Formulation and evaluation of matrix transdermal patches of meloxicam

The present study deals with the formulation and evaluation of transdermalpatches of meloxicam towards enhance its permeation through the skin and maintain the plasma levelconcentration. Transdermal patches were prepared by using polymers like Chitosan, HPMC 15cps and EC 20cpsat various concentrations by solvent casting technique employing dibutyl phthalate as plasticizer and isopropylmyristate as permeation enhancer. The transdermal patches were evaluated for their physico-chemical properties and in-vitro drug release. The transdermal patches were found to be transparent and smooth in texture. Amongthe formulations studied, at the end of 12th hour, the minimum and maximum in-vitro drug release was observedfor the formulations F12 and F4i.e. 80.012 ± 2.012 % and 98.365±3.012%. The mechanism of drugrelease was found to be Non-Fickian diffusion controlled. FT-IR studies revealed theintegrity of the drug in theformulations. Keywords: Transdermal Patches, Meloxicam, Chitosan, HPMC 15cps, EC 20 cps, in-vitro diffusion studies

Therapeutic Potential of Traditional Indian Herbal Medicine in COVID-19: A Narrative Review

Background: Coronavirus disease 2019 (COVID-19) has become a global challenge to the health care system. A novel agent to combat this deadly virus is still a matter of research. Herbal molecules have served humanity since the beginning. Objectives: This narrative review aims to study the antiviral properties of medicinal plants, which are already effectively used in the past against various viruses. It derives the importance of exploration of such phytochemicals, which can be complementarily used to treat COVID-19. Methods: Studies related to traditional medicine and treatment for viruses were retrieved from databases including PubMed, Google scholar until December 2020 using the keywords SARS-CoV-2, COVID-19, Immunological, Phyto-chemicals, Traditional Medicine. The resulting publications were analyzed to develop a narrative review on the traditional Indian phytochemicals that have been shown to effectively treat various viral infections and potentially treat or prevent COVID-19. Results: Many of the researches are showing that Indian herbal compounds have a significant potential against viral diseases. Plants like Azadirachta indica, Withania somnifera, Tinospora cordifolia, Ocimum basilicum, and many more have been shown tremendous antiviral, anti-inflammatory, and immune-modulatory activities. Conclusion: Phytochemicals obtained from the herbs can be helpful in the treatment and prevention of SARS-CoV-2via various modes such as inhibition of attachment, penetration, uncoating, replication, assembly, and release of respiratory viruses. Further analysis of the potential phytochemicals in treating SARS-CoV-2 in clinical trials is warranted

<span style="font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: EN-GB;mso-fareast-language:EN-US;mso-bidi-language:AR-SA" lang="EN-GB">Synthesis, antimicrobial, insecticidal and anthelmintic activity studies of some new alkyl/aryl 6-(4-(4-(4-methyl-1<i style="mso-bidi-font-style:normal">H</i>-1,2,3-triazol-1-yl)phenyl amino)phenyl)-N²,N⁴-bis(4-methoxyphenyl)-1,3,5-triazin-2,4-diamine carbamic acid ester derivatives</span>

1020-1026<span style="font-size:12.0pt;font-family: " times="" new="" roman";mso-fareast-font-family:"times="" roman";mso-ansi-language:="" en-gb;mso-fareast-language:en-us;mso-bidi-language:ar-sa"="" lang="EN-GB">New carbamic acid ester derivatives containing 1,2,3-triazole nucleus have been synthesized and their antimicrobial, insecticidal and anthelmintic activity investigated. 6-(4-(4-Methyl-1H-5-carbonyl azide-1,2,3-triazol-1-yl)phenyl amino)phenyl-N2-N4-bis(-methoxy phenyl)-1,3,5-triazin-2, 4-diamine has been used as a precursor to synthesize some new alkyl/aryl 6-(4-(4-methyl-1H-1,2,3-triazol-1-yl)phenylamino)phenyl-N2,N4–bis(4-methoxyphenyl)- 1,3,5-triazin-2,4-diamine carbamic acid ester derivatives. The compounds have been screened for their antibacterial efficacy against <i style="mso-bidi-font-style: normal">B. subtilis, E. coli, K. pneumonie and <i style="mso-bidi-font-style: normal">S. aureus and for their antifungal efficacy against A. flavus, A. niger, F. oxysporum and Trichoderma viridae. Insecticidal activity against Periplaneta americana and anthelmintic activity against Pheretima posthuma (Indian adult earthworm) have been studied.</span

