The Effect of Angiotensin Converting Enzyme Genotype on Aerobic Capacity Following High Intensity Interval Training

International Journal of Exercise Science 7(3) : 250-259, 2014. Obesity increases the risk of developing type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). Physical activity can reduce T2DM and CVD risk, and increase aerobic capacity, a significant predictor of all-cause mortality and morbidity. High intensity interval training (HIIT) produces similar improvements in aerobic capacity to continuous moderate exercise (CME). Different genotypes of angiotensin converting enzyme (ACE) have been implicated in improving aerobic capacity and therefore predicted health. This study investigated the effects of different ACE genotypes on the impact of 6 weeks of HIIT on aerobic capacity, and thus health status. 20 young adults were recruited for this study; test subjects completed 6 weeks of HIIT 3 times a week. VO2max was tested to determine aerobic capacity pre- and post-HIIT and DNA collected from saliva for determination ACE genotype. After 6 weeks of HIIT there was no significant change in VO2max; when subjects were separated into responder categories, high responders significantly increased their aerobic capacity whilst there was a large but non-significant decrease in non-responders. Subjects carrying a D-allele showed a significant increase in VO2max following HIIT indicating specific ACE genotypes may be associated with differing VO2max responses. These preliminary results suggest that HIIT can significantly reduce the time required for exercise whilst still achieving notable improvements in aerobic capacity in high responders; they also indicate that ACE D-allele carriers who would not usually be expected to show large VO2max responses following CME may yield equivalent aerobic capacity improvements following HIIT, and thereby reduce their overall morbidity and mortality disease risk

Association of Previous Measles Infection With Markers of Acute Infectious Disease Among 9- to 59-Month-Old Children in the Democratic Republic of the Congo.

BackgroundTransient immunosuppression and increased susceptibility to other infections after measles infection is well known, but recent studies have suggested the occurrence of an "immune amnesia" that could have long-term immunosuppressive effects.MethodsWe examined the association between past measles infection and acute episodes of fever, cough, and diarrhea among 2350 children aged 9 to 59 months whose mothers were selected for interview in the 2013-2014 Democratic Republic of the Congo (DRC) Demographic and Health Survey (DHS). Classification of children who had had measles was completed using maternal recall and measles immunoglobulin G serostatus obtained via dried-blood-spot analysis with a multiplex immunoassay. The association with time since measles infection and fever, cough, and diarrhea outcomes was also examined.ResultsThe odds of fever in the previous 2 weeks were 1.80 (95% confidence interval [CI], 1.25-2.60) among children for whom measles was reported compared to children with no history of measles. Measles vaccination demonstrated a protective association against selected clinical markers of acute infectious diseases.ConclusionOur results suggest that measles might have a long-term effect on selected clinical markers of acute infectious diseases among children aged 9 to 59 months in the DRC. These findings support the immune-amnesia hypothesis suggested by others and underscore the need for continued evaluation and improvement of the DRC's measles vaccination program

Pulsating hydrogen-deficient white dwarfs and pre-white dwarfs observed with TESS : II. Discovery of two new GW Vir stars: TIC 333432673 and TIC 095332541

