zanframundo C
- Zanni M
- Zayed M
- Zazza S
- Zeidan Z
- Zhang Y
- Zhu L
- Zhu X
- Ziolkowska K
- Ziolkowska K
- Zografos G
- Zonta S
- Ăetin B
- Ălmez M
- Ăzbalcı GS
- Ăzen D
- Ăzen D
- ĂztĂŒrk OU
- ÄustoviÄ S
- Ć tefanovĂĄ H
- ÎÏ ÏÏÎ±ÎžÎŻÎżÏ Î
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2022
- Field of study
Despite current guidelines, intraperitoneal drain placement after elective colorectal surgery remains widespread. Drains were not associated with earlier detection of intraperitoneal collections, but were associated with prolonged hospital stay and increased risk of surgical-site infections.Background Many surgeons routinely place intraperitoneal drains after elective colorectal surgery. However, enhanced recovery after surgery guidelines recommend against their routine use owing to a lack of clear clinical benefit. This study aimed to describe international variation in intraperitoneal drain placement and the safety of this practice. Methods COMPASS (COMPlicAted intra-abdominal collectionS after colorectal Surgery) was a prospective, international, cohort study which enrolled consecutive adults undergoing elective colorectal surgery (February to March 2020). The primary outcome was the rate of intraperitoneal drain placement. Secondary outcomes included: rate and time to diagnosis of postoperative intraperitoneal collections; rate of surgical site infections (SSIs); time to discharge; and 30-day major postoperative complications (Clavien-Dindo grade at least III). After propensity score matching, multivariable logistic regression and Cox proportional hazards regression were used to estimate the independent association of the secondary outcomes with drain placement. Results Overall, 1805 patients from 22 countries were included (798 women, 44.2 per cent; median age 67.0 years). The drain insertion rate was 51.9 per cent (937 patients). After matching, drains were not associated with reduced rates (odds ratio (OR) 1.33, 95 per cent c.i. 0.79 to 2.23; P = 0.287) or earlier detection (hazard ratio (HR) 0.87, 0.33 to 2.31; P = 0.780) of collections. Although not associated with worse major postoperative complications (OR 1.09, 0.68 to 1.75; P = 0.709), drains were associated with delayed hospital discharge (HR 0.58, 0.52 to 0.66; P < 0.001) and an increased risk of SSIs (OR 2.47, 1.50 to 4.05; P < 0.001). Conclusion Intraperitoneal drain placement after elective colorectal surgery is not associated with earlier detection of postoperative collections, but prolongs hospital stay and increases SSI risk
Predicting total knee replacement at 2 and 5 years in osteoarthritis patients using machine learning
- Publication venue
- 'BMJ'
- Publication date
- 09/12/2022
- Field of study
Objectives Knee osteoarthritis is a major cause of physical disability and reduced quality of life, with end-stage disease often treated by total knee replacement (TKR). We set out to develop and externally validate a machine learning model capable of predicting the need for a TKR in 2 and 5âyears time using routinely collected health data. Design A prospective study using datasets Osteoarthritis Initiative (OAI) and the Multicentre Osteoarthritis Study (MOST). OAI data were used to train the models while MOST data formed the external test set. The data were preprocessed using feature selection to curate 45 candidate features including demographics, medical history, imaging assessments, history of intervention and outcome. Setting The study was conducted using two multicentre USA-based datasets of participants with or at high risk of knee OA. Participants The study excluded participants with at least one existing TKR. OAI dataset included participants aged 45â79 years of which 3234 were used for training and 809 for internal testing, while MOST involved participants aged 50â79 and 2248 were used for external testing. Main outcome measures The primary outcome of this study was prediction of TKR onset at 2 and 5âyears. Performance was evaluated using area under the curve (AUC) and F1-score and key predictors identified. Results For the best performing model (gradient boosting machine), the AUC at 2 years was 0.913 (95% CI 0.876 to 0.951), and at 5 years 0.873 (95% CI 0.839 to 0.907). Radiographic-derived features, questionnaire-based assessments alongside the patientâs educational attainment were key predictors for these models. Conclusions Our approach suggests that routinely collected patient data are sufficient to drive a predictive model with a clinically acceptable level of accuracy (AUC>0.7) and is the first such tool to be externally validated. This level of accuracy is higher than previously published models utilising MRI data, which is not routinely collected
Osteopontin Enhances the Expression and Activity of MMP-2 via the SDF-1/CXCR4 Axis in Hepatocellular Carcinoma Cell Lines
- Author
- AS Budhu
- B Wang
- CD Rogers
- CF Lai
- CT Veldkamp
- D Javelaud
- G Song
- Georg F. Weber
- GJ McKenna
- Guoxin Zhang
- H Liu
- HM Lin
- I-K Hong
- IM Clark
- J Miroslaw
- Jean-Marc Vanacker
- K Jaszczynska-Nowinka
- K Ogawa
- KA Brakora
- LP Jakobsen
- M E1-Tanani
- M Gaviraghi
- M Junko
- M Scatena
- M-C Tiveron
- N Levicar
- O Kollet
- Q Lunxiu
- Rihua Zhang
- S Otsuru
- S Philip
- S Ye
- SK Ramaiah
- T Hu
- V Takafuji
- W Yan
- Xiaolin Pan
- Y Gazitt
- Y Kang
- YL Ling Wang
- Z Mi
- Z-L Xiang
- Zuhu Huang
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Intraperitoneal drain placement and outcomes after elective colorectal surgery: International matched, prospective, cohort study
- Author
- Ahmed W. U. R.