Synthesis, antimicrobial and insecticidal activity of some 4<i style="">H</i>-1,2,4 triazole derivatives

956-959 1-(Substituted benzylidene) semicarbazide has been used as a precursor to synthesize some important biologically active 3-substituted phenyl, 4H-1,2,4 triazole derivatives. Reaction of ethanolic solution of schiff's base of substituted aromatic aldehyde 1 with ethanolic solution of FeCl3.6H2O (1 mole FeCl3.6H2O in 10 mL ethanol) yields the 4H-1,2,4 triazole-3-derivative 2. Several derivatives have been synthesized and screened for their antibacterial efficacy against Bacillus subtilis, Escherichia coli, Staphyllococcus aureus and Klebsiella pneumoniae, Antifungal activity against Aspergillus flavus, Fusarium oxysporum, Aspergillus niger and Trichoderma viridae and insecticidal activity against Periplaneta americana. </smarttagtype

<span style="font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: EN-GB;mso-fareast-language:EN-US;mso-bidi-language:AR-SA" lang="EN-GB">Synthesis, characterization, antimicrobial, insecticidal and anthelmintic screening of some new s-triazine derivatives of pyrazoline, pyrimidine, isoxazoline and isothiazoline moiety</span>

1400-14101-(4-(4,6-Bis(4′-chlorophenylamino)-1,3,5-triazin-2-ylamino)-phenyl)-3-(aryl substituted) prop-2-en-1-one 3 has been used as precursor to synthesize some new pyrimidine, pyrazoline, isoxazoline and isothiazoline derivatives. Several derivatives have been synthesized and evaluated for their antimicrobial efficacy against Bacillus subtilis, <i style="mso-bidi-font-style: normal">Escherichia coli, Klebsiella pneumoniae and <i style="mso-bidi-font-style: normal">Staphyllococcus aureus, antifungal activity against B. fragilis, B. vulgatus, F. oxysporum and T. viridae, insecticidal activity against Periplaneta americana and anthelmintic activity against Pheretima posthuma (Indian adult earthworm)

Synthesis, antimicrobial and insecticidal activity of some new cinnoline based chalcones and cinnoline based pyrazoline derivatives

830-835 4-Methyl-3-acetyl cinnoline used as a precursor to synthesize some new cinnoline based chalcones 3a-l. Reaction of chalcone with hydrazine hydrate in acetic acid yields the cinnoline based pyrazoline derivatives 4a-l. The structures of synthesized compounds have been confirmed by elemental analysis, IR and NMR spectral studies and  evaluated for their antibacterial activity against Bacillus subtilis, Escherichia coli, Staphylococcus aureaus and Klebsiella pneumoniae, antifungal activity against Aspergillus flavus, Fusarium oxysporum, Aspergillus niger and Trichoderma viridae and insecticidal activity against Periplaneta americana. </smarttagtype

Supplementary figs & table - Effective uptake of folate-functionalized ethionamide-loaded hybrid system: targeting alveolar macrophages nnm-2021-0468

Aim: To assess the targeting ability of hybrid nanosystems functionalized with folate. It also aimed to reduce stomach intolerance by substituting the oral route for parenteral delivery. Method: The nanosystems, prepared by nanoprecipitation technique, utilized a one-step method to prepare nanoparticles followed by surface functionalization through adsorption. The prepared nanosystems underwent physical characterization, in vitro and in vivo evaluations. Result: The nanosystems were effective in targeting the alveolar macrophages. Ethionamide was released from the formulation over 5 days. Fourier-transform infrared results proved the structural characteristics, and the positive charge further improved the targeting efficacy on the functionalized system. Conclusion: The hybrid formulation improved the release characteristics. Reduction in dosing frequency due to prolonged release improves compliance with the dosage regimen.</p

Abstracts of Scientifica 2022

This book contains the abstracts of the papers presented at Scientifica 2022, Organized by the Sancheti Institute College of Physiotherapy, Pune, Maharashtra, India, held on 12–13 March 2022. This conference helps bring researchers together across the globe on one platform to help benefit the young researchers. There were six invited talks from different fields of Physiotherapy and seven panel discussions including over thirty speakers across the globe which made the conference interesting due to the diversity of topics covered during the conference. Conference Title:  Scientifica 2022Conference Date: 12–13 March 2022Conference Location: Sancheti Institute College of PhysiotherapyConference Organizer: Sancheti Institute College of Physiotherapy, Pune, Maharashtra, Indi