12 research outputs found
Goodbye Hartmann trial: a prospective, international, multicenter, observational study on the current use of a surgical procedure developed a century ago
- Author
- Abate Emmanuele
- Abbassi Imed
- Abdoun Ahmed K.
- Abdullaev Abakar
- Abu-Zidan Fikri
- Acheimastos Vasileios
- Agackiran Ibrahim
- Agnoletti Vanni
- Agrusa Antonino
- Agundez MariÌa Carmona
- Agus Marcello
- Aizza Giada
- Akin Emrah
- Alconchel Felipe
- Alegre Javier MartiÌnez
- Alemanno Giovanni
- Ali Ali Ben
- Almeida Filipe
- Altinel Yuksel
- Altıntaş Yasemin
- Altintoprak Fatih
- Ambrosi Antonio
- Ammar Houssem
- Anania Gabriele
- Andreuccetti Jacopo
- AndreÌs MariÌa Inmaculada PeÌrez
- Anestiadou Elissavet
- Ansaloni Luca
- Antona Francisco Blanco
- Aparicio-SaÌnchez Daniel
- Aprea Giovanni
- Aranaz-Ostariz Veronica
- Aranda-NarvaÌez Jose Manuel
- Ardito Antonella
- Argenio Giulio
- Armellino Mariano Fortunato
- Armento Isabella
- Asti Emanuele Luigi Giuseppe
- Atanasov Boyko
- Atici Semra Demirli
- Augustin Goran
- AureÌlien Venara
- Austin Tyler R.
- Avgerinos Konstantinos
- Ayed Karim
- Azzinnaro Antonio
- Bagolini Francesco
- Baili Efstratia
- Bains Lovenish
- Baiocchi Gian Luca
- Bajul Melinda
- Bala Miklosh
- Balık Emre
- Balla Andrea
- Banchini Filippo
- BanÌolas-Suarez Raquel
- Baraket Oussama
- Barberis Andrea
- Bardes James M.
- Bayhan Zulfu
- Bayrak Mehmet
- Belev Nikolay
- Belvedere Angela
- Benzoni Ilaria
- Bernardi Daniele Tiziano
- Berti Stefano
- Bertino Vanessa
- Bertoli Paolo
- Bianchi Valentina
- Biffl Walter L.
- Biloslavo Alan
- Boati Paolo
- BogdanicÌ Branko
- Bolzon Stefano
- Bombardini Cristina
- Bonati Elena
- Bonilauri Stefano
- Bonomi Alessandro
- Borghi Felice
- Bosch-RamiÌrez Marina
- Bougard Marie
- Bouliaris Konstantinos
- Boura Maria
- Bourbouteli Eirini
- Bozkurt Mehmet Abdussamet
- Brachini Gioia
- Bradley Alison
- Bravi Francesca
- Bravo Altea Arango
- Buffone Angelica
- Buonfantino Massimo
- Buscemi Salvatore
- CaamanÌo Aloia Guerreiro
- Cadeo Alessandro
- Cairl Nicholas
- Calu Valentin
- Campa Rossella Domenica
- Campana Juan P.
- Campos-Serra Andrea
- Cannavera Alessandro
- Canton Cassio Alfred Brattig
- Capelli Patrizio
- Capolupo Gabriella Teresa
- Capponi Michela Giulii
- Capuano Marianna
- Carannante Filippo
- Cardamone Eugenia
- Cardoso Paulo SebastiaÌo
- Caricato Marco
- Carmona Zahira GoÌmez
- Carneiro Carla
- Carvas JoaÌo
- Casadei Massimiliano
- Casati Massimiliano
- Casiraghi Silvia
- Casole Giovanni
- Castaldo Pasquale
- Catena Fausto
- Cattaneo Gaetano Maria
- Cavallo Fabio
- Cellerino Paola
- Cereda Marco
- Ceresoli Marco
- Chahrour Ali Chaouki
- Chamzin Alexandros
- Charalabopoulos Alexandros
- Chierici Andrea
- Chouillard Elie
- Chrysos Emmanuel
- Cianci Pasquale
- Cicconi Simone
- Cillara Nicola
- Clarizia Guglielmo
- Clerici Federico
- Cloquell Miriam Moratal
- Coccolini Federico
- Coffua Lauren S.
- Coimbra Raul
- Colak Elif
- Conti Luigi
- Corbellini Carlo
- Cordeiro-Fonseca Vinicius
- Cotsoglou Christian
- Cruz Daniel Rios
- Cuellar Jose Aurelio Navas
- Cumplido Paola Lora
- Curtiss William
- CzyzÌykowski Ćukasz
- da Costa Silvia Dantas
- Das Koray
- Dawoud Christopher
- de LeoÌn Laura RomaÌn GarciÌa
- de los AÌngeles Gil Olarte-Marquez Ma
- De Luca Maurizio
- de Manzoni Garberini Andrea
- de Mendonça Nuno Gonçalo Gonçalves
- de Mesquita Tauil Renato
- De Palma Giovanni Domenico
- de Quiros Javier Tomas Morales Bernaldo
- De Sario Giuseppina
- De Simone Belinda
- Degiuli Maurizio
- Del Monte Simone Rossi
- del Pozo Eduardo Perea
- Delgado Edward
- Delvecchio Antonella
- Demetrashvili Zaza
- Demirbas Eren
- Depalma Norma
- Di Buono Giuseppe
- Di Salvo Maria
- Dimov Stefan
- Dimova Ana
- Dinuzzi Vincenza Paola
- DiÌez-Alonso Manuel
- DomiÌnguez Carlota LoÌpez
- Dorken Ander
- Dos Barbeito Sandra
- Doudakmanis Christos
- Du Bois MariÌa Esther
- Dziakova Jana
- DâAcapito Fabrizio
- DâAlessio Rossella
- DâUgo Stefano
- Echeverria-Rosario Karla
- Edwards Sara
- Egodage Tanya
- Elizalde Aurea Barbara Rodriguez
- Ercolani Giorgio
- Esposito Francesco
- Esposito Giuseppe
- Esposito Marialusia
- Estaire-GoÌmez Mercedes
- Fabbri Anna
- Fabbri NicoloÌ
- FarreÌ Silvia PeÌrez
- Favi Francesco
- Felsenreich Daniel M.
- Feo Carlo V.
- Fernandes UraÌnia
- FernaÌndez Rocio Torres
- Ferrara Francesco
- Ferrari Davide
- Ferreira Ana Rita Oliveira
- Ferreira CaÌtia
- Filippelli Alice
- Firat Necattin
- Fleres Francesco
- Florence Charlotte
- Fnaiech Iskander
- Fogato Luisella
- Fontana Michele
- Fradelos Evangelos
- Fraga Gustavo P.
- Fransvea Pietro
- Frontali Alice
- Frountzas Maximos
- Fumagalli Chiara
- Gachabayov Mahir
- Gambino Giovanni
- GarciÌa Juan JesuÌs Rubio
- Garulli Gianluca
- Gasser Elisabeth
- Gattulli Domenico
- Gebran Anthony
- Germani Paola
- Gil-MartiÌnez JoseÌ
- Gioco Rossella
- Giraudo Giorgio
- Giuffrida Mario
- Gomes Carlos Augusto
- Gomes Felipe Couto
- Gomez Maite Santamaria
- Gonullu Emre
- Gonzaga Ricardo Alessandro Teixeira
- GonzaÌlez-Castillo Ana MariÌa
- Goulart AndreÌ
- Grassi Carmine
- GraÌcia-Roman Raquel
- Guaitoli Eleonora
- Guercioni Gianluca
- Guerra Enrico
- Guerra Martina
- Guner Ali
- Gupta Rahul
- Hacım Nadir Adnan
- Hamid Hytham K. S.
- Hemmila Mark
- Hentati Hassen
- Hernandez Edgard Efren Lozada
- Hinojosa-Ugarte Diego
- Huguet Jose MuguÌerza
- Hyman Theodore S.
- Iglesias Eva
- Ilhan Onur
- Inama Marco
- Ioannidis Orestis
- Isernia Roberta Maria
- Isik Arda
- Jakubauskas Matas
- Jalal-Eldin Sami
- Jimenez-Riera Granada
- Jimenez-Vega Javier
- JimeÌnez Beatriz MunÌoz
- Jovine Elio
- Jusoh Asri Che
- Kafka-Ritsch Reinhold
- Kara Yasin
- Karavokyros Ioannis
- Katunin Jevgeni
- Kavalieratos George
- Kaya Tayfun
- Kchaou Ali
- Kechagias Aristotelis
- Kedar Asaf
- Khalil Hany
- Khan Mansoor
- Khanduri Archana
- Kimpizi Despina
- Kobe Yoshiro
- Kocataş Ali
- Kokkinakis Stamatios
- Korkolis Dimitrios
- Koukoulis Georgios
- Kovachev Nikola
- Koylu Zehra Alan
- Kruger Vitor F.
- Kryzauskas Marius
- Kuzeridis Harilaos
- Kwiatkowski Andrzej
- Lacko VladimiÌr
- Laforgia Rita
- Lantone Giuliano
- Lantone Giulio
- Lapolla Pierfrancesco
- Latifi Rifat
- Latorraca JoseÌ
- Lauka Lelde
- LaÌtecÌkovaÌ Zuzana
- Leao Pedro
- Lecchi Francesca
- Leo Cosimo Alex
- Lepiane Pasquale
- Lepre Luca
- Lesko Dusan
- Letizia Laface
- Liasis Lampros
- Litvin Andrey
- Livrini Marco
- Lohsiriwat Varut
- Lombardi Raffaele
- Lopez Ana
- Lorusso Leonardo
- Lostoridis Eftychios
- Loutzidou Lydia
- Lovisetto Federico
- Lozano Rafael Calleja
- LoÌpez JoaquiÌn Ruiz
- LoÌpez-SaÌnchez Jaime
- Luppi Davide
- Luzzi Andrea-Pierre
- Magnone Stefano
- Major Piotr
- Manatakis Dimitrios K.
- Manca Giuseppe
- Manigrasso Michele
- Manso Maria Isabel Cerqueira
- Mantoglu Baris
- Manunza Romina
- Margaris Ioannis
- Maria Sotiropoulou
- Marinis Athanasios
- Marino Fabio
- Maroulis Ioannis
- Marques Rita
- Martines Gennaro
- MartiÌnez Manuel DuraÌn
- MartiÌnez-LoÌpez EliÌas
- MartiÌnez-PeÌrez Aleix
- Massucco Paolo
- Mazzini Federico N.
- McClure Amanda
- MeleÌndez L. Juan JoseÌ
- Membrilla-FernaÌndez Estela
- Memis Ufuk
- Mendoza-Moreno Fernando
- Mentz Ricardo
- Merabishvili Giorgi
- Meric Serhat
- Michalopoulos Nikolaos
- MicoÌ Silvia Sevila
- Milone Marco
- Mingoli Andrea
- Miron Adrian
- Mitei Mercy
- Moller Elsa GarciÌa
- Mongkhonsupphawan Aitsariya
- Monroy Jose maria Victor Palomo
- Monsellato Igor
- Morais Henrique Manuel Cardoso
- Morales-Sevillano Xavier
- Moreira Claudia Cristina Lopes
- Moreno Cristina Ruiz
- Moreno VeroÌnica Polaino
- Moretto Gianluigi
- MoricÌ Trpimir
- Mulita Francesk
- MunÌoz-CampanÌa Anna
- Musa Nicola
- Nagliati Carlo
- Nagorni Eleni-Aikaterini
- Napolitano Lena M.
- Nechay Taras
- NicolaÌs-LoÌpez Tatiana
- Nisa Francisca GarciÌa-Moreno
- Nita Gabriela Elisa
- Notarnicola Margherita
- Oliva Alba
- Olmi Stefano
- Omarov Nail
- Oragano Luigi
- Orio Gianluca
- Osella Giulia
- Oury Jeffrey
- Ozer Nazmi
- Ozkan Zeynep
- OâSullivan Sara NunÌez
- Palini Gian Marco
- Palisi Marco
- Palmer Amanda
- Palmieri Francesco
- Palomba Giuseppe
- Panebianco Annunziata
- Panis Yves
- Pantalone Desire
- Panyko ArpaÌd
- Papacostantinou Ioannis
- Papagni Vincenzo
- Papis Davide
- Pardo Pablo Sancho
- Parini Dario
- Parker Robert
- PatrociÌnio Sara Daniela Direito
- Pattacini Gianmaria Casoni
- Pauzas Henrikas
- Pavone Giovanna
- Pellino Gianluca
- Pelloni MariÌa
- Pereira Bela
- Pereira Bruno Monteiro
- Pereira Rita Gonçalves
- Perez Aintzane Lizarazu
- Perez Diego Pita
- Perrone Fabrizio
- Perrone Gennaro
- Pesce Antonio
- Petit Nuria Mestres
- Petracca Gabriele Luciano
- Petrakis Georgios
- Petropoulou Thalia
- Petruzzelli Luca
- Pezzoli Isabella
- Pezzolla Angela
- PeÌšdziwiatr MichaĆ
- Picardi Biagio
- Picariello Erika
- Picciariello Arcangelo
- Piccoli Micaela
- Picheo Roberto
- Pighin Marina
- Pignata Giusto
- Pinto Francisca Lima
- Pipia Irakli
- Pisano Marcello
- Pisano Michele
- Pisanu Adolfo
- Pisarska-Adamczyk Magdalena
- Podda Mauro
- Polat Suleyman
- Polenta Eleni
- Polydorou Andreas
- Ponce InÌigo Augusto
- Pontarolo Nicholas
- Pontillo Marcelo
- Portale Giuseppe
- Poskus Tomas
- Prando Daniela
- Pujante Antonio
- Quick Jacob A.
- Quiodettis Martha
- Radonak Jozef
- Rahy-Martin Aida Cristina
- Rampini Alessia
- Rana Mridul
- Ranieri Valerio
- Ranketi Sinkeet
- Ratnasekera Asanthi
- Reames Summer
- Reddavid Rossella
- Reis Murat Emre
- Restini Enrico
- Reynaud Alejandro BanÌon
- Ricci Claudio
- Riss Stefan
- Rivera-Alonso Daniel
- Rocha Catarina
- Rocha Ricardo
- Rodas MariÌa Elisa Valle
- Romacho-LoÌpez Laura
- Ronconi Maurizio
- Roscio Francesco
- Rossi Giorgio
- Rossi Stefano
- Rottoli Matteo
- Roulet Maxime
- Ruiz Enrique ColaÌs
- Russo Iris Shari
- Salazar Yeniffer Tatiana Moreno
- Salvans Silvia
- Sampietro Gianluca Matteo
- Sangji Naveen F.
- Sarnari Jlenia
- Sarro Giuliano
- Sartelli Massimo
- Sasia Diego
- SaÌnchez-GuilleÌn Luis
- Scandroglio Ildo
- Scaramuzzo Rosa
- Schaffer Kathryn
- Scheiterle Maximilian
- Schifano Domenico
- Schizas Dimitrios
- SebastiaÌn-TomaÌs Juan Carlos
- Seker Ahmet
- Sena Giuseppe
- Seng Sirivan Suon
- Serradilla-MartiÌn Mario
- Sganga Gabriele
- Shimamura Fumihiko
- Siannis Ioannis
- Sierra Isabel Blesa
- SimoÌ Ignacio Rey
- Singh Sudhir K.
- Sofia Silvia
- Solaini Leonardo
- Soltes Marek
- Spampinato Marcello
- Spinelli Stefano
- Spolini Alessandro
- Spolverato Ylenia
- Stylianos Kapiris
- Svagzdys Saulius
- Swaminathan Christie
- Syllaios Athanasios
- Tanzanu Marta
- Tarasconi Antonio
- Tartaglia Nicola
- Tasis Nikolaos
- Tebala Giovanni D.
- Termes-Serra Roser
- Theodorou Dimitrios
- Tian Brian W. C. A.
- Titos-GarciÌa Alberto
- Tlili Ahmed
- Toma Elena Adelina
- Toma Takayuki
- Tonucci Tommaso Panici
- Torre Beatrice
- Torres AÌlvaro Naranjo
- Totaro Luigi
- Toutouzas Konstantinos
- Triantafyllou Tania
- Trigiante Giuseppe
- Troian Marina
- Trostchansky Ivan
- Truong Hung P.
