Noise shaping Asynchronous SAR ADC based time to digital converter

Time-to-digital converters (TDCs) are key elements for the digitization of timing information in modern mixed-signal circuits such as digital PLLs, DLLs, ADCs, and on-chip jitter-monitoring circuits. Especially, high-resolution TDCs are increasingly employed in on-chip timing tests, such as jitter and clock skew measurements, as advanced fabrication technologies allow fine on-chip time resolutions. Its main purpose is to quantize the time interval of a pulse signal or the time interval between the rising edges of two clock signals. Similarly to ADCs, the performance of TDCs are also primarily characterized by Resolution, Sampling Rate, FOM, SNDR, Dynamic Range and DNL/INL. This work proposes and demonstrates 2nd order noise shaping Asynchronous SAR ADC based TDC architecture with highest resolution of 0.25 ps among current state of art designs with respect to post-layout simulation results. This circuit is a combination of low power/High Resolution 2nd Order Noise Shaped Asynchronous SAR ADC backend with simple Time to Amplitude converter (TAC) front-end and is implemented in 40nm CMOS technology. Additionally, special emphasis is given on the discussion on various current state of art TDC architectures.Electrical and Computer Engineerin

Creating effective focus cues in multi-plane 3D displays.

Focus cues are incorrect in conventional stereoscopic displays. This causes a dissociation of vergence and accommodation, which leads to visual fatigue and perceptual distortions. Multi-plane displays can minimize these problems by creating nearly correct focus cues. But to create the appearance of continuous depth in a multi-plane display, one needs to use depth-weighted blending: i.e., distribute light intensity between adjacent planes. Akeley et al. [ACM Trans. Graph. 23, 804 (2004)] and Liu and Hua [Opt. Express 18, 11562 (2009)] described rather different rules for depth-weighted blending. We examined the effectiveness of those and other rules using a model of a typical human eye and biologically plausible metrics for image quality. We find that the linear blending rule proposed by Akeley and colleagues [ACM Trans. Graph. 23, 804 (2004)] is the best solution for natural stimuli

Conformational changes in the GTPase modules of the signal reception particle and its receptor drive initiation of protein translocation

During cotranslational protein targeting, two guanosine triphosphatase (GTPase) in the signal recognition particle (SRP) and its receptor (SR) form a unique complex in which hydrolyses of both guanosine triphosphates (GTP) are activated in a shared active site. It was thought that GTP hydrolysis drives the recycling of SRP and SR, but is not crucial for protein targeting. Here, we examined the translocation efficiency of mutant GTPases that block the interaction between SRP and SR at specific stages. Surprisingly, mutants that allow SRP–SR complex assembly but block GTPase activation severely compromise protein translocation. These mutations map to the highly conserved insertion box domain loops that rearrange upon complex formation to form multiple catalytic interactions with the two GTPs. Thus, although GTP hydrolysis is not required, the molecular rearrangements that lead to GTPase activation are essential for protein targeting. Most importantly, our results show that an elaborate rearrangement within the SRP–SR GTPase complex is required to drive the unloading and initiate translocation of cargo proteins

Social Dynamics of Gang Involvement: A Mathematical Approach

Gangs have played a significant role in the social and political history of the United States, and continue to impact the country today, as gang violence and participation rates continue to grow. In this paper, we explore the dynamics of gang involvement between at-risk individuals, gang members, and reformed gang members using an SIR-type model. We investigate the effect that social influence of reformed gang members has on the at-risk population using a general function, which takes into account the cost of gang membership and a threat factor. Our results show that the influence of the reformed population is highly sensitive to initial gang member population size, recidivism, and cost