- Ahmed W. U. R.
- Akhbari M.
- Aktas M. K.
- Alsaif A.
- Amjad T.
- Anabitarte Bautista O.
- Antypas A.
- Augestad K. M.
- Baker D.
- Baki B. E.
- Bhatia S.
- Bini S.
- Bissett I. P.
- Blanco-Colino R.
- Brindl N.
- Brindl N.
- Brown S.
- Cambridge W.
- Chapman S. J.
- Chia W. L.
- Delibegovic S.
- Dudi-Venkata N. N.
- Dörr-Harim C.
- Egoroff N.
- El Kasmy El Kasmy Y.
- EspĂn-Basany E.
- EspĂn-Basany E.
- Foster K.
- Gallo G.
- Gedeon N.
- Glasbey J. C.
- Gori A.
- Grossi U.
- Gsenger J.
- Gujjuri R. R.
- Hassane A.
- Hughes J. T.
- Jakubauskas M.
- Juloski J.
- Kakodkar P.
- Kamarajah S. K.
- Khaw R. A.
- Kouli O.
- Kryzauskas M.
- Kuiper S. Z.
- Lapolla P.
- Lapolla P.
- Ludbrook I.
- Luu J.
- Machatschek M. J.
- MartĂn-BorregĂłn P.
- McLean K. A.
- McLean K. A.
- Mihaljevic A.
- Mihaljevic A.
- Mills E. C.
- Mills E. C.
- Mirza M.
- Murray V.
- Nepogodiev D.
- Nguyen A.
- Nowinka Z.
- Ossola Revilla M.
- Pancharatnam R.
- Pata F.
- Pata F.
- Pellino G.
- Pellino G.
- Picciariello A.
- Pockney P.
- Pockney P.
- Podda M.
- Poskus T.
- PĂ©rez-Ajates S.
- PĂ©rez-Ajates S.
- Raubenheimer K.
- Reyhani H.
- Riboni C.
- Richards T.
- Saeed D.
- Salibasic M.
- SgrĂČ A.
- Soares A. S.
- Soares A. S.
- Steinholt I.
- Tachezy M.
- Trout I.
- Van Straten S.
- Varghese C.
- Vieira B. N.
- Walmsley A.
- Walters B.
- Wang B.
- Wang J.
- Wells C. I.
- Wong J. Y.
- Wong K. H. F.
- Xu W.
- Yasin I.
- Yogarajah T.
- Publication venue
- Publication date
- 01/01/2022
- Field of study
CXCL12/CXCR4: a symbiotic bridge linking cancer cells and their stromal neighbors in oncogenic communication networks
- Author
- A Agarwal
- A Boudot
- A de Lourdes Perim
- A Guyon
- A Kawaguchi
- A Muller
- A Orimo
- A Popple
- A Rigo
- A Vater
- AA Staton
- AC Zannettino
- AF Huang
- AJ Deutsch
- AM Roccaro
- Anyan Liao
- AO Rehman
- AY Limon-Flores
- B Nervi
- B Romain
- B Uygur
- B Xue
- BF Ganzfried
- BG Yang
- C Durr
- C Feig
- C Ierano
- C Monteagudo
- C Porcile
- C Porcile
- CJ Scotton
- CJ Scotton
- CY Chu
- D Crowther-Swanepoel
- D Heckmann
- D Uchida
- DG Duda
- DJ Ceradini
- E Bignotti
- E Righi
- E Salomonnson
- E Zhao
- EA Ramos
- EA Ramos
- EL Heinrich
- ES Jeon
- F Balkwill
- F Barbieri
- F de Nigris
- F Guo
- F Liu
- F Xue
- FT Duan
- H Kajiyama
- H Kajiyama
- H Kulbe
- H Kulbe
- H Tsukamoto
- H Wang
- HN Luo
- I Ghanem
- I Kryczek
- I Kryczek
- I Spinello
- I Wertel
- J Hoellenriegel
- J Kim
- J Kwong
- J Liu
- J Lu
- J Tang
- J Wang
- J Wang
- J Zhou
- JB Lim
- JJ Liang
- JM Hall
- JY Hsieh
- K Beider
- K Jaszczynska-Nowinka
- K Kojima
- K Polyak
- KM Archibald
- KS Kang
- L Chen
- L Guo
- L Lin
- L Quattrocchi
- L Sanchez-Martin
- L Xu
- M Darash-Yahana
- M Gil
- M Gil
- M Grunewald
- M Monterrubio
- M Niedermeier
- M Ramakrishnan
- M Shirozu
- M Toritsuka
- M Wu
- MC Smith
- ME Buechli
- MH Lu
- MK Conley-LaComb
- MM Pillai
- MV Barbolina
- MY Konopleva
- MZ Ratajczak
- MZ Ratajczak
- N Karin
- N Moskovits
- N Obermajer
- N Redjal
- P Ray
- P Yang
- PF Shen
- PL Wagner
- PP Pietkiewicz
- Q Guo
- QX Qu
- R Sanz-Pamplona
- R Siegel
- R Welschinger
- RA Bartolome
- RK Ganju
- RM Thomas
- S Barbero
- S C Mok
- S Chatterjee
- S Douglass
- S Forde
- S Gelmini
- S Infantino
- S Iwasa
- S Taverna
- S Thiele
- S Wei
- S Zhu
- SC Liu
- SF Madden
- SH Jee
- SK Martin
- SN Byrne
- SN Sarchio
- SY Ko
- SY Lin
- T Cohen
- T Yu
- TH Hu
- UM Domanska
- V Leone
- V Machelon
- W Zhang
- W Zhou
- X Li
- X Li
- X Meng
- X Shen
- Y Huang
- Y Liu
- Y Liu
- Y Shaked
- Y Wang
- Y Yang-Hartwich
- Y Yoon
- Y Yu
- Y Yu
- Y Yu
- Y Yuecheng
- Y Zhang
- Y Zhi
- YC Su
- YF Ping
- YH Lee
- YP Jiang
- YP Jiang
- Yunching Chen
- Z Huang
- Z Liang
- Z Liu
- Z Wang
- Z Zeng
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Safety and efficacy of intraperitoneal drain placement after emergency colorectal surgery. An international, prospective cohort study
- Author
- A Adefolaju
- A Afzal
- A Agnes
- A Akintunde
- A AktaĆ
- A AljiÄ
- A Alsaif
- A Amendola
- A Anastasi
- A Anthony
- A Antypas
- A Antypas
- A Argyriou
- A Arnold
- A Arnold
- A Ashaye
- A Aslam