- Tsouknidas Ioannis
- Tuncer Korhan
- Turrado-Rodriguez Victor
- Tyagunov Alexander
- Uccelli Matteo
- Usta Mehmet Arif
- Uymaz Derya Salim
- Uzunoglu Mustafa Yener
- Vailas Michail
- ValcaÌrcel Cristina Rey
- Valle Naila PageÌs
- Vallicelli Carlo
- Vassiliu Panteleimon
- Velmahos George
- Veneroni Simone
- Veroux Gastone
- Veroux Massimiliano
- Vincenti Leonardo
- Visconti Diego
- VitoÌn-Herrero Rebeca
- WaleÌšdziak Maciej
- Watfah Josef
- Wilson Michael
- Wong Michael Pak-Kai
- Xenaki Sofia
- Yuldashev Anvar
- Zakaria Andee Dzulkarnaen
- Zakaria Muhammad Nazreen
- Zakaria Zaidi
- Zanzi Federico
- ZelicÌ Zdravko
- Zem Leticia Gonçalves
- Zese Monica
- Zilinskas Justas
- Zonta Sandro
- Zribi Imen
- Zuin Matteo
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Literature suggests colonic resection and primary anastomosis (RPA) instead of Hartmann's procedure (HP) for the treatment of left-sided colonic emergencies. We aim to evaluate the surgical options globally used to treat patients with acute left-sided colonic emergencies and the factors that leading to the choice of treatment, comparing HP and RPA. Methods: This is a prospective, international, multicenter, observational study registered on ClinicalTrials.gov. A total 1215 patients with left-sided colonic emergencies who required surgery were included from 204 centers during the period of March 1, 2020, to May 31, 2020. with a 1-year follow-up. Results: 564 patients (43.1%) were females. The mean age was 65.9 ± 15.6 years. HP was performed in 697 (57.3%) patients and RPA in 384 (31.6%) cases. Complicated acute diverticulitis was the most common cause of left-sided colonic emergencies (40.2%), followed by colorectal malignancy (36.6%). Severe complications (Clavien-Dindo ℠3b) were higher in the HP group (P < 0.001). 30-day mortality was higher in HP patients (13.7%), especially in case of bowel perforation and diffused peritonitis. 1-year follow-up showed no differences on ostomy reversal rate between HP and RPA. (P = 0.127). A backward likelihood logistic regression model showed that RPA was preferred in younger patients, having low ASA score (†3), in case of large bowel obstruction, absence of colonic ischemia, longer time from admission to surgery, operating early at the day working hours, by a surgeon who performed more than 50 colorectal resections. Conclusions: After 100 years since the first Hartmann's procedure, HP remains the most common treatment for left-sided colorectal emergencies. Treatment's choice depends on patient characteristics, the time of surgery and the experience of the surgeon. RPA should be considered as the gold standard for surgery, with HP being an exception
Infected pancreatic necrosis: outcomes and clinical predictors of mortality. A post hoc analysis of the MANCTRA-1 international study
- Author
- Ababneh Hazim
- Abbas Kinan
- Abdalah Haidar M.
- Abdelsalam Wafaa
- Abdullaev Abakar
- Abid Izza
- Abradelo Manuel
- Acheimastos Vasileios
- Afzal Ameer
- Agarwal Rajendra
- Agnoletti Vanni
- Agresta Ferdinando
- Ahmed Salma
- Aiolfi Alberto
- Akalin Murat
- Akbar Ali
- Akin Emrah
- Aktimur Yunus Emre
- Al-Raimi Ibrahim
- Al-Shami Khayry
- Alawadhi Kamel
- Alconchel Felipe
- Alexandridou Eirini
- Ali Iyad
- Ali Syed Muhammad
- Aljaiuossi Osama
- Alla-Angelina Volovich
- Alshaikh Abdulrahman
- Alshargabi Haneen
- Altinel Yuksel
- Altintoprak Fatih
- Alvarez Fernando AndreÌs
- Ammendola Michele
- Anania Gabriele
- Andreotti Dario
- Andreuccetti Jacopo
- Anestiadou Elissavet
- Ani Mohd Firdaus Che
- Ansaloni Luca
- Anwaar Muhammad Hassan
- Aonzo Paolo
- Aparicio Antonio Carlos Maya
- Apollos Jeyakumar
- Argenio Giulio
- Arina Tsurbanova
- Armellino Mariano Fortunato
- Assenza Marco
- Atanasov Boyko
- Atici Semra Demirli
- Ausania Fabio
- Awad Ahmed
- Awadi Sajeda
- Azamat Ibrahim Fethi
- AÌlvarez-Torrado Andrea
- Badran Ali
- Bagaglini Giulia
- Baili Efstratia
- Bains Lovenish
- Balla Andrea
- Barone Mirko
- Bayhan HuÌseyin
- Bayo Jose Muros
- Beasley Daniel
- Belev Nikolay
- Bellato Vittoria
- Belloni Elena
- Benuzzi Laura
- Bergamini Carlo
- Beristain-Hernandez Jose-Luis
- Bianchi Valentina
- Bianchini Matteo
- Biffl Walter
- Biloslavo Alan
- Bilyak Andriy
- Bini Roberto
- Bogoni Selene
- Bombardini Cristina
- Bona Davide
- Bond-smith Giles
- Bono Dario
- Bottari Andrea
- Bozkurt Mehmet Abdussamet
- Bracale Umberto
- Brachet Contul Riccardo
- Brachini Gioia
- Bradley Alison
- Butturini Giovanni
- Buwaitel Mohammad Musallam Khalil
- Cabrera Vicente Herrera
- Cabrera Zamiara Solange Leon
- Cal Fernando Bonilla
- Calderan Thiago R. A.
- Calik Bulent
- CaliÌ Matteo
- Calleja-Lozano Rafael
- Calu Valentin
- Campanella Gaetano
- Candio Giulio
- Cannavera Alessandro
- Cantafio Stefano
- Caravaca Iban
- Caronna Roberto
- Casadei Massimiliano
- Catena Fausto
- Ceresoli Marco
- Cerioli Alessandra
- Cervellera Maurizio
- Chan Shannon Melissa
- Charalabopoulos Alexandros
- Chiara Osvaldo
- Chiarugi Massimo
- Chidumije Nnaemeka
- Chirletti Piero
- Chiuyari JoseÌ RiÌos
- Chooklin Serge
- Choudhary Hasham
- Chouillard Elie
- Chouliaras Christos
- Chuklin Serhii
- Ciabatti Giulia
- Cianci Pasquale
- Cicako Atea
- Cicuttin Enrico
- Cillara Nicola
- Cioffi Stefano
- Cioffi Stefano Piero Bernardo
- CiuroÌ Felipe Parej
- Clarizia Guglielmo
- Coccolini Federico
- Colak Elif
- Condoy Jefferson Nieves
- Conti Lorenzo
- Coretti Guido
- Cossa Alessandra
- Costea Radu Virgil
- Couto Gomes Felipe
- Cozzani Federico
- Cremonini Camilla
- Crespi Michele
- Cristaudi Alessandra
- CurroÌ Giuseppe
- Dakis Konstantinos
- Damaskos Dimitrios
- Danna Riccardo
- Dardanov Dragomir
- Das Koray
- Davies Brooke
- de Araujo Jorann
- De Francisco Mario
- De Manzini Nicoloâ
- De Nicola Enrico
- de SantibanÌes Martin
- de SaÌ Tiago Correia
- De Simone Belinda
- de Villar JoseÌ Manuel Perez
- del Alamo Yaiza GarciÌa
- del Pozo Eduardo Perea
- Delis Spiros
- Delogu Daniele
- Demetrashvili Zaza
- Deserra Antonello
- Devi Jalpa
- Di Bella Annamaria
- Di Carlo Isidoro
- Di Donato Luca
- Di Lascio Pierpaolo
- Di Lorenzo Nicola
- Di Martino Marcello
- Di Menno Stavron Juliana
- Di Nuzzo Maria Michela
- Di Saverio Salomone
- Dinuzzi Vincenza Paola
- Domenico Lacavalla
- Domingo-Gonzalez Marta
- DomiÌnguez Fabiana
- Doria Emanuele
- Doulias Triantafyllos
- Draghici Andreea Diana
- Drigo Davide
- DuraÌn Manuel
- Duval Jean-Luc
- DâAcapito Fabrizio
- DâAmbrosio Giancarlo
- Ebied Husam
- Elbadawy Merihan
- Elbahnasawy Mohamed
- Elfallal Ahmed
- Elfeki Hossam
- Elghadban Hosam
- Elmehrath Ahmed
- Elserafy Amr
- Elshami Mohamedraed
- Emile Sameh
- Ercolani Giorgio
- Estevez Sergio
- Estraviz-Mateos BegonÌa
- Fabbri NicoloÌ
- Farazi-Chongouki Christos
- Farguell Jordi
- Farid Ahmed
- Fathil Ida Nadiah Ahmed
- Favi Francesco
- FeijoÌo Eva Pont
- Feo Carlo Vittorio
- Ferrara Francesco
- Ferrari Luca
- Ferrario Luca
- First Necattin
- Fleres Francesco
- Fontana Tommaso
- Fortuna Laura
- Fox Katherine
- Fraga Gustavo
- Fransvea Pietro
- Fratini Geri
- Frontali Alice
- Gaber Mohannad
- Gachabayov Mahir
- Galleano Raffaele
- Garcia-Meza Alejandro
- GarciÌa Francisco C. Becerra
- GarciÌa HaydeÌe Calvo
- GarciÌa-Moreno-Nisa Francisca
- Garino Mauro
- Garzali Ibrahim-Umar
- Gendrikson George
- Genovese Valerio
- Gerardi Chiara
- Germani Paola
- Gerogiannis Ioannis
- Gessa Emanuela
- Ghazouani Omar
- Gianazza Simone
- Giannarakis Miltiadis
- Gioco Rossella
- Giordano Alessio
- Giraudo Giorgio
- Giuffrida Mario
- Giuliani Antonio
- Gomes Carlos Augusto
- GonzaÌlez-AboÌs Carolina
- Gourgiotis Stavros
- Grande Michele
- Grigorean Valentin Titus
- Grimaldi Sergio
- Guadagni Simone
- Guerci Claudio
- Guerci Claudio
- Guerrieri Mario
- Guida Anna
- Gumbs Andrew
- Gundara Justin
- Gupta Amit
- Hamdan Alaa
- Hamed Emad Fawzi
- Hamid Hytham K. S.
- Hanafy Asmaa
- Hasan Layla
- HernaÌndez Edgard Efren Lozada
- Hirano Elcio S.
- Hudson Victoria
- Huei Jih
- Ielpo Benedetto
- Iiritano Elena
- Ilzarbe Lucas
- Inama Marco
- Ioannidis Argyrios
- Ioannidis Orestis
- Ioia Giovanna
- Ippoliti Massimo
- Isik Arda
- Jayant Kumar
- Jovine Elio
- Julianov Alexander
- Julianov Alexander
- Kadir Bushra
- Kalaitzakis Evangelos
- Kalaitzakis Evangelos
- Kaldarov Ayrat
- Kaldarov Ayrat
- Kamar Jubin
- Kapiris Stylianos
- Kara Yasin
- Karamarkovic Milovan
- Kaur Mandeep
- Kchaou Ali
- Kefili Despoina
- Khalil Usama Ahmed
- Khamees Almuâatasim
- Khan Mansoor
- Khutsishvili Kakhi
- Kocataş Ali
- Kokoropoulos Panagiotis
- Komaei Iman
- Konstantinidis Konstantinis
- Konstantinidou Sofia
- Kotecha Pinky
- Kovacevic Bojan
- Kovachev Nikola
- Kozadinos Alexandros
- Kruger Yoram
- Kunitsyna Maria
- Kurtenkov Mikhail
- Kwiatkowski Andrzej
- Kykalos Stylianos
- Lagouvardou Elpiniki
- Lal Pawan
- Lancellotti Francesco
- Landaluce-Olavarria Aitor
- Lapolla Pierfrancesco
- Lasithiotakis Konstantinos
- Leo Cosimo Alex
- Lepiane Pasquale
- Leppaniemi Ari
- Lesko Dusan
- Lezama Tamara
- Liakakos Theodore
- LianÌo Julian Ezequiel
- Licitra Edelweiss
- Litvin Andrey
- Lohse Helmut Segovia
- Lohse Herald Segovia
- Lok Hon-Ting
- Lombardo Francesca
- Lostoridis Eftychios
- Loutzidou Lydia
- Lui Rashid
- Lunghi Elia Giuseppe
- Luppi Davide
- Mabilia Andrea
- Machain Gustavo M
- Machairas Nikolaos
- Magee Conor
- Magnoli Matteo
- Manak Jan
- Manatakis Dimitrios
- Manca Roberto
- Manoochehri Farshad
- Marafante Chiara
- Marchese Tiziana Rita Lucia
- Mariani NicoloÌ Maria
- Marino Marco Vito
- Maroulis Ioannis
- Marra Ester
- Martellucci Jacopo
- Martines Gennaro
- MartiÌn BeleÌn
- Mastrangelo Laura
- Mastronardi Manuela
- Mathur Pawan
- MatiÌas-GarciÌa BeleÌn
- MawlichanoÌw Maciej
- Mazza Oscar
- McCormack Kieran
- Medappil Noushif
- Meead Abdullah
- MeleÌndez Blas DuraÌn
- Mendoza-Moreno Fernando
- Meric Serhat
- Metaxas Panagiotis
- Michalopoulos Nikolaos
- Miglietta Claudio
- Milentijevic Milica
- Millo Paolo
- Mingoli Andrea
- Moggia Elisabetta
- Mohamad Ikhwan Sani
- Mohamad Ikhwan Sani
- Mohamed Salem
- Mole Damian
- Molina ViÌctor
- Monti Marco
- MoraÌn Laura AÌlvarez
- Morelli Luca
- Moretto Gianluigi
- Morino Mario
- Morrison Tamsin
- Mouzakis Odysseas
- Mucilli Felice
- Mulita Francesk
- MunÌoz-Cruzado Virginia Duran
- Muratore Andrea
- Murgese Alessandra
- Murgia Raimondo
- Murzi Valentina
- Muthukrishnan Vijayanand
- Muttillo Edoardo Maria
- Muttillo Irnerio Angelo
- Nafea Ahmed
- Naffaâ Moâtaz Fawzat Naief
- Nagliati Carlo
- Nagorni Eleni-Aikaterini
- Navarra Giuseppe
- NicolaÌs-LoÌpez Tatiana
- Nicotera Antonella
- Nigri Giuseppe
- Noel Colin
- null null
- Occhionorelli Savino
- Olmi Stefano
- Omarov Nail
- Oms Luis
- Oppici Dario
- Orantia Abigail Cheska C.
- Orantia-Carlos Abigail Cheska C.