Context. The Transiting Exoplanet Survey Satellite (TESS) mission is revolutionizing the blossoming area of asteroseismology, particularly of pulsating white dwarfs and pre-white dwarfs, thus continuing the impulse of its predecessor, the Kepler mission. Aims. In this paper, we present the observations from the extended TESS mission in both 120 s short-cadence and 20 s ultra-short cadence mode of two pre-white dwarf stars showing hydrogen deficiency. We identify them as two new GW Vir stars, TIC 333432673 and TIC 095332541. We apply the tools of asteroseismology with the aim of deriving their structural parameters and seismological distances. Methods. We carried out a spectroscopic analysis and a spectral fitting of TIC 333432673 and TIC 095332541. We also processed and analyzed the high-precision TESS photometric light curves of the two target stars, and derived their oscillation frequencies. We performed an asteroseismological analysis of these stars on the basis of PG 1159 evolutionary models that take into account the complete evolution of the progenitor stars. We searched for patterns of uniform period spacings in order to constrain the stellar mass of the stars. We employed the individual observed periods to search for a representative seismological model. Results. The analysis of the TESS light curves of TIC 333432673 and TIC 095332541 reveals the presence of several oscillations with periods ranging from 350 to 500 s associated to typical gravity (g)-modes. From follow-up ground-based spectroscopy, we find that both stars have a similar effective temperature (Teff = 120 000 ± 10 000 K) and surface gravity (log g = 7.5 ± 0.5), but a different He/C composition of their atmosphere. On the basis of PG 1159 evolutionary tracks, we derived a spectroscopic mass of M? = 0.58+0.16 −0.08 M for both stars. Our asteroseismological analysis of TIC 333432673 allowed us to find a constant period spacing compatible with a stellar mass M? ∼ 0.60 − 0.61 M , and an asteroseismological model for this star with a stellar mass M? = 0.589 ± 0.020 M , as well as a seismological distance of d = 459+188 −156 pc. For this star, we find an excellent agreement between the different methods to infer the stellar mass, and also between the seismological distance and that measured with Gaia (dGaia = 389+5.6 −5.2 pc). For TIC 095332541, we have found a possible period spacing that suggests a stellar mass of M? ∼ 0.55−0.57 M . Unfortunately, we have not been able to find an asteroseismological model for this star. Conclusions. Using the high-quality data collected by the TESS space mission and follow-up spectroscopy, we have been able to discover and characterize two new GW Vir stars. The TESS mission is having, and will continue to have, an unprecedented impact on the area of white-dwarf asteroseismology

Pulsating hydrogen-deficient white dwarfs and pre-white dwarfs observed with TESS : II. Discovery of two new GW Vir stars: TIC 333432673 and TIC 095332541

Context. The Transiting Exoplanet Survey Satellite (TESS) mission is revolutionizing the blossoming area of asteroseismology, particularly of pulsating white dwarfs and pre-white dwarfs, thus continuing the impulse of its predecessor, the Kepler mission. Aims. In this paper, we present the observations from the extended TESS mission in both 120 s short-cadence and 20 s ultra-short cadence mode of two pre-white dwarf stars showing hydrogen deficiency. We identify them as two new GW Vir stars, TIC 333432673 and TIC 095332541. We apply the tools of asteroseismology with the aim of deriving their structural parameters and seismological distances. Methods. We carried out a spectroscopic analysis and a spectral fitting of TIC 333432673 and TIC 095332541. We also processed and analyzed the high-precision TESS photometric light curves of the two target stars, and derived their oscillation frequencies. We performed an asteroseismological analysis of these stars on the basis of PG 1159 evolutionary models that take into account the complete evolution of the progenitor stars. We searched for patterns of uniform period spacings in order to constrain the stellar mass of the stars. We employed the individual observed periods to search for a representative seismological model. Results. The analysis of the TESS light curves of TIC 333432673 and TIC 095332541 reveals the presence of several oscillations with periods ranging from 350 to 500 s associated to typical gravity (g)-modes. From follow-up ground-based spectroscopy, we find that both stars have a similar effective temperature (Teff = 120 000 ± 10 000 K) and surface gravity (log g = 7.5 ± 0.5), but a different He/C composition of their atmosphere. On the basis of PG 1159 evolutionary tracks, we derived a spectroscopic mass of M? = 0.58+0.16 −0.08 M for both stars. Our asteroseismological analysis of TIC 333432673 allowed us to find a constant period spacing compatible with a stellar mass M? ∼ 0.60 − 0.61 M , and an asteroseismological model for this star with a stellar mass M? = 0.589 ± 0.020 M , as well as a seismological distance of d = 459+188 −156 pc. For this star, we find an excellent agreement between the different methods to infer the stellar mass, and also between the seismological distance and that measured with Gaia (dGaia = 389+5.6 −5.2 pc). For TIC 095332541, we have found a possible period spacing that suggests a stellar mass of M? ∼ 0.55−0.57 M . Unfortunately, we have not been able to find an asteroseismological model for this star. Conclusions. Using the high-quality data collected by the TESS space mission and follow-up spectroscopy, we have been able to discover and characterize two new GW Vir stars. The TESS mission is having, and will continue to have, an unprecedented impact on the area of white-dwarf asteroseismology

Влияние тяжелых металлов на жизнеспособность пыльцы некоторых древесных

The influence of Сu, Zn, Pb, Cr on sensitivity male gametophyte of Acer negundo, Robinia pseudoacacia, Philadelphus coronarius, Aesculus hippocastanum, Betula pendula, Catalpa bignonioides, Tilia cordata, Elaeagnus angustifolia was investigated. The most sensitive to metals have appeared the following species: to Cu and Zn - Betula pendula, Catalpa bignonoides, to Pb - Philadelphus coronarius, Catalpa bignonoides to Cr - Philadelphus coronarius, Catalpa bignonoides. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/1074