- A Aversano
- A Azmi
- A B Eskici
- A B Turhan
- A Banji-Kelan
- A Bardon
- A Belli
- A Ben Sassi
- A Berry
- A Beuca
- A Beuca
- A Beuca
- A Biancafarina
- A Biancafarina
- A Biondi
- A Borrello
- A BoÄa
- A Braniste
- A Brazukas
- A Caneparo
- A Cannavera
- A Cappiello
- A Cappiello
- A Caridi
- A Carmichael
- A Castaldi
- A Castaldi
- A Castaldi
- A Charalabopoulos
- A Chitul
- A Clynch
- A D'Amore
- A David
- A Davies
- A de Manzoni Garberini
- A de Manzoni Garberini
- A de Manzoni Garberini
- A Devine
- A Devine
- A Duku
- A E Sever
- A Edwards
- A Fancellu
- A Farren
- A Fassari
- A Fitzpatrick
- A G Durmaz
- A Gabarski
- A Gardener
- A GegĂșndez SimĂłn
- A George Pandeth
- A Ghanchi
- A Giani
- A Gicquel
- A Gil CatalĂĄn
- A Giuliani
- A Giuliani
- A Goede
- A Goede
- A Gori
- A Gori
- A Gori
- A Graham
- A Grassam-Rowe
- A Guner
- A Gurung
- A Hamidovic
- A Handa
- A Harun
- A Hassane
- A Hegazi
- A Hegazi
- A Hoather
- A Hooper
- A Hounat
- A Iacomino
- A Isaac
- A Isaac
- A Isik
- A Isik
- A Jani
- A Jukaku
- A K Lala
- A K Mann
- A Kangatharan
- A Kapustina
- A Karamarkovic
- A Khan
- A Khanna
- A Kimpizi
- A KinÄius
- A Kruczynska
- A Langone
- A Larcinese
- A Licata
- A Light
- A Light
- A Litvin
- A Lloyd
- A Lovett
- A Lucarini
- A Lucchi
- A M Cinza
- A M Riad
- A M Scanu
- A Maan
- A Madras
- A Maffioli
- A MalaĆĄonoks
- A MalaĆĄonoks
- A Mallon
- A Mallon
- A Mansor
- A Marano
- A Mark-Christensen
- A Mark-Christensen
- A McCann
- A Mcforrester
- A Mekhralyzade
- A Mhaisalkar
- A Mighiu
- A Mihaljevic
- A Mihaljevic
- A Mingoli
- A Mirza
- A Murphy
- A Murphy
- A Nasehi
- A Nathan
- A Nguyen
- A Nguyen
- A Nogués
- A O'Neill
- A O'Neill
- A Oddi
- A Oseira
- A OzoliĆĆĄ
- A Palumbo
- A Panahi Sharif
- A Panyko
- A Panyko
- A Panyko
- A Paspala
- A Pesce
- A Piangerelli
- A Picciariello
- A Picciariello
- A Picciariello
- A Pisanu
- A Porcu
- A Quigley
- A Quigley
- A Rafie
- A Rafie
- A Rahman
- A Rencuzogullari
- A Rottenberg
- A S Soares
- A S Soares
- A S van Dalen
- A Sagnotta
- A Sagnotta
- A Sagnotta
- A Sarpanov
- A Sattar
- A SgrĂČ
- A Silva
- A Silva
- A Stanley
- A Suarez
- A Suresh
- A Syllaios
- A Szal
- A Thaker
- A Ting
- A Tremlett
- A Triantafyllou
- A Truskovs
- A Urbani
- A Urbieta
- A Utrilla Fornals
- A Valnarov-Boulter
- A van de Ven
- A van de Ven
- A Wagstaff
- A Walmsley
- A Wilson
- A Yalcinkaya
- A Yalcinkaya
- A Yıldırım
- A Zahid
- B A Pop
- B Appleton
- B B Ozkan
- B B Ozkan
- B B Ozmen
- B B Ozmen
- B Bakar
- B Balak
- B Braccio
- B Catchpole
- B Chan
- B Cirillo
- B Cros
- B De Andrés-Asenjo
- B E Baki
- B E Baki
- B E Karaca
- B Furfaro
- B Ibis
- B Ibrahim
- B Martin
- B N Vieira
- B Perotti
- B Picardi
- B Randisi
- B Ribeiro da Silva
- B Ribeiro da Silva
- B Rzeszowski
- B Sensi
- B Singh
- B Tailor
- B Thompson
- B Turner
- B Turner
- B Ular
- B Uyar
- B Villalonga
- B Walker
- B Walters
- B Wang
- B Ăetin
- C A Schena
- C Acil
- C Antropoli
- C Atar
- C Bezede
- C Ciulli
- C D'Alterio
- C De Lucia
- C Di Martino
- C Diler
- C Dörr-Harim
- C Elsworth
- C Elter
- C F Feo
- C Fornasier
- C G Mitrofan
- C Gallagher
- C Giuseppe
- C Grieco
- C Guerci
- C H Li
- C Hawkes
- C Ho
- C Hughed
- C Hughes
- C Hughes
- C Huscher
- C I Wells
- C James
- C Jezieniecki
- C Leseman
- C Linari
- C Lowe
- C Lyon-Dean
- C Magistro
- C Manning
- C Massy-Westropp
- C Matos
- C Mazzeo
- C Mcquoid
- C Milliken
- C Montano King
- C Monteiro
- C Monteiro
- C Nevado GarcĂa
- C O'Sullivan
- C Parmar
- C Pedrazzani
- C Reid
- C Reid
- C Riboni
- C Roxburgh
- C S Ong
- C Silva
- C Simpson
- C Soare
- C Soddu
- C Soldevila Verdeguer
- C Soldevila Verdeguer
- C Spilsbury
- C Spilsbury
- C Stokell
- C SĂĄnchez GarcĂa
- C Theodoropoulos
- C Thomas
- C Tijare
- C Top
- C Trovato
- C Varghese
- C Velez
- C Vignotto
- C WeiĂ
- C Wenban
- C White
- C Wong
- C Y Williams
- C Yates
- C Yates
- C Yick
- C Yick
- C YĂĄnez
- C Zanframundo
- D Ahari
- D Baker
- D Balalis
- D Balalis
- D Banerjee
- D Bhojwani
- D Bhojwani
- D Browne
- D Cincilei
- D Coletta
- D Coletta
- D Daudu
- D Deeny
