SYSTEM TO ENABLE CONTRACT-LESS/AGREEMENT-LESS ROAMING ACROSS MOBILE OPERATORS

Mobile roaming is a service that allows mobile users to continue to use their mobile phones or other mobile devices to make and receive voice calls and text messages, browse the internet, and send and receive emails while visiting another geography where a home network connection does not exist. However, issues may arise for scenarios in which a visited network may not have a roaming agreement with a user\u27s home network in a given country and/or an agreement may be cost prohibitive for the user to utilize. Presented herein are techniques to facilitate agreement-free or contract-less roaming across network operators using a priority list of predetermined Public Land Mobile Network (PLMN) based rules that can be defined through home operator preferences

Practices of Personal Protective Measures against SARS-Cov-2 among Undergraduate Medical Students in South India

Introduction: The use of personal protective measures holds relevance despite mass immunization coverage of COVID-19 vaccination in the population. This is because vaccination only gives protection from severe COVID-19 and does not prevent the risk of infection. Medical students can be vital in training people in infection control practices. The study aimed to assess the practices of undergraduate medical students regarding personal protective measures against COVID-19. Methods: A cross-sectional study was done among first to final-year students at a private medical college in Mangalore. Data were collected using a Microsoft form. Results: The mean age of the 302 participants was 21.2±1.6 years. The majority of them were females [179 (59.3%)]. Face mask was worn by 295(97.7%) participants. Non-recommended types of face masks like using cloth masks [108 (36.6%)] and handkerchiefs [7 (2.4%)] were reported by participants. 35 (11.9%) of them wore the face mask incorrectly. Periodicity of replacement of disposable type masks was not done every day by 181(61.4%) participants. 142(48.1%) of them did not dispose of masks whenever they became moist on every occasion. Only 79 (26.8%) always practiced proper disposal of face masks. Hand sanitizer to disinfect hands was always used by 102 (33.8%) participants. Only 42 (13.9%) participants practiced correct practice of hygiene hand wash always. Only 58 (19.2%) participants had a good level of practice. Practice level was significantly poorer among males and first-year students. Conclusion: Several gaps in preventive practices against COVID-19 were identified, particularly among males and first-year students. These issues need to be addressed among medical students in future training programs

The effect of small solar powered 'Bͻkͻͻ' net fans on mosquito net use : results from a randomized controlled cross-over trial in southern Ghana

Long-lasting insecticidal nets (LLINs) are ineffective malaria transmission prevention tools if they are unused. Discomfort due to heat is the most commonly reported reason for not using nets, but this problem is largely unaddressed. With increasing rural electrification and the dropping price of solar power, fans could improve comfort inside nets and be affordable to populations in malaria endemic areas. Here, results are presented from a pilot randomized controlled cross-over study testing the effect of fans on LLIN use.; Eighty-three households from two rural communities in Greater Accra, Ghana, randomized into three groups, participated in a 10-month cross-over trial. After a screening survey to identify eligible households, all households received new LLINs. Bͻkͻͻ net fan systems (one fan per member) were given to households in Group 1 and water filters were given to households in Group 2. At mid-point, Group 1 and 2 crossed over interventions. Households in Group 1 and 2 participated in fortnightly surveys on households' practices related to nets, fans and water filters, while households in Group 3 were surveyed only at screening, mid-point and study end. Entomological and weather data were collected throughout the study. Analysis took both 'per protocol' (PP) and 'intention to treat' (ITT) approaches. The mid- and end-point survey data from Group 1 and 2 were analysed using Firth logistic regressions. Fortnightly survey data from all groups were analysed using logistic regressions with random effects.; Provision of fans to households appeared to increase net use in this study. Although the increase in net use explained by fans was not significant in the primary analyses (ITT odds ratio 3.24, p > 0.01; PP odds ratio = 1.17, p > 0.01), it was significant in secondary PP analysis (odds ratio = 1.95, p < 0.01). Net use was high at screening and even higher after provision of new LLINs and with follow up. Fan use was 90-100% depending on the fortnightly visit.; This pilot study could not provide definitive evidence that fans increase net use. A larger study with additional statistical power is needed to assess this association across communities with diverse environmental and socio-demographic characteristics

Sorting live stem cells based on Sox2 mRNA expression.

