Phytochemical Study On Sesbania Grandiflora Roots And Synthesis Of Selected Flavonoid Precursors (Chalcones Derivatives)

Sesbania grandiflora, a small tree up to 15 m tall, is a traditional medicinal plant collected from South Lampung, Indonesia. Some new and known compounds were isolated from the roots of this plant. They were identified as one terpenoid, betulinic acid (81), ten flavonoids, malindonesianin A-C (82, 86, 88), xenognosin B (83), liquiritigenin (84), 7,2’,4’-trihydroxyisoflavone (85), demethylvestitol (87), vestitol (89), medicarpin (90) and sativan (91), together with one biaryl compound, l,l’-binaphthalene-2,2’-diol (92). Among them, three compounds (82, 86, 88) were established as novel isoflavonoid dimers, while one compound (92) was found as new biaryl natural product. Chalcone is an important biosynthetic precursor, due to the diverse pharmacological activities. The aim of this current study was to synthesize 28 new chalcone derivatives compounds by incorporating p-alkoxyacetophenones with substituted benzaldehydes. Four new series of chalcone derivatives have been synthesized using the alkylation and the base catalysed Claisen-Schmidt condensation. All the synthesized compounds were fully characterized by IR, 1D NMR (1H and 13C NMR) and 2D NMR (COSY, HMQC, HMBC) as well as mass spectrometry analysis

Ketahanan Lima Kultivar Padi Lokal (Oryza sativa L.) terhadap Wereng Batang Cokelat (Nilaparvata lugens Stål, Hemiptera)

Wereng batang cokelat (Nilaparvata lugens) merupakan hama utama padi di Indonesia. Salah satu cara penanggulangan hama wereng batang coklat yaitu menggunakan kultivar padi unggul yang mempunyai sifat tahan terhadap OPT tersebut. Kultivar lokal dapat digunakan sebagai tetua utama maupun tetua donor gen ketahanan. Penelitian ini bertujuan untuk menguji ketahanan lima kultivar padi lokal Tebidah, Irik, Gadjah Rante, Boyan dan Gadung Mlati terhadap wereng batang coklat. Uji penapisan modifikasi kotak bibit digunakan dengan kultivar pembanding IR64 dan Cisadane. Kultivar padi tahan terpilih diuji lebih lanjut untuk mengetahui perkembangan populasi N. lugens pada kultivar tersebut. Lima kultivar yang diuji hanya tiga yang berhasil tumbuh yaitu Tebidah, Irik, dan Boyan. Uji penapisan menunjukkan bahwa kultivar Boyan termasuk kategori agak tahan, sedangkan kultivar Tebidah dan Irik termasuk kategori agak rentan. Kultivar Boyan menunjukkan hasil yang konstan dengan uji kotak benih karena populasi N. lugens pada kultivar ini sama dengan populasi pada kultivar IR64 yang merupakan kultivar tahan. Kultivar Boyan agak tahan terhadap serangan wereng batang coklat, karena pertumbuhannya tidak begitu terpengaruh oleh serangan wereng batang coklat berdasarkan tingkat kerusakan, jumlah imago, dan jumlah nimfa generasi selanjutnya

Influence Service Quality and Customer Relationship Marketing to Customer Value and it’s implications for Customer Satisfaction in Branch Office BRI Bandung

This study aims to determine the effect Service Quality and Customer Relationship Marketing to Customer Value and it’s implications for Customer Satisfaction in Branch Office BRI Soekarno Hatta Bandung. The population in this study were customer who have used banking service in BRI, while the sample in this study was 100 respondents using purposive sampling technique. Data analysis technique used is the technique Correlation Analysis (Path Analysis) to determine the degree of closeness of the relationship between variables. The results showed that effect direct Service Quality for 0379. Service Quality indirect effect through the CRM of 0.149. CRM direct influence on Customer Value of 0.092 and indirectly influence the CRM through Service Quality of 0.149 so that the total effect of 0771. The direct effect of Customer Value on Customer Satisfaction of 0,816. The results show determination coefficient of 77.1% and 22.9% Pye, and partial variable Service Quality more dominant effect of the variable CRM. Obtained the conclusion that the effect of Service Quality have the greatest influence. Customer Value showing determination coefficient of 81.6% and 18.4% Pye, from satisfaction to Customer Satisfaction variable