- D Delogu
- D Dimitrov
- D El-Dalil
- D El-Dalil
- D F Altomare
- D F Altomare
- D Gattulli
- D Gordon
- D Hadzhiev
- D Hurmuzlu
- D Hurmuzlu
- D Kalivaci
- D Kavanagh
- D Kavanagh
- D Kim
- D Korkolis
- D M Dominici
- D Maduka
- D Mantas
- D Nepogodiev
- D Nitisa
- D Ntuiabane
- D Papakonstantinou
- D Papakonstantinou
- D Pinto
- D Rega
- D Rossi
- D Sabbagh
- D Saeed
- D Sasia
- D Sasia
- D Scala
- D Schizas
- D Speake
- D Spoletini
- D Stark
- D Stark
- D Theodorou
- D Theodorou
- D Xu
- D ZagibovĂĄ
- D Ăzen
- D Ăzen
- Dyc Ong
- E Alonso Batanero
- E Alonso Batanero
- E Andolfi
- E Andolfi
- E Angarano
- E Angelini
- E Bailey
- E Baili
- E Baker
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- M P Menna
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- M Ricciardiello
- M Ricciardiello
- M Ricciardiello
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- M Salibasic
- M Sarkin
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- M Shah
- M Shaikh
- M Shimato
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- M Slavchev
- M T Aung
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- M Tancredi
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- M Tansey
- M Taser
- M Ugur
- M Ugur
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- M Ălmez
- Mhk Roshan
- N Ahmed
- N Ahmed
- N Atıcı
- N Azizan
- N Belev
- N Brindl
- N Brindl
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- N Gouvas
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- N Grace
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- N Hagan
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- N Kaka
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- N M Vaselli
- N Machairas
- N Machairas
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- N Minhas
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- N Nandra
- N Nikiteas
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- N Sanderson
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- N Slim
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- O Adderley
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- P Adarkwah
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- Q A Qhaireel Anwar
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- S A GĂŒler
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- S A Vigna
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- S Balasubramanya
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- S Bhatia
- S Bini
- S Bini
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- S Brown
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- S C Reiser
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- S Chan
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- S D Sa
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- S D'Amico
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- S Delibegovic
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- S Iliev
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- S Jamal
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- S Jassim
- S Jauhari
- S Jeffery
- S Jeri
- S K Bylapudi
- S K Bylapudi
- S K Kamarajah
- S Kural
- S Kural
- S Latif
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- S O'Brien
- S O'Brien
- S O'Hara
- S Palagi
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- S S Sundaralingam
- S Salih
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- S Shafi
- S Shah
- S Sheefat
- S Smolarek
- S Smyth
- S Sreenivasan
- S Takar
- S Toh
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- S Van Straten
- S Vertaldi
- S Y Choo
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- S Z Gan
- S Z Kuiper
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- S Zonta
- S ÄustoviÄ
- Shk Yap
- T Ali
- T Almeida
- T Amjad
- T Amjad
- T Ashdown
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- T Banaz
- T Bargellini
- T Brankin-Frisby
- T Burchi-Khairy
- T Burgher
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- T Cavus
- T Choudhary
- T DuĆĄek
- T DuĆĄek
- T Gala
- T Gala
- T Georgiou
- T Gimenez Maurel
