Association between dental extractions and implant installations - a retrospective clinical study/ Associação entre exodontias dentárias e instalações de implantes – estudo clínico retrospectivo

Aim: The retrospective study aimed to draw, the profile of a series of patients who received immediate implants, emphasizing the causes for exodontia. Materials and Methods: This 10-year retrospective study (2006-2016) conducted a data survey on patients subjected to exodontia and immediate implant installation. The study was based on the analysis of the clinical data collected from the records of dental offices of Implantology specialists. The instrument contained questions regarding the patients' systemic condition, dental causes for exodontia, and types of implants installed. Results: Out of 846 teeth extracted from the 407 patients analyzed, 242 were replaced with single implants, 276 with implants for upper protocols, and 328 with implants for lower protocols. The highest rate of implant installations occurred between 2010 and 2014, corresponding to 51.4% of the sample, in which 64.1% of patients were women and 58.3% were aged 41 through 60 years. The highest incidence of extractions presented periodontal (19.2%), prosthetic (17.4%) and endodontic causes (15.2%). Among the prosthetic causes, caries was present in 111 cases. For periodontal causes, generalized chronic periodontitis was present in 200 teeth. In endodontic causes, root fracture was evident in 114 teeth and more prevalent in single-tooth exodontias (p<0.001). In addition, the highest rate of tooth losses (32.4%) occurred from strategic exodontias for single-tooth replacement or upper and lower protocols (p <0.001). Conclusion: Immediate implants proved to be an important alternative for the rehabilitation of compromised teeth, which was shown by the success of the technique and patient satisfaction

Validade de peso, estatura e IMC referidos por puérperas do estudo Nascer no Brasil

OBJETIVO: Avaliar a acurácia das informações de peso pré-gestacional, estatura, índice de massa corporal pré-gestacional e peso na última consulta de pré-natal, segundo características maternas, variáveis sociodemográficas e de pré-natal. MÉTODOS: O estudo foi desenvolvido com dados do questionário face a face e do cartão da gestante (padrão-ouro) do estudo “Nascer no Brasil, 2011–2012”. Para avaliar as diferenças entre as variáveis antropométricas medidas e referidas, utilizou-se o teste de Kruskal-Wallis para as variáveis dividas em quartis. Para as variáveis contínuas, adotou-se o teste de Wilcoxon, gráficos de Bland e Altman, diferença média entre as informações medidas e referidas pelas mulheres. Estimou-se a sensibilidade e o coeficiente de correlação intraclasse. RESULTADOS: No estudo, 17.093 mulheres possuíam cartão de gestante. Observou-se uma subestimação do peso pré-gestacional em 1,51 kg (DP = 3,44) e do índice de massa corporal em 0,79 kg/m2 (DP = 1,72), e superestimação da estatura em 0,75 cm (DP = 3,03) e do peso na última consulta em 0,22 kg (DP = 2,09). Os coeficientes de correlação intraclasse (CCIC) obtidos para as variáveis antropométricas foram: estatura (CCIC = 0,89), peso pré-gestacional (CCIC = 0,96), índice de massa corporal pré-gestacional (CCIC = 0,92) e peso na última consulta (CCIC = 0,98). CONCLUSÕES: Os resultados sugerem que as variáveis antropométricas referidas foram válidas para a população de estudo, e podem ser utilizadas em estudos com populações que tenham características semelhantes.OBJECTIVE: To evaluate the accuracy of information on pre-gestational weight, height, pre-gestational body mass index, and weight at the last prenatal appointment, according to maternal characteristics and sociodemographic and prenatal variables. METHODS: The study was developed using data from the face-to-face questionnaire and prenatal card (gold standard) of the study “Birth in Brazil, 2011–2012”. To evaluate the differences between the measured and self-reported anthropometric variables, we used the the Kruskal-Wallis test for the variables divided into quartiles. For the continuous variables, we used the Wilcoxon test, Bland-Altman plot, and average difference between the information measured and reported by the women. We estimated sensitivity and the intraclass correlation coefficient. RESULTS: In the study, 17,093 women had the prenatal card. There was an underestimation of pre-gestational weight of 1.51 kg (SD = 3.44) and body mass index of 0.79 kg/m2 (SD = 1.72) andoverestimation of height of 0.75 cm (SD = 3.03) and weight at the last appointment of 0.22 kg (SD = 2.09). The intraclass correlation coefficients (ICC) obtained for the anthropometric variables were: height (ICC = 0.89), pre-gestational weight (ICC = 0.96), pre-gestational body mass index (ICC = 0.92), and weight at the last appointment (ICC = 0.98). CONCLUSIONS: The results suggest that the mentioned anthropometric variables were valid for the study population, and they may be used in studies of populations with similar characteristics

