A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes

dentification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential to provide insights into the pathophysiological mechanisms responsible. We conducted a genome-wide association study (GWAS) of DKD in type 2 diabetes (T2D) using eight complementary dichotomous and quantitative DKD phenotypes: the principal dichotomous analysis involved 5,717 T2D subjects, 3,345 with DKD. Promising association signals were evaluated in up to 26,827 subjects with T2D (12,710 with DKD). A combined T1D+T2D GWAS was performed using complementary data available for subjects with T1D, which, with replication samples, involved up to 40,340 subjects with diabetes (18,582 with DKD). Analysis of specific DKD phenotypes identified a novel signal near GABRR1 (rs9942471, P = 4.5 x 10(-8)) associated with microalbuminuria in European T2D case subjects. However, no replication of this signal was observed in Asian subjects with T2D or in the equivalent T1D analysis. There was only limited support, in this substantially enlarged analysis, for association at previously reported DKD signals, except for those at UMOD and PRKAG2, both associated with estimated glomerular filtration rate. We conclude that, despite challenges in addressing phenotypic heterogeneity, access to increased sample sizes will continue to provide more robust inference regarding risk variant discovery for DKD.Peer reviewe

Dual-polarized 2x2 element sub-array at 15 GHz with high port isolation

Abstract This paper presents simulation results of a dual-polarized 2×2 element sub-array antenna element at 15 GHz center frequency. The basic idea is to use two waveguides stacked on in a right-angle configuration to excite the orthogonal polarizations by using radiating slots. Above the slots, 4 parasitic patches are set to a form of 2×2 element sub-array. Antenna presents -10 dB impedance bandwidth from 14.3 to 15.6 GHz with better than 68 dB isolation between the excitation ports. At the aforementioned bandwidth, the total efficiency is better than -0.7 dB (> 85%). Antenna shows very good polarization properties and difference between φ, θ components is greater than 45 dB. Also the radiation patterns and surface current distributions at 15 GHz center frequency are presented and compared