Acute inflammatory response to contrast agent aspiration and its mechanisms in the rat lung.

Objectives/hypothesisContrast agent (CA) aspiration is an established complication of upper gastrointestinal and videofluoroscopic swallow studies. The underlying molecular biological mechanisms of acute response to CA aspiration in the respiratory organs remain unclear. The aims of this study were to elucidate the histological and biological influences of three kinds of CAs on the lung and to clarify the differences in acute responses.Study designAnimal model.MethodsEight-week-old male Sprague Dawley rats were divided into five groups (n = 6 in each group). Three groups underwent tracheal instillation of one of three different CAs: barium (Ba) sulfate, nonionic contrast agents (NICAs), and ionic contrast agents (ICAs). A control group was instilled with saline and a sham group was instilled with air. All animals were euthanized on day 2 after treatment and histological and gene analysis was performed.ResultsNo animal died after CA or control/sham aspiration. Ba caused severe histopathologic changes and more prominent inflammatory cell infiltration in the lungs compared with the two other iodinated contrast agents. Increases in expressions of inflammatory cytokines (tumor necrosis factor [Tnf], interleukin-1β [Il1b], and interferon-γ [Ifng]) were observed in Ba aspiration rats, and upregulation of Il1b was seen in ICA aspiration rats. NICA did not cause obvious histologic changes or expressions of inflammatory cytokines and fibrosis-related genes in the lungs.ConclusionsBa caused significantly more acute lung inflammation in a rodent model than did ioinic and nonionic iodinated CAs. Nonionic contrast did not cause any discernible inflammatory response in the lungs, suggesting that it may be the safest contrast for videofluoroscopic swallow studies.Level of evidenceNA Laryngoscope, 129:1533-1538, 2019

DAMPAK KEGIATAN OFF-BALANCE SHEET TERHADAP RETURN ON EQUITY (Studi Kasus BUSN Devisa Periode 2012-2014)

One of financial innovations undertaken by the banking industry is the rapid growth in transaction activities of off-balance sheet (OBS). Where off-balance sheet activity is one instrument diversification of revenue related to the profitability of banks. This study aims to determine the effect of off-balance sheet activities (share of non-interest income, loan loss provision, net open position on spot and derivatives, and unused loan commitment) to return on equity. The samples used in this study were 15 Foreign Exchange Commercial Banks during 2012-2014. The analytical method used in this study was multiple linear regression on panel data approach using Fixed Effect Model and The Generalized Least Square. The results of this study showed that the share of non-interest income and loan loss provision have negative significant effect on return on equity, unused loan commitment has a positive significant effect on return on equity, and net open position on spot and derivative has insignificant effect on return on equity

ANIMASI INTERAKTIF PENGENALAN 25 NABI DAN MUKJIZATNYA

Kemajuan zaman, teknologi dan informasi mempermudah dalam proses pembelajaran ilmu pengetahuan dan agama. Selayaknya ilmu pengetahuan tidak terlepas dari ajaran agama dan dipisahkan dari ilmu agama itu sendiri. Agama merupakan sebuah kepercayaan yang dianut oleh manusia kepada Sang Pencipta Nya. Sebuah ajaran agama pasti menanamkan kepada umatnya untuk berbuat baik dengan sesama makhluk hidup. Oleh karena hal tersebut, maka seseorang dianjurkan memeluk agama agar berperilaku terpuji sesama umat manusia. Telah dijelaskan dalam rukun iman yang ke-4 sebagai umat beragama islam, kita wajib beriman kepada para Nabi, dan Rasul, maka Allah SWT memberikan mukjizat-mukjizat kepada para Nabi dan Rasul tersebut untuk membuktikan kebenaran tentang kenabian dan kerasulan, serta untuk melemahkan tuduhan dari kaum-kaum yang ingkar kepada Allah SWT, yaitu melalui kejadian-kejadian atau peristiwa besar yang luar biasa. Sebagaimana Firman Allah SWT dalam Al-Qur’an surah Al-Mu’min ayat 78. Maka itu perlu adanya kemudahan bagi kalangan masyarakat luas terutama pada anak-anak untuk lebih mengetahui 25 Nabi dan Rasulnya, merancang sebuah program yang dapat membantu penyajian informasi yang dibutuhkan oleh user pada android, membuat pembelajaran dalam bentuk animasi interaktif yang bersifat menarik

Folk Devotion in the Waterscape of the Pasig River: The 1653 and 1748 Fluvial Processions of the Nuestra Señora de la Paz y Buen Viaje