- T Glynn
- T GĂłmez Sanz
- T Ivanov
- T Jamadar
- T K Uprak
- T Kouli
- T Liassides
- T Morey
- T Nelli
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- T Noton
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- T Perra
- T Poskus
- T Rafe
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- T Sammour
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- T Thomas
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- T Triantafyllou
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- T Yogarajah
- T Yoldas
- T Yotsov
- U G Vo
- U Grossi
- U JankoviÄ
- U Okwu
- U Pace
- U Shafiq
- V Albino
- V Bastiaenen
- V Bellato
- V Bellato
- V Bintintan
- V Chan
- V Cuk
- V De Peppo
- V Fagarasan
- V Ford
- V Grillo
- V Ivanov
- V Kaminskaite
- V Kaminskaite
- V Mario
- V Murray
- V Nichita
- V Novikovs
- V Ntomi
- V Ozben
- V Ozben
- V Papagni
- V Tanna
- V Testa
- V Tiesi
- V Tonini
- V Tsimplis
- V Verlingieri
- Vwy Soh
- W Allison
- W Attaallah
- W Cambridge
- W Chung
- W H Toh
- W Hurst
- W L Chia
- W Ravindran
- W Roberts
- W Seow
- W X Neo
- W Xu
- W Y Yek
- Wur Ahmed
- Wur Ahmed
- X Hysejni
- X Zhu
- Y Akula
- Y Altinel
- Y Kasmy El Kasmy
- Y Kaya
- Y Kaya
- Y Lim
- Y M Akkaya
- Y Ma
- Y Salama
- Y Shafiq
- Y Zhang
- Yhl Lau
- Z Afzal
- Z Atiyah
- Z Garoufalia
- Z H Sam
- Z Halford
- Z Hussain
- Z Karim
- Z Karmally
- Z Nowinka
- Z Nowinka
- Z S Sabrina
- Z Seymour
- Z Zagorac
- Z Zeidan
- Î ÎÏ ÏÏαΞίοÏ
- Publication venue
- place:Oxford
- Publication date
- 01/01/2023
- Field of study
Intraperitoneal drains are often placed during emergency colorectal surgery. However, there is a lack of evidence supporting their use. This study aimed to describe the efficacy and safety of intraperitoneal drain placement after emergency colorectal surgery. Method: COMPlicAted intra-abdominal collectionS after colorectal Surgery (COMPASS) is a prospective, international, cohort study into which consecutive adult patients undergoing emergency colorectal surgery were enrolled (from 3 February 2020 to 8 March 2020). The primary outcome was the rate of intraperitoneal drain placement. Secondary outcomes included rate and time-to-diagnosis of postoperative intraperitoneal collections, rate of surgical site infections (SSIs), time to discharge and 30-day major postoperative complications (Clavien-Dindo III-V). Multivariable logistic and Cox proportional hazards regressions were used to estimate the independent association of the outcomes with drain placement. Results: Some 725 patients (median age 68.0âyears; 349 [48.1%] women) from 22 countries were included. The drain insertion rate was 53.7% (389 patients). Following multivariable adjustment, drains were not significantly associated with reduced rates (odds ratio [OR] =â1.56, 95% CI: 0.48-5.02, pâ=â0.457) or earlier detection (hazard ratio [HR] =â1.07, 95% CI: 0.61-1.90, pâ=â0.805) of collections. Drains were not significantly associated with worse major postoperative complications (ORâ=â1.26, 95% CI: 0.67-2.36, pâ=â0.478), delayed hospital discharge (HRâ=â1.11, 95% CI: 0.91-1.36, pâ=â0.303) or increased risk of SSIs (ORâ=â1.61, 95% CI: 0.87-2.99, pâ=â0.128). Conclusion: This is the first study investigating placement of intraperitoneal drains following emergency colorectal surgery. The safety and clinical benefit of drains remain uncertain. Equipoise exists for randomized trials to define the safety and efficacy of drains in emergency colorectal surgery
Intraperitoneal drain placement and outcomes after elective colorectal surgery: international matched, prospective, cohort study
- Author
- Aba M.
- Abdellatif M.
- Abdelmahmoud S.
- Abu Hassan F.
- Acil C.
- Adarkwah P.
- Adarraga J.
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- Yogarajah T.
- Yoldas T.
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- Yousaf H.
- Yousuff M.
- Yuksel E.
- Zabiyaka M.
- Zafer F.
- Zafer F.
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- Zagibova D.
- Zagorac Z.
- Zaheer M.
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- Zammit-Maempel M.
- Zanframundo C.
