Two rival versions of historical inquiry and their application to the study of the Sixteenth Amendment

In this dissertation I identify the philosophy of Giambattista Vico and Karl Marx as representing, broadly, two rival versions of historical inquiry. Put simply, these rival versions endorse either reasons or causes, respectively, as the proper objects of study for historians. After introducing the study of the ratification of the Sixteenth Amendment to the U.S. Constitution as an example of the type of historical event towards which these versions of inquiry might by directed, I then outline the arguments Vico and Marx give for these rival versions. Paying special attention to the assumptions about human nature, reason, and freedom at work in these arguments, I propose that comparing the plausibility and feasibility of these assumptions might allow a means of adjudicating between these comprehensive and mutually incompatible methods of historical study. I proceed to draw on the work of John Rawls and Alasdair MacIntyre, among others, to show that MarxÂs conceptions of human nature, reason, and freedom are ultimately flawed and therefore untenable. I conclude by arguing that VicoÂs version of historical inquiry relies on an understanding of these concepts that is more plausible than MarxÂs and withstands the objections to which MarxÂs understanding succumbs. Finally, I return my focus to the study of the Sixteenth Amendment and consider how VicoÂs version of historical inquiry might inform this project

Utilización de modelos de reflectancia como nexo entre muestras foliares y la cobertura forestal: aplicación a datos hiperespectrales

[ES] El presente trabajo demuestra la utilización de modelos de simulación de la cobertura forestal mediante su aplicación a datos hiperespectrales del sensor aerotransportado CASI. Los modelos SAIL y Kuusk permiten ser utilizados como nexo de unión entre los niveles de hoja y de cobertura: las relaciones a nivel de hoja obtenidas entre índices ópticos y bioindicadores de estrés, como contenido clorofílico o fluorescencia clorofílica, pueden ser transformadas a un nivel superior de cobertura mediante la utilización de dichos modelos. Finalmente se realiza una demostración de la utilización de modelos de cobertura a través de los resultados obtenidos en el proyecto Bioindicators of Forest Sustainability, desarrollado en 12 zonas de Acer saccharum M. localizadas en Ontario (Canadá) donde se obtuvieron medidas de campo de muestras foliares, así como datos hiperespectrales del sensor aerotransportado CASI en 1997, 1998 y 1999. Los indices ópticos desarrollados a nivel de hoja fueron aplicados, a través de modelos de cobertura, a los datos de reflectancia obtenidos por CASI de 2 m de resolución espacial y 72 bandas[EN] This paper demonstrates the use and applications of Canopy Reflectance Models (CR) with airborne hyperspectral CASI data. SAIL and Kuusk canopy reflectance models are the link between the leaf and canopy levels: leaf-level relationships obtained between optical indices and stress bioindicators, such as chlorophyll content and chlorophyll fluorescence can be scaled-up to the canopy level using canopy reflectance models. The application of canopy reflectance models is demonstrated with the results obtained in the Bioindicators of Forest Sustainability Project. The work was carried out in 12 study areas of Acer saccharum M. in the Algoma Region, Ontario (Canada), where field measurements and hyperspectral CASI imagery have been collected in 1997, 1998 and 1999 deployments. Single leaf reflectance and transmittance, chlorophyll and carotenoid content, and chlorophyll fluorescence of broad leaves were measured. The physiological indices and derivative analysis indices extracted from leaf spectral reflectance were tested at canopy level using CASI data of 72 channels and 2 m spatial resolution.Peer reviewe

Norway spruce as a model system for somatic embryogenesis in conifers

"July, 1986.

Researching the lived experiences of cancer patients with malignant fungating wounds

Background: Researching the experiences of terminally ill patients with disfiguring wounds is likely to be a challenge anywhere, and this investigation came face-to-face with different attitudes on the part of both patients and nurses and doctors in England (the South-East) and Italy (Tuscany). Aim: To highlight the complexity of researching sensitive subjects and the difficulties encountered from the perspective of the researcher(s). Methods: Fourteen patients were interviewed. In England access was relatively straightforward, with nurses linked to the hospice doing most of the recruitment. Access was more difficult in Italy, with some doctors expressing opposition. Discussion: How ethical is it to treat dying patients as subjects for research? How does research of this kind vary from one culture to another? Conclusions: Interviewees can find it therapeutic to talk about their experiences to a sympathetic listener—although the listening does pose a considerable strain on the researcher