The Nuestra Señora de la Paz y Buen Viaje or Our Lady of Antipolo is oneof the most prolific Marian sites or devotions in the Philippines. Theimage of Our Lady of Antipolo also served as the patroness of somegalleon ships during the 17th and 18th century. The return of the imageto its shrine in Antipolo would be occasions for a fluvial procession alongthe Pasig River. This paper analyzes the 1653 and 1748 fluvialprocessions of the Nuestra Señora de la Paz y Buen Viaje along the PasigRiver as documented by Pedro Murillo Velarde S.J., which werereprinted in 1887 as the Historia de la Nuestra Señora de la Paz y BuenViaje. The detailed descriptions from this account captures thewaterscape of the Pasig River during the procession, which Velardecompares to a theater because of the great number of people inattendance. The account also details the performance of folk devotionparticularly from the Tagalog towns participating in the procession. Byfocusing on the Pasig River, this study brings to the fore the value of theriver as a cultural-religious space unifying the Tagalog towns thatcomplete its waterscape. Lastly, the conclusions of this study highlightthe communal experience of the procession and the role of populardevotions in the articulation of folk culture and identity especially duringearly modern colonial Philippines.Keywords: Our Lady of Antipolo, Pasig river, fluvial processions, folkdevotion, waterscap

Rethinking the Concept of Competencies for Public Managers

This chapter will go deeper in analyzing the concept of competency according to a managerial perspective, and will then clarify the relation with the Public Sector both from a theoretical and from a practical view

Online Assessment during Covid-19 Pandemic: EFL Teachers’ Perspectives and Their Practices

The Covid-19 pandemic made a change in learning activities from face-to-face into online distance learning. Meanwhile, teachers need to evaluate student achievements weekly even during the Covid-19 pandemic. This study aims to find out about teachers’ perspectives and their practices on the use of online assessment during Covid-19 in the context of ELT classroom. A case study design was used to answer the purpose of this research. An open-ended questionnaire and online interviews were performed to collect the data. This study revealed the teachers had a negative perception about online assessment during the Covid-19 pandemic. They got some obstacles while conducting the assessment test such as (1) the internet connection; (2) the validity of the assessment; (3) and the low of students’ enthusiasm. However, in practice, during Covid-19, the use of online assessment helps the teachers in distributing the material and assessing students’ achievement. Implications for perception and practice are also discussed

Navigating הבל (hbl): Qohelet's Meaning of Life and its Affinity with Frankl's Logotherapy

How can Qohelet in the book of Ecclesiastes give us a new perspective on the modern understanding of the meaning of life? For us to answer this question, the paper attempts to investigate the concept of the word commonly translated as ‘absurd,’ ‘worthless,’ or ‘meaningless’ used by Qohelet, originally a Hebrew word הבל (hbl). In order to clarify Qohelet's perspective of life’s meaning, the paper uses a word study on הבל (hbl). The paper aims to discuss that הבל (hbl) can properly be read as a symbolic metaphor which is ‘vapor’ that can have varying degrees of meaning which include insubstantiality, transience, and foulness. By understanding Qohelet's concept of הבל (hbl) as a symbolic metaphor, the paper elucidates how to better understand the perspective of the book of Ecclesiastes on the meaning of life as it squares with Viktor Frankl’s theory of logotherapy, a leading contemporary view of life’s meaning in modern existential philosophy. Finally, the paper encourages a new examination of life's intricacies and aims to provide insights that resonate with today's meaning-seekers by tying the book of Ecclesiastes to the writings of Viktor Frankl. Each of our life journeys is unique, nevertheless, the paper provides a new perspective and suggests common values for which we all can travel forward in life to seek meaning in our daily lives

Model Pengukuran Tax Evasion berbasis Money Ethics dan Tax Morals

This study aims to measure tax evasion using money ethics and tax morals. The approach used is quantitative with a sample of 100 KPP Pratama employees of Karawang Regency. The analytical method uses regression with the help of the SmartPLS version 4.0 application. The results showed that money ethics has a significant effect on tax evasion, which means that the higher the nature of a person's money ethics, the higher the tendency to take tax evasion. While the conclusion regarding tax morale on tax evasion is found that tax morale does not significantly influence tax evasion, which means that a person's tax morale does not influence that person to commit tax evasion. An important suggestion for the DGT is that it is hoped that they can always maintain the good name of the institution so that public trust in the Directorate General of Taxation does not decrease so that it does not trigger tax evasion crimes so that tax revenues in Indonesia can always reach the revenue target