416 research outputs found
Plasma 1-carbon metabolites and academic achievement in 15-yr-old adolescents
Academic achievement in adolescents is correlated with 1-carbon metabolism (1-CM), as folate intake is positively related and total plasma homocysteine (tHcy) negatively related to academic success. Because another 1-CM nutrient, choline is essential for fetal neurocognitive development, we hypothesized that choline and betaine could also be positively related to academic achievement in adolescents. In a sample of 15-yr-old children (n = 324), we measured plasma concentrations of homocysteine, choline, and betaine and genotyped them for 2 polymorphisms with effects on 1-CM, methylenetetrahydrofolate reductase (MTHFR) 677C>T, rs1801133, and phosphatidylethanolamine N-methyltransferase (PEMT), rs12325817 (G>C). The sum of school grades in 17 major subjects was used as an outcome measure for academic achievement. Lifestyle and family socioeconomic status (SES) data were obtained from questionnaires. Plasma choline was significantly and positively associated with academic achievement independent of SES factors (paternal education and income, maternal education and income, smoking, school) and of folate intake (P = 0.009, R2 = 0.285). With the addition of the PEMT rs12325817 polymorphism, the association value was only marginally changed. Plasma betaine concentration, tHcy, and the MTHFR 677C>T polymorphism did not affect academic achievement in any tested model involving choline. Dietary intake of choline is marginal in many adolescents and may be a public health concern
Event Reconstruction in the PHENIX Central Arm Spectrometers
The central arm spectrometers for the PHENIX experiment at the Relativistic
Heavy Ion Collider have been designed for the optimization of particle
identification in relativistic heavy ion collisions. The spectrometers present
a challenging environment for event reconstruction due to a very high track
multiplicity in a complicated, focusing, magnetic field. In order to meet this
challenge, nine distinct detector types are integrated for charged particle
tracking, momentum reconstruction, and particle identification. The techniques
which have been developed for the task of event reconstruction are described.Comment: Accepted for publication in Nucl. Instrum. A. 34 pages, 23 figure
Coexistence of 'alpha+ 208Pb' cluster structures and single-particle excitations in 212Po
Excited states in 212Po have been populated by alpha transfer using the
208Pb(18O,14C) reaction at 85MeV beam energy and studied with the EUROBALL IV
gamma multidetector array. The level scheme has been extended up to ~ 3.2 MeV
excitation energy from the triple gamma coincidence data. Spin and parity
values of most of the observed states have been assigned from the gamma angular
distributions and gamma -gamma angular correlations. Several gamma lines with
E(gamma) < 1 MeV have been found to be shifted by the Doppler effect, allowing
for the measurements of the associated lifetimes by the DSAM method. The
values, found in the range [0.1-0.6] ps, lead to very enhanced E1 transitions.
All the emitting states, which have non-natural parity values, are discussed in
terms of alpha-208Pb structure. They are in the same excitation-energy range as
the states issued from shell-model configurations.Comment: 21 pages, 19 figures, corrected typos, revised arguments in Sect.
III
Pion Freeze-Out Time in Pb+Pb Collisions at 158 A GeV/c Studied via pi-/pi+ and K-/K+ Ratios
The effect of the final state Coulomb interaction on particles produced in
Pb+Pb collisions at 158 A GeV/c has been investigated in the WA98 experiment
through the study of the pi-/pi+ and K-/K+ ratios measured as a function of
transverse mass. While the ratio for kaons shows no significant transverse mass
dependence, the pi-/pi+ ratio is enhanced at small transverse mass values with
an enhancement that increases with centrality. A silicon pad detector located
near the target is used to estimate the contribution of hyperon decays to the
pi-/pi+ ratio. The comparison of results with predictions of the RQMD model in
which the Coulomb interaction has been incorporated allows to place constraints
on the time of the pion freeze-out.Comment: 9 pages, 12 figure
Central Pb+Pb Collisions at 158 A GeV/c Studied by Pion-Pion Interferometry
Two-particle correlations have been measured for identified negative pions
from central 158 AGeV Pb+Pb collisions and fitted radii of about 7 fm in all
dimensions have been obtained. A multi-dimensional study of the radii as a
function of kT is presented, including a full correction for the resolution
effects of the apparatus. The cross term Rout-long of the standard fit in the
Longitudinally CoMoving System (LCMS) and the vl parameter of the generalised
Yano-Koonin fit are compatible with 0, suggesting that the source undergoes a
boost invariant expansion. The shapes of the correlation functions in Qinv and
Qspace have been analyzed in detail. They are not Gaussian but better
represented by exponentials. As a consequence, fitting Gaussians to these
correlation functions may produce different radii depending on the acceptance
of the experimental setup used for the measurement.Comment: 13 pages including 10 figure
Search for Disoriented Chiral Condensates in 158 AGeV Pb+Pb Collisions
The restoration of chiral symmetry and its subsequent breaking through a
phase transition has been predicted to create regions of Disoriented Chiral
Condensates (DCC). This phenomenon has been predicted to cause anomalous
fluctuations in the relative production of charged and neutral pions in
high-energy hadronic and nuclear collisions. The WA98 experiment has been used
to measure charged and photon multiplicities in the central region of 158 AGeV
Pb+Pb collisions at the CERN SPS. In a sample of 212646 events, no clear DCC
signal can be distinguished. Using a simple DCC model, we have set a 90% C.L.
