Global model of differential rotation in the Sun

The isorotation contours of the solar convective zone (SCZ) show three distinct morphologies, corresponding to two boundary layers (inner and outer), and the bulk of the interior. Previous work has shown that the thermal wind equation together with informal arguments on the nature of convection in a rotating fluid could be used to deduce the shape of the isorotation surfaces in the bulk of the SCZ with great fidelity, and that the tachocline contours could also be described by relatively simple phenomenology. In this paper, we show that the form of these surfaces can be understood more broadly as a mathematical consequence of the thermal wind equation and a narrow convective shell. The analysis does not yield the angular velocity function directly, an additional surface boundary condition is required. But much can already be deduced without constructing the entire rotation profile. The mathematics may be combined with dynamical arguments put forth in previous works to the mutual benefit of each. An important element of our approach is to regard the constant angular velocity surfaces as an independent coordinate variable for what is termed the "residual entropy," a quantity that plays a key role in the equation of thermal wind balance. The difference between the dynamics of the bulk of the SCZ and the tachocline is due to a different functional form of the residual entropy in each region. We develop a unified theory for the rotational behavior of both the SCZ and the tachocline, using the solutions for the characteristics of the thermal wind equation. These characteristics are identical to the isorotation contours in the bulk of the SCZ, but the two deviate in the tachocline. The outer layer may be treated, at least descriptively, by similar mathematical techniques, but this region probably does not obey thermal wind balance.Comment: 26 pages, 7 figures, accepted to MNRA

On Differential Rotation and Convection in the Sun

We show that the differential rotation profile of the solar convection zone, apart from inner and outer boundary layers, can be reproduced with great accu- racy if the isorotation contours correspond to characteristics of the thermal wind equation. This requires that there be a formal quantitative relationship involving the entropy and the angular velocity. Earlier work has suggested that this could arise from magnetohydrodynamic stability constraints; here we argue that purely hydrodynamical processes could also lead to such a result. Of special importance to the hydrodynamical solution is the fact that the thermal wind equation is insensitive to radial entropy gradients. This allows a much more general class of solutions to fit the solar isorotation contours, beyond just those in which the entropy itself must be a function of the angular velocity. In particular, for this expanded class, the thermal wind solution of the solar rotation profile remains valid even when large radial entropy gradients are present. A clear and explicit example of this class of solution appears to be present in published numerical simulations of the solar convective zone. Though hydrodynamical in character, the theory is not sensitive to the presence of weak magnetic fields. Thus, the identification of solar isorotation contours with the characteristics of the thermal wind equation appears to be robust, accommodating, but by no means requiring, magnetic field dynamics.Comment: 16 pages, 2 figures. Accepted for publication in MNRA

Differential rotation in fully convective stars

Under the assumption of thermal wind balance and effective entropy mixing in constant rotation surfaces, the isorotational contours of the solar convective zone may be reproduced with great fidelity. Even at this early stage of development, this helioseismology fit may be used to put a lower bound on the midlatitude {\em radial} solar entropy gradient, which in good accord with standard mixing length theory. In this paper, we generalize this solar calculation to fully convective stars (and potentially planets), retaining the assumptions of thermal wind balance and effective entropy mixing in isorotational surfaces. It is found that each isorotation contour is of the form $R^2 = A+B\Phi(r)$, where $R$ is the radius from the rotation axis, $\Phi(r)$ is the (assumed spherical) gravitational potential, and $A$ and $B$ are constant along the contour. This result is applied to simple models of fully convective stars. Both solar-like surface rotation profiles (angular velocity decreasing toward the poles) as well as "antisolar" profiles (angular velocity increasing toward the poles) are modeled; the latter bear some suggestive resemblance to numerical simulations. We also perform exploratory studies of zonal surface flows similar to those seen in Jupiter and Saturn. In addition to providing a practical framework for understanding the results of large scale numerical simulations, our findings may also prove useful in dynamical calculations for which a simple but viable model for the background rotation profile in a convecting fluid is needed. Finally, our work bears directly on an important goal of the CoRoT program: to elucidate the internal structure of rotating, convecting stars.Comment: 21 pages, 20 figures. Accepted for publication in MNRA

Timing of descriptions shapes experience‐based risky choice

Risky decisions based on the combination of different sources of information (e.g., decisions from description‐plus‐experience) have mostly been ignored, as research has focused on examining each source separately. Across three experiments, we explore the intricate relationship between experience and description by manipulating when descriptive information about risky options is made available during an experience‐based task. The results show that the amount of prior experience moderates the way that descriptive information is considered and integrated in the decision‐making process: Descriptions affected behavior more when participants had little experience with the task, whereas their effect was less pronounced with extended experience. This relationship reversed when participants had access to foregone payoffs, with descriptions being considered more when participants had more time to interact with the task. Potential mechanisms and theoretical accounts are discussed with an emphasis on how the results and conclusions of the present work can be applied to the effective design of warning labels

Clinical validation of a smartphone-based adapter for optic disc imaging in Kenya

