48 research outputs found

    The Role of Gender in Descriptive Representation

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    This article broadens consideration of the gender gap from voting differ ences to the larger question of affective preferences for descriptive represen tation (Pitkin 1967). The results, based on a 1993 survey of 416 individuals, suggest that women are far more likely than men to be "gender conscious" in their evaluation of a candidate or a preferred representative. Differences among the 224 women in the sample can be traced to at least four sources. Group interests and feminist attitudes are positive sources of women's preferences for descriptive representation. Conversely, conservative political views deter some women from supporting women in politics. The results also provide partial support for Carroll's (1987) psychological and economic autonomy thesis. Finally, the results suggest that in part the "gender gap" may be a generational gap most prevalent among "baby boomers."Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline

    Real-time Relaxation and Kinetics in Hot Scalar QED: Landau Damping

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    The real time evolution of field condensates with soft length scales k^{-1}>(eT)^{-1} is solved in hot scalar electrodynamics, with a view towards understanding relaxational phenomena in the QGP and the electroweak plasma. We find that transverse gauge invariant non-equilibrium expectation values of fields relax via {\em power laws} to asymptotic amplitudes that are determined by the quasiparticle poles. The long time relaxational dynamics and relevant time scales are determined by the behaviour of the retarded self-energy not at the small frequencies, but at the Landau damping thresholds. This explains the presence of power laws and not of exponential decay. Furthermore, we derive the influence functional, the Langevin equation and the fluctuation-dissipation theorem for the soft modes, identifying the correlation functions that emerge in the classical limit. We show that a Markovian approximation fails to describe the dynamics {\em both} at short and long times. We also introduce a novel kinetic approach that goes beyond the standard Boltzmann equation and incorporates off-shell processes and find that the distribution function for soft quasiparticles relaxes with a power law through Landau damping. We also find an unusual dressing dynamics of bare particles and anomalous (logarithmic) relaxation of hard quasiparticles.Comment: 41 pages, 5 figures, uses revtex, replaced with version to appear in Phys. Rev.

    The United States COVID-19 Forecast Hub dataset

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    Academic researchers, government agencies, industry groups, and individuals have produced forecasts at an unprecedented scale during the COVID-19 pandemic. To leverage these forecasts, the United States Centers for Disease Control and Prevention (CDC) partnered with an academic research lab at the University of Massachusetts Amherst to create the US COVID-19 Forecast Hub. Launched in April 2020, the Forecast Hub is a dataset with point and probabilistic forecasts of incident cases, incident hospitalizations, incident deaths, and cumulative deaths due to COVID-19 at county, state, and national, levels in the United States. Included forecasts represent a variety of modeling approaches, data sources, and assumptions regarding the spread of COVID-19. The goal of this dataset is to establish a standardized and comparable set of short-term forecasts from modeling teams. These data can be used to develop ensemble models, communicate forecasts to the public, create visualizations, compare models, and inform policies regarding COVID-19 mitigation. These open-source data are available via download from GitHub, through an online API, and through R packages

    Genetic mechanisms of critical illness in COVID-19.

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    Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 ×  10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice

    A first update on mapping the human genetic architecture of COVID-19

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