Dairy-CropSyst: Gaseous emissions and nutrient fate modeling tool

Dairy confined animal feeding operations (CAFO) are required to implement nutrient management plans for minimizing the risk of water resource degradation and report gaseous emissions when exceeding certain threshold values. Although tools exist to aid in completing such tasks, few integrate the impact of on-farm manure treatment unit operations such as anaerobic digestion, solids separation, and nutrient recovery. Furthermore, existing tools do not estimate the nutrient value of recovered products and effluent leaving the dairy system or the nutrient fate after effluent is applied to crop fields. Dairy-CropSyst is a decision support tool for researchers and CAFO managers aimed at evaluating the effects of different manure treatment unit operations on gaseous emission and nutrient fate in dairy systems. The model tracks nutrients through the dairy system, including inorganic and organic forms of carbon, nitrogen, and phosphorus. This is accomplished by integrating established transformation and emission equations, performance parameters of manure treatments from industrial data and literature, and using a cropping system model for the land application evaluation. Predicted and observed emission values for greenhouse gases (GHG) and ammonia from different dairy unit operations were found in good agreement. The use of Dairy-CropSyst has the potential to assist the dairy industry in decision making on manure management treatment strategies and as a tool for reporting GHG and ammonia emissions

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.

Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and indices of beta-cell function (HOMA-B) and insulin resistance (HOMA-IR) in up to 46,186 nondiabetic participants. Follow-up of 25 loci in up to 76,558 additional subjects identified 16 loci associated with fasting glucose and HOMA-B and two loci associated with fasting insulin and HOMA-IR. These include nine loci newly associated with fasting glucose (in or near ADCY5, MADD, ADRA2A, CRY2, FADS1, GLIS3, SLC2A2, PROX1 and C2CD4B) and one influencing fasting insulin and HOMA-IR (near IGF1). We also demonstrated association of ADCY5, PROX1, GCK, GCKR and DGKB-TMEM195 with type 2 diabetes. Within these loci, likely biological candidate genes influence signal transduction, cell proliferation, development, glucose-sensing and circadian regulation. Our results demonstrate that genetic studies of glycemic traits can identify type 2 diabetes risk loci, as well as loci containing gene variants that are associated with a modest elevation in glucose levels but are not associated with overt diabetes

Personalized Nutrition as a Key Contributor to Improving Radiation Response in Breast Cancer

Understanding metabolic and immune regulation inherent to patient populations is key to improving the radiation response for our patients. To date, radiation therapy regimens are prescribed based on tumor type and stage. Patient populations who are noted to have a poor response to radiation such as those of African American descent, those who have obesity or metabolic syndrome, or senior adult oncology patients, should be considered for concurrent therapies with radiation that will improve response. Here, we explore these populations of breast cancer patients, who frequently display radiation resistance and increased mortality rates, and identify the molecular underpinnings that are, in part, responsible for the radiation response and that result in an immune-suppressive tumor microenvironment. The resulting immune phenotype is discussed to understand how antitumor immunity could be improved. Correcting nutrient deficiencies observed in these populations should be considered as a means to improve the therapeutic index of radiation therapy

Efficacy of Structural-Level Condom Distribution Interventions: A Meta-Analysis of U.S. and International Studies, 1998–2007

This systematic review examines the overall efficacy of U.S. and international-based structural-level condom distribution interventions (SLCDIs) on HIV risk behaviors and STIs and identifies factors associated with intervention efficacy. A comprehensive literature search of studies published from January 1988 through September 2007 yielded 21 relevant studies. Significant intervention effects were found for the following outcomes: condom use, condom acquisition/condom carrying, delayed sexual initiation among youth, and reduced incident STIs. The stratified analyses for condom use indicated that interventions were efficacious for various groups (e.g., youth, adults, males, commercial sex workers, clinic populations, and populations in areas with high STI incidence). Interventions increasing the availability of or accessibility to condoms or including additional individual, small-group or community-level components along with condom distribution were shown to be efficacious in increasing condom use behaviors. This review suggests that SLCDIs provide an efficacious means of HIV/STI prevention