Six-color photometry of Iapetus, Titan, Rhea, Dione and Tethys

The extensive photometric observations of Titan, Iapetus, Rhea, Dione and Tethys have made it possible to separate the solar phase and orbital phase contributions to the observed light variations of these satellites. For Titan, the wavelength dependence of its solar phase coefficient has been obtained. This dependence should prove useful in constructing future model atmospheres. The other four satellites show a surprising array of different photometric behaviors. Despite these differences, all four satellites have similar spectral reflectivities. Clearly Iapetus, Rhea, Dione and Tethys are complex objects, varying substantially from one another in surface structure and/or composition

Vegetation stress detection through chlorophyll a+b estimation and fluorescence effects on hyperspectral imagery",

ABSTRACT between the light and the canopy under observation, physical methods must be developed (Zarco-Tejada, Physical principles applied to remote sensing data are key to suc- 2000). cessfully quantifying vegetation physiological condition from the study of the light interaction with the canopy under observation. We used The C aϩb content is a potential indicator of vegetatio

Impaired mitochondrial fat oxidation induces adaptive remodeling of muscle metabolism

© 2015, National Academy of Sciences. All rights reserved. The correlations between intramyocellular lipid (IMCL), decreased fatty acid oxidation (FAO), and insulin resistance have led to the hypothesis that impaired FAO causes accumulation of lipotoxic intermediates that inhibit muscle insulin signaling. Using a skeletal muscle-specific carnitine palmitoyltransferase-1 KO model, we show that prolonged and severe mitochondrial FAO inhibition results in increased carbohydrate utilization, along with reduced physical activity; increased circulating nonesterified fatty acids; and increased IMCLs, diacylglycerols, and ceramides. Perhaps more importantly, inhibition of mitochondrial FAO also initiates a local, adaptive response in muscle that invokes mitochondrial biogenesis, compensatory peroxisomal fat oxidation, and amino acid catabolism. Loss of its major fuel source (lipid) induces an energy deprivation response in muscle coordinated by signaling through AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) to maintain energy supply for locomotion and survival. At the whole-body level, these adaptations result in resistance to obesity

Thiobenzothiazole-modified hydrocortisones display anti-inflammatory activity with reduced impact on islet β-cell function

© 2015, American Society for Biochemistry and Molecular Biology Inc. All rights reserved. Glucocorticoids signal through the glucocorticoid receptor (GR) and are administered clinically for a variety of situations, including inflammatory disorders, specific cancers, rheumatoid arthritis, and organ/tissue transplantation. However, glucocorticoid therapy is also associated with additional complications, including steroid-induced diabetes. We hypothesized that modification of the steroid backbone is one strategy to enhance the therapeutic potential of GR activation. Toward this goal, two commercially unavailable, thiobenzothiazole-containing derivatives of hydrocortisone (termed MS4 and MS6) were examined using 832/13 rat insulinoma cells as well as rodent and human islets. We found that MS4 had transrepression properties but lacked transactivation ability, whereas MS6 retained both transactivation and transrepression activities. In addition, MS4 and MS6 both displayed anti-inflammatory activity. Furthermore, MS4 displayed reduced impact on islet β-cell function in both rodent and human islets. Similar to dexamethasone, MS6 promoted adipocyte development in vitro, whereas MS4 did not. Moreover, neither MS4 nor MS6 activated the Pck1 (Pepck) gene in primary rat hepatocytes. We conclude that modification of the functional groups attached to the D-ring of the hydrocortisone steroid molecule produces compounds with altered structure-function GR agonist activity with decreased impact on insulin secretion and reduced adipogenic potential but with preservation of anti-inflammatory activity

Measurement of Sibling Violence: A Two-Factor Model of Severity

The measurement of violence is a major challenge in aggression research. Because of the heterogeneous nature of violent behavior, problems arise when applying blanket measures to inherently distinct subtypes of aggression. Incidents of intersibling violence (ISV) exacerbate these problems because siblinghood represents a unique offender–victim situation. This research explored whether an existing two-factor model for severe violence found in a sample of 250 adult offenders (age M = 26.8, SD = 5.9) could be generalized to deliberate severe ISV in a sample of 111 young offenders (age M = 14.83, SD = 1.45). Exploratory factor analysis revealed a two-factor model encompassing severe ISV perpetration with weapon use (Factor 1) and severe ISV perpetration without weapon use (Factor 2). The results provide strong empirical support for the two-factor model of violence severity previously established with adult offenders. This analysis demonstrates construct validity of the severity measures among the different types of offenders studied and provides support for generalization across populations

Rats selectively bred for low aerobic capacity have reduced hepatic mitochondrial oxidative capacity and susceptibility to hepatic steatosis and injury

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65411/1/jphysiol.2009.169060.pd