- Ordemar Jorge
- Ortenzi Monica
- Ozer Nazmi
- Pacella Daniela
- Pachajoa Diana Alejandra Pantoja
- Palacios Andrea MasiaÌ
- Palepa Anna
- Palmieri Francesco
- Palmisano Silvia
- Panyko ArpaÌd
- Papa Gennaro
- Papa Mario Virgilio
- Papadoliopoulou Maria
- Papadopoulos Aristeidis
- Papagni Vincenzo
- Pata Francesco
- Paul Michaela
- Pellino Gianluca
- Peltrini Roberto
- Penalba-PalmiÌ Rafael
- Perotti Bruno
- Perra Elena Sofia
- Perrone Gennaro
- Perrone Stefano
- Pesce Antonio
- Petra Giorgia
- Petracca Gabriele Luciano
- Petrakis George
- PeÌrez-Bru Susana
- Picardi Biagio
- Picariello Erika
- Picchetto Andrea
- Picciariello Arcangelo
- Pignata Giusto
- Pilia Tiziana
- Pimentel Samuel
- Pinto Margherita
- PinzoÌn Camilo Levi AcunÌa
- Piras Enrico
- Pisanu Adolfo
- Pizarro Sergio Olivares
- Podda Mauro
- Poillucci Gaetano
- Police Andrea
- Ponte Elisa
- Porfidia Raffaele
- Portale Giuseppe
- Prasanti Alekhya Kotta
- Prieto Calvo Mikel
- Prioriello Concetta
- Puccioni Caterina
- Quispe-Cruz Darwin Artidoro
- Quitoy Margie Antionette
- Radonak Jozef
- Radulescu Raluca Bievel
- Ralon Sergio
- RamiÌrez Pablo
- Rampini Alessia
- Riboni Cristiana
- Ricci Claudio
- Rizzi Andrea
- Robayo Diana
- Roccamatisi Linda
- Rocha MoÌnica
- RodriÌguez Martha
- Roesel Raffaello
- Rojas-Bonet Noel
- Rossi Stefano
- Rossini Matteo
- Rottoli Matteo
- Rubicondo Carolina
- Russo Iris Shari
- Saad Ahmed
- Sadik Mohammad
- Sahani Saaz
- Sahani Saaz
- Salah Alzhraa Abbas
- Salcedo Diego
- Salomone Sara
- Salvetti Francesco
- Samhouri Ahmad
- Sammartano Fabrizio
- Sandhar Pardip
- Santini Andrea
- Saroglu Azize
- Sarro Giuliano
- Sartarelli Lodovico
- Sartelli Massimo
- Sartori Alberto
- Sasia Diego
- Saullo Paolina
- Savino Grazia
- Sawalha Hatem
- SaÌnchez Lianet
- SaÌnchez-CabuÌs Santiago
- SaÌnchez-GuilleÌn Luis
- Scaravilli Luca
- Schizas Dimitrios
- Scifo Giovanna
- Sederino Mariagrazia
- Seerani Nandlal
- Segalini Edoardo
- Seker Ahmet
- Sensi Bruno
- Sepulveda-Rdriguez Rafael
- Sergi William
- Serventi Alberto
- Seth Shatadru
- Sethi Ananya
- Seto Gaby Susana Yamamoto
- Sganga Gabriele
- Sheikh Zara
- Sherief Ghozy
- Sheth Hemant
- Shetiwy Mohamed
- Shoma Ashraf
- Sica Giuseppe
- Siragusa Leandro
- Soares Carlos
- Soggiu Fiammetta
- Sohail-Asghar Mohammad
- Solaini Leonardo
- Soltes Marek
- Sotiropoulou Maria
- Spolini Alessandro
- Stamopoulos Paraskevas
- Stella Marco
- Stoian Alexandru Rares
- Syllaios Athanasios
- Synekidou Eirini
- Tartaglia Dario
- Tasis Nikolaos
- Tebala Giovanni
- Tefay Joan
- Tejedor-Tejada Javier
- Theodorou Dimitrios
- Tlili Ahmed
- Tomasi Ivan
- Tonello Alice Sabrina
- Tonini Valeria
- Tourountzi Paraskevi
- Triantafyllou Tania
- Trigiante Giuseppe
- Triguero-CaÌnovas Daniel
- TrivinÌo MariÌa Alejandra
- Troian Marina
- Troiano Raffaele
- Tsouknidas Ioannis
- Tur-MartiÌnez Jaume
- TuÌrkogÌlu Mehmet Akif
- Tvaladze Anano
- Uccelli Matteo
- Ullah Syed Osama Zohaib
- Uymaz Derya Salim
- Uzunoglu Mustafa Yener
- Vailas Michail
- Valenzuela JoseÌ Ignacio
- Vega Pilar SuaÌrez
- Veroux Gastone
- Veroux Massimiliano
- ViganoÌ Jacopo
- Villalabeitia Ibabe
- Vincenti Leonardo
- Virdis Francesco
- Visconti Diego
- WaleÌšdziak Maciej
- Wilson Michael
- Yusoff Ahmad Ramzi
- Zafar Noman
- Zago Marcello
- Zainab null
- Zarnescu Eugenia Claudia
- Zarnescu Narcis Octavian
- Zarnescu Narcis Octavian
- Zuin Matteo
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2023
- Field of study
: The identification of high-risk patients in the early stages of infected pancreatic necrosis (IPN) is critical, because it could help the clinicians to adopt more effective management strategies. We conducted a post hoc analysis of the MANCTRA-1 international study to assess the association between clinical risk factors and mortality among adult patients with IPN. Univariable and multivariable logistic regression models were used to identify prognostic factors of mortality. We identified 247 consecutive patients with IPN hospitalised between January 2019 and December 2020. History of uncontrolled arterial hypertension (pâ=â0.032; 95% CI 1.135-15.882; aOR 4.245), qSOFA (pâ=â0.005; 95% CI 1.359-5.879; aOR 2.828), renal failure (pâ=â0.022; 95% CI 1.138-5.442; aOR 2.489), and haemodynamic failure (pâ=â0.018; 95% CI 1.184-5.978; aOR 2.661), were identified as independent predictors of mortality in IPN patients. Cholangitis (pâ=â0.003; 95% CI 1.598-9.930; aOR 3.983), abdominal compartment syndrome (pâ=â0.032; 95% CI 1.090-6.967; aOR 2.735), and gastrointestinal/intra-abdominal bleeding (pâ=â0.009; 95% CI 1.286-5.712; aOR 2.710) were independently associated with the risk of mortality. Upfront open surgical necrosectomy was strongly associated with the risk of mortality (pâ<â0.001; 95% CI 1.912-7.442; aOR 3.772), whereas endoscopic drainage of pancreatic necrosis (pâ=â0.018; 95% CI 0.138-0.834; aOR 0.339) and enteral nutrition (pâ=â0.003; 95% CI 0.143-0.716; aOR 0.320) were found as protective factors. Organ failure, acute cholangitis, and upfront open surgical necrosectomy were the most significant predictors of mortality. Our study confirmed that, even in a subgroup of particularly ill patients such as those with IPN, upfront open surgery should be avoided as much as possible. Study protocol registered in ClinicalTrials.Gov (I.D. Number NCT04747990)
Alternative RNA SplicingâThe Trojan Horse of Cancer Cells in Chemotherapy
- Author
- Publication venue
- 'MDPI AG'
- Publication date
- 01/07/2021
- Field of study
Almost all transcribed human genes undergo alternative RNA splicing, which increases the diversity of the coding and non-coding cellular landscape. The resultant gene products might have distinctly different and, in some cases, even opposite functions. Therefore, the abnormal regulation of alternative splicing plays a crucial role in malignant transformation, development, and progression, a fact supported by the distinct splicing profiles identified in both healthy and tumor cells. Drug resistance, resulting in treatment failure, still remains a major challenge for current cancer therapy. Furthermore, tumor cells often take advantage of aberrant RNA splicing to overcome the toxicity of the administered chemotherapeutic agents. Thus, deciphering the alternative RNA splicing variants in tumor cells would provide opportunities for designing novel therapeutics combating cancer more efficiently. In the present review, we provide a comprehensive outline of the recent findings in alternative splicing in the most common neoplasms, including lung, breast, prostate, head and neck, glioma, colon, and blood malignancies. Molecular mechanisms developed by cancer cells to promote oncogenesis as well as to evade anticancer drug treatment and the subsequent chemotherapy failure are also discussed. Taken together, these findings offer novel opportunities for future studies and the development of targeted therapy for cancer-specific splicing variants
Upregulation of YKL-40 Promotes Metastatic Phenotype and Correlates with Poor Prognosis and Therapy Response in Patients with Colorectal Cancer
- Author
- Publication venue
- MDPI AG
- Publication date
- 01/01/2022
- Field of study
YKL-40 is a heparin- and chitin-binding glycoprotein that belongs to the family of glycosyl hydrolases but lacks enzymatic properties. It affects different (patho)physiological processes, including cancer. In different tumors, YKL-40 gene overexpression has been linked to higher cell proliferation, angiogenesis, and vasculogenic mimicry, migration, and invasion. Because, in colorectal cancer (CRC), the serological YKL-40 level may serve as a risk predictor and prognostic biomarker, we investigated the underlying mechanisms by which it may contribute to tumor progression and the clinical significance of its tissue expression in metastatic CRC. We demonstrated that high-YKL-40-expressing HCT116 and Caco2 cells showed increased motility, invasion, and proliferation. YKL-40 upregulation was associated with EMT signaling activation. In the AOM/DSS mouse model, as well as in tumors and sera from CRC patients, elevated YKL-40 levels correlated with high-grade tumors. In retrospective analyses of six independent cohorts of CRC patients, elevated YKL-40 expression correlated with shorter survival in patients with advanced CRC. Strikingly, high YKL-40 tissue levels showed a predictive value for a better response to cetuximab, even in patients with stage IV CRC and mutant KRAS, and worse sensitivity to oxaliplatin. Taken together, our findings establish that tissue YKL-40 overexpression enhances CRC metastatic potential, highlighting this gene as a novel prognostic candidate, a predictive biomarker for therapy response, and an attractive target for future therapy in CRC
Timing of Cholecystectomy After Moderate and Severe Acute Biliary Pancreatitis
- Author
- Ababneh Hazim
- Abbas Kinan
- Abdalah Haidar M
- Abdelsalam Wafaa
- Abdullaev Abakar
- Abid Izza
- Acheimastos Vasileios
- AcunÌa PinzoÌn Camilo L
- Afzal Ameer
- Agarwal Rajendra
- Agresta Ferdinando
- Ahmed Salma
- Aiolfi Alberto
- Akalin Murat
- Akbar Ali
- Akin Emrah
- Aktimur Yunus E
- Al-Raimi Ibrahim
- Al-Shami Khayry
- Alawadhi Kamel
- Alconchel Felipe
- Alexandridou Eirini
- Ali Iyad
- Aljaiuossi Osama
- Alla-Angelina Volovich
- Alshaikh Abdulrahman
- Alshargabi Haneen
- Altinel Yuksel
- Altintoprak Fatih
- Alvarez Fernando A
- Ammendola Michele
- Anania Gabriele
- Andreotti Dario
- Andreuccetti Jacopo
- Anestiadou Elissavet
- Ansaloni Luca
- Anwaar Muhammad H
- Aonzo Paolo
- Apollos Jeyakumar
- Argenio Giulio
- Armellino Mariano F
- Assenza Marco
- Atanasov Boyko
- Atici Semra D
- Ausania Fabio
- Awad Ahmed
- Awadi Sajeda
- Azamat Ibrahim F
- AÌlvarez MoraÌn Laura
- AÌlvarez-Torrado Andrea
- Badran Ali
- Bagaglini Giulia
- Baili Efstratia
- Bains Lovenish
- Balla Andrea
- Barone Mirko
- Bayhan HuÌseyin
- Beasley Daniel
- Becerra GarciÌa Francisco C
- Belev Nikolay
- Bellato Vittoria
- Belloni Elena
- Benuzzi Laura
- Bergamini Carlo
- Beristain-Hernandez Jose L
- Bianchi Valentina
- Bianchini Matteo
- Biloslavo Alan
- Bilyak Andriy
- Bini Roberto
- Bogoni Selene
- Bombardini Cristina
- Bona Davide
- Bond-Smith Giles
- Bonilla Cal Fernando
- Bono Dario
- Bottari Andrea
- Bozkurt Mehmet A
- Bracale Umberto
- Brachet-Contul Riccardo
- Brachini Gioia
- Bradley Alison
- Butturini Giovanni
- Buwaitel Mohammad MK
- Cabrera Zamiara SL
- Calderan Thiago RA
- Calik Bulent
- CaliÌ Matteo
- Calleja-Lozano Rafael
- Calu Valentin
- Calvo GarciÌa HaydeÌe
- Campanella Gaetano
- Cannavera Alessandro
- Cantafio Stefano
- Caravaca Iban
- Caronna Roberto
- Casadei Massimiliano
- Catena Fausto
- Ceresoli Marco
- Cerioli Alessandra
- Cervellera Maurizio
- Chan Shannon M
- Charalabopoulos Alexandros
- Che Ani Mohd F
- Chiara Osvaldo
- Chiarugi Massimo
- Chidumije Nnaemeka
- Chirletti Piero
- Chiuyari JoseÌ R
- Chooklin Serge
- Choudhary Hasham
- Chouillard Elie
- Chouliaras Christos
- Chuklin Serhii
- Ciabatti Giulia
- Cianci Pasquale
- Cicako Atea
- Cicuttin Enrico
- Cillara Nicola
- Cioffi Stefano PB
- Clarizia Guglielmo
- Coccolini Federico
- Colak Elif
- Condoy Jefferson N
- Conti Lorenzo
- Coretti Guido
- Correia de SaÌ Tiago
- Cossa Alessandra
- Costea Radu V
- Cozzani Federico
- Cremonini Camilla
- Crespi Michele
- Cristaudi Alessandra
- CurroÌ Giuseppe
- D'Acapito Fabrizio
- D'Ambrosio Giancarlo
- Dakis Konstantinos
- Damaskos Dimitrios
- Danna Riccardo
- Dardanov Dragomir
- Das Koray
- Davies Brooke
- de Araujo Jorann
- De Francisco Mario
- De Manzini NicoloÌ
- De Nicola Enrico
- de SantibanÌes Martin
- De Simone Belinda
- Delis Spiros
- Delogu Daniele
- Demetrashvili Zaza
- Deserra Antonello
- Devi Jalpa
- Di Bella Annamaria
- Di Candio Giulio
- Di Carlo Isidoro
- Di Donato Luca
- Di Lascio Pierpaolo
- Di Martino Marcello
- Di Menno Stavron Juliana
- Di Nuzzo Maria M
- Di Saverio Salomone
- Dinuzzi Vincenza P
- Domingo-Gonzalez Marta
- DomiÌnguez Fabiana
- Doria Emanuele
- Doulias Triantafyllos
- Draghici Andreea D
- Drigo Davide
- DuraÌn MeleÌndez Blas
- DuraÌn Manuel
- Duval Jean-Luc
- Ebied Husam
- Elbadawy Merihan
- Elbahnasawy Mohamed
- Elfallal Ahmed
- Elfeki Hossam
- Elghadban Hosam
- Elserafy Amr
- Emile Sameh
- Ercolani Giorgio
- Estevez Sergio
- Estraviz-Mateos BegonÌa
- Fabbri NicoloÌ
- Farazi-Chongouki Christos
- Farguell Jordi
- Farid Ahmed
- Fathil Ida NA
- Favi Francesco
- Feo Carlo V
- Ferrara Francesco
- Ferrari Luca
- Ferrario Luca
- First Necattin
- Fleres Francesco
- Fontana Tommaso
- Fortuna Laura
- Fox Katherine
- Fraga Gustavo P
- Fransvea Pietro
- Fratini Geri
- Frontali Alice
- Gaber Mohannad
- Gachabayov Mahir
- Galleano Raffaele
- Garcia-Meza Alejandro
- GarciÌa del Alamo Yaiza
- GarciÌa-Moreno-Nisa Francisca
- Garino Mauro
- Garzali Ibrahim U
- Gendrikson George
- Genovese Valerio
- Gerardi Chiara
- Germani Paola
- Gerogiannis Ioannis
- Gessa Emanuela
- Ghazouani Omar
- Ghozy Sherief
- Gianazza Simone
- Giannarakis Miltiadis
- Gioco Rossella
- Giordano Alessio
- Giraudo Giorgio
- Giuffrida Mario
- Giuliani Antonio
- Gomes Carlos A
- Gomes Felipe C
- GonzaÌlez-AboÌs Carolina
- Gourgiotis Stavros
- Grande Michele
- Grigorean Valentin T
- Grimaldi Sergio
- Guadagni Simone
- Guerci Claudio
- Guida Anna
- Gumbs Andrew
- Gundara Justin
- Gupta Amit
- Hamdan Alaa
- Hamed Emad F
- Hamid Hytham KS
- Hanafy Asmaa
- Hasan Layla
- Herrera Cabrera Vicente
- Hirano Elcio S
- Hudson Victoria
- Huei Jih
- Ielpo Benedetto
- Ilzarbe Lucas
- Inama Marco
- Ioannidis Argyrios
- Ioannidis Orestis
- Ioia Giovanna
- Ippoliti Massimo
- Isik Arda
- Jayant Kumar
- Jovine Elio
- Julianov Alexander
- Kadir Bushra
- Kalaitzakis Evangelos
- Kaldarov Ayrat
- Kamar Jubin
- Kapiris Stylianos
- Kara Yasin
- Karamarkovic Milovan
- Kaur Mandeep
- Kchaou Ali
- Kefili Despoina
- Khalil Usama A
- Khamees Almu'atasim
- Khan Mansoor
