Symmetries and solutions of field equations of axion electrodynamics

The group classification of models of axion electrodynamics with arbitrary self interaction of axionic field is carried out. It is shown that extensions of the basic Poincar\'e invariance of these models appear only for constant and exponential interactions. The related conservation laws are discussed. Using the In\"on\"u-Wigner contraction the non-relativistic limit of equations of axion electrodynamics is found. An extended class of exact solutions for the electromagnetic and axion fields is obtained. Among them there are solutions including up to six arbitrary functions. In particular, solutions which describe propagation with velocities faster than the velocity of light are found. These solutions are smooth and bounded functions which correspond to positive definite and bounded energy density.Comment: New section 6 ia added where the superluminal propagation velocities are discusse

Relativistic Coulomb problem for particles with arbitrary half-integer spin

Using relativistic tensor-bispinorial equations proposed in hep-th/0412213 we solve the Kepler problem for a charged particle with arbitrary half-integer spin interacting with the Coulomb potential.Comment: Misprints are correcte

Galilei invariant theories. I. Constructions of indecomposable finite-dimensional representations of the homogeneous Galilei group: directly and via contractions

All indecomposable finite-dimensional representations of the homogeneous Galilei group which when restricted to the rotation subgroup are decomposed to spin 0, 1/2 and 1 representations are constructed and classified. These representations are also obtained via contractions of the corresponding representations of the Lorentz group. Finally the obtained representations are used to derive a general Pauli anomalous interaction term and Darwin and spin-orbit couplings of a Galilean particle interacting with an external electric field.Comment: 23 pages, 2 table

Os desafios da inclusão produtiva: o caso do programa nacional de inovação e sustentabilidade na agricultura familiar no Tocantins.

Este artigo se propõe compreender como foi construída a agenda voltada à inclusão produtiva e seus desafios a partir das oficinas temáticas do Programa Nacional de Inovação e Sustentabilidade na Agricultura Familiar no Estado do Tocantins, por meio do uso da técnica de observação participante e análise documental. Os resultados apontam que as oficinas possibilitaram a construção de uma agenda de trabalho com a articulação de esforços e competências, criando um ambiente de integração e compartilhamento de expectativas, o que pode corroborar com a formação de nichos de inovação e espaços de concertação para a promoção da inclusão produtiva dos agricultores familiares

Transferência de tecnologia e estratégias de comercialização do pescado da agricultura familiar para a alimentação escolar: a experiência da Embrapa no Estado do Tocantins.

Este artigo tem por objetivo analisar a experiência de transferência de tecnologias e estratégias de comercialização do pescado da agricultura familiar para a alimentação escolar no Tocantins, por meio da articulação de diferentes competências interinstitucionais a fim de promover o desenvolvimento rural e a promoção da segurança alimentar através do incentivo ao consumo de peixe nas escolas públicas. Foram descritas duas ações pilotos coordenadas pela Embrapa Pesca e Aquicultura, ambas com foco em estratégias específicas de comercialização para o público das colônias de pescadores e associações de aquicultores familiares do Tocantins. A construção das estratégias de comercialização foram desenvolvidas a partir da contribuição de cada instituição que atua no projeto e de demandas advindas da agricultura familiar para a inserção do pescado em políticas públicas. Os resultados apontam que as estratégias propostas podem servir como benchmarking para que outras realidades tenham alternativas de comercialização em mercados institucionais

Cabozantinib in progressive medullary thyroid cancer

Purpose Cabozantinib, a tyrosine kinase inhibitor (TKI) of hepatocyte growth factor receptor (MET), vascular endothelial growth factor receptor 2, and rearranged during transfection (RET), demonstrated clinical activity in patients with medullary thyroid cancer (MTC) in phase I. Patients and Methods We conducted a double-blind, phase III trial comparing cabozantinib with placebo in 330 patients with documented radiographic progression of metastatic MTC. Patients were randomly assigned (2:1) to cabozantinib (140 mg per day) or placebo. The primary end point was progression-free survival (PFS). Additional outcome measures included tumor response rate, overall survival, and safety. Results The estimated median PFS was 11.2 months for cabozantinib versus 4.0 months for placebo (hazard ratio, 0.28; 95% CI, 0.19 to 0.40; P < .001). Prolonged PFS with cabozantinib was observed across all subgroups including by age, prior TKI treatment, and RET mutation status (hereditary or sporadic). Response rate was 28% for cabozantinib and 0% for placebo; responses were seen regardless of RET mutation status. Kaplan-Meier estimates of patients alive and progression-free at 1 year are 47.3% for cabozantinib and 7.2% for placebo. Common cabozantinib-associated adverse events included diarrhea, palmar-plantar erythrodysesthesia, decreased weight and appetite, nausea, and fatigue and resulted in dose reductions in 79% and holds in 65% of patients. Adverse events led to treatment discontinuation in 16% of cabozantinib-treated patients and in 8% of placebo-treated patients. Conclusion Cabozantinib (140 mg per day) achieved a statistically significant improvement of PFS in patients with progressive metastatic MTC and represents an important new treatment option for patients with this rare disease. This dose of cabozantinib was associated with significant but manageable toxicity

Relativistic wave equations for interacting massive particles with arbitrary half-intreger spins

New formulation of relativistic wave equations (RWE) for massive particles with arbitrary half-integer spins s interacting with external electromagnetic fields are proposed. They are based on wave functions which are irreducible tensors of rank $n ($n=s-\frac12$) antisymmetric w.r.t. n pairs of indices, whose components are bispinors. The form of RWE is straightforward and free of inconsistencies associated with the other approaches to equations describing interacting higher spin particles