Diseño de las Osteotomías Digitales Incompletas. Técnicas ODI

Tomando como referencia el estudio estadístico realizado, proponemos la utilización de las Técnicas de Osteotomías Digitales Incompletas (Técnicas ODI) para las correcciones quirúrgicas de los dedos, ya que estás cumplen los fundamentos de osificación y fijación mejor que el resto de las osteotomías descritas. Mostramos en este trabajo su diseño y forma de ejecución en función de la patología digital.After doing a statistic study, we propose the use of the incomplete osteotomies (IDO techniques) to correct in a surgical way digit deformities. These kinds of osteotomies have a better fixation and quicker consolidation than the classical complete osteotomies that have been usually applied. In this work we show how to design IDO osteotomies and the way of execution depending on digit deformities.Podologí

The impact of associated tenotomies on the outcome of incomplete phalangeal osteotomies for lesser toe deformities

Partial or incomplete osteotomy (IO) of the phalanx is recently described in the literature. However, the clinical outcome and the rate of complications when applied to lesser toe deformities (LTD) have been never addressed. This study aims to find out if the association of tenotomies to incomplete or partial phalanx osteotomies has a significant impact on the clinical outcomes, the occurrence of complications, and the recovery time after surgery. Methods: A retrospective review of two cohorts of cases operated in our institution for hallux abductus valgus (HAV) and associated LTD from 2008 to 2014 was carried out. The surgical correction of both HAV and the associated LTD was always performed by minimally invasive techniques. The study included a total of 223 patients (723 IO in 556 toes). In 129 cases, the IO for LTD correction was performed without tenotomies, and in 94, the procedure was combined with flexor and/or extensor tenotomies. Patients were assessed with the American Orthopaedic Foot and Ankle Society (AOFAS) questionnaire before surgery and at 6- and 12-month follow-up. Results: The mean preoperative AOFAS score before surgery was similar in both cohorts. At 12-month follow-up, the cohort without tenotomies showed better recovery (95.7 ± 2.8 versus 92.5 ± 6.8; p < 0.01). AOFAS scores decreased as the number of associated LTD increased (r = − 0.814; p < 0.001). Cases operated on by PO + tenotomy showed a high rate of complications such as delayed union of the osteotomy (p < 0.01), hypertrophic callus (p < 0.01), phalangeal fracture at the osteotomy site (p < 0.01), and lack of correction (p < 0.05). The overall occurrence of adverse events was 38.6% in cases operated by PO + tenotomy and 13.9% in cases receiving PO alone (p < 0.0001). Cases operated on without tenotomy showed a shorter time to complete recovery for daily life activities (37.4 ± 2.3 versus 43.0 ± 1.7 days; p < 0.01). Conclusion: The performance of associated tenotomies to incomplete phalanx osteotomies provides worse clinical outcomes, higher complication rates, and longer recovery time as compared to similar forefoot surgeries without tenotomies.Podologí

Pessary with perineal suture for treatment of pelvic organ prolapse: description and benefit of the technique

Producción CientíficaIntroduction and hypothesis:Vaginal pessaries are used as a conservative treatment for POP in women who do not want or are not candidates for surgery, or as a preliminary step to surgery. Our goals are: evaluate the evolution of patients with advanced POP and repeated expulsion of the pessary, who underwent perineal suture to try to maintain the device. Describe the epidemiological characteristics of patients treated with pessaries in our environment, with or without perineal closure. Methods: Observational, descriptive and prospective study (October 2016-March 2021) that includes 352 women with advanced-stage POP treated with a pessary, of which 55, after repeated expulsion of the pessary, were treated with a pessary and perineal suture. Results: After pessary insertion associated with perineal closure, 26 patients (47.2%) expelled the pessary and underwent surgery, and 29 (52.8%) kept the device, avoiding surgery. Regarding the women who required perineal suture: The mean age was higher than in the group of patients who did not need this intervention (75.3 vs. 68.3 years), 94.5% had POP ≥ grade III and 100% had a perineal width > 2.5 cm. Conclusions: Treatment with pessary and perineal closure avoids surgery in women with advanced age and repeated expulsion. Although age should not be an independent factor that limits surgical treatment or the type of intervention, it would be useful to have scales to quantify the frailty of patients, being able to standardize perineal closure in elderly and/or frail women, and in those who do not want or have contraindications for surgery.Publicación en abierto financiada por el Consorcio de Bibliotecas Universitarias de Castilla y León (BUCLE), con cargo al Programa Operativo 2014ES16RFOP009 FEDER 2014-2020 DE CASTILLA Y LEÓN, Actuación:20007-CL - Apoyo Consorcio BUCL