upper limit on the maximum DCC production allowed by the data.Comment: 20 Pages, LaTeX, uses elsart.cls, 8 eps figures included, submitted
to Physics Letters
ERβ-dependent effects on uterine endothelial cells are cell specific and mediated via Sp1
STUDY QUESTION: What are the in vitro effects of estrogen receptor β (ERβ) activation on the function of endothelial cells (ECs) from different vascular beds: human endometrial ECs (HEECs; endometrium), uterine myometrial microvascular ECs (UtMVECs; myometrium) and human umbilical vein ECs (HUVECs)? SUMMARY ANSWER: Studies conducted in vitro demonstrate that the ERβ agonist 2,3-bis(4-hydroxy-phenyl)-propionitrile (DPN) has EC type-specific effects on patterns of gene expression and network formation. Identification of a key role for the transcription factor Sp1 in ERβ-dependent signaling in uterine ECs offers new insights into cell-specific molecular mechanisms of estrogen action in the human uterus. WHAT IS KNOWN ALREADY: Estrogens, acting via ERs (ERα and ERβ), have important, body-wide impacts on the vasculature. The human uterus is an estrogen target organ, the endometrial lining of which exhibits physiological, cyclical angiogenesis. In fixed tissue sections, human endometrial ECs are immunopositive for ERβ. STUDY DESIGN, SIZE, DURATION: Cells were treated with a vehicle control or the ERβ agonist, DPN, for 2 h or 24 h (n = 5) followed by gene expression analysis. Functional assays were analyzed after a 16 h incubation with ligand (n = 5). PARTICIPANT/MATERIALS, SETTING, METHODS: Analysis of DPN-treated ECs using Taqman gene array cards focused on genes involved in angiogenesis and inflammation identified cell type-specific ERβ-dependent changes in gene expression, with validation using qPCR and immunohistochemistry. Molecular mechanisms involved in ERβ signaling were investigated using bioinformatics, reporter assays, immunoprecipitation, siRNA and a specific inhibitor blocking Sp1-binding sites. The endometrium and myometrium from women with regular menses were used to validate the protein expression of candidate genes. MAIN RESULTS AND THE ROLE OF CHANCE: HEECs and UtMVECs were ERβ+/ERα−. Treatment of ECs with DPN had opposite effects on network formation: a decrease in network formation in HEECs (P ≤ 0.001) but an increase in UtMVECs (P ≤ 0.05). Genomic analysis identified opposite changes in ERβ target gene expression with only three common transcripts (HEY1, ICAM1, CASP1) in all three ECs; a unique profile was observed for each. An important role for Sp1 was identified, consistent with the regulation of ERβ target genes via association with the transcription factor (‘tethered’ mechanism). LIMITATIONS, REASONS FOR CAUTION: The study was mainly carried out in vitro using ECs of which one type was immortalized. Although the analysis of the protein expression of candidate genes was carried out using intact tissue samples from patients, investigations into in vivo angiogenesis were not carried out. WIDER IMPLICATIONS OF THE FINDINGS: These results have implications for our understanding of the mechanisms responsible for ERβ-dependent changes in EC gene expression in hormone-dependent disorders. STUDY FUNDING/COMPETEING INTEREST(S): The study was funded by a Medical Research Council Programme Grant. E.G. is the recipient of an MRC Career Development Fellowship. The authors have nothing to disclose
Suppression of High-p_T Neutral Pion Production in Central Pb+Pb Collisions at sqrt{s_NN} = 17.3 GeV Relative to p+C and p+Pb Collisions
Neutral pion transverse momentum spectra were measured in p+C and p+Pb
collisions at sqrt{s_NN} = 17.4 GeV at mid-rapidity 2.3 < eta_lab < 3.0 over
the range 0.7< p_T < 3.5 GeV/c. The spectra are compared to pi0 spectra
measured in Pb+Pb collisions at sqrt{s_NN} = 17.3 GeV in the same experiment.
For a wide range of Pb+Pb centralities (N_part < 300) the yield of pi0's with
p_T > 2 GeV/c is larger than or consistent with the p+C or p+Pb yields scaled
with the number of nucleon-nucleon collisions (N_coll), while for central Pb+Pb
collisions with N_part > 350 the pi0 yield is suppressed.Comment: 5 pages, 4 figure
Centrality Dependence of the High p_T Charged Hadron Suppression in Au+Au collisions at sqrt(s_NN) = 130 GeV
PHENIX has measured the centrality dependence of charged hadron p_T spectra
from central Au+Au collisions at sqrt(s_NN)=130 GeV. The truncated mean p_T
decreases with centrality for p_T > 2 GeV/c, indicating an apparent reduction
of the contribution from hard scattering to high p_T hadron production. For
central collisions the yield at high p_T is shown to be suppressed compared to
binary nucleon-nucleon collision scaling of p+p data. This suppression is
monotonically increasing with centrality, but most of the change occurs below
30% centrality, i.e. for collisions with less than about 140 participating
nucleons. The observed p_T and centrality dependence is consistent with the
particle production predicted by models including hard scattering and
subsequent energy loss of the scattered partons in the dense matter created in
the collisions.Comment: 7 pages text, LaTeX, 6 figures, 2 tables, 307 authors, resubmitted to
Phys. Lett. B. Revised to address referee concerns. Plain text data tables
for the points plotted in figures for this and previous PHENIX publications
are publicly available at
http://www.phenix.bnl.gov/phenix/WWW/run/phenix/papers.htm
Heavy Quarks and Heavy Quarkonia as Tests of Thermalization
We present here a brief summary of new results on heavy quarks and heavy
quarkonia from the PHENIX experiment as presented at the "Quark Gluon Plasma
Thermalization" Workshop in Vienna, Austria in August 2005, directly following
the International Quark Matter Conference in Hungary.Comment: 8 pages, 5 figures, Quark Gluon Plasma Thermalization Workshop
(Vienna August 2005) Proceeding
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