Sedentary behaviour and cerebrovascular disease: molecular mechanisms and the impact of bout duration. : A multicentre cohort study.

Abstract Background: Sedentary behaviour is associated with vascular disease, and being sedentary for long periods at a time is believed to be associated with the highest risk. The molecular mechanisms are presumed to follow metabolic and inflammatory pathways. Details about these pathways or the length of a clinical significant sedentary bout is not known. Aims: The primary aim of this study was to investigate the association between sedentary behaviour and novel blood biomarkers with potential predictive and explanatory properties. The secondary aim was to investigate the impact of sedentary behaviour bout length on these biomarkers. Materials and methods: Patients admitted to hospital for acute stroke were included in the multicentre cohort study entitled the Norwegian Cognitive Impairment After Stroke (Nor-COAST) study (n=815). At the three-month assessment (n=700), sedentary behaviour was measured using the body-worn sensor ActivPAL. Blood samples were drawn for analyses at the local laboratory directly, and biobank samples were stored and later analysed for inflammatory biomarkers at two research laboratories. The long-term outcomes, ischemic stroke recurrence and mortality was identified using national registries. Results: Glycated haemoglobin A (HbA1c) was positively associated with sedentary behaviour accumulated through bouts of 90 minutes or more. Total sedentary time was associated with higher levels of the inflammatory biomarkers C-reactive protein (CRP), interleukin-6 (IL-6), the pyridoxic acid ratio-index (PAr-index), and neopterin, and lower levels of kynurenic acid (KA). The study did not have enough power for investigating the impact of bout length on these biomarkers. There were no associations between the biomarkers and ischemic stroke recurrence. Mortality was associated with higher levels of CRP. When added to the same model, neopterin and KA showed positive and negative associations to mortality, respectively. Conclusion and implications: The results support that the impact of sedentary behaviour on disease progression is mediated through known vascular risk factors and novel biomarkers can be useful for future intervention studies.Doktorgradsavhandlin

The Hamilton-jacobi Theory of Dynamics

Canonical equations, transformations, and integration principles in Hamilton-Jacobi theory of dynamic

The Belo Monte hydropower complex in Brazil : actors, interests, and environmental justice

B-D

Chronic kidney disease in patients with diabetes mellitus

Chronic kidney disease is a common complication and concomitant condition of diabetes mellitus. The treatment of patients with diabetes and chronic kidney disease, including intensive control of blood sugar and blood pressure, has been very similar for type 1 and type 2 diabetes patients. New therapeutic targets have shown promising results and may lead to more specific treatment options for patients with type 1 and type 2 diabetes

Observation of Physiological Changes During Transcendental Meditation

Techniques of yoga have been associated with alterations in physiology, but until recently there has been only haphazard and uncontrolled research . Since 1970, information has been gathered which suggests that the practice of Transcendental Meditation (TM), a derivative of yoga, significantly affects changes in several physiological areas. This study observed changes in breath rate and peripheral circulation before, during, and after the practice of TM. Results showed a significant decrease in breath rate and changes in circulation patterns in the hand and forehead of subjects

Electrons and phonons in the ternary alloy CaAl2−x_{2-x}Six_x} as a function of composition

We report a detailed first-principles study of the structural, electronic and vibrational properties of the superconducting C$_{32}$ phase of the ternary alloy CaAl$_{2-x}$Si$_x$, both in the experimental range $0.6 \leq x \leq 1.2$, for which the alloy has been synthesised, and in the theoretical limits of high aluminium and high silicon concentration. Our results indicate that, in the experimental range, the dependence of the electronic bands on composition is well described by a rigid-band model, which breaks down outside this range. Such a breakdown, in the (theoretical) limit of high aluminium concentration, is connected to the appearance of vibrational instabilities, and results in important differences between CaAl$_2$ and MgB$_2$. Unlike MgB$_2$, the interlayer band and the out-of-plane phonons play a major role on the stability and superconductivity of CaAlSi and related C$_{32}$ intermetallic compounds