Are Traditional Lima Bean (Phaseolus lunatus L.) Landraces Valuable to Cope with Climate Change? Effects of Drought on Growth and Biochemical Stress Markers

[EN] Agrobiodiversity and adaptability to environmental changes derived from global warming are challenges for the future of agriculture. In this sense, landraces often have high levels of genetic variation, tightly connected with the changing environmental conditions of a territory. The genus Phaseolus, with five domesticated species, is one of the most important sources of proteins, carbohydrates and micronutrients in various countries. This study aimed to compare the adaptation capacity to drought, in the vegetative growth phase, of a commercial cultivar and two landraces traditionally cultivated in the Mediterranean basin of Phaseolus lunatus (Lima bean). Growth and biochemical responses of the analysed genotypes to different water¿deficit treatments were evaluated and compared. In addition, the effectiveness of the voltammetric method for evaluating stress levels in cultivated plants was tested. The studied parameters revealed that P. lunatus is a drought tolerant species, showing similar results for the three cultivars. However, contrary to what was expected from the germination phase results, the commercial variety Peru showed some better responses under water stress conditions. Finally, the voltammetric method proved to be a good and fast tool for assessing oxidative stress in cultivated plants, showing results in agreement with total phenolic compounds and total flavonoid fluctuations.Martínez-Nieto, MI.; González-Orenga, S.; Soriano, P.; Prieto-Mossi, J.; Larrea, E.; Doménech-Carbó, A.; Tofei, AM.... (2022). Are Traditional Lima Bean (Phaseolus lunatus L.) Landraces Valuable to Cope with Climate Change? Effects of Drought on Growth and Biochemical Stress Markers. Agronomy. 12(7):1-20. https://doi.org/10.3390/agronomy1207171512012

Adverse events related to central venous catheters (CVC) and the influence of CVC characteristics on peripheral blood hematopoietic progenitor cell collection in children

Introduction: The use of peripheral blood progenitor cells (PBPCs) as a source for hematopoietic stem cell transplantation (HSCT) in pediatric healthy donors is still under debate. The risk of a central venous catheter (CVC) placement and catheter-related complications continue to be the main arguments to discourage its use. Methods: we present a retrospective analysis of 140 PBPC collections in pediatric patients and donors, describing adverse events (AE) related to CVCs as well as the influence of catheterrelated variables on the efficiency of the leukapheresis. Results: 14 CVC-related AEs were recorded (10%). The most common was fever in 5 patients, 4 of which had a catheter-related bacteriemia. Thrombotic events were only observed in 3 patients with active malignancy. A healthy donor presented a moderate bleeding after catheter withdrawal that resolved with local measures, and none of the rest presented any AE. Regarding variables related to the development of AEs, the subject group (patient or donor) was the only one significantly associated (p < 0.0001). Of interest, efficiency was also related to catheter location, being worse in those located in the femoral vein than in into the jugular or the subclavian veins (p < 0.05). In a multivariate analysis, the only variable significantly associated was catheter size (beta 0.238, p < 0.01). Discussion: Placing a CVC for PBPC collection in pediatric subjects is overall safe; CVC-related complications in pediatric healthy donors are very rare. Furthermore, we should try to place catheters of the largest caliber possible, since the efficiency of the collection is related to this variabl

CRÓNICAS DE LA UNIVERSIDAD AUTÓNOMA DEL ESTADO DE MÉXICO

La Universidad Autónoma del Estado de México una institución múltiple, constituida por áreas diferentes, orientadas, cada una de ellas, al cumplimiento de labores específicas, de acuerdo con la estructura jurídica que le señalan su propia ley y los diferentes reglamentos derivados de la misma. En consecuencia, la urdimbre funcional de sus actividades diversas puede ser expresada, de una manera sencilla, mediante el siguiente esquema: - Área educativo-académica. - Área de investigaciones genéricas. - Área de comunicación y difusión cultura. - Área administrativa. - Área de proyección universitaria hacia la sociedad