- Khutsishvili Kakhi
- Kluger Yoram
- Kocataş Ali
- Kokoropoulos Panagiotis
- Komaei Iman
- Konstantinidis Konstantinis
- Konstantinidou Sofia
- Kotecha Pinky
- Kovacevic Bojan
- Kovachev Nikola
- Kozadinos Alexandros
- Kunitsyna Maria
- Kurtenkov Mikhail
- Kwiatkowski Andrzej
- Kykalos Stylianos
- Lacavalla Domenico
- Lagouvardou Elpiniki
- Lal Pawan
- Lancellotti Francesco
- Landaluce-Olavarria Aitor
- Lapolla Pierfrancesco
- Lasithiotakis Konstantinos
- Leo Cosimo A
- Lepiane Pasquale
- Leppaniemi Ari
- Lesko Dusan
- Lezama Tamara
- Liakakos Theodore
- LianÌo Julian E
- Licitra Edelweiss
- Liritano Elena
- Litvin Andrey
- Locci Eleonora
- Lok Hon-Ting
- Lombardo Francesca
- Lostoridis Eftychios
- Loutzidou Lydia
- Lozada HernaÌndez Edgard E
- Lui Rashid
- Lunghi Elia G
- Luppi Davide
- Mabilia Andrea
- Machain Gustavo M
- Machairas Nikolaos
- Magee Conor
- Magnoli Matteo
- Manak Jan
- Manatakis Dimitrios
- Manca Roberto
- Manoochehri Farshad
- Marafante Chiara
- Marchese Tiziana RL
- Mariani NicoloÌ M
- Marino Marco V
- Maroulis Ioannis
- Marra Ester
- Martellucci Jacopo
- Martines Gennaro
- MartiÌn BeleÌn
- MasiaÌ Palacios Andrea
- Mastrangelo Laura
- Mastronardi Manuela
- Mathur Pawan
- MatiÌas-GarciÌa BeleÌn
- MawlichanoÌw Maciej
- Maya Aparicio Antonio C
- Mazza Oscar
- McCormack Kieran
- Medappil Noushif
- Meead Abdullah
- Mendoza-Moreno Fernando
- Meric Serhat
- Metaxas Panagiotis
- Michalopoulos Nikolaos
- Miglietta Claudio
- Milentijevic Milica
- Millo Paolo
- Mingoli Andrea
- Moggia Elisabetta
- Mohamad Ikhwan S
- Mohamed Salem
- Mole Damian
- Molina ViÌctor
- Monti Marco
- Morelli Luca
- Moretto Gianluigi
- Morino Mario
- Morrison Tamsin
- Mouzakis Odysseas
- Mucilli Felice
- Muhammad Ali Syed
- Mulita Francesk
- MunÌoz-Cruzado Virginia D
- Muratore Andrea
- Murgese Alessandra
- Murgia Raimondo
- Muros Bayo Jose
- Murzi Valentina
- Murzi Valentina
- Muthukrishnan Vijayanand
- Muttillo Edoardo M
- Muttillo Irnerio A
- Nafea Ahmed
- Naffa' Mo'taz FN
- Nagliati Carlo
- Nagorni Eleni A
- Navarra Giuseppe
- NicolaÌs-LoÌpez Tatiana
- Nicotera Antonella
- Nigri Giuseppe
- Noel Colin
- null null
- Occhionorelli Savino
- Olivares Pizarro Sergio
- Olmi Stefano
- Omarov Nail
- Oms Luis
- Oppici Dario
- Orantia-Carlos Abigail CC
- Ordemar Jorge
- Ortenzi Monica
- Ozer Nazmi
- Pacella Daniela
- Pachajoa Diana AP
- Palepa Anna
- Palmieri Francesco
- Palmisano Silvia
- Panyko ArpaÌd
- Papa Gennaro
- Papa Mario V
- Papadoliopoulou Maria
- Papadopoulos Aristeidis
- Papagni Vincenzo
- Pareja CiuroÌ Felipe
- Pata Francesco
- Paul Michaela
- Pellino Gianluca
- Peltrini Roberto
- Penalba-PalmiÌ Rafael
- Perea del Pozo Eduardo
- Perez de Villar JoseÌ M
- Perotti Bruno
- Perra Elena S
- Perrone Gennaro
- Perrone Stefano
- Pesce Antonio
- Petra Giorgia
- Petracca Gabriele L
- Petrakis George
- PeÌrez-Bru Susana
- Picardi Biagio
- Picariello Erika
- Picchetto Andrea
- Picciariello Arcangelo
- Pignata Giusto
- Pilia Tiziana
- Pimentel Samuel
- Pinto Margherita
- Piras Enrico
- Pisanu Adolfo
- Podda Mauro
- Poillucci Gaetano
- Police AndreÌa
- Pont FeijoÌo Eva
- Ponte Elisa
- Porfidia Raffaele
- Portale Giuseppe
- Prasanti Alekhya K
- Prieto Calvo Mikel
- Prioriello Concetta
- Puccioni Caterina
- Quispe-Cruz Darwin A
- Quitoy Margie A
- Radonak Jozef
- Radulescu Raluca B
- Ralon Sergio
- RamiÌrez Pablo
- Rampini Alessia
- Riboni Cristiana
- Ricci Claudio
- Rizzi Andrea
- Robayo Diana
- Roccamatisi Linda
- Rocha MoÌnica
- RodriÌguez Martha
- Roesel Raffaello
- Rojas-Bonet Noel
- Rossi Stefano
- Rossini Matteo
- Rottoli Matteo
- Rubicondo Carolina
- Russo Iris S
- Saad Ahmed
- Sadik Mohammad
- Sahani Saaz
- SalahâAbbas Alzhraa
- Salcedo Diego
- Salomone Sara
- Salvetti Francesco
- Samhouri Ahmad
- Sammartano Fabrizio
- Sandhar Pardip
- Santini Andrea
- Saroglu Azize
- Sarro Giuliano
- Sartarelli Lodovico
- Sartelli Massimo
- Sasia Diego
- Saullo Paolina
- Savino Grazia
- Sawalha Hatem
- SaÌnchez Lianet
- SaÌnchez-CabuÌs Santiago
- SaÌnchez-GuilleÌn Luis
- Scaravilli Luca
- Schizas Dimitrios
- Scifo Giovanna
- Sederino Mariagrazia
- Seerani Nandlal
- Segalini Edoardo
- Segovia Lohse Helmut
- Segovia Lohse Herald
- Seker Ahmet
- Sensi Bruno
- Sepulveda-Rodriguez Rafael
- Sergi William
- Serventi Alberto
- Seth Shatadru
- Sethi Ananya
- Sganga Gabriele
- Sheikh Zara
- Sheth Hemant
- Shetiwy Mohamed
- Shoma Ashraf
- Sica Giuseppe
- Siragusa Leandro
- Soares Carlos
- Soggiu Fiammetta
- Sohail- Asghar Mohammad
- Solaini Leonardo
- Soltes Marek
- Sotiropoulou Maria
- Spolini Alessandro
- Stamopoulos Paraskevas
- Stella Marco
- Stoian Alexandru R
- SuaÌrez Vega Pilar
- Syllaios Athanasios
- Synekidou Eirini
- Tartaglia Dario
- Tasis Nikolaos
- Tebala Giovanni
- Tefay Joan
- Tejedor-Tejada Javier
- Theodorou Dimitrios
- Tlili Ahmed
- Tomasi Ivan
- Tonello Alice S
- Tonini Valeria
- Tourountzi Paraskevi
- Triantafyllou Tania
- Trigiante Giuseppe
- Triguero-CaÌnovas Daniel
- TrivinÌo Maria A
- Troian Marina
- Troiano Raffaele
- Tsouknidas Ioannis
- Tsurbanova Arina
- Tur-MartiÌnez Jaume
- TuÌrkogÌlu Mehmet A
- Tvaladze Anano
- Uccelli Matteo
- Ullah Syed OZ
- Uymaz Derya S
- Uzunoglu Mustafa Y
- Vaccari Samuele
- Vailas Michail
- Valenzuela JoseÌ I
- Veroux Gastone
- Veroux Massimiliano
- ViganoÌ Jacopo
- Villalabeitia Ibabe
- Vincenti Leonardo
- Virdis Francesco
- Visconti Diego
- WaleÌšdziak Maciej
- Wilson Michael
- Ya'acob Mohammad Z
- Yamamoto Seto Gaby S
- Yusoff Ahmad R
- Zafar Noman
- Zago Marcello
- Zakaria Andee D
- Zarnescu Eugenia C
- Zarnescu Narcis O
- Zuin Matteo
- Publication venue
- AMER MEDICAL ASSOC
- Publication date
- 01/01/2023
- Field of study
IMPORTANCE Considering the lack of equipoise regarding the timing of cholecystectomy in patients with moderately severe and severe acute biliary pancreatitis (ABP), it is critical to assess this issue.OBJECTIVE To assess the outcomes of early cholecystectomy (EC) in patients with moderately severe and severe ABP.DESIGN, SETTINGS, AND PARTICIPANTS This cohort study retrospectively analyzed real-life data from the MANCTRA-1 (Compliance With Evidence-Based Clinical Guidelines in the Management of Acute Biliary Pancreatitis) data set, assessing 5304 consecutive patients hospitalized between January 1, 2019, and December 31, 2020, for ABP from 42 countries. A total of 3696 patients who were hospitalized for ABP and underwent cholecystectomy were included in the analysis; of these, 1202 underwent EC, defined as a cholecystectomy performed within 14 days of admission. Univariable and multivariable logistic regression models were used to identify prognostic factors of mortality and morbidity. Data analysis was performed from January to February 2023.MAIN OUTCOMES Mortality and morbidity after EC.RESULTS Of the 3696 patients (mean [SD] age, 58.5 [17.8] years; 1907 [51.5%] female) included in the analysis, 1202 (32.5%) underwent EC and 2494 (67.5%) underwent delayed cholecystectomy (DC). Overall, EC presented an increased risk of postoperative mortality (1.4% vs 0.1%, P <.001) and morbidity (7.7% vs 3.7%, P < .001) compared with DC. On the multivariable analysis, moderately severe and severe ABP were associated with increased mortality (odds ratio [OR], 361.46; 95% CI, 2.28-57 212.31; P = .02) and morbidity (OR, 2.64; 95% CI, 1.35-5.19; P = .005). In patients with moderately severe and severe ABP (n = 108), EC was associated with an increased risk of mortality (16 [15.6%] vs 0 [0%], P < .001), morbidity (30 [30.3%] vs 57 [5.5%], P < .001), bile leakage (2 [2.4%] vs 4 [0.4%], P = .02), and infections (12 [14.6%] vs 4 [0.4%], P < .001) compared with patients with mild ABP who underwent EC. In patients with moderately severe and severe ABP (n = 108), EC was associated with higher mortality (16 [15.6%] vs 2 [1.2%], P < .001), morbidity (30 [30.3%] vs 17 [10.3%], P < .001), and infections (12 [14.6%] vs 2 [1.3%], P < .001) compared with patients with moderately severe and severe ABP who underwent DC. On the multivariable analysis, the patient's age (OR, 1.12; 95% CI, 1.02-1.36; P = .03) and American Society of Anesthesiologists score (OR, 5.91; 95% CI, 1.06-32.78; P = .04) were associated with mortality; severe complications of ABP were associated with increased mortality (OR, 50.04; 95% CI, 2.37-1058.01; P = .01) and morbidity (OR, 33.64; 95% CI, 3.19-354.73; P = .003).CONCLUSIONS AND RELEVANCE This cohort study's findings suggest that EC should be considered carefully in patients with moderately severe and severe ABP, as it was associated with increased postoperative mortality and morbidity. However, older and more fragile patients manifesting severe complications related to ABP should most likely not be considered for EC
Stoma-free survival after anastomotic leak following rectal cancer resection: worldwide cohort of 2470 patients
- Author
- Aalbers Arend G.J.
- Abbas Ayman
- Abbood Ali Hashim
- Abdeen Basel
- Abdelaal Ahmed Samir
- Abdullah Nik A.N.
- Abdulwahed Eman
- Abelevich Alexander
- Abujamra Saleh
- Acar Nihan CoĆgun
- Afzal Asma
- Agalianos Christos
- Agapov Mikhail N.
- Agostinelli Laura
- Ahmed Nagm Eldin Abu Elnga
- Ahmed Safia
- Aigner Felix
- Akyol Cihangir
- Al-Eryani Fatima
- Al-Juaifari Maytham A.
- Al-Najami Issam
- Alanez-Saavedra Javier
- Albakry Rudaina
- Alhardan Anas
- Alhisi Ahmed Jehad
- Ali Ahmed K.
- Alkady Eithar
- Allmer Caterina
- Alonso Alfredo
- Alrayes Bourhan M.H.
- Alshareea Entisar
- Altomare Donato F.
- Altrabulsi Amani
- Alvarez-Bautista Francisco E.
- Amano Takahiro
- Amelung Femke J.
- Anderin Kajsa
- Annicchiarico Alfredo
- Ansorena Yolanda Saralegui
- Antona Francisco Blanco
- Antonopoulou Maria-Ioanna
- Aprile Alessandra
- Aranda MarĂa J. Pizarro
- Aretxabala Izaskun del Hoyo
- Armao Francesca T.
- Arroyo Antonio
- Ashmore Daniel
- Ashoush Fouad M. Bassyouni
- Atak Ä°brahim
- Atanasov Boyko
- Atici Semra Demirli
- Atienza Paula GonzĂĄlez
- Avanagh Dara O.
- Avellaneda Nicolas
- Aversano Alessia
- Aybar Ahmet B. CiftciEngin
- Aydin Oguzhan
- Ayoub Kusay
- Azevedo Constanca
- Baatrup Gunnar
- Baban Bayar
- Badiani Sarit
- Bahadoer Renu R.
- Baili Efstratia
- Balalis Dimitrios
- Balci Bengi
- Balik Emre
- Ballabio Michele
- Baloyiannis Ioannis
- Barbero-Valenzuela Alejandro
- Bavikatte Akshay
- Bazaev Andrey
- Belev Nikolay
- Bellato Vittoria
- BeltrĂĄn de Heredia Juan P.
- Belvedere Angela
- Benkabbou Amine
- BenÄurik Vladimir
- Bernal-Sprekelsen Juan C.
- Berney Christophe
- Bethune Rob M.
- Bhandari Santosh
- Bhat Sameer
- Binder Alf-Dorian
- Biondi Alberto
- Bisagni Pietro
- Bislenghi Gabriele
- Bissett Ian
- BiĆgin Tayfun
- Bjorsum-Meyer Thomas
- Blas Juan L.
- Bloemen Johanne G.
- Boerma Evert-Jan G.
- Bonito Alba Correa
- Borda Francisco Javier GarcĂa
- Borda-Arrizabalaga Nerea
- Bottazzoli Elisa I.
- Boutall Adam
- Bouvy Nicole D.
- BoĆŸiÄ Tajda KoĆĄir
- Brachini Gioia
- Bradley Nicholas
- Bremers Andreas J.A.
- Buchs Nicolas
- Buchwald Pamela
- Bulut Mehmet Turker
- Burger Jacobus W.A.
- Burghgraef Thijs A.
- Busund Sondre
- Buzzi Gianluca
- BuÄra Dursun
- Calabro Marcello
- Calero-Lillo ArĂĄnzazu
- Calik Bulent
- Carbone Fabio
- Carreño-Villarreal Guillermo
- Carrie Augusto
- Carvello Michele
- Carvello Michele
- Catena Fausto
- Cengiz Fevzi
- Cerbo Daniele
- Ceretti Andrea P.
- Chandio Ashfaq
- Chaoui Ahmed
- Charalabopoulos Alexandros
- Chaudhri Sanjay
- Chautems Roland
- Chawla Tabish
- Chawla Tabish
- Cholewa Hannia
- Christodoulidis Grigorios
- Chrysos Emmanuel
- Cifuentes-Ródenas José A.
- Cirillo Bruno
- Ciubotaru Cezar
- Ciubotaru Cezar
- Clerici Federico
- Coco Claudio
- Coetzee Emile
- Colak Elif
- Collard Maxime K.
- Colucci Nicola
- ColĂĄs-Ruiz Enrique
- Connelly Tara M.
- Consten Esther C.J.
- Consten Esther C.J.
- Corbellini Carlo
- Cotte Eddy
- Creemers Davy M.J.
- Crescentini Giacomo
- D'Agostino Luca
- D'Alimonte Lucrezia
- D'Hoore André
- da Costa Devesa Helena M.
- da Silva Nigel
- Daester Silvio
- Darias IvĂĄn Soto
- Darlin Lotten
- Darwich Haitham
- Dattani Mit
- de Andrés Beatriz
- de Gheldere Charles
- de Graaf Eelco J.R.
- de Groot-Van Veen Irene
- de Haan Jael
- de La Cruz Cuadrado Cristina
- de Lacy F. Borja
- de Manzoni Giovanni
- de Nes Lindsey C.F.
- de Paola Gilda
- de Pasqual Carlo A.
- de Simone Belinda D.
- de Vriendt Stefanie
- de Wilt Johannes H.W.
- de Ăngelis Nicola
- Deeknah Abdulqudus
- Defoort Barbara
- deGiuli Maurizio
- Dekker Jan-Willem T.
- Delrio Paolo
- Demirkiran Ahmet
- den Boer Frank
- Denost Quentin
- Dewulf Maxime
- di Cosmo Maria A.
- Di Saverio Salomone
- Dimofte Gabriel-Mihail
- Dinaux Anne M.
- Dittrich Luca S.
- Diéguez Beatriz
- Docampo Iria Losada
- Dogan Lutfi
- Doornebosch Pascal G.
- Drozdov Evgeniy S.
- Dudi-Venkata Nagendra N.
- Dursun Ayberk
- Duzgun Ozgul
- Dziakova Jana
- DĂez-Alonso Manuel
- Echaniz Garazi Elorza
- Echiguer Sabrillah
- Eduard Galliamov
- Egea Jorge GarcĂa
- el Muhtaseb Mohammad S.
- El-Massoudi Youssef
- Elhadi Muhammed
- Elshennawy Eslam M.
- Enriquez-Navascués José M.
- Erdinc Kemal
- Eriksen Jacob D.
- Ersryd Amanda L.
- EscartĂn Jorge
- EspĂn-Basany Eloy
- Estaire-GĂłmez Mercedes
- Estefania Diego
- Ewedah Moataz
- Fabbri Nicolo
- Fares Hala
- Farguell Jordi
- Faria Luis Queiroz
- Farnesi Francesca
- Fazzin Marta
- Feo Carlo V.
- Ferenschild Floris T.
- FernĂĄndez C.L.
- FernĂĄndez-Hevia MarĂa
- FernĂĄndez-Hurtado Ignacio
- FernĂĄndez-MartĂnez Daniel
- Ferreira Catia
- Ferreira Rita Marques
- Ferrer RocĂo
- Filimonov Victor B.
- Filipov Emil
- Fioravanti Emanuela
- Flamey Nicolas
- Florea Sabrina
- Folkesson Joakim
- Foppa Caterina
- Foppa Caterina
- Forgan Tim
- Fowler George E.
- Frasson Matteo
- Frivold Tone
- Frontali Alice
- Fujiwara Hajime
- Futaba Kaori
- Gaard Maria
- Gadan Soran
- Galleano Raffaele
- Gallo Gaetano
- GarcĂa-FlĂłrez Luis J.
- Gareb Fahed
- Garmanova Tatiana
- Garulli Gianluca
- Gecim Ibrahim E.
