Simulation and Comparison of Efficency in Pathfinding algorithms in Games

There are several routes to go from point A to point B in many computer games and computer player have to choose the best route. To do this, the pathfinding algorithms is used. Currently, several algorithms have been proposed for routing in games so that the general challenges of them is high consumption of memory and a long Execution time. Due to these problems, the development and introduction of new algorithms will be continued. At the first part of this article, in addition to basic and important used algorithms, the new algorithm BIDDFS is introduced.In the second part, these algorithms in the various modes, are simulated on 2D-Grid, and compared based on their efficency (memory consumption and execution time) , Simulated algorithms include: Dijkstra, Iddfs, Biddfs, Bfs (Breadth), Greedy Best First Search, Ida*, A*, Jump point search, HPA*

Signal detection in extracellular neural ensemble recordings using higher criticism

Information processing in the brain is conducted by a concerted action of multiple neural populations. Gaining insights in the organization and dynamics of such populations can best be studied with broadband intracranial recordings of so-called extracellular field potential, reflecting neuronal spiking as well as mesoscopic activities, such as waves, oscillations, intrinsic large deflections, and multiunit spiking activity. Such signals are critical for our understanding of how neuronal ensembles encode sensory information and how such information is integrated in the large networks underlying cognition. The aforementioned principles are now well accepted, yet the efficacy of extracting information out of the complex neural data, and their employment for improving our understanding of neural networks, critically depends on the mathematical processing steps ranging from simple detection of action potentials in noisy traces - to fitting advanced mathematical models to distinct patterns of the neural signal potentially underlying intra-processing of information, e.g. interneuronal interactions. Here, we present a robust strategy for detecting signals in broadband and noisy time series such as spikes, sharp waves and multi-unit activity data that is solely based on the intrinsic statistical distribution of the recorded data. By using so-called higher criticism - a second-level significance testing procedure comparing the fraction of observed significances to an expected fraction under the global null - we are able to detect small signals in correlated noisy time-series without prior filtering, denoising or data regression. Results demonstrate the efficiency and reliability of the method and versatility over a wide range of experimental conditions and suggest the appropriateness of higher criticism to characterize neuronal dynamics without prior manipulation of the data

Pulmonary manifestations in a cohort of patients with inborn errors of immunity : an 8-year follow-up study

Background: Inborn errors of immunity (IEIs) are a group of congenital diseases caused by genetic defects in the development and function of the immune system. The involvement of the respiratory tract is one of the most common presentations in IEIs. Methods: Overall, 117 patients with diagnosed IEIs were followed-up within 8 years at the National Research Institute of Tuberculosis and Lung Diseases (NRITLD). Demographic, clinical, and laboratory data were collected in a questionnaire. Pulmonary function test (PFT), chest X-ray (CXR), and high-resolution computed tomography (HRCT) scans were obtained where applicable. Results: Our study population consisted of 48 (41%) patients with predominantly antibody deficiencies (PADs), 39 (32%) patients with congenital defects of phagocytes, 14 (11.9%) patients with combined immunodeficiency (CID), and 16 (14%) patients with Mendelian susceptibility to mycobacterial diseases (MSMD).. Recurrent pneumonia was the most common manifestation, while productive cough appeared to be the most common symptom in almost all diseases. PFT showed an obstructive pattern in patients with PAD, a restrictive pattern in patients with CID, and a mixed pattern in patients with CGD. HRCT findings were consistent with bronchiectasis in most PAD patients, whereas consolidation and mediastinal lesions were more common in the other groups. Conclusions: Pulmonary manifestations vary among different groups of IEIs. The screening for lung complications should be performed regularly to reveal respiratory pathologies in early stages and follow-up on already existing abnormalities. (C) 2022 Codon Publications. Published by Codon Publications.Peer reviewe

The global burden of cancer attributable to risk factors, 2010-19 : a systematic analysis for the Global Burden of Disease Study 2019

Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings Globally, in 2019, the risk factors included in this analysis accounted for 4.45 million (95% uncertainty interval 4.01-4.94) deaths and 105 million (95.0-116) DALYs for both sexes combined, representing 44.4% (41.3-48.4) of all cancer deaths and 42.0% (39.1-45.6) of all DALYs. There were 2.88 million (2.60-3.18) risk-attributable cancer deaths in males (50.6% [47.8-54.1] of all male cancer deaths) and 1.58 million (1.36-1.84) risk-attributable cancer deaths in females (36.3% [32.5-41.3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20.4% (12.6-28.4) and DALYs by 16.8% (8.8-25.0), with the greatest percentage increase in metabolic risks (34.7% [27.9-42.8] and 33.3% [25.8-42.0]). Interpretation The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.Peer reviewe