PMCID: PMC3507951This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.While cell sorting usually relies on cell-surface protein markers, molecular beacons (MBs) offer the potential to sort cells based on the presence of any expressed mRNA and in principle could be extremely useful to sort rare cell populations from primary isolates. We show here how stem cells can be purified from mixed cell populations by sorting based on MBs. Specifically, we designed molecular beacons targeting Sox2, a well-known stem cell marker for murine embryonic (mES) and neural stem cells (NSC). One of our designed molecular beacons displayed an increase in fluorescence compared to a nonspecific molecular beacon both in vitro and in vivo when tested in mES and NSCs. We sorted Sox2-MB(+)SSEA1(+) cells from a mixed population of 4-day retinoic acid-treated mES cells and effectively isolated live undifferentiated stem cells. Additionally, Sox2-MB(+) cells isolated from primary mouse brains were sorted and generated neurospheres with higher efficiency than Sox2-MB(-) cells. These results demonstrate the utility of MBs for stem cell sorting in an mRNA-specific manner

Shorter Disease Duration Is Associated With Higher Rates of Response to Vedolizumab in Patients With Crohn's Disease But Not Ulcerative Colitis.

Background & aimsPatients with Crohn's disease (CD), but not ulcerative colitis (UC), of shorter duration have higher rates of response to tumor necrosis factor (TNF) antagonists than patients with longer disease duration. Little is known about the association between disease duration and response to other biologic agents. We aimed to evaluate response of patients with CD or UC to vedolizumab, stratified by disease duration.MethodsWe analyzed data from a retrospective, multicenter, consortium of patients with CD (n = 650) or UC (n = 437) treated with vedolizumab from May 2014 through December 2016. Using time to event analyses, we compared rates of clinical remission, corticosteroid-free remission (CSFR), and endoscopic remission between patients with early-stage (≤2 years duration) and later-stage (>2 years) CD or UC. We used Cox proportional hazards models to identify factors associated with outcomes.ResultsWithin 6 months initiation of treatment with vedolizumab, significantly higher proportions of patients with early-stage CD, vs later-stage CD, achieved clinical remission (38% vs 23%), CSFR (43% vs 14%), and endoscopic remission (29% vs 13%) (P < .05 for all comparisons). After adjusting for disease-related factors including previous exposure to TNF antagonists, patients with early-stage CD were significantly more likely than patients with later-stage CD to achieve clinical remission (adjusted hazard ratio [aHR], 1.59; 95% CI, 1.02-2.49), CSFR (aHR, 3.39; 95% CI, 1.66-6.92), and endoscopic remission (aHR, 1.90; 95% CI, 1.06-3.39). In contrast, disease duration was not a significant predictor of response among patients with UC.ConclusionsPatients with CD for 2 years or less are significantly more likely to achieve a complete response, CSFR, or endoscopic response to vedolizumab than patients with longer disease duration. Disease duration does not associate with response vedolizumab in patients with UC

Beyond Medicine: Transforming Healthcare for a Sustainable Future

Aim:To assess the integration of sustainability principles in the Indian health care sector, by gauging the impact of Environmental, Social and Governance (ESG) factors across the healthcare value chain, and to navigate their way towards a sustainable health care system. Subjects and Methods:A detailed literature review was done first, and different stakeholders were carried out in order to identify key sustainability issues. Data collection focused on ESG elements within hospitals. The study collected data from a range of healthcare professional by taking into consideration hospital size, complexity and organizational strategies. Results: The assessment pointed out the healthcare establishments’ attitude towards sustainability, especially in the Economy & Governance, Environmental and Social domains. The hospitals had advantages, including but not limited to, information security, sustainable procurement strategies, as well as increasing women in managerial positions. At the same time, certain environmental challenges showed efficient waste disposal, possible improvement of carbon footprint management, particularly monitoring of GHG emissions. Social dimension, the hospitals focused on providing safe services to patients and training their personnel adequately, did not engage in child labor, and complied with minimum wage regulations in the country.Conclusion:The research underscores the importance of hospitals going beyond simple institutional commitments to sustainability and adapting practices to manage climate change risks and other environmental issues. The findings are intended to help policymakers adopt a more integrated perspective by promoting the adoption of sustainability in the Indian health system in terms of economic, environmental, and social dimensions

Applying an Epidemiological Model to Evaluate the Propagation of Toxicity related to COVID-19 on Twitter

The prevalence of social media has increased the propagation of toxic behavior among users. Toxicity can have detrimental effects on users’ emotion and insight and disrupt beneficial discourse. Evaluating the propagation of toxic content on social networks such as Twitter can provide the opportunity to understand the characteristics of this harmful phenomena. Identifying a mathematical model that can describe the propagation of toxic content on social networks is a valuable approach to this evaluation. In this paper, we utilized the SEIZ (Susceptible, Exposed, Infected, Skeptic) epidemiological model to find a proper mathematical model for the propagation of toxic content related to COVID-19 topics on Twitter. We collected Twitter data based on specific hashtags related to different COVID-19 topics such as Covid, Mask, Vaccine, and Lockdown. The findings demonstrate that the SEIZ model can properly model the propagation of toxicity on a social network with relatively low error. Determining an efficient mathematical model can increase the understanding of the dynamics of the propagation of toxicity on a social network such as Twitter. This understanding can help researchers and policy-makers to develop methods to limit the propagation of toxic content on social networks