A beam-beam monitoring detector for the MPD experiment at NICA

The Multi-Purpose Detector (MPD) is to be installed at the Nuclotron Ion Collider fAcility (NICA) of the Joint Institute for Nuclear Research (JINR). Its main goal is to study the phase diagram of the strongly interacting matter produced in heavy-ion collisions. These studies, while providing insight into the physics of heavy-ion collisions, are relevant for improving our understanding of the evolution of the early Universe and the formation of neutron stars. In order to extend the MPD trigger capabilities, we propose to include a high granularity beam-beam monitoring detector (BE-BE) to provide a level-0 trigger signal with an expected time resolution of 30 ps. This new detector will improve the determination of the reaction plane by the MPD experiment, a key measurement for flow studies that provides physics insight into the early stages of the reaction. In this work, we use simulated Au+Au collisions at NICA energies to show the potential of such a detector to determine the event plane resolution, providing further redundancy to the detectors originally considered for this purpose namely, the Fast Forward Detector (FFD) and the Hadron Calorimeter (HCAL). We also show our results for the time resolution studies of two prototype cells carried out at the T10 beam line at the CERN PS complex.Comment: 16 pages, 12 figures. Updated to published version with added comments and correction

Jejunal microvilli atrophy and reduced nutrient transport in rats with advanced liver cirrhosis: improvement by Insulin-like Growth Factor I

Es reproducción del documenteo publicado en http://dx.doi.org/10.1186/1471-230X-4-12Background: Previous results have shown that in rats with non-ascitic cirrhosis there is an altered transport of sugars and amino acids associated with elongated microvilli. These alterations returned to normal with the administration of Insulin-Like Growth Factor-I (IGF-I). The aims of this study were to explore the evolution of these alterations and analyse the effect of IGF-I in rats with advanced cirrhosis and ascites. Thus, jejunal structure and nutrient transport (D-galactose, L-leucine, L-proline, L-glutamic acid and L-cystine) were studied in rats with ascitic cirrhosis. Methods: Advanced cirrhosis was induced by CCl4 inhalation and Phenobarbital administration for 30 weeks. Cirrhotic animals were divided into two groups which received IGF-I or saline during two weeks. Control group was studied in parallel. Jejunal microvilli were studied by electron microscopy. Nutrient transport was assessed in brush border membrane vesicles using C-14 or S-35-labelled subtracts in the three experimental groups. Results: Intestinal active Na+-dependent transport was significantly reduced in untreated cirrhotic rats. Kinetic studies showed a decreased V-max and a reduced affinity for sugar and four amino acids transporters ( expressed as an increased K-t) in the brush border membrane vesicles from untreated cirrhotic rats as compared with controls. Both parameters were normalised in the IGF-I-treated cirrhotic group. Electron microscopy showed elongation and fusion of microvilli with degenerative membrane lesions and/or notable atrophy. Conclusions: The initial microvilli elongation reported in non ascitic cirrhosis develops into atrophy in rats with advanced cirrhosis and nutrient transports (monosaccharides and amino acids) are progressively reduced. Both morphological and functional alterations improved significantly with low doses of IGF-I

Nanoantibiotics Based in Mesoporous Silica Nanoparticles: New Formulations for Bacterial Infection Treatment.

This review focuses on the design of mesoporous silica nanoparticles for infection treat‐ment. Written within a general context of contributions in the field, this manuscript highlights the major scientific achievements accomplished by Prof. Vallet‐Regí’s research group in the field of silica‐based mesoporous materials for drug delivery. The aim is to bring out her pivotal role on the envisage of a new era of nanoantibiotics by using a deep knowledge on mesoporous materials as drug delivery systems and applying cutting‐edge technologies to design and engineer advanced nanoweapons to fight infection. This review has been divided in two main sections: the first part overviews the influence of the textural and chemical properties of silica‐based mesoporous materials on the loading and release of antibiotic molecules, depending on the host‐guest interactions.Furthermore, this section also remarks the potential of molecular modelling in the design and comprehension of the performance of these release systems. The second part describes the more recent advances in the use of mesoporous silica nanoparticles as versatile nanoplatforms for the development of novel targeted and stimuli‐responsive antimicrobial nanoformulations for future application in personalized infection therapies