The Effect of Product Diversification on the Purchase Decision of Telkomsel Loop Simcards (Case Study of Bandung State Polytechnic Students)

This study aims to determine and analyze the Effect of Product Diversification on the Purchase Decision of Telkomsel Loop Simcards (Case Study in Bandung State Polytechnic Students). The research method used in this research is a descriptive analysis and verification method with a population of 100 students by using accidental sampling technique by providing a link to fill out the questionnaire via Google Drive. The data analysis technique used is the Correlation Analysis Technique to determine the degree of closeness of the relationship between variables. The results showed that the direct effect of Product Diversification was 3.97. The indirect effect of the Purchasing Decision is 4.13. The test results are known to the constant value (a) of 2.537 and partially Product Diversification variable influences the Purchasing Decision variable. It was concluded that the effect of Product Diversification on Purchasing Decisions showed a positive regression coefficient of 0.468

The Impact of Internal Audit Function Effectiveness on Quality of Financial Reporting and its Implications on Good Government Governance Research on Local Government Indonesia

The purpose of this research is to examine the impact of Internal Audit Function Effectiveness on the Quality of Financial Reporting and Its Implications on Good Government Governance. The research conducted on 70 working unit area device on 7 District Local Government in eks Karesidenan Pekalongan Indonesia uses survey methods. The data is primary data collected  through questionnaire. The samples selection uses proportionate stratified random sampling method. The data was processed using structural equation modeling (Partial Least Square). The results of this research show that: (1) From the results of test Krusskal Wallis, there are no significant differences between the effectiveness of the internal audit, quality financial reporting and the good government governance in 7 local government (2 )the effectiveness of the internal audit function has significant effect on the quality of financial reporting. 3) Internal audit function  has significant effect on Good Goverment Governance Application, 4) Quality of financial reporting has significant effect on Good Government Governance Application Keywords: Effectiveness of Internal Audit Function, Quality of Financial Reporting, Good Government Governanc

The Improvement of Paclitaxel Cytotoxicity using Nanocellulose based Nature Resources

Paclitaxel is one of the cancer drugs that often used. These drug kills cancer cells by inhibiting mitotic cycle. The efficiency of paclitaxel is increased by the use of nanomaterials as a carrier of paclitaxel. Nanomaterials can enhance encapsulation efficiency, improve the drug release to the target cell following nanomaterial degradation, and improve local accumulation of drug in the cellthrough endocytosis receptor. Nanomaterial that often used forencapsulation of paclitaxel is a polymer derived from natural resources such as cellulose. The advantages of cellulose as a carrier of paclitaxel are nontoxic, biodegradable, and very abundant from various sources. One of the potential sources of cellulose for drug delivery system is cassava baggase

Analisis Kinerja Keuangan PT Mustika Ratu, Tbk Sebelum dan Setelah Memperoleh Sertifikat ISO 9001:2008