Visualization and interpretation of the optic nerve and retina are essential parts of most physical examinations. To design and validate a smartphone-based retinal adapter enabling image capture and remote grading of the retina. This validation study compared the grading of optic nerves from smartphone images with those of a digital retinal camera. Both image sets were independently graded at Moorfields Eye Hospital Reading Centre. Nested within the 6-year follow-up (January 7, 2013, to March 12, 2014) of the Nakuru Eye Disease Cohort in Kenya, 1460 adults (2920 eyes) 55 years and older were recruited consecutively from the study. A subset of 100 optic disc images from both methods were further used to validate a grading app for the optic nerves. Data analysis was performed April 7 to April 12, 2015. Vertical cup-disc ratio for each testwas compared in terms of agreement (Bland-Altman and weighted κ) and test-retest variability. A total of 2152 optic nerve images were available from both methods (also 371 from the reference camera but not the smartphone, 170 from the smartphone but not the reference camera, and 227 from neither the reference camera nor the smartphone). Bland-Altman analysis revealed a mean difference of 0.02 (95%CI, −0.21 to 0.17) and a weighted κ coefficient of 0.69 (excellent agreement). The grades of an experienced retinal photographer were compared with those of a lay photographer (no health care experience before the study), and no observable difference in image acquisition quality was found. Nonclinical photographers using the low-cost smartphone adapter were able to acquire optic nerve images at a standard that enabled independent remote grading of the images comparable to those acquired using a desktop retinal camera operated by an ophthalmic assistant. The potential for task shifting and the detection of avoidable causes of blindness in the most at-risk communities makes this an attractive public health intervention

Downward pumping of magnetic flux as the cause of filamentary structures in sunspot penumbrae

The structure of a sunspot is determined by the local interaction between magnetic fields and convection near the Sun's surface. The dark central umbra is surrounded by a filamentary penumbra, whose complicated fine structure has only recently been revealed by high-resolution observations. The penumbral magnetic field has an intricate and unexpected interlocking-comb structure and some field lines, with associated outflows of gas, dive back down below the solar surface at the outer edge of the spot. These field lines might be expected to float quickly back to the surface because of magnetic buoyancy, but they remain submerged. Here we show that the field lines are kept submerged outside the spot by turbulent, compressible convection, which is dominated by strong, coherent, descending plumes. Moreover, this downward pumping of magnetic flux explains the origin of the interlocking-comb structure of the penumbral magnetic field, and the behaviour of other magnetic features near the sunspot

Itk Negatively Regulates Induction of T Cell Proliferation by CD28 Costimulation

CD28 is a cell surface molecule that mediates a costimulatory signal crucial for T cell proliferation and lymphokine production. The signal transduction mechanisms of CD28 are not well understood. Itk, a nonreceptor protein tyrosine kinase specifically expressed in T cells and mast cells, has been implicated in the CD28 signaling pathway because of reports that it becomes phosphorylated on tyrosines and associates with CD28 upon cross-linking of the cell surface molecule. To determine whether Itk plays a functional role in CD28 signaling, we compared T cells from Itk-deficient mice and control mice for their responses to CD28 costimulation. T cells defective in Itk were found to be fully competent to respond to costimulation. Whereas the CD3-mediated proliferative response was severely compromised in the absence of Itk, the calcineurin-independent CD28-mediated response was significantly elevated when compared with cells from control animals. The augmented proliferation was not due to increased production of interleukin-2. The results suggest that Itk has distinct roles in the CD3 versus the CD28 signaling pathways. By negatively regulating the amplitude of signaling upon CD28 costimulation, Itk may provide a means for modulating the outcome of T cell activation during development and during antigen-driven immune responses

Investigating antibody neutralization of lyssaviruses using lentiviral pseudotypes: a cross-species comparison

Cross-neutralization between rabies virus (RABV) and two European bat lyssaviruses (EBLV-1 and -2) was analysed using lentiviral pseudotypes as antigen vectors. Glycoprotein (G-protein) cDNA from RABV challenge virus standard-11 (CVS-11) and EBLV-1 and -2 were cloned and co-expressed with human immunodeficiency virus (HIV) or murine leukemia virus (MLV) gag–pol and packageable green fluorescent protein (GFP) or luciferase reporter genes in human cells. The harvested lentiviral (HIV) vector infected over 40 % of baby hamster kidney (BHK) target cells, providing high-titre pseudotype stocks. Tests on blinded antibody-positive (n=15) and -negative (n=45) sera, predetermined by the fluorescent antibody virus neutralization (FAVN) test approved by the World Health Organization (WHO) and Office International des Epizooties (OIE), revealed that the CVS-11 pseudotype assay had 100 % concordance with FAVN and strongly correlated with neutralization titres (r2=0.89). Cross-neutralization tests using sera from RABV-vaccinated humans and animals on pseudotypes with CVS-11, EBLV-1 and EBLV-2 envelopes showed that the relative neutralization titres correlated broadly with the degree of G-protein diversity. Pseudotypes have three major advantages over live-virus neutralization tests: (i) they can be handled in low-biohazard-level laboratories; (ii) the use of reporter genes such as GFP or β-galactosidase will allow the assay to be undertaken at low cost in laboratories worldwide; (iii) each assay requires <10 μl serum. This robust microassay will improve our understanding of the protective humoral immunity that current rabies vaccines confer against emerging lyssaviruses, and will be applicable to surveillance studies, thus helping to control the spread of rabies

Infliximab for the treatment of intravenous immunoglobulin resistant Kawasaki disease complicated by coronary artery aneurysms: a case report

This case report describes an 8 year old boy with IVIG resistant Kawasaki disease complicated by severe bilateral coronary artery aneurysms successfully treated with infliximab, a monoclonal antibody against tumour necrosis factor alpha

Longitudinally Profiling Neutralizing Antibody Response to SARS Coronavirus with Pseudotypes

SARS-CoV spike protein pseudotypes are the basis of an in vitro microneutralization assay sensitive and specific for SARS-CoV neutralizing antibodies