- Geitenbeek Ritch
- George Sarah
- Ghazouani Omar
- Ghignone Federico
- Ghmagh Reem
- Gialamas Eleftherios
- Gielis Manuel
- Giuffrida Mario
- Gobut Huseyin
- Golshani Parisa
- Gonzalez Ricardo
- GonzĂĄlvez Paula
- Goutard Claire-Angéline
- Grass Julia-Kristin
- Graure Giorgiana M.
- Gregussen Hilde
- Greijdanus Nynke G.
- Gribnev Petar
- Grosek Jan
- Grossi Ugo
- Grotenhuis Brechtje A.
- Gruter Alexander A.J.
- Guel-Klein Safak
- Guenin Marc-Olivier
- Gunenc ErĆan
- Gurjar Shashank
- Gurtler Thomas
- Guzel Melek
- GĂłmez Tania
- GĂłmez-Abril Segundo Ă.
- GĂłmez-Jurado MarĂa J.
- Haberal Elifcan
- Haddad Anis
- Hajjaj Baraa Nabil
- Hamdan Alaa
- Hamid Hytham K.S.
- Hammoodi Hayder
- Hani Mohammad Bani
- Hannink Gerjon
- Hasan Bassam
- Hassan Naya
- Hassan Soha Y.
- Havenga Klaas
- Hazen Sanne J.A.
- Heemskerk Jeroen
- Heesink Vera
- Heidsma Charlotte M.
- Heijnen Bob H.M.
- Herman Ayesiga
- HernĂĄndez Miguel
- Herrero Eduardo Ferrero
- Hess Gabriel F.
- Ho Man-Fung
- Ho Yiu M.
- Hoff Christiaan
- Hol Jeroen C.
- Hollington Paul
- Holman Fabian A.
- Hompes Roel
- Hoogteijling Tijs J.
- Huguet José M. Muguerza
- Hulshof Lorenzo G.W.L.
- Hussein Mohamed
- Iacomino Alessandro
- Ibrahim Aini F.
- Ismail Razif
- Ivanov Tsvetomir
- Iversen Lene H.
- Jadid Kaveh Dehlaghi
- Jakubauskas Matas
- Jakubauskiene Lina
- Jangmalm Staffan
- Janssen Paul T.J.
- Jarimba Aldo M. Rodrigues
- Jou-Valencia Daniela
- Julaihi Rokayah
- Jutesten Henrik
- Kacem Montasser
- Kader Rawaz
- Kamer Erdinc
- Kapadia Raj
- Kara Yasin
- Karamanliev Martin
- Karavokyros Ioannis
- Karmi Fahed
- Karsten Tom
- Karydakis Lysandros
- Kaya Tayfun
- Kelly Michael E.
- Keskin Metin
- Ketelaers Stijn H.J.
- Khader Ahmed A.E.
- Khedr Gehan Abd Elatti
- Koc Mehmet A.
- Koemans Willem J.
- Konishi Tsuyoshi
- Korkolis Dimitrios
- Kostromitskiy Dmitriy N.
- Kozan Ramazan
- KoĆĄir Jurij A.
- Kraft Miquel
- Krastev Panche
- Krohn Nina
- Kroon Hidde M.
- Kryzauskas Marius
- Kulle Cemil B.
- Kulle Cemil B.
- Kusters Miranda
- Kynaston James
- La Terra Antonio
- Lacy Antonio M.
- Lambrechts Anton
- Lamme Bas
- Lamparelli Michael
- Lantone Giuliano
- Lapolla Pierfrancesco
- Lara Juan E. SĂĄnchez
- Larcinese Antonella
- Larkin John O.
- Larkin John O.
- Larsson Per-Anders
- Latkauskas Tadas
- Lauka Lelde
- Leeuwenburgh Marjolein M.
- Lefevre Jérémie H.
- Leijtens Jeroen W.A.
- Leung Edmund
- LeventoÄlu Sezai
- Lindqvist Ebba
- Liu Jianliang
- Longhi Marco
- Lopez Jose M. Gil
- Lorenzon Laura
- Lorusso Leonardo
- Losada Manuel
- Lucchi Andrea
- LuncÄ Sorinel
- Lutfi Hamid
- Lydrup Marie-Louise
- LĂłpez-Lara Manuel
- LĂłpez-RodrĂguez-Arias Francisco
- Macau Florin
- Machackova Maria
- Maghrebi Houcine
- Majbar Mohammed A.
- Mak Tony Wing-Chung
- Manatakis Dimitrios
- Mansour Ali
- Manzo Carlo A.
- Marchegiani Francesco
- Marcos Elena Bermejo
- Mariani NicolĂČ M.
- Marinelli Andreas
- Markaryan Daniil G.
- Maroli Annalisa
- Marques Sonia M. Ribeiro
- Martinek Lubomir
- Martins Sonia Fortuna
- MartĂnez MarĂa Labalde
- MartĂnez-Pinedo Carlos
- Maslyankov Svilen
- Massey Lisa
- Matthiessen Peter
- Mattioni Laura A.
- MatĂas-GarcĂa BelĂ©n
- McCormick Paul H.
- McCullough Peter
- Mehigan Brian J.
- Melling Nathaniel
- Melnikov Andrey A.
- Mendes Ana Filipa Dias
- Mendoza-Moreno Fernando
- Meroni Paola
- Mia Imraan
- Mikalauskas Saulius
- Mingoli Andrea
- Mishra Amitabh
- Mitteregger Martin
- Miu Victor
- Moctezuma-VelĂĄzquez Paulina
- Mohamed Abudi
- Mohsine Raouf
- Monib Fatma A.
- Monson John
- Montero José A. Alcåzar
- Montroni Isacco
- Morales Bernaldo de QuirĂłs Javier T.
- Morgan Matthew
- Msherghi Ahmed A.
- Mueller Simone
- Mugla Naser
- Mukherjee Tanmoy
- Muratore Andrea
- Muriel Jorge Sancho
- Musters Gijsbert D.
- Muñoz-Collado Salvador
- MuĆinÄ Ana-Maria
- MĂnguez-Ruiz GermĂĄn
- Nair Gavin
- Navarro-SĂĄnchez Antonio
- Neary Peter
- Negoi Ionut
- Negoita Valentina M.
- Nespoli Luca
- Ng Simon Siuman
- Niazi Ammar
- Nichita Vladimir-Ion
- Niemer Quirine
- Nieto-Moreno Elena
- Nilsson Karl
- Nonner Joost
- Novello Simone
- Nygren Jonas
- O'Grady Greg
- Obihara Ndidi J.
- Oldani Massimo
- Oliveira Antonio
- Oosterling Steven J.
- Opocher Enrico
- Osborne Laura
- Ozata Ä°brahim H.
- Ozgur Ä°lker
- Ozkan Omer Faruk
- Pachajoa Diana A. Pantoja
- Palini Gian M.
- Panel Nathalie
- Panis Yves
- Parc Yann
- Parise Cristiano
- Park Jennifer M.
- Parodi Matias
- Pasini Francesco
- Pasini Franceso
- Passuello Nicola
- Pattyn Paul
- Pavlov Vasil
- Peeters Koen C.M.J.
- Pellino Gianluca
- Pennings Alexander J.
- Pereira Ricardo
- Perez Daniel
- Perez Rodrigo O.
- Perivoliotis Konstantinos
- Perrone Gennaro
- Persiani Roberto
- Pesce Antonio
- Petropolou Thalia
- Pezzuto Roberto
- Picciariello Arcangelo
- Picone Emanuele
- Pikuniene Ingrida
- Pinto Francisca Lima
- Pire-Abaitua Gerardo
- Pirozzolo Giovanni
- PiyadeoÄlu Deniz
- Plastiras Aris
- Pletinckx Pieter
- Polat Fatih
- Polle Sebastiaan W.
- Polydorou Adreas
- Porta Andrea
- Poskus Tomas
- Pratschke Johann
- Pringle Heather C.M.
- Puca Lucia
- Pucciarelli Salvatore
- Qandeel Mahmoud W.M.
- Quintana Rita E. Medina
- Quiroga Ignacio Bodega
- Quiroga-ValcĂĄrcel Ana
- Rabadi Alexander
- Ramboiu Stefan Patrascu Sandu D.
- Ramsay George
- Rani Pallavi
- Rani Pallavi
- Rauf Hareem
- Rauf Hareem
- Recordare Alfonso
- Reddavid Rossella
- Rega Daniela
- Reudink Muriël
- Riedl Peter
- Riis Rolf
- Ripoli Maria Cristina
- Ris Frederic
- Rizzo Gianluca
- RoatÄ Cristian-Ene
- Rodimov Sergey V.
- RodrĂguez Carlos SĂĄez-Cazallas
- RodrĂguez-Infante Antonio
- Romano Angela
- Rompou Aliki
- Roos Daphne
- Roscio Francesco
- Rosman Camiel
- Rotholtz Nicolas
- Rottoli Matteo
- Ruiz Hernan
- Runau Francois
- RutegÄrd Martin
- Rutten Harm J.T.
- RuĂz-GarcĂa Pablo
- Ryan Jessica
- Rydbeck Daniel
- Saad Ahmad
- Sacchi Matteo M.
- Sacchi Matteo M.
- Sainz-HernĂĄndez Juan C.
- Salgado-Nesme Noel
- Salomon Mario
- Sambucci Daniele
- Sammarco Giuseppe
- Sammour Tarik
- Sampietro Gianluca M.
- Samsa Mehmet Veysi
- Santacruz Carlos CerdĂĄn
- Santillan Mateo
- Santoro Giulio A.
- Sari Ahmet Can
- Sarmah Panchali
- Sarveswaran Janahan
- Sauvain Marc-Olivier
- Scabini Stefano
- Scheurink Lieke
- Schizas Dimitrios
- Schultz Johannes K.
- Sebai Amine
- Sebastian Boby
- Segelman Josefin
- Seitinger Gerald
- Semiao Miguel
- Septiem Javier GarcĂa
- Serralta Daniel
- Shaban Mohamed
- Shaikh Shafaque
- Shapiro Joël
- Siaw Oliver
- Sibiç Osman
- Sica Giuseppe
- Sietses Colin
- Singh Baljit
- Singh Nirbhaibir
- Singh-Ranger Deepak
- Sinibaldi Giovanni
- Siragusa Leandro
- Sivrikoz Emre
- Sjo Ole H.
- Sjostrom Olle
- Skrovina Matej
- Sköldberg Filip
- Slavchev Mihail
- Slooter Gerrit D.
- Smeeing Diederik P.J.
- Sokmen Selman
- Sokolov Manol
- Soler-Silva Ălvaro
- Solomon Michael
- Soriero Domenico
- Souadka Amine
- Spinelli Antonino
- Spinelli Antonino
- Spolverato Gaya
- Staffan Maria
- Stefanescu Victor
- Steller Ernst J.
- Stienstra Roxane M.
- Stoica Bogdan
- Stoica Bogdan
- Suchkov Igor A.
- Sultan Hytham
- Surlin Valeriu M.
- SuĂĄrez Marta Castro
- SuĂĄrez-SĂĄnchez Aida
- Syllaios Athanasios
- SĂĄnchez Teresa Rubio
- Sånchez-Guillén Luis
- Tababa Osama W.E.
- Taha-Mehlitz Stephanie
- Talboom Kevin
- Talsma Aaldert K.
- Tamelis Algimantas
- Tamini NicolĂČ
- Tanase Ioan
- Tanis Pieter J.
- Tantoura Mohammad
- Tanzanu Marta
- Tasende-Presedo Marta M.
- Tasis Nikolaos
- Taverne Sophie B.M.
- Tejedor Patricia
- Teras Juri
- Teras Roland M.
- Tiefenthal Marit
- Tomasicchio Giovanni
- TomaĆŸiÄ AleĆĄ
- Tonchev Pencho
- Toorenvliet Boudewijn R.
- Torres MarĂa T.
- Toso Christian
- Tsimogiannis Konstantinos
- Tuynmann Jurriaan B.
- Tzovaras George
- Ubels Sander
- Ugolini Giampaolo
- Ulgur Hanife Ćeyda
- Uluk Deniz
- Vailas Michail
- Vailati Bruna B.
- van Dalsen Annette D.
- van den Broek Nathalie E.J.
- van den Hengel Berber
- van der Burg Sjirk
- van der Zijden CharlĂšne J.
- van Gerven Pieter
- van Kessel Charlotte S.
- van Praagh Jasper B.
- van Schaik Ted G.
- van Westreenen Hendrik L.
- van Workum Frans
- Vanclooster Patrick
- Vansteenbrugge Louis
- Vasile Mihai
- Venianaki Maria
- Verdaasdonk Emiel G.G.
- Vergara-FernĂĄndez Omar
- Vermaas Maarten
- Verstappen Sonja
- Vignotto Chiara
- Villar Ăscar GarcĂa
- Vittori Laura
- Vles Wouter J.
- von Flue Markus
- Voron Thibault
- Vosbeek Noortje
- Vuagniaux Aurelie
- VĂĄzquez Andrea
- Waqar Usama
- Waqar Usama
- Ward Nicholas
- Warden Claire
- Westerterp Marinke
- Wienholts Kiedo
- Wiering Bastiaan
- Wijma Allard G.
- Wildeboer Aurelia C.L.
- Wolthuis Albert
- Wong Michael P.K.
- Woods Kayla
- Xenaki Sofia
- Xynos Evangelos
- Yalkin Omer
- Yanishev Alexey
- Yuksel Osman
- Zabala JesĂșs GĂłmez
- Zakaria Andee D.
- Zakaria Zaidi
- Zanini Nicola
- Zanus Giacomo
- Zazo Aya
- Zazo Rama
- Zucchella Martino
- ZukanoviÄ Goran
- Zwakman Marije
- Ăakir Murat
- ÄosiÄ Jurica
- Ć antak Goran
- Ć imleĆĄa Damir
- Ć lenfuktas Vygintas
- Ćœilinskas Justas
- Publication venue
- Publication date
- 01/12/2023
- Field of study
Background: The optimal treatment of anastomotic leak after rectal cancer resection is unclear. This worldwide cohort study aimed to provide an overview of four treatment strategies applied. Methods: Patients from 216 centres and 45 countries with anastomotic leak after rectal cancer resection between 2014 and 2018 were included. Treatment was categorized as salvage surgery, faecal diversion with passive or active (vacuum) drainage, and no primary/secondary faecal diversion. The primary outcome was 1-year stoma-free survival. In addition, passive and active drainage were compared using propensity score matching (2: 1). Results: Of 2470 evaluable patients, 388 (16.0 per cent) underwent salvage surgery, 1524 (62.0 per cent) passive drainage, 278 (11.0 per cent) active drainage, and 280 (11.0 per cent) had no faecal diversion. One-year stoma-free survival rates were 13.7, 48.3, 48.2, and 65.4 per cent respectively. Propensity score matching resulted in 556 patients with passive and 278 with active drainage. There was no statistically significant difference between these groups in 1-year stoma-free survival (OR 0.95, 95 per cent c.i. 0.66 to 1.33), with a risk difference of -1.1 (95 per cent c.i. -9.0 to 7.0) per cent. After active drainage, more patients required secondary salvage surgery (OR 2.32, 1.49 to 3.59), prolonged hospital admission (an additional 6 (95 per cent c.i. 2 to 10) days), and ICU admission (OR 1.41, 1.02 to 1.94). Mean duration of leak healing did not differ significantly (an additional 12 (-28 to 52) days). Conclusion: Primary salvage surgery or omission of faecal diversion likely correspond to the most severe and least severe leaks respectively. In patients with diverted leaks, stoma-free survival did not differ statistically between passive and active drainage, although the increased risk of secondary salvage surgery and ICU admission suggests residual confounding
Stoma-free Survival After Rectal Cancer Resection With Anastomotic Leakage: Development and Validation of a Prediction Model in a Large International Cohort.
