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Efforts Towards the Synthesis of Silanes for Their Use in Catalysis and as Molecular Wires
The Leighton group has long been interested in developing strained silanes for their use in polyketide synthesis. Recently, our interests have led us to develop a new type of silicon Lewis acid and catalyst with high levels of reactivity. Upon activation with a thiourea, a stabilized silylium ion is formed allowing for the facile allylation of aldehydes and ketones, in addition to Diels-Alder catalysis. This represents one of the first examples of the merger between anion-binding catalysis and silylium ion catalysis. Our group’s interest in strained silanes has also led us to investigate their conductance properties in molecular break junctions. To further understand the nature of the bond-ruptured species we have proposed new synthetic targets and have described herein our progress towards synthesizing these targets
An Oxidopyrylium Cyclization/Ring-Opening Route to Polysubstituted α‑Hydroxytropolones
α-Hydroxytropolones are a class of molecules with therapeutic potential against several human diseases. However, structure–activity relationship studies on these molecules have been limited due to a scarcity of efficient synthetic methods to access them. It is demonstrated herein that α-hydroxytropolones can be generated through a BCl<sub>3</sub>-mediated ring-opening/aromatization/demethylation process on 8-oxabicyclo[3.2.1]octenes. Used in conjunction with an improved method based on established oxidopyrylium dipolar cycloadditions, several polysubstituted α-hydroxytropolones can be accessed in three steps from readily available α-hydroxy-γ-pyrones
Gum ghatti mediated, one pot green synthesis of optimized gold nanoparticles: Investigation of process-variables impact using Box-Behnken based statistical design
Development of amino-functionalized silica nanoparticles for efficient and rapid removal of COD from pre-treated palm oil effluent
Inhibition of the ANT(2″)-Ia resistance enzyme and rescue of aminoglycoside antibiotic activity by synthetic α-hydroxytropolones
Triflic Acid-Mediated Rearrangements of 3-Methoxy-8-oxabicyclo[3.2.1]octa-3,6-dien-2-ones: Synthesis of Methoxytropolones and Furans
Proceedings of International Web Conference in Civil Engineering for a Sustainable Planet
This proceeding contains articles of the various research ideas of the academic community and practitioners accepted at the "International Web Conference in Civil Engineering for a Sustainable Planet (ICCESP 2021)". ICCESP 2021 is being Organized by the Habilete Learning Solutions, Kollam in Collaboration with American Society of Civil Engineers (ASCE), TKM College of Engineering, Kollam, and Baselios Mathews II College of Engineering, Kollam, Kerala, India.
Conference Title: International Web Conference in Civil Engineering for a Sustainable PlanetConference Acronym: ICCESP 2021Conference Date: 05–06 March 2021Conference Location: Online (Virtual Mode)Conference Organizer: Habilete Learning Solutions, Kollam, Kerala, IndiaCollaborators: American Society of Civil Engineers (ASCE), TKM College of Engineering, Kollam, and Baselios Mathews II College of Engineering, Kollam, Kerala, India