Menghadapi persaingan yang kompetitif PT Mustika Ratu, Tbk (MRAT) mengutamakan kualitas sebagai salah satu keunggulan kompetitif. Kualitas yang baik terbentuk melalui sistem manajemen mutu yang baik. Untuk meningkatkan sistem manajemen mutu perusahaan pada tahun 2009 MRAT menerapkan suatu standar sistem manajemen mutu internasional yang disebut ISO 9001:2008. Penelitian ini bertujuan untuk mengetahui perbedaan kinerja keuangan MRAT tiga tahun sebelum dan tiga tahun setelah memperoleh sertifikat ISO 9001:2008. Kinerja keuangan diteliti melalui rasio Gross Profit Margin (GPM) untuk menunjukan efisiensi, rasio Sales Growth untuk menunjukan kenaikan penjualan, dan rasio Return On Assets (ROA) untuk menunjukan profitabilitas. Untuk mengetahui perbedaan GPM, Sales Growth, dan ROA sebelum dan setelah sertifikasi ISO 9001:2008 metode penelitian yang digunakan adalah uji independent sample t-test. Hasil penelitian menunjukan sebelum memperoleh sertifikat ISO 9001:2008 rata-rata GPM adalah 55,74% dan setelah memperoleh sertifikat ISO 9001:2008 adalah 56,03%. Rata-rata GPM setelah sertifikasi ISO 9001:2008 hanya meningkat sebesar 0,0053%, sehingga dapat disimpulkan bahwa tidak ada perbedaan yang signifikan antara sebelum dan setelah memperoleh sertifikasi ISO 9001:2008. Begitu pula pada Sales Growth, sebelum memperoleh sertifikat ISO 9001:2008 rata-rata Sales Growth adalah 14,08% dan kemudian menurun 29,8% menjadi 9,88% setelah MRAT memperoleh sertifikat ISO 9001:2008, sehingga disimpulkan bahwa tidak terdapat perbedaan yang signifikan pada Sales Growth sebelum dan setelah memperoleh sertifikat ISO 9001:2008. Sedangkan, rata-rata ROA sebelum memperoleh sertifikat ISO 9001:2008 adalah 6,38%, kemudian meningkat sevara signifikan menjadi 9,52% setelah memperoleh sertifikat ISO 9001:2008. Rata-rata ROA MRAT menunjukan kenaikan sebesar 49,11%, dengan demikian terdapat perbedaan ROA yang signifikan antara sebelum dan setelah MRAT memperoleh sertifikat ISO 9001:2008. Berdasarkan hasil penelitian, penulis dapat menyarankan bagi MRAT untuk secara optimal dan konsisten memanfaatkan ISO 9001:2008 dalam semua proses, termasuk dalam mengatur biaya produksi secara efisien, usaha peningkatan pangsa pasar, dan pengelolaan aktiva, sehingga MRAT dapat meningkatkan kinerja keuangan secara berkesinambungan

DIFERENSIASI THUMBPRINT COOKIES BERBAHAN DASAR TEPUNG PISANG RAJA SEBAGAI KUDAPAN BEBAS GLUTEN

Tanaman pisang tumbuh subur di Indonesia menjadikan buah ini mudah untuk ditemukan. Sejak lama, tepung pisang banyak diolah sebagai alternatif pengganti tepung terigu. Tepung terigu mengandung protein glutenin yang bersifat lengket apabila terkena air. Produk yang menggunakan tepung terigu adalah olahan bakery dan pastry. Namun kenyataannya tidak semua orang dapat mengkonsumsi produk yang mengandung gluten adapun saat ini peminat olahan produk bebas gluten cukup banyak (Grandview research, 2020). Penelitian ini bertujuan untuk membuat sebuah diferensiasi produk thumbprint cookies yang menggunakan tepung pisang raja dengan isian selai coklat. Metode penelitian yang digunakan adalah experimental, produk diujikan dalam 3 formulasi yang berbeda dengan sampel TC01 dengan persentase 100% tepung pisang raja, sampel TC02 menggunakan 75% tepung pisang raja dan 25 % tepung beras, sampel TC03 menggunakan 50% tepung pisang raja dan 50% tepung beras, selanjutnya melakukan uji sampel produk kepada panelis ahli dan terlatih yang berjumlah 6 orang untuk menemukan produk terbaik dan menjadikannya standar resep. kemudian dilakukan uji penerimaan kepada 30 orang panelis konsumen untuk mengukur tingkat kesukaan dan penerimaan terhadap produk thumbprint cookies. Kata kunci : diferensiasi produk, thumbprint cookies, tepung pisang raja Banana plants thrive in Indonesia make this fruit easy to find. For a long time, banana flour has been processed as an alternative to wheat flour. Wheat flour contains glutenin protein which is sticky when exposed to water. Products that use wheat flour are processed bakery and pastry. But the fact is that not everyone can consume products that contain gluten, while there are quite a lot of enthusiasts of processed gluten-free products (Grandview research, 2020). This study aims to make a product differentiation thumbprint cookies using plantain flour with chocolate jam filling. The research method used is experimental, the product is tested into 3 different formulations with TC01 samples with a percentage of 100% plantain flour, sample TC02 used 75% plantain flour and 25% rice flour, sample TC03 used 50% plantain flour and 50% rice flour, then tested product samples to expert and trained panelists of 6 people to find the best product and make it a standard recipe . then an acceptance test was conducted on 30 consumer panelists to measure the level of liking and acceptance of the thumbprint cookie product. Keywords: differentiation product, thumbprint cookies, plantain flou