2,761 research outputs found
Frutas e legumes cristalizados: opção para redução de perdas e ganhos extras.
bitstream/item/29395/1/2010-298.pd
Ensaio em vasos com leguminosas num delineamento em 'spli-plot', onde ocorreu perda de parcela.
Verificar os efeitos de adubação em 11 tipos de solos da Rod. BR-319 e um de Matão-SP, utilizando-se Galactia striata IRI-2961 e Centrosema pubescens IRI1282, como plantas indicadoras
Role of the RAD51 G172T polymorphism in the clinical outcome of cervical cancer patients under concomitant chemoradiotherapy
INTRODUCTION:
Cervical cancer is one of the most common cancers diagnosed in women worldwide. Mammalian cells are constantly exposed to a wide variety of genotoxic agents from both endogenous and exogenous sources. The RAD51 protein is required for meiotic and mitotic recombination and plays a central role in homology-dependent recombinational repair of double-strand breaks (DSBs). Given the functional relevance of the DNA repair system on carcinogenesis, potential associations between genetic polymorphisms of DNA repair genes, cancer risk and response to therapy have been intensively evaluated. This is the first study evaluating the role of the RAD51 G172T genetic variants in cancer prognosis and clinical outcome of cervical cancer patients.
MATERIAL AND METHODS:
We analyzed RAD51 G172T polymorphism genotypes in cervical cancer patients who underwent a platinum-based chemotherapy in combination with radiotherapy. Genotyping was performed by Taqman™ Allelic Discrimination methodology.
RESULTS AND DISCUSSION:
Concerning the overall survival rates found using Kaplan-Meier method and Log Rank Test, we observed that the mean survival rates were statistically different according to the patients RAD51 genotypes. The group of patients carrying the T allele present a higher mean survival rate than the other patients (102.3months vs. 86.4months, P=0.020). Using the Cox regression analysis, we found an increased overall survival time for T-carrier patients, when compared with GG genotype, with tumor stage, age and presence of lymph nodes as covariates [hazard ratio (HR), 0.373; 95% CI, 0.181-0.770; P=0.008]. Among patients (n=193), RAD51 genotype frequency distributions were not under the influence of clinicopathologic characteristics, namely, treatment response (P=0.508), recurrence (P=0.150) and tumor stage (P=0.250).
CONCLUSIONS:
This is the first study evaluating the role of the RAD51 G172T genetic variants in cancer prognosis and clinical outcome of cervical cancer patients. Our results indicate an influence of the RAD51 genetic variants in overall survival of cervical cancer. Thereby, RAD51 G172T genotypes may provide additional prognostic information in cervical cancer patients who underwent cisplatin-based chemotherapy in combination with radiotherapy
Gauge dependenceof the order parameter anomalous dimension in the Ginzburg-Landau model and the critical fluctuations in superconductors
The critical fluctuations of superconductors are discussed in a fixed
dimension scaling suited to describe the type II regime. The gauge dependence
of the anomalous dimension of the scalar field is stablished exactly from the
Ward-Takahashi identities. Its fixed point value gives the critical
exponent and it is shown that is gauge independent, as expected on
physical grounds. In the scaling considered, is found to be zero at
1-loop order, while . This result is just the 1-loop values
for the XY model obtained in the fixed dimension renormalization group
approach. It is shown that this XY behavior holds at all orders. The result
should be contrasted with the negative values frequently
reported in the literature.Comment: EuroLaTex, 7 pages, 2 figures, reference updated; version to be
published in Europhysics Letter
Wall material selection for microencapsulating glicine max and punica granatum oils by spray drying.
Pomegranate seed oil, even though highly sensitive to oxidation, has been extensively studied due to its anti-inflammatory potential. Microencapsulation by spray drying can protect the oil and increase its shelf life. Modified starch, maltodextrin and gum arabic are evaluated by a mixture design to get the better wall material composition. The better response for drying process yield (41%) and oxidative stability (42%) were achieved using modified starch and gum arabic at the same proportion as wall material
The superconducting phase transition and gauge dependence
The gauge dependence of the renormalization group functions of the
Ginzburg-Landau model is investigated. The analysis is done by means of the
Ward-Takahashi identities. After defining the local superconducting order
parameter, it is shown that its exponent is in fact gauge independent.
This happens because in the Landau gauge is the only gauge having a
physical meaning, a property not shared by the four-dimensional model where any
gauge choice is possible. The analysis is done in both the context of the
-expansion and in the fixed dimension approach. It is pointed out the
differences that arise in both of these approaches concerning the gauge
dependence.Comment: RevTex, 3 pages, no figures; accepted for publication in PRB; this
paper is a short version of cond-mat/990527
Manual para a produção em pequena escala de conserva de tomate desidratado.
Higiene e sanitização. Fluxograma básico de processamento de tomate. Etapas de processamento de tomate seco. Elaboração de conserva de tomate. Etapas de processamento de conserva. Como estimar o lucro e os custos envolvidos no processamento.bitstream/item/65526/1/2003-DOC-0052.pd
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