Comunidade de abelhas (Hymenoptera, Apidae) e plantas associadas em área de mata atlântica em São Francisco do Sul, Santa Catarina, Brasil

A comunidade de abelhas nativas em uma área de mata atlântica no sul do Brasil foi estudada no período 2001-2003, utilizando-se rede entomológica em plantas floridas. Foram amostrados 1.519 indivíduos de 80 espécies e 4 subfamílias de abelhas. Houve predomínio de espécies de Apinae não corbiculadas e Halictinae e de indivíduos de Apinae corbiculados e Halictinae. As plantas associadas totalizaram 124 espécies de 46 famílias, das quais as mais visitadas foram Asteraceae, Fabaceae, Lamiaceae e Melastomataceae. Foram amostradas 11 espécies de abelhas não assinaladas para Santa Catarina. As abelhas mais amostradas foram Apis mellifera, Trigona spinipes, Bombus morio, Dialictus sp., Augochloropsis sp. 07, Trigona braueri, Augochlora (Oxystoglossella) sp. 05 e Tetragonisca angustula. A quantidade de indivíduos amostrados por mês, ao longo do período de coleta, evidencia um padrão bivoltino (maio e setembro-novembro). Algumas espécies de plantas foram visitadas apenas por Apis mellifera. Os índices de diversidade e equabilidade ficaram em 2,315 e 0,528, respectivamente. A curva de acumulação mostrou-se crescente. Os estimadores de riqueza apontam mais espécies. A riqueza e a abundância evidenciam um padrão de atividade de clima temperado. A composição da apifauna demonstrou maior similaridade com formação de floresta ombrófila densa de terras baixas

A Cost-Effective Way To Expressively Increase the Blood-Stage Antimalarial Activity of Primaquine

Funding Information: The authors thank Fundação para a Ciência e Tecnologia (FCT, Portugal), for funding Research Units LAQV‐REQUIMTE (UIDB/50006/2020), CIQUP (UIDB/00081/2020), and GHTM (UID/Multi/04413/2013), and for project grant PTDC/BTM‐SAL/29786/2017. ATS thanks FCT and Sociedade Portuguesa de Química (SPQ, Portugal) for her doctoral grant SFRH/BD/150649/2020 Publisher Copyright: © 2021 Wiley-VCH GmbHInspired by previous disclosure of room-temperature ionic liquids derived from primaquine and cinnamic acids, which displayed slightly enhanced blood-stage activity compared to the parent drug, we have now combined this emblematic antimalarial with natural fatty acids. This affords surface-active ionic liquids whose liver-stage antiplasmodial activity is either retained or slightly enhanced, while revealing blood-stage antiplasmodial activity at least one order of magnitude higher than that of the parent compound. These findings open new perspectives towards the cost-effective recycling of classical drugs that are either shelved or in decline, and which is not limited to antimalarial agents.publishersversionpublishe

Genetic analysis of an insular population of Sapajus nigritus (Primates: Cebidae) in Rio de Janeiro state, Brazil