- Author
- Abbas Ayman
- Abbood Ali Hashim
- Abdeen Basel
- Abdelaal Ahmed Samir
- Abdullah Nik A N
- Abdulwahed Eman
- Abelevich Alexander
- Abu Elnga Ahmed Nagm Eldin
- Abujamra Saleh
- Acar Nihan CoĆgun
- Afzal Asma
- Agalianos Christos
- Agapov Mikhail N
- Agostinelli Laura
- Ahmed Safia
- Aigner Felix
- Akyol Cihangir
- Al-Eryani Fatima
- Al-Juaifari Maytham A
- Al-Najami Issam
- Alanez-Saavedra Javier
- Albakry Rudaina
- Alcåzar Montero José A
- Alhardan Anas
- Alhisi Ahmed Jehad
- Ali Ahmed K
- Alkady Eithar
- Allmer Caterina
- Alonso Alfredo
- Alrayes Bourhan M H
- Alshareea Entisar
- Altomare Donato F
- Altrabulsi Amani
- Alvarez-Bautista Francisco E
- Amano Takahiro
- Amelung Femke J
- Anderin Kajsa
- Annicchiarico Alfredo
- Ansorena Yolanda Saralegui
- Antona Francisco Blanco
- Antonopoulou Maria-Ioanna
- Aprile Alessandra
- Armao Francesca T
- Arroyo Antonio
- Ashmore Daniel
- Atak Ä°brahim
- Atanasov Boyko
- Atici Semra Demirli
- Atienza Paula GonzĂĄlez
- Avanagh Dara O
- Avellaneda Nicolas
- Aversano Alessia
- Aydın Oguzhan
- Ayoub Kusay
- Azevedo Constança
- Baatrup Gunnar
- Baban Bayar
- Badiani Sarit
- Baili Efstratia
- Balalis Dimitrios
- Balci Bengi
- Balık Emre
- Ballabio Michele
- Baloyiannis Ioannis
- Barbero-Valenzuela Alejandro
- Bassyouni Ashoush Fouad M
- Bavikatte Akshay
- Bazaev Andrey
- Belev Nikolay
- Bellato Vittoria
- BeltrĂĄn de Heredia Juan P
- Belvedere Angela
- Benkabbou Amine
- BenÄurik Vladimir
- Bernal-Sprekelsen Juan C
- Berney Christophe
- Bethune Rob M
- Bhandari Santosh
- Bhat Sameer
- Binder Alf-Dorian
- Biondi Alberto
- Bisagni Pietro
- Bislenghi Gabriele
- Bissett Ian
- BiĆgin TAYFUN
- BjĂžrsum-Meyer Thomas
- Blas Juan L
- Bloemen Johanne G
- Boerma Evert-Jan G
- Bonito Alba Correa
- Borda Francisco Javier GarcĂa
- Borda-Arrizabalaga Nerea
- Bottazzoli Elisa I
- Boutall Adam
- Bouvy Nicole D
- BoĆŸiÄ Tajda KoĆĄir
- Brachini Gioia
- Bradley Nicholas
- Bremers Andreas J A
- Buchs Nicolas
- Buchwald Pamela
- Bulut Mehmet TĂŒrker
- Burger Jacobus W A
- Burghgraef Thijs A
- Busund Sondre
- Buzzi Gianluca
- BuÄra Dursun
- CalabrĂČ Marcello
- Calero-Lillo ArĂĄnzazu
- Calik Bulent
- Carbone Fabio
- Carreño-Villarreal Guillermo
- Carrie Augusto
- Carvello Michele
- Carvello Michele
- Catena Fausto
- Cengiz Fevzi
- Cerbo Daniele
- Ceretti Andrea P
- Chandio Ashfaq
- Chaoui Ahmed
- Charalabopoulos Alexandros
- Chaudhri Sanjay
- Chautems Roland
- Chawla Tabish
- Chawla Tabish
- Cholewa Hannia
- Christodoulidis Grigorios
- Chrysos Emmanuel
- CiftciEngin Aybar Ahmet B
- Cifuentes-Ródenas José A
- Cirillo Bruno
- Ciubotaru Cezar
- Ciubotaru Cezar
- Clerici Federico
- Coco Claudio
- Coetzee Emile
- Colak Elif
- Collard Maxime K
- Colucci Nicola
- ColĂĄs-Ruiz Enrique
- Connelly Tara M
- Consten Esther C J
- Consten Esther C J
- Corbellini Carlo
- Cotte Eddy
- Creemers Davy M J
- Crescentini Giacomo
- D'Agostino Luca
- D'Alimonte Lucrezia
- D'Hoore André
- da Costa Devesa Helena M
- da Silva Nigel
- Daester Silvio
- Darias IvĂĄn Soto
- Darlin Lotten
- Darwich Haitham
- Dattani Mit
- de Andrés Beatriz
- de Gheldere Charles
- de Graaf Eelco J R
- de Groot-van Veen Irene
- de Haan Jael
- de La Cruz Cuadrado Cristina
- de Lacy Francisco B
- de Manzoni Giovanni
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- de Paola Gilda
- de Pasqual Carlo A
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- de Vriendt Stefanie
- de Wilt Johannes H W
- Deeknah Abdulqudus
- Defoort Barbara
- deGiuli Maurizio
- Dekker Jan-Willem T
- Del Hoyo Aretxabala Izaskun
- Delrio Paolo
- Demirkiran Ahmet
- den Boer Frank
- Denost Quentin
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- di Cosmo Maria A
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- Dimofte Gabriel-Mihail
- Dinaux Anne M
- Dittrich Luca S
- Diéguez Beatriz
- Docampo Iria Losada
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- Doornebosch Pascal G
- Drozdov EvgeniyS
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- Dursun Ayberk
- Dziakova Jana
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- Echaniz Garazi Elorza
- Echiguer Sabrillah
- Eduard Galliamov
- Egea Jorge GarcĂa
- El Muhtaseb Mohammad S
- El-Massoudi Youssef
- Elhadi Muhammed
- Elshennawy Eslam M
- Enriquez-Navascués José M
- Erdinc Kemal
- Eriksen Jacob D
- Ersryd Amanda L
- EscartĂn Jorge
- EspĂn-Basany Eloy
- Estaire-GĂłmez Mercedes
- EstefanĂa Diego
- Ewedah Moataz
- Fabbri NicolĂČ
- Fares Hala
- Farguell Jordi
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- Farnesi Francesca
- Fazzin Marta
- Feo Carlo V
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- FernĂĄndez Cristina LĂłpez
- FernĂĄndez-Hevia MarĂa
- FernĂĄndez-Hevia MarĂa
- FernĂĄndez-Hurtado Ignacio
- FernĂĄndez-MartĂnez Daniel
- FernĂĄndez-MartĂnez Daniel
- Ferreira CĂĄtia
- Ferreira Rita Marques
- Ferrer RocĂo
- Filimonov Victor B
- Filipov Emil
- Fioravanti Emanuela
- Flamey Nicolas
- Florea Sabrina
- Folkesson Joakim
- Foppa Caterina
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- Forgan Tim
- Fowler George E
- Frasson Matteo
- Frivold Tone
- Frontali Alice
- Fujiwara Hajime
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- Gadan Soran
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- GarcĂa-FlĂłrez Luis J
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- Gareb Fahed
- Garmanova Tatiana
- Garulli Gianluca
- Gecim Ibrahim E
- Geitenbeek Ritch
- George Sarah
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- Ghignone Federico
- Ghmagh Reem
- Gialamas Eleftherios
- Gielis Manuel
- Gil Lopez Jose M
- Giuffrida Mario
- Golshani Parisa
- Gonzalez Ricardo
- GonzĂĄlvez Paula
- Goutard Claire-Angéline
- Grass Julia-Kristin
- Graure Giorgiana M
- Gregussen Hilde
- Greijdanus Nynke G
- Gribnev Petar
- Grosek Jan
- Grossi Ugo
- Grotenhuis Brechtje A
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- Guel-Klein Safak
- Guenin Marc-Olivier
- Gurjar Shashank
- GĂłmez Tania
- GĂłmez-Abril Segundo Ă
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- GöbĂŒt HĂŒseyin
- GĂŒnenç ErĆan
- GĂŒrtler Thomas
- GĂŒzel Melek
- Haberal Elifcan
- Haddad Anis
- Hajjaj Baraa Nabil
- Hamdan Alaa
- Hamid Hytham K S
- Hammoodi Hayder
- Hani Mohammad Bani
- Hannink Gerjon
- Hasan Bassam
- Hassan Naya
- Hassan Soha Y
- Havenga Klaas
- Hazen Sanne J A
- Heemskerk Jeroen
- Heesink Vera
- Heidsma Charlotte M
- Heijnen Bob H M
- Herman Ayesiga
- HernĂĄndez Miguel
- Herrero Eduardo Ferrero
- Hess Gabriel F
- Ho Man-Fung
- Ho Yiu M
- Hoff Christiaan
- Hol Jeroen C
- Hollington Paul
- Holman Fabian A
- Hompes Roel
- Hoogteijling Tijs J
- Hulshof Lorenzo G W L
- Hussein Mohamed
- Iacomino Alessandro
- Ibrahim Aini F
- Ismail Razif
- Ivanov Tsvetomir
- Iversen Lene H
- Jadid Kaveh Dehlaghi
- Jakubauskas Matas
- Jakubauskiene Lina
- Jangmalm Staffan
- Janssen Paul T J
- Jou-Valencia Daniela
- Julaihi Rokayah
- Jutesten Henrik
- Kacem Montasser
- Kader Rawaz
- Kamer Erdinc
- Kapadia Raj
- Kara Yasin
- Karamanliev Martin
- Karavokyros Ioannis
- Karmi Fahed
- Karsten Tom
- Karydakis Lysandros
- Kaya Tayfun
- Kelly Michael E
- Keskin Metin
- Ketelaers Stijn H J
- Khader Ahmed A E
- Khedr Gehan Abd Elatti
- Koc Mehmet A
- Koemans Willem J
- Konishi Tsuyoshi
- Korkolis Dimitrios
- Kostromitskiy Dmitriy N
- Kozan Ramazan
- KoĆĄir Jurij A
- Kraft Miquel
- Krastev Panche
- Krohn Nina
- Kroon Hidde M
- Kryzauskas Marius
- Kulle Cemil B
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- Kusters Miranda
- Kynaston James
- Lacy Antonio M
- Lambrechts Anton
- Lamme Bas
- Lamparelli Michael
- Lantone Giuliano
- Lapolla Pierfrancesco
- Larcinese Antonella
- Larkin John O
- Larkin John O
- Larsson Per-Anders
- Latkauskas Tadas
- Lauka Lelde
- Leeuwenburgh Marjolein M
- Lefevre Jérémie H
- Leijtens Jeroen W A
- Leung Edmund
- LeventoÄlu Sezai
- Lindqvist Ebba
- Liu Jianliang
- Longhi Marco
- Lorenzon Laura
- Lorusso Leonardo
- Losada Manuel
- Lucchi Andrea
- LuncÄ Sorinel
- Lutfi Hamid
- Lydrup Marie-Louise
- LĂłpez-Lara Manuel
- LĂłpez-RodrĂguez-Arias Francisco
- Macau Florin
- Machackova Maria
- Maghrebi Houcine
- Majbar Mohammed A
- Mak Tony Wing-Chung
- Manatakis Dimitrios
- Mansour Ali
- Manzo Carlo A
- Marchegiani Francesco
- Marcos Elena Bermejo
- Mariani NicolĂČ M
- Marinelli Andreas
- Markaryan Daniil G
- Maroli Annalisa
- Martins SĂłnia Fortuna
- MartĂnek LubomĂr
- MartĂnez MarĂa Labalde
- MartĂnez-Pinedo Carlos
- Maslyankov Svilen
- Massey Lisa
- Matthiessen Peter
- Mattioni Laura A
- McCormick Paul H
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- Medina Quintana Rita E
- Mehigan Brian J
- Melling Nathaniel
- Melnikov Andrey A
- Mendes Ana Filipa Dias
- Meroni Paola
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- Mikalauskas Saulius
- Mingoli Andrea
- Mishra Amitabh
- Mitteregger Martin
- Miu Victor
- Moctezuma-VelĂĄzquez Paulina
- Mohamed Abudi
- Mohsine Raouf
- Monib Fatma A
- Monson John
- Montroni Isacco
- Morales Bernaldo de QuirĂłs Javier T
- Morgan Matthew
- Msherghi Ahmed A
- Mueller Simone
- Mugla Naser
- Muguerza Huguet José M
- Mukherjee Tanmoy
- Muratore Andrea
- Muriel Jorge Sancho
- Musters Gijsbert D
- Muñoz-Collado Salvador
- MuÈinÄ Ana-Maria
- MĂnguez-Ruiz GermĂĄn
- Nair Gavin
- Navarro-SĂĄnchez Antonio
- Neary Peter
- Negoi Ionut
- Negoita Valentina M
- Nespoli Luca
- Ng Simon Siu-Man
- Niazi Ammar
- Nichita Vladimir-Ion
- Niemer Quirine
- Nieto-Moreno Elena
- Nilsson Karl
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- Novello Simone
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- Oldani Massimo
- Oliveira AntĂłnio
- Oosterling Steven J
- Opocher Enrico
- Osborne Laura
- OsiÄ Jurica
- Palini Gian M
- Panel Nathalie
- Panis Yves
- Pantoja Pachajoa Diana A
- Parc Yann
- Parise Cristiano
- Park Jennifer M
- Parodi Matias
- Pasini Francesco
- Pasini Franceso
- Passuello Nicola
- Pattyn Paul
- Pavlov Vasil
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- Pennings Alexander J
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- Perivoliotis Konstantinos
- Perrone Gennaro
- Persiani Roberto
- Pesce Antonio
- Petropolou Thalia
- Pezzuto Roberto
- Picciariello Arcangelo
- Picone Emanuele
- PikĆ«nienÄ Ingrida
- Pinto Francisca Lima
- Pire-Abaitua Gerardo
- Pirozzolo Giovanni
- PiyadeoÄlu Deniz
- Pizarro Aranda MarĂa J
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- Polat Fatih
- Polle Sebastiaan W
- Polydorou Adreas
- Porta Andrea
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- Ramsay George
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- RoatÄ Cristian-Ene
- Rodimov Sergey V
- Rodrigues Jarimba Aldo M
- RodrĂguez Carlos SĂĄez-Cazallas
- RodrĂguez-Infante Antonio
- Romano Angela
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- Roos Daphne
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- Rosman Camiel
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- Sampietro Gianluca M
- Samsa Mehmet Veysi
- Santacruz Carlos CerdĂĄn
- Santillan Mateo
- Santoro Giulio A
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- Schultz Johannes K
- Sebai Amine
- Sebastian Boby
- Segelman Josefin
- Seitinger Gerald
- SemiĂŁo Miguel
- Septiem Javier GarcĂa
- Serralta Daniel
- Shaban Mohamed
- Shaikh Shafaque
- Shapiro Joël
- Siaw Oliver
- Sıbıç Osman
- Sica Giuseppe
- Sietses Colin
- Singh Baljit
- Singh Nirbhaibir
- Singh-Ranger Deepak
- Sinibaldi Giovanni
- Siragusa Leandro
- Sivrikoz Emre
- Sjo Ole H
- Sjöström Olle
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- Slavchev Mihail
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- Solomon Michael
- Soriero Domenico
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- Spinelli Antonino
- Spolverato Gaya
- Staffan Maria
- Stefanescu Victor
- Steller Arend G J Aalbers Ernst J
- Stienstra Roxane M
- Stoica Bogdan
- Stoica Bogdan
- Suchkov Igor A
- Sultan Hytham
- Surlin Valeriu M
- SuĂĄrez Marta Castro
- SuĂĄrez-SĂĄnchez Aida
- SuĂĄrez-SĂĄnchez Aida
- Syllaios Athanasios
- SĂĄnchez Lara Juan E
- SĂĄnchez Teresa Rubio
- Sånchez-Guillén Luis
- Sökmen SELMAN
- Tababa Osama W E
- Taha-Mehlitz Stephanie
- Talboom Kevin
- Talsma Aaldert K
- Tamelis Algimantas
- Tamini NicolĂČ
- Tanase Ioan
- Tanis Pieter J
- Tantoura Mohammad
- Tanzanu Marta
- Tasende-Presedo Marta M
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- Taverne Sophie B M
- Tejedor Patricia
- Teras JĂŒri
- Teras Roland M
- Terra Antonio La
- Tiefenthal Marit
- Tomasicchio Giovanni
- TomaĆŸiÄ AleĆĄ
- Tonchev Pencho
- Toorenvliet Boudewijn R
- Torres MarĂa T
- Toso Christian
- Tsimogiannis Konstantinos
- Tuynmann Jurriaan B
- Tzovaras George
- Ubels Sander
- Ugolini Giampaolo
- Uluk Deniz
- Vailas Michail
- Vailati Bruna B
- van Dalsen Annette D
- van den Broek Nathalie E J
- van den Hengel Berber
- van der Burg Sjirk
- van der Zijden CharlĂšne J
- van Gerven Pieter
- van Kessel Charlotte S
- van Praagh Jasper B
- van Schaik Ted G
- van Westreenen Hendrik L
- van Workum Frans
- Vanclooster Patrick
- Vansteenbrugge Louis
- Vasile Mihai