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- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2022
- Field of study
Many surgeons routinely place intraperitoneal drains after elective colorectal surgery. However, enhanced recovery after surgery guidelines recommend against their routine use owing to a lack of clear clinical benefit. This study aimed to describe international variation in intraperitoneal drain placement and the safety of this practice
Immunology and Immunotherapy of Ovarian Cancer
- Author
- A Agarwal
- A Agarwal
- A Ayantunde
- A Bamias
- A Bamias
- A Ben-Baruch
- A Chlenski
- A Coliva
- A Fasciani
- A Flyvbjerg
- A Green
- A Greenhough
- A MacciĂČ
- A MacciĂČ
- A MacciĂČ
- A MacciĂČ
- A Munkarah
- A Mustea
- A Mustea
- A Okamoto
- A Orimo
- A Rabinovich
- A Rabinovich
- A Rainczuk
- A Sakamoto
- A Santin
- A Sawano
- A Sica
- A Sica
- A Strandell
- A Walz
- A Ăstman
- AA Garcia
- AA Link
- AA Noujaim
- AB Heimberger
- AC Ziogas
- AD Santin
- AE Karnoub
- AE Loercher
- AE Lokshin
- AE Prizment
- AG Jarnicki
- AG Zee Van Der
- AH Klimp
- AJ Lambeck
- AK Styer
- AM Vlad
- AM Westermann
- AP Vicari
- AS Dehaghani
- AS Whittmore
- AT Byrne
- B Dobrzycka
- B Melichar
- B Sredni
- B Weigang
- B Xin
- BC Cooper
- BE Loveland
- BH Nelson
- BJ Moeller
- BM Kacinski
- BM Kacinski
- BM Sandmaier
- BR Bloom
- C Aghajanian
- C Becker
- C Bokemeyer
- C Chen
- C Denkert
- C Marth
- C Marth
- C Murdoch
- C Parham
- C RodrĂguez-Burford
- C Tempfer
- C Yee
- C-W Lo
- CA Boocock
- CA Herrera
- CA Shah
- CH Arnott
- CJ Scotton
- CM Kyama
- CN Landen
- CS Chu
- D Belotti
- D Belotti
- D Cao
- D Lane
- D Matei
- D Milliken
- D Stark
- D Wang
- DA Fishman
- DB Agus
- DC Lockhart
- DE Machado
- DE Spaner
- DI Gabrilovich
- DJ Chung
- DK Armstrong
- DR Parkinson
- DR Senger
- DS Alberts
- DW Cramer
- E Bamberger
- E Casado
- E DaraĂŻ
- E Gorelik
- E Halapi
- E Huarte
- E Pujade-Lauraine
- E Righi
- E Sato
- EB Haura
- EL Johnson
- EM Conway
- EP Beck
- EP Toy
- EY Woo
- F Balkwill
- F Balkwill
- F Spinella
- F Spinella
- F VĂĄnky
- FG Berger
- FV Price
- G Coukos
- G Ferrandina
- G Ferrandina
- G Hall
- G Jego
- G Mantovani
- G Mantovani
- G Mantovani
- G McMahon
- G Mor
- G Scambia
- G Shen
- G Windbichler
- G Yang
- G Yang
- G Yang
- GK Siddiqui
- GM Abu-Jawdeh
- GM Yousef
- GM Yousef
- GP Bertenshaw
- GP Dunn
- H Chen
- H Kajiyama
- H Kulbe
- H Kulbe
- H Kulbe
- H Lu
- H Min
- H Naora
- H Sowter
- H Takeyama
- H Thanaa El-A
- H Yoshiji
- H Zhang
- HA Risch
- HA Risch
- HN Jabbour
- HT Khong
- I Clark-Lewis
- I Goldstein
- I Kryczek
- I Kryczek
- I Kryczek
- I Kryczek
- I Matte
- I Wertel
- IH Roland
- IO Gordon
- J Bartlett
- J Berek
- J Coward
- J Dellacasagrande
- J Fang
- J Fang
- J Fujimoto
- J Gong
- J Graham
- J Hamanishi
- J Khunnarong
- J Kim
- J Kim
- J Krempski
- J Lewis
- J Liu
- J Mattern
- J Mendelsohn
- J Mu
- J Symowicz
- J Vane
- J Xu
- J Yin
- J-M Wang
- J-P Coppé
- J-Y Li
- JA Foekens
- JA Foekens
- JC Chura
- JC Luo
- JD Hudson
- JE Naschitz
- JG Asschert
- JG Zhang
- JH Harmey
- JJ Hernando
- JJ Schumacher
- JJPT Hernando
- JL Langowski
- JL Luo
- JM Argilés
- JM Lancaster
- JR WilczyĆski
- JS Berek
- JS Berek
- JS Berek
- JS Fleming
- JW Pollard
- JWF Sun
- K Bennaceur
- K Bennaceur
- K Chang
- K Ivarsson
- K Jaszczynska-Nowinka
- K Maisey
- K Mayerhofer
- K Odunsi
- K Rask
- K Sundfeldt
- K Takeda
- K Yanagisawa
- K-J Huang
- K-T Yeo
- KA Charles
- KD Elgert
- KF McGonigle
- KH Kim
- KJ Kim
- KS Rath
- KT Schmeidler-Sapiro
- L Amler
- L C-z
- L Cervenak
- L Guo
- L Turner
- L Wong Te Fong
- L Xu
- L Xu
- L Xu
- L Zhang
- L Zhang
- L Zhang
- LA Brinton
- LA Hefler
- LA Hefler
- LA Hefler
- LA Sullivan
- LB Epstein
- LF Wong Te Fong
- LM Coussens
- LS Cook
- LZ Liu
- M Altinoz
- M Balzar
- M Booth
- M Bruzzone
- M Cecchini
- M Chechlinska
- M Colomiere
- M Cuello
- M Duechler
- M Friedlander
- M Hampl
- M Jaiswal
- M JĂ€ger
- M Klink
- M Krockenberger
- M Liu
- M Markman
- M Meyer
- M Muccioli
- M Nash
- M Naylor
- M Nowak
- M Nowak
- M Orre
- M Raspollini
- M Schmitt
- M Schummer
- M Urosevic
- M Zhou
- M-T Lau
- MA Bookman
- MC Franklin
- MD Cooper
- MD Sharma
- ME Burg van der
- ME Gordinier
- ME Stearns
- MG Kelly
- MG Ott
- MG Resenblum
- MH Pourgholami
- MJ Cannon
- MJ Delano
- MJ Grimshaw
- MJ Smyth
- MJ Smyth
- ML Disis
- ML Disis
- MM Heiss
- MR Raspollini
- MR Schneider
- MS Gordon
- MS OâReilly
- MS Pepper
- MS Piver
- N Auersperg
- N Bozkurt
- N Einhorn
- N Ferrara
- N Kundu
- N Matsumura
- N Miyanishi
- N Nishida
- N Obermajer