National, sub-national, and risk-attributed burden of thyroid cancer in Iran from 1990 to 2019

An updated exploration of the burden of thyroid cancer across a country is always required for making correct decisions. The objective of this study is to present the thyroid cancer burden and attributed burden to the high Body Mass Index (BMI) in Iran at national and sub-national levels from 1990 to 2019. The data was obtained from the GBD 2019 study estimates. To explain the pattern of changes in incidence from 1990 to 2019, decomposition analysis was conducted. Besides, the attribution of high BMI in the thyroid cancer DALYs and deaths were obtained. The age-standardized incidence rate of thyroid cancer was 1.57 (95% UI: 1.33–1.86) in 1990 and increased 131% (53–191) until 2019. The age-standardized prevalence rate of thyroid cancer was 30.19 (18.75–34.55) in 2019 which increased 164% (77–246) from 11.44 (9.38–13.85) in 1990. In 2019, the death rate, and Disability-adjusted life years of thyroid cancer was 0.49 (0.36–0.53), and 13.16 (8.93–14.62), respectively. These numbers also increased since 1990. The DALYs and deaths attributable to high BMI was 1.91 (0.95–3.11) and 0.07 (0.04–0.11), respectively. The thyroid cancer burden and high BMI attributed burden has increased from 1990 to 2019 in Iran. This study and similar studies’ results can be used for accurate resource allocation for efficient management and all potential risks’ modification for thyroid cancer with a cost-conscious view

Burden of tracheal, bronchus, and lung cancer in North Africa and Middle East countries, 1990 to 2019: Results from the GBD study 2019

ObjectiveTo provide estimates on the regional and national burden of tracheal, bronchus, and lung (TBL) cancer and its attributable risk factors from 1990 to 2019 in the North Africa and Middle East (NAME) region.Methods and materialsThe Global Burden of Disease (GBD) 2019 data were used. Disability-adjusted life years (DALYs), death, incidence, and prevalence rates were categorized by sex and age groups in the NAME region, in 21 countries, from 1990 to 2019. Decomposition analysis was performed to calculate the proportion of responsible factors in the emergence of new cases. Data are presented as point estimates with their 95% uncertainty intervals (UIs).ResultsIn the NAME region, TBL cancer caused 15,396 and 57,114 deaths in women and men, respectively, in 2019. The age-standardized incidence rate (ASIR) increased by 0.7% (95% UI -20.6 to 24.1) and reached 16.8 per 100,000 (14.9 to 19.0) in 2019. All the age-standardized indices had a decreasing trend in men and an increasing trend in women from 1990 to 2019. Turkey (34.9 per 100,000 [27.6 to 43.5]) and Sudan (8.0 per 100,000 [5.2 to 12.5]) had the highest and lowest age-standardized prevalence rates (ASPRs) in 2019, respectively. The highest and lowest absolute slopes of change in ASPR, from 1990 to 2019, were seen in Bahrain (-50.0% (-63.6 to -31.7)) and the United Arab Emirates (-1.2% (-34.1 to 53.8)), respectively. The number of deaths attributable to risk factors was 58,816 (51,709 to 67,323) in 2019 and increased by 136.5%. Decomposition analysis showed that population growth and age structure change positively contributed to new incident cases. More than 80% of DALYs could be decreased by controlling risk factors, particularly tobacco use.ConclusionThe incidence, prevalence, and DALY rates of TBL cancer increased, and the death rate remained unchanged from 1990 to 2019. All the indices and contribution of risk factors decreased in men but increased in women. Tobacco is still the leading risk factor. Early diagnosis and tobacco cessation policies should be improved

Investigation of Groundwater Resources Quality for Drinking Purposes Using GWQI and GIS: A Case Study of Ottawa City, Ontario, Canada

Evaluating groundwater quality for certain purposes requires accurate quantitative and qualitative management, accessibility to the study area, and knowledge of the governing environmental processes. Groundwater resources are used to supply drinking water consumption alongside surface water in most countries. This study aims to investigate the quality of groundwater resources in the city of Ottawa, located in Ontario, Canada, using the Schoeller diagram and the Canadian Groundwater Quality Index (GWQI) in a fuzzy environment. To determine the water quality, the qualitative groundwater parameters including Ca, Mg, Na, Cl, SO4, HCO3, NO3, F, pH, TDS, TH, K, EC, and Alkalinity were considered in the Schoeller diagram and GWQI. Each parameter’s interpolated water quality map layer was prepared using the Kriging method in a GIS environment. The results of Schoeller’s diagram indicated that the range of drinking water quality was non-potable to inappropriate in more than 22% of the investigated groundwater resources. Moreover, the obtained results of the groundwater quality interpolation map layer based on the GWQI revealed that more than 70% of the groundwater resources were examined in the good and excellent range for drinking purposes. Finally, the obtained interpolated map layers of the Schoeller diagram and GWQI were integrated using GIS. Accordingly, the results indicate that the interpolation values of an integrated layer in the study area are well within the permissible limits, and the quality of the groundwater is suitable for drinking and other consumption purposes