- Venianaki Maria
- Verdaasdonk Emiel G G
- Vergara-FernĂĄndez Omar
- Vermaas Maarten
- Verstappen Sonja
- Vignotto Chiara
- Villar Ăscar GarcĂa
- Vittori Laura
- Vles Wouter J
- von FlĂŒe Markus
- Voron Thibault
- Vosbeek Noortje
- Vuagniaux Aurélie
- VĂĄzquez Andrea
- Waqar Usama
- Waqar Usama
- Ward Nicholas
- Warden Claire
- Westerterp Marinke
- Wienholts Kiedo
- Wiering Bastiaan
- Wijma Allard G
- Wildeboer Aurelia C L
- Wolthuis Albert
- Wong Michael P K
- Woods Kayla
- Xenaki Sofia
- Xynos Evangelos
- Yalkın Ămer
- Yanishev Alexey
- YĂŒksel Osman
- Zabala JesĂșs GĂłmez
- Zakaria Andee D
- Zakaria Zaidi
- Zanini Nicola
- Zanus Giacomo
- Zazo Aya
- Zazo Rama
- Zucchella Martino
- ZukanoviÄ Goran
- Zwakman Marije
- Ăakır Murat
- Ăzata Ä°brahim H
- ĂzgĂŒr Ä°lker
- Ăzkan Ămer Faruk
- ĂlgĂŒr Hanife Ćeyda
- Ć antak Goran
- Ć imleĆĄa Damir
- Ć lenfuktas Vygintas
- Ćœilinskas Justas
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Objective:To develop and validate a prediction model (STOMA score) for 1-year stoma-free survival in patients with rectal cancer (RC) with anastomotic leakage (AL).Background:AL after RC resection often results in a permanent stoma.Methods:This international retrospective cohort study (TENTACLE-Rectum) encompassed 216 participating centres and included patients who developed AL after RC surgery between 2014 and 2018. Clinically relevant predictors for 1-year stoma-free survival were included in uni and multivariable logistic regression models. The STOMA score was developed and internally validated in a cohort of patients operated between 2014 and 2017, with subsequent temporal validation in a 2018 cohort. The discriminative power and calibration of the models' performance were evaluated.Results:This study included 2499 patients with AL, 1954 in the development cohort and 545 in the validation cohort. Baseline characteristics were comparable. One-year stoma-free survival was 45.0% in the development cohort and 43.7% in the validation cohort. The following predictors were included in the STOMA score: sex, age, American Society of Anestesiologist classification, body mass index, clinical M-disease, neoadjuvant therapy, abdominal and transanal approach, primary defunctioning stoma, multivisceral resection, clinical setting in which AL was diagnosed, postoperative day of AL diagnosis, abdominal contamination, anastomotic defect circumference, bowel wall ischemia, anastomotic fistula, retraction, and reactivation leakage. The STOMA score showed good discrimination and calibration (c-index: 0.71, 95% CI: 0.66-0.76).Conclusions:The STOMA score consists of 18 clinically relevant factors and estimates the individual risk for 1-year stoma-free survival in patients with AL after RC surgery, which may improve patient counseling and give guidance when analyzing the efficacy of different treatment strategies in future studies
Pancreatic surgery outcomes: multicentre prospective snapshot study in 67 countries
- Author
- A Nizarudeen
- Aalem Hajer Abd Alhamed
- Ababneh Hazim
- Abbas Ahmed
- Abbas Aram
- Abbas Hussain
- Abbasi Arezou
- Abbassi Fariba
- Abbasy Jibran
- Abbood Ali H
- Abboud Kirellos
- Abdallah Ahmed
- Abdalsalam Sabriya Juma Ali
- Abdelaal Abdelrahman
- Abdelalemm Mohamed
- Abdelhafez Mohammed Hisham Zayan
- Abdelhalim Karim
- Abdeljalil Mahmoud
- Abdelkarem Mohamed
- Abdelmageed Abdelfatah
- Abdelmageed Abdelfatah
- Abdelmaksoud Mohamed
- Abdelmawgoud Sherif
- Abdelmawla Mohamed
- Abdelmawla Mohamed Osama Mohammed Kamel
- Abdelmoneim Noha
- Abdelnoor Ahmad
- Abdelrahman Fatma
- Abdelrazek Hussein A
- Abdelrhman Reham
- Abdelzaher Abdurrahman
- Abdelzaher Abdurrahman Taha
- Abdou Khaled
- Abdoun Meriem
- Abdualqader Mahmmoud
- Abdualqader Mahmmoud Yehia Mohammed
- Abdulhaq Aram
- Abduljawad Heba
- Abdullaev Abakar
- Abdullah Nik Azim Nik
- Abdulmonem Aya
- Abdulwahed Eman
- Abebrese John
- Abiyere Henry
- Abobakr Abobakr Mahfoz
- Aboelfath Shiamaa
- Abosamak Nour Eldin
- Abu-Elfatth Ahmed Mohammed
- Abu-Ghazal Sara
- Abu-Ghazal Sara Yassir
- Abuali Ahmed S A M E
- Abuelazm Mohamed
- Abuelnaga Yasmeen
- Abuelnaga Yasmeen
- Abughazal Sara Yasser
- Abuleil Amro
- Abusannuga Malek
- Abuzaina Khalil
- Adam Islam
- Aday Ulaş
- Adeyeye Ademola
- Adeyeye Nigeria Ademola
- Adham Mustapha
- Adhikari Krishna Mohan
- Affary Anter Al
- Afzal Ameer
- Afzal Iqraa
- Aghdassi Ali
- Ahmed Emad Ali
- Ahmed Mohamed Bahaa Eldin
- Ahmed Randa
- Ahmeed Sultan
- Ajayi Peter
- Akahoshi Keiichi
- Akbar Ali
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- Elazeem Hossam Aldein Abd
- Elbadawy Merihan A
- Elbalka Saleh S
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- Fareed Ahmed M
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- Szwedziak Krzysztof
- SĆodkowski Maciej
- SÌileikis Audrius
- SÌlepavicÌius Algirdas
- SÌtironja Ivan
- Tabeti Benali
- Taddei Antonio
- Tagar Esteem
- Taha Ahmed
- Taha Samah Suliman Osman
- Takorov Ivelin
- Talib Hashim
- Tamburrino Domenico
- Tamburrino Domenico
- Tammik Olav
- Tammik Olav
- Tan Jih Huei
- Tanabayeva Shynar
- Tanabe Minoru
- Tanas Yousef
- Tang Ephraim
- Tang Ephraim
- Tani Masaji
- Tanyous Samuel
- Tarantino Ignazio
- Targarona Javier
- Tarik Bouhout
- Tarkhan Yasmeen
- Tayiawi Mosaab
- Taylor Lillian
- Taylor Mark
- Taylor Mark
- Teh Catherine
- Teixeira UiraÌ Fernandes
- Tekin Enver
- Tenreiro Nadia
- Tepetes Konstantinos
- Tesarikova Jana
- Testa Valentina
- Testini Mario
- Tez Mesut
- Thakkar Rohan
- The Catherine
- Theab Mohammad
- Theab Reem Abdelrahman Khader
- Thiruchelvam Nita
- Thomaidis Panagiotis
- Thompson Rachel
- Tidjane Anisse
- Tijani El Harroudi
- Tilak Shruti
- Tingstedt Bobby
- Tinguely Pascale
- Tinguely Pascale
- Tishreen Alaa Hamdan
- Tisone Giuseppe
- Titi Rawand
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- Tokarev Mark
- Tolin Francesca
- Tolis Engy Amgad Nasr
- Tomara Nefeli
- Tomara Nefeli Kaiti
- Tomazic Ales
- TomaÌSÌ SkalickyÌ
- Tommaso Stecca
- Tonini Valeria
- Tooulias Andreas
- Torab Sana Shaikh
- Torelly Lucas
- Torgomyan Gaik
- Torres Orlando
- Torres Orlando Jorge M
- Torres Silvio Melo
- Torres-Quevedo Rodrigo
- Toso Christian
- Touabti Souhem
- Toutouzas Konstantinos
- ToÌlgyes TamaÌs
- Triantafyllidis Ioannis
- Tripathi Mayank
- Trizzino Arianna
- Troci Albert
- Troisi Roberto Ivan
- TrotovsÌek BlazÌ
- TrotovSÌek BlazÌ
- Truant SteÌphanie
- Tsakiris Charalampos
- Tsalis Konstantinos
- Tsaramanidis Savvas
- Tschuor Christoph
- Tsiotos Gregory
- Tsirlis Theodoros
- Tsoukalas Nikolaos
- Tumas Jaroslav
- Tuvin Daniel
- TuÌrkogÌlu Mehmet Akif
- TuÌzuÌner Acar
- Tyutyunnik Pavel
- Tzimas George
- Uemura Kenichiro
- Uggeri Fabio
- Ugrekhelidze Keti
- Uguz Alper
- Uhl Waldemar
- Ulgur Hanife Seyda
- Ullah Sami
- Unalp Omer Vedat
- Urciuoli Irene
- Uzir Sofia Suhda Binti Mohd
- Uzunoglu Faik G
- Vaccara Vincenzo La
- Vaia Aliki
- Vailas Michail
- Vaishnav Dhaivat
- Val Alejandro Ramirez-Del
- Valaroutsos Alexandros
- Valcarcel Ana Quiroga
- Valente Roberto
- Valeriia Sumarokova
- Valladares Andre Moguel
- Valmorisco Marcos Alba
- Valverde David Padilla
- Van Dam Jacob L
- Van den Bossche Bert
- van Eijck Casper HJ
- van Laarhoven Stijn
- Vanagas Tomas
- Varshney Vaibhav
- Vasavada Bhavin
- Vaslamatzis Michalis
- Vass David
- Vassiliu Pantelis
- Vazquez Pedro Gil
- Velagala Jayapala Reddy
- Velagala Jayapala Reddy
- VelaÌzquez Patricia SaÌnchez
- Velenciuc Natalia
- Veneroni Luigi
- Venkatesh N R
- Vennarecci Giovanni
- Vera Valle
- Vereczkei Andras
- Vezakis Antonios
- Vigia Emanuel
- Vilcu Mihaela
- Vilhav Caroline
- Vincenti Leonardo
- Virk Sargun
- Vishnoi Jeewan Ram
- Vito Deblasi
- Vivarelli Marco
- Vladov Nikola
- Vodyala Charishma
- Vougas Vasileios
- Vouros Dimitrios
- Vrakopoulou Gavriella Zoi
- Waechter FaÌbio Luiz
- Waffa Zuraiha
- Wagner Ki
- Wahib El Mahdi
- Wake Rudyard
- Wang Huaizhi
- Wang Jiping
- Waqar Usama
- Waqar Usama
- Wardeh Salah
- Wardeszkiewicz Aleksander
- Wassmer Charles-Henri
- Weber Markus
- Wei Alice
- Wei Kongyuan
- Wei Kongyuan
- Weitz JuÌrgen
- Wellner Ulrich
- Welsch Thilo
- Welsh Fraser
- Wen Daniel
- Wennerblom Johanna Hansson
- Wenning Anna Silvia
- Wicherts Dennis
- Wierzchowski MichaĆ
- Wikar Tomasz
- Williamsson Caroline
- Windsor John
- Winslow Emily
- Wlazlak Michal
- Wolfgang Christopher
- Wu Chien Hui
- Wu Chien Hui
- WuÌllenweber Hans-Peter
- WyrosÌlak-Najs Justyna
- Yadav Kaushal
- Yadev Induprabha
- Yadev Induprabha
- Yaghan Rami
- Yamamoto Tomohisa
- Yang Po-Chih
- Yassin Laya Moayyad Ahmed
- Yassin Raya
- Yegen Cumhur
- Yeo Charles
- Yesilyurt Degercan
- Yip Vincent
- Yoong Boon
- Yoong Boon Koon
- Younes Eman
- Younes Eman
- Young Alistair
- Yousef Amal
- Youssef Amal
- Yu Ming-Chin
- Zacharakis Emmanouil
- Zacharoulis Dimitrios
- Zachiotis Marinos
- Zagainov Vladimir
- Zaharie Florin
- Zahed Mohamed
- Zahed Mohamed Samir Mohamed
- Zakaria Andee Dzulkarnaen
- Zamri Fatimah Mardhiyyah Binti
- Zanatta Michela
- Zanello Matteo
- Zanini Nicola
- Zanus Giacomo
- Zanus Giacomo
- Zaruba Pavel
- Zawia Ali
- Zayed Ahmed
- Zdujic Predrag
- Zedelj Jurica
- Zeh Herbert J
- Zentar Aziz
- Zerbi Alessandro
- Zidan Taha
- Zidan Taha
- Zironda Andrea
- Zitawi Abdullah
- Zivanovic Marko
- Zogopoulos George
- Zonta Sandro
- Zonta Sandro
- Zorrilla Carlos Florez
- Zozaya Gabriel
- Zreqat Qusai
- Zuhdi Zamri
- Zuhdy Mohammad
- Zygomalas Apollon
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Pancreatic surgery remains associated with high morbidity rates. Although postoperative mortality appears to have improved with specialization, the outcomes reported in the literature reflect the activity of highly specialized centres. The aim of this study was to evaluate the outcomes following pancreatic surgery worldwide.Methods: This was an international, prospective, multicentre, cross-sectional snapshot study of consecutive patients undergoing pancreatic operations worldwide in a 3-month interval in 2021. The primary outcome was postoperative mortality within 90 days of surgery. Multivariable logistic regression was used to explore relationships with Human Development Index (HDI) and other parameters.Results: A total of 4223 patients from 67 countries were analysed. A complication of any severity was detected in 68.7 percent of patients (2901 of 4223). Major complication rates (Clavien-Dindo grade at least IIIa) were 24, 18, and 27 percent, and mortality rates were 10, 5, and 5 per cent in low-to-middle-, high-, and very high-HDI countries respectively. The 90-day postoperative mortality rate was 5.4 per cent (229 of 4223) overall, but was significantly higher in the low-to-middle-HDI group (adjusted OR 2.88, 95 per cent c.i. 1.80 to 4.48). The overall failure-to-rescue rate was 21 percent; however, it was 41 per cent in low-to-middle-compared with 19 per cent in very high-HDI countries.Conclusion: Excess mortality in low-to-middle-HDI countries could be attributable to failure to rescue of patients from severe complications. The authors call for a collaborative response from international and regional associations of pancreatic surgeons to address management related to death from postoperative complications to tackle the global disparities in the outcomes of pancreatic surgery (NCT04652271; ISRCTN95140761)
Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries
- Author
- Aarts Frits
- Ababneh Hazim
- Abad-Motos Ane
- Abaidalla Ahmed
- Abbakar Malaz
- Abd El Aal Ahmed
- Abd-Errazik Mohammad Ahmad
- Abdalradiy Abdalrahmman G
- Abdelkhalek Mohamed
- Abdelkhalek Mostafa
- Abdellatif Ahmed
- Abdellatif Mohamed
- Abdelsaid Kirolas
- Abdou Khaled
- Abdulfatah Mustapha
- Abdullah Mohammad Amer
- Abdullahi Mustapha Miko Mohammed
- AbellĂĄn Antonio Melero
- Abeysinghe Nayana
- Abiyere Henry
- Achimas-Cadariu Patriciu Andrei
- Adakaya Sıla
- Adam Nicolas
- Adams Benita
- Adams Ferdinand
- Adegboye Kazeem
- Adeyeye Ademola
- Adra Lama
- Adu-Poku Patricia
- Afuwape Oludolapo
- Afzal Ameer
- Afzal Muhammad Farooq
- Agapov Mihail
- Agara Daniel
- Aggarwal Manisha
- Agger Erika
- Aghadi Ifeanyi Kene
- Ahmed Amjed Yassir
- Ahmed Haleemasahdia
- Ahmed Khalil
- Ahmed Manar
- Ahmed Masood
- Ahmed Safia
- Ahn Hong Min
- Aibe Raquel
- Aigner Felix
- Aissat Abdenour
- Aitbaeva Arai
- Akay Omer
- Akbar Ali
- Akbas Ahmet
- Akere Abidemi
- Akesen Selcan
- Akgun Erhan
- Akhtar Naseem
- Akın Emrah
- Akova Elif
- Aktas Serhat
- Akçay Ăzlem
- Al Masri Mahmoud
- Al-Alnsi Ahmed
- Al-Hutheifi Roqia'A
- Al-Jarrah Amar
- Al-Naggar Hamza
- Al-Shehari Mohammed
- Alamin Nadeen
- Alawi Raneen
- Alawlaqi Dina
- Alawneh Fade
- Alberola Maria José
- Albers Michael
- Alcolea Natalia GonzĂĄlez
- Aleem Muhammad
- Alegre InĂȘs
- Alegre Javier Martinez
- Alexandre Flavia
- Alexandrescu Corina
- Alexnder Abelevich
- Alexopoulou Kalliopi
- Alfonso Beatriz AmorĂłs
- Ali Ahmed
- Ali Che Saniati Che
- Ali Danish
- Ali Madeeha
- Ali Mahmoud Abdelwahab
- Ali Manhal Hashim
- Ali Noura Al
- Alikhanli Jhale
- Aliyeva Zumrud
- Aliyu Mohammed
- Aljawder Hasan