The black-horned capuchin (Sapajus nigritus) is a neotropical primate with wide distribution from southeastern Brazil to northeastern Argentina. Although this species has been described with coat pattern variation, even with intrapopulational differences, and characterized as having the greatest genetic diversity among Sapajus species, there are still few studies on natural populations that contribute to the knowledge of this intraspecific variability. We examined individuals from an as yet unstudied population of Ilha da Marambaia, Rio de Janeiro (RJ) state, Brazil, compared with published data for S. nigritus. We sought to confirm the species through phenotypic and genetic characterization using C-banding and fluorescence in situ hybridization with #11qHe+/21WCP probes for chromosomal constitutive heterochromatin (He+) patterns, and cytochrome c oxidase I and II gene sequences for phylogenetic analysis. The coat presented two color patterns, varying from brown to blackish on the body, yellow to brown on the chest, and white to yellow on the face, besides the presence and shape of the tufts on the head, corresponding to S. nigritus. He+ was identified in pairs 4, 12, 13 and 17, and less consistently in pairs 6, 19 and 21, already described for this species. While most Sapajus species have a large He+ block, here pair 11 was identified without extracentromeric He+, the same as reported for S. nigritus from Argentina. Molecular analysis showed divergence of this population from other S. nigritus sequences, reinforcing a trend already demonstrated when samples from RJ are compared with the rest of the distribution, which may represent an evolutionary deviation.Fil: Mattos Penedo, Diego. Universidade Federal Rural do Rio de Janeiro; BrasilFil: Azevedo de Armada, Jorge Luís. Universidade Federal Rural do Rio de Janeiro; BrasilFil: Nieves, Mariela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; ArgentinaFil: da Silva Verona, Carlos Eduardo. No especifíca;Fil: de Oliveira, Andréa Maria. Universidade Do Estado de Rio Do Janeiro. Instituto de Biologia "roberto Alcantara Gomes".; BrasilFil: de Sousa dos Santo, Emidio José. Universidade Federal do Rio de Janeiro; BrasilFil: Monnerat Nogueira, Denise. Universidade Federal Rural do Rio de Janeiro; Brasi

IMPACTO DA IMPLANTAÇÃO DAS EQUIPES DE SAÚDE BUCAL NA ESTRATÉGIA SAÚDE DA FAMÍLIA EM DOIS MUNICÍPIOS DO ESTADO DA BAHIA

Objetivo: Avaliar o impacto da Estratégia Saúde da Família (ESF) sobre utilização de serviços e morbidade referida em saúde bucal em dois municípios com mais de 100.000 habitantes. Métodos: Estudo observacional, de base populacional e arquitetura transversal que entrevistou 1.652 famílias de 22 setores censitários no município A e 1.371 famílias em 20 setores no município B. Resultados: Em A, verificou-se maior necessidade de tratamento em áreas não cobertas e maior utilização de serviços nas áreas cobertas, com diferenças estatisticamente significantes para todas variáveis. A prevalência de dor de dente não apresentou diferença entre os grupos (RP=0,99; IC95% 0,96-1,03). A cobertura de tratamento foi maior em áreas cobertas (RP=0,65; IC95% 0,59-0,72). O maior acesso a informações em saúde bucal nessas áreas (RP=0,59; IC95% 0,56-0,62) pode ter interferido na identificação de problemas pela população, resultando em prevalências mais elevadas. Em B, verificou-se menor necessidade de tratamento em áreas não cobertas (RP=0,91; IC95% 0,86-0,96) e menor utilização dos serviços nas áreas cobertas, com diferenças estatisticamente significantes. Conclusão: A implantação de ESB/ESF significou uma ampliação da utilização dos serviços, entretanto, o uso de medidas de morbidade referida não revelou impacto sobre as condições de saúde bucal da população, sendo necessário o uso de indicadores mais sensíveis.