High-throughput genomic and proteomic interpretation of gene duplication in Vibrio cholera genomes: An in silico study

Background: Vibrio cholerae leads to severe acute watery diarrhea with a high mortality rate; owing to several virulence factors, especially the cholera toxin. Generally, gene duplication is a major evolutionary process that affects the environmental adaptation of bacteria. In this study, we aimed to investigate the repetitive virulence factors in V. cholera genomes. Method: Totally, 1530 genomes were collected and the possible duplication of 25 known virulence factors was assessed. Next, the genomes carrying duplicated cholera toxins (e.g. ctxA and ctxB) were further analyzed for the identification of novel repetitive virulence factors. All duplicated potential virulence proteins were classified based on clusters of orthologous groups (COGs) and their functions in different pathways were assessed. Results: Genome-wide analysis showed eight repetitive known virulence factors including rstA, ctxA, ctxB, zot, ace, espA, VC_RS09110, and mshA in V. cholerae genomes. It seems that the majority of the duplicated virulence factors are encoded on the CTXφ such as cholera toxin. Interestingly, our analysis revealed that fourteen genomes had simultaneously two copy numbers of ctxA and ctxB. The proteome of these strains harbored some repetitive proteins that resembled virulence factors of other bacteria. These duplicated proteins were mainly involved in replication, transcription, metabolism, and pathogenesis including Elongation factor Tu, Transketolase, Methyl-accepting chemotaxis protein, GNAT family N-acetyltransferases, cGAMP-activated phospholipase of Vibrio (CapV), HigA, and Helix-turn-helix transcriptional regulator. Conclusion: Surprisingly, a considerable number of duplicated genes have essential roles in the virulence and pathogenesis of V. cholerae. Moreover, it seems that novel duplicated genes had different roles in cellular processes or metabolic pathways

Trehalose Activates Autophagy and Prevents Hydrogen Peroxide-Induced Apoptosis in the Bone Marrow Stromal Cells

Bone marrow stromal stem cells (BMSCs) play a significant role in cell therapy. These cells quickly die after transplantation to the affected area due to oxidative stress. The natural disaccharide, trehalose which can be known as autophagy inducer. The present study aimed to investigate the role of trehalose in preventing BMSCs from oxidative stress caused by H2O2. BMSCs were isolated from the adult rats. The cells were divided into three groups: (a) control; (b) 100 μM H2O2; (c) 100 μM H2O2 and trehalose 3%. The morality rate was analyzed by viability test. Immunocytochemistry and Western blot was used in order to evaluate p62 protein and LC3II/LC3I ratio, respectively. In order to evaluate apoptosis, cleaved caspase-3 protein was used. In viability test, the survival rate for BMSCs after 8 h were 82%, 72%, 49%, and 39% (for groups who received 50, 100, 200, and 400 μM H2O2, respectively) compared to the control group. Pre-treatment with the use of trehalose 3% increased cell survivals. The levels of p62 protein, were increased in the cells under H2O2 treatment, while the levels of p62 protein in the cytoplasm, as autophagy inclusions, reduced for the group with trehalose pre-treatment. In addition, trehalose caused to increase LC3II/LC3I ratio and decreased the expression of cleaved caspase-3. Trehalose decreased apoptosis and increased the autophagy and survival levels of the cells against H2O2. Due to the unique properties of trehalose and its low toxicity, it can be used as a pharmaceutical agent in cellular transplantation to reduce oxidative stress. Keywords: Stress oxidative; Autophagy; Apoptosis; Bone marrow stromal cells; Trehalose

Speed sensorless and sensor-fault tolerant optimal PI regulator for networked DC motor system with unknown time-delay and packet dropout

Sensorless and sensor-fault-resilient control of a networked dc motor system (NDCMS) with an optimal integral-square-error proportional-integral (PI) controller is considered, while network-induced delays and packet dropouts are taken into account. A sliding-mode observer is developed to estimate rotor speed and unknown load torque for the networked system. Then, a PI controller is designed such that the overall NDCMS with complete or partial sensor failure is stabilized and a linear quadratic cost function is sufficiently minimized. Optimal controller parameters are determined by solving bilinear matrix inequalities. The numerical and experimental tests are performed to evaluate the feasibility and applicability of the networked sensorless or sensor-fault-tolerant controller. The results show good performance in both estimation and control objectives