- N Parker
- N Raghunand
- N Seo
- N Tariverdian
- N Wang
- NG Gavalas
- NM Moutsopoulos
- O Gallo
- O Toutirais
- P Brossart
- P Dam Van
- P DeJaco
- P Heinonen
- P Jeannin
- P Kenemans
- P Roszkowski
- P Ruf
- P Sabbatini
- P Sarraf
- P Serafini
- P Serafini
- P Sinha
- P Willemse
- P Yu
- PJ Paley
- R AliâFehmi
- R Berger
- R Cao
- R Edwards
- R Fujiwaki
- R Garg
- R Kalluri
- R Medzhitov
- R Negus
- R Negus
- R Uslu
- R Werling
- R Zang
- R Zeidler
- R Zeidler
- RA Burger
- RA Burger
- RA Gupta
- RA Mitchell
- RB Ness
- RI Demopoulos
- RJ Kurman
- RK Jain
- RL Giuntoli
- RM Steinman
- RM Steinman
- RN Kaplan
- RS Freedman
- RS Freedman
- S Berger
- S Chakrabarty
- S Chambers
- S Ghosh
- S Huang
- S Huang
- S Koido
- S Kooi
- S Liao
- S Liao
- S Mabuchi
- S Majewski
- S Malik
- S Mesiano
- S Mocellin
- S Mocellin
- S Ostrand-Rosenberg
- S Peter
- S Ramakrishnan
- S Reinartz
- S Scholl
- S Wang
- S Wei
- S Weis
- S Wu
- SA Cannistra
- SAA Stadlmann
- SD Yamada
- SE Erdman
- SI Labidi-Galy
- SK Biswas
- SK Bunt
- SK Chambers
- SK Chambers
- SK Chambers
- SK Lutgendorf
- SP Hussain
- SV Litvinov
- T Abdollahi
- T Blankenstein
- T Calandra
- T Cheng
- T Cramer
- T Daikoku
- T Daikoku
- T Daikoku
- T Ehlen
- T Hagemann
- T Hagemann
- T Hagemann
- T Inaba
- T Kammertoens
- T Kohno
- T Kusuda
- T Mainou-Fowler
- T Oyama
- T Wang
- T-L Erkinheimo
- TA Hembrough
- TA Olson
- TJ Curiel
- TJ Curiel
- TJ Curiel
- TJ Perren
- TL Whiteside
- TM Robinson-Smith
- TV Clendenen
- TV Do
- UK Scarlett
- V Ranpura
- W Dummer
- W Kuhn
- W Li
- W Li
- W Li
- W Shan
- W Zou
- W-W Lin
- WH Gotlieb
- WJ Murdoch
- WL Smith
- WM Merritt
- X Fang
- X Fang
- X Su
- X Wang
- X Zhang
- Y Cao
- Y Hasumi
- Y Hirashima
- Y Miyahara
- Y Nakanishi
- Y Xu
- Y Yokoyama
- Y-p Jiang
- Y-p Jiang
- YC Chung
- Z Cao
- Z Duan
- Z Liu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Evaluation of prognostic risk models for postoperative pulmonary complications in adult patients undergoing major abdominal surgery: a systematic review and international external validation cohort study
- Author
- Abada S
- Abbas Syed R
- Abbas JD
- Abdalla M
- Abdel-Khaleq S
- Abdelrahim ASA
- Abdelrazek M
- Abdelrazik Y
- Abdi M
- Abdolrazaghi S
- Abdul-Fattah S
- Abdulla S
- Abdullah M
- Abi Aoun R
- Abid S
- Abigail S
- Abou El Ela Bourquin B
- Abousamra M
- Adabavazeh B
- Adams J
- Adams M
- Adams N
- Adcock A
- Adebambo D
- Adeboyejo O
- Adeeko ES
- Adelekan K
- Adelowo T
- Adeniken E
- Adeoye A
- Adeusi L
- Afsheen N
- Agarwal A
- Agarwal G
- Agarwal N
- Agbinya N
- Aghanenu O
- Agiotakis S
- Aguirrezabala Armbruster B
- Ahari D
- Ahmad Fuad MF
- Ahmad MA
- Ahmad NA
- Ahmadi H
- Ahmed Osman A
- Ahmed A
- Ahmed I
- Ahmed J
- Ahmed M
- Ahmed O
- Ahmed S
- Ahmed SK
- Ahmed W
- Ainsworth J
- Ainsworth K
- Aitken S
- Ajdarpasic D
- Ajekigbe F
- Akbar Z
- Akhbari M
- Akintunde A
- Akinyemi J
- Akmal A
- Akmal K
- Akram B
- Al Bahri T
- Al Bakry M
- Al Dabbagh A
- Al Rawi M
- Al Sadek Y
- Al-Hamid Z
- Al-Khafaji M
- Alam F
- Alattas A
- Alawattegama LH
- Alberts J
- Alfadhel S
- Alhwaishel K
- Ali Butt S
- Ali A
- Ali K
- Ali M
- Ali N
- Ali S
- Alim L
- Alkandari B
- Alkoot M
- Allan D
- Allan J
- Allen K
- Allen R
- Allin D
- Almoosawy SA
- Alom J
- Alsaady A
- Alsadoun L
- Alsusa H
- Alves do Canto Brum H
- Alves D
- Aly R
- Alyacoubi S
- Amakye NY
- Amarnath T
- Amin A
- Amin M
- Amini B
- Anandampillai R
- Anarfi S
- Anderson E
- Anderson P
- Anderton J
- Andrew F
- Anjum Z
- Ansar Z
- Anthony Wilkinson J
- Antypas A
- Anuar A
- Apata A
- Appanna T
- Appleton B
- Appleyard T
- Arain Z
- Aranha M
- Arnold A
- Arnold C
- Arora E
- Arrayeh A
- Arshad M
- Arshad SR
- Arthur-Quarm S
- Arumugam V
- Arwi G
- Ashai S
- Asharaf H
- Ashaye A
- Ashcroft-Quinn S
- Ashdown T
- Ashman M
- Ashok A
- Ashwell W
- Ashworth I
- Asif A
- Asvandi S
- Atherton R
- Atiyah A
- Atkins W
- Aung E
- Aung YY
- Austin T
- Ayandokun P
- Ayub H
- Azam R
- Azam Z
- Azeez Z
- Azizan N
- Azizi S
- Azlan A
- Azouaghe O
- Bachelet B
- Bacigalupo V
- Bacon H
- Badminton R
- Badran A
- Bahl S
- Bailey A
- Bain J
- Bajaj M
- Bajaj S
- Bajaj V
- Baker C
- Baker D
- Baker J
- Baker O
- Bakina C
- Balakumar V
- Balasubramanian A
- Balasubramanian N
- Bald A
- Balfour J
- Ball M
- Bandyopadhyay D
- Bandyopadhyay S
- Bangi S
- Bani W
- Bannister J
- Barabas M
- Baraza W
- Barciela C
- Bardon A
- Barham E
- Barnes R
- Barrett G
- Barrington J
- Barrington M
- Barry I
- Barry J
- Barry K
- Bartlett M
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/06/2022
- Field of study