Indole-Containing Pyrazino[2,1-b]quinazoline-3,6-diones Active against Plasmodium and Trypanosomatids

The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsmedchemlett.1c00589.Malaria, leishmaniasis, and sleeping sickness are potentially fatal diseases that represent a real health risk for more than 3,5 billion people. New antiparasitic compounds are urgent leading to a constant search for novel scaffolds. Herein, pyrazino[2,1-b]quinazoline-3,6-diones containing indole alkaloids were explored for their antiparasitic potential against Plasmodium falciparum, Trypanosoma brucei, and Leishmania infantum. The synthetic libraries furnished promising hit compounds that are species specific (7, 12) or with broad antiparasitic activity (8). Structure-activity relationships were more evident for Plasmodium with anti-isomers (1S,4R) possessing excellent antimalarial activity, while the presence of a substituent on the anthranilic acid moiety had a negative effect on the activity. Hit compounds against malaria did not inhibit β-hematin, and in silico studies predicted these molecules as possible inhibitors for prolyl-tRNA synthetase both from Plasmodium and Leishmania. These results disclosed a potential new chemotype for further optimization toward novel and affordable antiparasitic drugs.publishersversionpublishe

Clinical and x-ray oral evaluation in patients with congenital Zika Virus

Objective: The aim of this study was to investigate possible malformations in the soft, bone and/or dental tissues in patients with congenital Zika Virus (ZIKV) by clinical and x-ray evaluation. Methodology: Thirty children born with ZIKV and 30 children born without ZIKV (control group) were included in the study. Patients were evaluated over 24 consecutive months according to the variables: sex, age, cleft palates, soft tissue lesions, alveolar ridge hyperplasia, short labial and lingual frenums, inadequate posture of the lingual and perioral muscles at rest, micrognathia, narrow palatine vaults, changes in the teeth shape and/or number, sequence eruption, spasms, seizures and eruption delay were evaluated. Chi-square test, Student’s t-test and nominal logistic regression were used (p<0.05). Results: Among the 30 babies examined, the mean age of the first dental eruption was 10.8±3.8 with almost two-thirds of the children (n=18, 60%) experiencing eruptions of their first tooth after 9 months of age, nine children (30%) had inadequate lingual posture at rest, more than half of the children (n=18, 60%) had short labial or lingual frenums. ZIKV babies showed a high prevalence of clef palate (p<0.001), inadequate lingual posture at rest (p=0.004), micrognathia (p=0.002), changes in the shape and/or number of teeth (p=0.006), alteration in sequence of dental eruption (p<0.001) and muscles spasms (p=0.002). The delay eruption was associated with inadequate lingual posture at rest (p=0.047), micrognathia (p=0.002) and changes in the shape and/or number of teeth (p=0.021). The delayed eruption (p=0.006) and narrow palatine vaults (p=0.008) were independently associated with ZIKV. Moreover, female patients showed the most narrow palatine vaults (p=0.010). Conclusions: The children with ZIKV showed a greater tendency to have delayed eruption of the first deciduous tooth, inadequate lingual posture and short labial and lingual frenums

PANDEMIA DE COVID-19: REFLEXÕES ACERCA DO AUXÍLIO EMERGENCIAL E SEUS IMPACTOS SOCIAIS

O objetivo da pesquisa é analisar o impacto da pandemia do Covid-19 acerca do mercado de trabalho e com ênfase na política pública que estabeleceu o pagamento do auxílio emergencial em prol de pessoas em situação de vulnerabilidade econômica. Para tanto, a pesquisa se faz bibliográfica, referenciada em dados governamentais oficiais de mídias, corroborados com doutrinas que alargam a temática, a partir da pesquisa de natureza qualitativa, para elaboração das tratativas referentes ao tema, enfatizando a conceituação científica relativa ao momento pandêmico, ao vírus propagado, posteriormente a narrativa do mercado de trabalho e renda permissiva aos sujeitos acerca do auxílio emergencial