- Allen Kate
- Almahmeed Ebrahim
- Alonso Alfredo
- Alonso Javier Etreros
- Alsamneh Muneer
- Alsayadi Ramzi
- Altinel Yuksel
- Altintoprak Fatih
- Altomare Donato F
- Alvarenga Isabella
- Alvarez Laura Jimenez
- Alvarez-Bautista Francisco Emmanuel
- Alvarez-DĂez Marcos
- Alves Brenda Chayanny
- Amadigwe Rita
- Amado Andreia
- Amado FabĂola
- Amador Cristina GarcĂa
- Amanullah Nazli
- Amaral HĂ©lida Aline Tomacheski
- Amaral Luis
- Amin-Tai Hizami
- Aminu Bashiru
- Amir Ahmad Suhaimi
- Ammar Ahmed Siddique
- Ammar Mona Ahmed
- Ammendola Michele
- Ammerata Giorgio
- Amorim Edgar
- Ancans Guntis
- Anderson Tom
- Andrade Diogo
- Andrejevic Predrag
- AndrĂ©s Beatriz DĂaz San
- Anestiadou Elissavet
- Ang Chin Wee
- Angelo Franceschi
- Anokhin Evgeny
- Anoldo Pietro
- Antakia Ramez
- Anton Majd
- Antonelli Serena
- Antropoli Carmine
- Anula Rocio
- Anwar Jamal
- Anyadike Florence
- Apostolakidou Magda
- Apostolidi Eirini
- Aprea Giovanni
- Arabadzhiev Angel
- Arakawa Satoshi
- Arauz Jazmin
- Aravindan U
- Aremu Abdurrahman
- Aremu Isiaka
- Argawy Osama
- Arican Can
- Arida Zahed Abu
- Armellin Claudia
- Arnaoutoglou Eleni
- Arreguy-Borges Kanthya
- Artigot Mariano
- Arturi Alessandro
- Arulappan Nirupama
- Arya Shobhit
- Arynov Ardak
- Asaad Peter
- Asano Yukio
- Ascari Francesca
- Asgarov Mohsum
- Ashmawy Soad
- Aslam Muhammad Imran
- Assimakopoulou Elena
- Assis Ana
- Astilleta Romina
- Atanasov Boyko
- Atendido Tiffany
- Athanasakis Elias
- Atici Semra Demirli
- Avellaneda Nicholas
- Avellaneda Nicolas
- Avseren Goksu
- Awead Marwa
- Ayandipo Omobolaji
- Aybar Engin
- Aydin Funda
- Aydin Gaye
- Ayoub Kusay
- Aytac Erman
- Aytaç Erman
- Azevedo Jose
- Azevedo Patricia
- Azhar Najia
- Aziz Gowhar
- Azman Zairul Azwan Mohd
- AĆkar Ahmet
- Babatunde Olanrewaju
- Badawi Marwa
- Baek Jeong-Heum
- Baez Noelia FernĂĄndez
- Baeza-Murcia Melody
- Bagnardi Francesco
- Baharom Salahudin
- Baik Seung Hyuk
- Baimakhanov Abylai
- Bains Lovenish
- Baker Aleksandra
- Bakmaz Bernarda
- Bala Abubakar Muhammad
- Balaban Vladimir
- Balalis Dimitrios
- Balasubramaniam Dinesh
- Balathayalan Yathev
- Baldi Claudio
- Balestri Riccardo
- Balfour James
- Ballah Abubakar
- Ballian Nikiforos
- Balooshi Iman Al
- Baloyiannis Ioannis
- Bamford Richard
- Bandar Mahdi Al
- Banham Gail
- Bannoud Mohammad Hassan
- Baptista Victor
- Baral Jörg
- Barbalace Nicolas
- Barbato Giuseppe
- Barbosa Anderson
- Bareka Metaxia
- Baris Baver
- Barradas Renato
- Barreda Sara Castillo
- Barrena-Blazquez Silvestra
- Barton Jess
- Bartosiak Katarzyna
- Bashilkina Olga
- Bashir Mohammed
- Basile Raffaele
- Basnyat Pradeep
- Batool Sana
- Bautista Wilson Manuel SĂĄnchez
- Bayhan ZĂŒlfĂŒ
- Bayo José Manuel Muros
- BayĂłn Raquel Ălvaro
- Baños Pedro Antonio Parra
- Beard David
- Bedzhanyan Arkady
- Behilil Chakib
- Bekele Kebebe
- Belarmino Armin
- Belay Million
- Belev Nikolay
- Bellato Vittoria
- BeltrĂĄn de Heredia Juan
- Belvedere Angela
- Benetti Emilio
- Benetti Sara
- Bengueddach Aicha
- Benjelloun El Bachir
- Benkabbou Amine
- Bennett James
- Bensafir Salim
- Bergamini Carlo
- Bernotaite Vlada
- Beron Reinaldo Isaacs
- Bethune Robert
- Bezede Cosmin
- Beznosenko Andriy
- Bhangu Aneel
- Bhargava Aman
- Bhat Rama Rani Krishna
- Bianchi Romina
- Bianco Francesco
- Bigoni Irene
- Binetti Margherita
- Bintintan Vasile
- Biondi Alberto
- Biondo Santino Antonio
- Bisgin Tayfun
- Bisheet George
- Bissett Ian
- Biswas Jyotirmoy
- Blackwell Sue
- Blanco Pablo
- Blanco Raquel RĂos
- Blanco-Colino Ruth
- Blasco Laura Fraile
- Blazquez-Martin Alma
- Bobadilla Billy Jimenez
- Bocancia Raluca
- Boccia Giuseppe
- Bogatikov Alexander
- Bolanle Olajide Edward
- Bomfa-Barbosa Alysson
- Bompou Effrosyni
- Bonardello Michela
- Bonci Eduard-Alexandru
- Bordom Daniel Osei
- Borges Filipe
- Borghi Felice
- Boschiero Matheus Negri
- Bose Bodhisattva
- Bouchagier Konstantinos
- Boudjenan-Serradj Nabil
- Boudoux Sabrina
- Bourazani Maria
- Boyce Stephen
- Bozbiyik Osman
- Bracale Umberto
- Brachini Gioia
- Bradulskis Saulius
- Brainsa Eneida
- Brandström Gustav
- Braumille Markus
- Bravo Ana Minaya
- Bravo Raquel
- Bredikhin Mikhail
- Brito Noelia
- Bruni Andrea
- Buccianti Piero
- Buchs Nicolas
- Buchwald Pamela
- Budnikova Ina
- BudrikienÄ Rima
- Buey Lourdes
- Buijs Louis
- Buleje Jorge Alejandro Benavides
- Burlov Nikita
- Butt Anam
- Byshetty Rajendar
- Bywater Edward
- Bzikha Ilham
- BĂĄnky BalĂĄzs
- BĂŠlum Jens Kristian
- Caballero-Delgado Javier
- Cabrera Claudia
- Cafranga EstĂbaliz GutiĂ©rrez
- Cagnazzo Federica
- Calabria Mariangela
- Calabro' Marcello
- Caliendo Domenico
- Calin Camelia
- Caliskan Cemil
- Callan Rory
- Callari Cosimo
- Caltea Mihaela
- Calvo Almudena Castro
- Camacho Amparo
- Cammarata Francesco
- Campanati Renato
- Campanelli Michela
- Campbell Marion
- Canals LucĂa Otazu
- Canda Aras Emre
- Cano-Matias Auxiliadora
- Cao Victor Hugo Bruno
- Capolupo Gabriella Teresa
- Cappiello Antonio
- Capuano Marianna
- Capusan Alina
- Carannante Filippo
- Carbone Ludovico
- Cardelli Stefano
- Carden Claire
- Cardoso Diogo
- Caricato Marco
- Carlin Patricia Saez
- Carlini Massimo
- Carlos Sandra
- Carneros Virginia Jimenez
- Carosso Fabio
- Caroço Teresa Vieira
- Carpelan Anu
- Carpenter Holly
- Carrascosa-Morales Irene
- Carrie Augusto
- Carrizo Claudia
- Carta Giuseppina
- Carvalho Alexandre
- Carvello Michele
- Casanova Daniel
- Cascais Raquel
- Cassia Gabriela
- Castaldi Antonio
- Castaño Renata
- Castiglioni Simone
- Castillo Enrique Roca
- Castro Marta Cuartero
- Catalano Pablo
- Cato Liam
- Caz Esra
- Cebolla Elena Sagarra
- Cecchini Ilaria
- CeldrĂĄn Rebeca GonzĂĄlez
- Celik Hale Kefeli
- Ceretti Andrea Pisani
- Ceron Silvia Ferrer
- Cervellera Maurizio
- Cervone Carmela
- Chacko Anil
- Chandrasinghe Pramodh
- Charakopoulou Alexandra
- Chardalias Leonidas
- Chaturvedi Arun
- Chatzikomnitsa Paraskevi
- Chaudhari Abhishek
- Chaudhry Sanjay
- Chawla Tabish
- Chee Corissa
- Chen Nevin
- Cheng Kuang I
- Chiarugi Massimo
- Chisthi Meer
- Chitnis Abhishek
- Chitul Andrei
- Chmielewski Gaspard
- Cholewa Hanna
- Chornet Marta RosellĂł
- Chowdhary Manish
- Chowdhury Sharfuddin
- Chowdhury Sharfuddin M
- Chowdri Nisar
- Christensen Peter
- Christodoulidis Grigorios
- Chrysos Emmanuel
- Chua Lorna
- Chubukova Natlia
- Chung Jun Seong
- Church Robert
- Chwat Carina
- Ciabattari Paula
- Cianchi Fabio
- Cianci Pasquale
- Ciccarese Angelo Antonio
- Ciftci Ahmet Burak
- Cigagna Luca
- Cini Charles
- Ciotarla Danut Constantin
- Cirocchi Nicholas
- Ciubotaru Cezar
- Ciulli Cristina
- Ck Harikumar
- Clark Thomas
- Clarke Nicola
- Coccolini Federico
- Codes Lina
- Coelho Ana Margarida
- Cois Alessandro
- Coladonato Massimiliano
- Colak Elif
- Coldwell Chris
- Collins Jen
- Colombo Francesco
- ColĂĄs-Ruiz Enrique
- Conceição Luis
- Conde Juan Guillermo Ais
- Connolly Lewis
- Conversano Ivana
- Convertini Ornella
- Cook Esther
- Cooke Fiachra
- Coppolino Francesco
- Coratti Francesco
- Cordeiro Lisbete
- Correia Angela
- Correia DĂ©bora
- Cortes Bruno Giusti Werneck
- Cortés Guillermo Felipe Valderas
- Coskun Nurcan
- Costa Breno Xaia Martins
- Costa Susana
- Costa SĂlvia
- Cour Kenn La
- Crabtree Nicholas
- Creavin Ben
- Cremonini Camilla
- Crescentini Giacomo
- CricrĂŹ Michele
- Crisan Dana
- Cristian Daniel
- Croce Gianni Di
- Cruz Isabela
- Cucinotta Eugenio
- Cuichan Marco Vinicio Yugsi
- Cullinane Carolyn
- Cuneo Davide
- Cunha Miguel
- Curbelo Jacqueline
- Curcio Silvia
- Curro Giuseppe
- CurrĂ Maria Cristina
- CurrĂĄs Rosana PĂ©rez
- CustĂłdio Pedro
- CutellĂš Clelia
- Czarnecki Roman
- D'Angelo Salvatore
- D'Ugo Stefano
- da Luz Magda
- da Silveira Sete Alexandre
- Dainius Edvinas
- Dalton Richard
- Damieta Marta Pascual
- Danassi Despoina
- Danelli Piergiorgio
- Danial Aghyad Kudra
- Daniels Ian R
- Daniyan Muhammad
- Danna Riccardo
- Danys Donatas
- Dardanov Dragomir
- Daryanani Deepu
- Dassanayake Vihara
- DaugÄla Edvardas
- Dauri Mario
- Davidovskaja Larisa
- Davies Emma
- Davis Cian
- Dawson Brett E
- Dawson Carmel
- de Andrés-Asenjo Beatriz
- de Deken Julie
- de Franciscis Silvia
- de Kort Chantal
- de La Plaza Llamas Roberto
- de Lacy Antonio Maria
- de Lebrusant FernĂĄndez Sara
- de LeĂłn RendĂłn Jorge Luis
- de Luca Michele
- de Lucia Chiara
- de Miranda Silvestre Simone Chaves
- de Oliveira GĂłes Igor Arantes
- de Oliveira FlĂĄvia Gomes
- de Oliveira JoĂŁo Carlos Costa
- de Palma Giovanni Domenico
- de Paoli Massimo
- de Queiroz FĂĄbio Lopes
- de San PĂo Carvajal Eduardo
- de Silva Dulantha
- de Simone Giuseppe
- de Souza Artioli Luana Maria
- de Souza Pires Bruno Lucena
- de Stefano Mauro
- de Zoysa Ishan
- Deac Vasile
- Debono Marianne
- Dedeu-Bastardas Imma
- Degiuli Maurizio
- Del Carmen Casas GarcĂa Maria
- Del Castillo Vanesa Crespo Garcia
- Del Olmo Maria Inmaculada Ureña
- Del Pueblo Cristina Sanchez
- Del-Rio-Lafuente Francisco-Javier
- Delgado Eduardo
- Delgado Marina
- Delibegovic Samir
- Delimpalta Christina
- Delrio Paolo
- Demir Mehmet
- Demirel Emel
- Demirgan Serdar
- Dempsy Charlotte
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- Desai Neha
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- Devesa Helena
- Dhali Arkadeep
- Dhali Gopal Krishna
- Dhar Puneet
- Diaconescu Cati
- Diego Alejandro Romero-De
- Diez-Alonso Manuel
- Dijan Emilio
- Dilawar Maha
- Dimitriou Nikoletta
- Dimitrov Dobromir
- Dimitrova Slavina
- Dimofte Mihail-Gabriel
- Dindelegan George
- Dindri Franco
- Dinkci Mustafa Deniz
- Diéguez Beatriz
- Djumabayev Khasan
- Dobkowski Grzegorz
- Dodhy Afia Arshed
- Dolhai Erika
- Domanskiy Andrei
- Domingos Hugo
- Dominguez Fabiana
- Dominguez Sara HernĂĄndez
- Dominioni Tommaso
- Donatiello Valerio
- Doniquian Alejandro Marcelo
- Doree Nicholas
- Dorovinis Panagiotis
- Dos Santos José Mauro
- Dos Santos Marco AntĂŽnio Miranda
- Dos Santos Maria Beatriz Alves
- Douba Zain
- Drissi Farouk
- Drozdov Evgeniy
- Duarte Maria José
- Duchalais Emilie
- Dudas Gabor
- Dudric Vlad
- Dulskas Audrius
- Dupret Luc
- Durai Sheela
- Dushimova Zaure
- Duzgun Ozgul
- Dychko Aleksander
- Dzharov Georgi
- Dzhumabekov Berik
- Dziakova Jana
- DĂez Miguel Cuende
- Earley Helen
- Ebdewi Hamdi
- Ebrahem Aamal
- Edington John
- Egwuonwu Ochonma Amobi
- Ejiofor Gloria
- Ekepil Anna
- Ekwesianya Andrew
- Ekwunife Okechukwu
- El Ahmadi Brahim
- El Jamali Faek
- El Metwally Aziza
- El Sorogy Mohamed
- El-Hussuna Alaa
- El-Wafa Yahya Abou
- Elbahrawy Khaled
- Eldakroury Israa
- Eldin Sami Jalal
- Elena Fanti
- Elfallal Ahmed
- Elfeki Hossam
- Elhadi Muhammed
- Elisiario Luisa
- EllebĂŠk Mark Bremholm
- Elmore Ugo
- Elrefai Mohamad
- Elshami Mohamedraed
- Emar Mohammed
- Emegoakor Chiemelu
- Emhareb Abdalla
- Emile Sameh
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- Lococo Julio
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- Mazaz Khalid
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- Mba Emmanuel Louis
- Mcdermott Frank D
- Mcintosh Katrina
- McKay Siobhan
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- Meric Serhat
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- Mesli Smain Nabil
- Metwally Islam H
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- Meyer Jeremy
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- Moglan Mihaela
- Mohamad Aya Haji
- Mohamed Haiba A
- Mohamed Mohamed
- Mohamed Nada
- Mohammad Saleh
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- Mohmmad Walid A S
- Mohsin Hassan
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- Pellicer-Franco Enrique M
- Pellino Gianluca
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- Potter Mark A
- Prakash Sharath
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- Yilmazlar Tuncay
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- Yoldas Tayfun
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- Yorkmui Liu
- Yoshino Kenji
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- Yule Michael
- Yusoff Zakiah Mohd
- Zaari Fatimazahraa
- Zabiyaka Mikhail
- ZadroĆŒna Monika
- Zafar Madiha
- Zagaynov Eugeny
- Zaidi Syed-Nadeem
- Zaimis Tilemachos
- Zain Wan Zainira Wan
- Zainy Rhendra Hardy Mohamad
- Zakaria Andee Dzulkarnaen
- Zakaria Maheen
- Zakaria Zaidi
- Zamudio-Bautista Jorge Luis
- Zanc Loredana
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- Zanus Giacomo
- Zapparoli Alessandro
- Zappone Anna
- Zarzava Eirini
- Zatari Dirar
- Zawadzki Marek
- Zayakov Georgi
- Zaycev Andrey
- Zazo Aya
- Zazo Rama
- Zdravkovic Maja
- Zengin Abdullah KaÄan
- Zeringa Georgia
- Zimmerman David D E
- Zuhdy Mohammad
- Zvirych Vitalii
- Zywicka Ewa
- Ălvarez-Llano Laura
- Ăngelo Miguel Duarte
- ĂSullivan Sara Nuñez
- Ăzçelik Mehmet Faik
- Äoza Ivo
- Ćanlı Ahmet Necati
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Background
Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks.
Methods
The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned.
Results
A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31).
Conclusion
Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)