Background Stratifying risk of postoperative pulmonary complications after major abdominal surgery allows clinicians to modify risk through targeted interventions and enhanced monitoring. In this study, we aimed to identify and validate prognostic models against a new consensus definition of postoperative pulmonary complications. Methods We did a systematic review and international external validation cohort study. The systematic review was done in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We searched MEDLINE and Embase on March 1, 2020, for articles published in English that reported on risk prediction models for postoperative pulmonary complications following abdominal surgery. External validation of existing models was done within a prospective international cohort study of adult patients (â„18 years) undergoing major abdominal surgery. Data were collected between Jan 1, 2019, and April 30, 2019, in the UK, Ireland, and Australia. Discriminative ability and prognostic accuracy summary statistics were compared between models for the 30-day postoperative pulmonary complication rate as defined by the Standardised Endpoints in Perioperative Medicine Core Outcome Measures in Perioperative and Anaesthetic Care (StEP-COMPAC). Model performance was compared using the area under the receiver operating characteristic curve (AUROCC). Findings In total, we identified 2903 records from our literature search; of which, 2514 (86·6%) unique records were screened, 121 (4·8%) of 2514 full texts were assessed for eligibility, and 29 unique prognostic models were identified. Nine (31·0%) of 29 models had score development reported only, 19 (65·5%) had undergone internal validation, and only four (13·8%) had been externally validated. Data to validate six eligible models were collected in the international external validation cohort study. Data from 11â591 patients were available, with an overall postoperative pulmonary complication rate of 7·8% (n=903). None of the six models showed good discrimination (defined as AUROCC â„0·70) for identifying postoperative pulmonary complications, with the Assess Respiratory Risk in Surgical Patients in Catalonia score showing the best discrimination (AUROCC 0·700 [95% CI 0·683â0·717]). Interpretation In the pre-COVID-19 pandemic data, variability in the risk of pulmonary complications (StEP-COMPAC definition) following major abdominal surgery was poorly described by existing prognostication tools. To improve surgical safety during the COVID-19 pandemic recovery and beyond, novel risk stratification tools are required. Funding British Journal of Surgery Society
BJS commission on surgery and perioperative care post-COVID-19
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- Ăhlberger L.
- ĂlĂ§ĂŒm M.
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2021
- Field of study
Background: Coronavirus disease 2019 (COVID-19) was declared a pandemic by the WHO on 11 March 2020 and global surgical practice was compromised. This Commission aimed to document and reflect on the changes seen in the surgical environment during the pandemic, by reviewing colleagues experiences and published evidence. Methods: In late 2020, BJS contacted colleagues across the global surgical community and asked them to describe how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had affected their practice. In addition to this, the Commission undertook a literature review on the impact of COVID-19 on surgery and perioperative care. A thematic analysis was performed to identify the issues most frequently encountered by the correspondents, as well as the solutions and ideas suggested to address them. Results: BJS received communications for this Commission from leading clinicians and academics across a variety of surgical specialties in every inhabited continent. The responses from all over the world provided insights into multiple facets of surgical practice from a governmental level to individual clinical practice and training. Conclusion: The COVID-19 pandemic has uncovered a variety of problems in healthcare systems, including negative impacts on surgical practice. Global surgical multidisciplinary teams are working collaboratively to address research questions about the future of surgery in the post-COVID-19 era. The COVID-19 pandemic is severely damaging surgical training. The establishment of a multidisciplinary ethics committee should be encouraged at all surgical oncology centres. Innovative leadership and collaboration is vital in the post-COVID-19 era