629 research outputs found
Mini école de médecine : pourquoi vous devriez tenter les séminaires virtuels, animés par des étudiants
Implication Statement
Mini Med School (MMS) programs led by medical students provide a unique opportunity for community members to access free and accurate health information while engaging with the education of medical students. Virtually delivered MMS programs reduce barriers to access. 90.3% of participants in a recent MMS enjoyed medical students delivering the seminars. 63.6% of participants preferred virtual MMS seminars, with 31.8% preferring a combination of virtual and in-person delivery. Student-led, virtually delivered MMS programs are an engaging way to support both medical student and community education while strengthening community ties with local medical schools.ĂnoncĂ© des implications de la recherche
Les sĂ©minaires de la Mini Ă©cole de mĂ©decine (MĂM) prĂ©sentĂ©s par des Ă©tudiants en mĂ©decine offrent une occasion unique aux membres de la communautĂ© de profiter dâinformations gratuites et prĂ©cises en matiĂšre de santĂ© tout en contribuant Ă la formation des Ă©tudiants. Lâoffre de sĂ©minaires MĂM en mode virtuel rend ces activitĂ©s plus accessibles. Une grande majoritĂ© des participants (90,3 %) Ă une MĂM tenue rĂ©cemment ont aimĂ© le fait que des sĂ©minaires soient animĂ©s par des Ă©tudiants, 63,6 % dâentre eux ont prĂ©fĂ©rĂ© les sĂ©minaires MĂM virtuels et 31,8 % se sont dits favorables Ă une combinaison de sĂ©minaires virtuels et en personne. Les exposĂ©s prĂ©sentĂ©s virtuellement par des Ă©tudiants dans le cadre de la MĂM constituent un moyen intĂ©ressant de promouvoir aussi bien lâĂ©ducation des Ă©tudiants que celle de la communautĂ©, tout en renforçant les liens entre cette derniĂšre et les facultĂ©s de mĂ©decine locales
Mini Med School: why you should try a virtual, medical student-led program
Implication Statement
Mini Med School (MMS) programs led by medical students provide a unique opportunity for community members to access free and accurate health information while engaging with the education of medical students. Virtually delivered MMS programs reduce barriers to access. 90.3% of participants in a recent MMS enjoyed medical students delivering the seminars. 63.6% of participants preferred virtual MMS seminars, with 31.8% preferring a combination of virtual and in-person delivery. Student-led, virtually delivered MMS programs are an engaging way to support both medical student and community education while strengthening community ties with local medical schools
Impact of Porous Silica Nanosphere Architectures on the Catalytic Performance of Supported Sulphonic Acid Sites for Fructose Dehydration to 5âHydroxymethylfurfural
5âhydroxymethylfurfural represents a key chemical in the drive towards a sustainable circular economy within the chemical industry. The final step in 5âhydroxymethylfurfural production is the acid catalysed dehydration of fructose, for which supported organoacids are excellent potential catalyst candidates. Here we report a range of solid acid catalysis based on sulphonic acid grafted onto different porous silica nanosphere architectures, as confirmed by TEM, N2 porosimetry, XPS and ATRâIR. All four catalysts display enhanced active site normalised activity and productivity, relative to alternative silica supported equivalent systems in the literature, with inâpore diffusion of both substrate and product key to both performance and humin formation pathway. An increase inâpore diffusion coefficient of 5âhydroxymethylfurfural within wormlike and stellate structures results in optimal productivity. In contrast, poor diffusion within a raspberryâlike morphology decreases rates of 5âhydroxymethylfurfural production and increases its consumption within humin formation
Impact of Porous Silica Nanosphere Architectures on the Catalytic Performance of Supported Sulphonic Acid Sites for Fructose Dehydration to 5-Hydroxymethylfurfural
5-hydroxymethylfurfural represents a key chemical in the drive towards a sustainable circular economy within the chemical industry. The final step in 5-hydroxymethylfurfural production is the acid catalysed dehydration of fructose, for which supported organoacids are excellent potential catalyst candidates. Here we report a range of solid acid catalysis based on sulphonic acid grafted onto different porous silica nanosphere architectures, as confirmed by TEM, N2 porosimetry, XPS and ATR-IR. All four catalysts display enhanced active site normalised activity and productivity, relative to alternative silica supported equivalent systems in the literature, with in-pore diffusion of both substrate and product key to both performance and humin formation pathway. An increase in-pore diffusion coefficient of 5-hydroxymethylfurfural within wormlike and stellate structures results in optimal productivity. In contrast, poor diffusion within a raspberry-like morphology decreases rates of 5-hydroxymethylfurfural production and increases its consumption within humin formation
Residual Energy Harvesting from Light Transients Using Hematite as an Intrinsic Photocapacitor in a Symmetrical Cell
Hematite as a sustainable photoabsorber material offers a band gap close to 2 eV and photoanode characteristics, but usually requires additional catalysts to enhance surface redox chemistry during steady state light energy harvesting for water splitting. Here, for a highly doped hematite film, sufficient intrinsic photocapacitor behavior is reported for the conversion of light transients into energy. Residual energy is harvested in a symmetric architecture with two opposing mesoporous hematite films on conductive glass. Transient light energy harvesting is shown to occur without the need for water splitting
Random field sampling for a simplified model of melt-blowing considering turbulent velocity fluctuations
In melt-blowing very thin liquid fiber jets are spun due to high-velocity air
streams. In literature there is a clear, unsolved discrepancy between the
measured and computed jet attenuation. In this paper we will verify numerically
that the turbulent velocity fluctuations causing a random aerodynamic drag on
the fiber jets -- that has been neglected so far -- are the crucial effect to
close this gap. For this purpose, we model the velocity fluctuations as vector
Gaussian random fields on top of a k-epsilon turbulence description and develop
an efficient sampling procedure. Taking advantage of the special covariance
structure the effort of the sampling is linear in the discretization and makes
the realization possible
Gonadal sex patterns p21-induced cellular senescence in mouse and human glioblastoma
Males exhibit higher incidence and worse prognosis for the majority of cancers, including glioblastoma (GBM). Disparate survival may be related to sex-biased responses to treatment, including radiation. Using a mouse model of GBM, we show that female cells are more sensitive to radiation, and that senescence represents a major component of the radiation therapeutic response in both sexes. Correlation analyses revealed that the CDK inhibitor p21 and irradiation induced senescence were differentially regulated between male and female cells. Indeed, female cellular senescence was more sensitive to changes in p21 levels, a finding that was observed in wildtype and transformed murine astrocytes, as well as patient-derived GBM cell lines. Using a novel Four Core Genotypes model of GBM, we further show that sex differences in p21-induced senescence are patterned during early development by gonadal sex. These data provide a rationale for the further study of sex differences in radiation response and how senescence might be enhanced for radiation sensitization. The determination that p21 and gonadal sex are required for sex differences in radiation response will serve as a foundation for these future mechanistic studies
Development of Measure Yourself Concerns and Wellbeing for informal caregivers of people with cancer â a multicentred study
Purpose: Measure Yourself Concerns and Wellbeing (MYCaW) is a validated person-centred measure of the concerns and wellbeing of people affected by cancer. Research suggests that the concerns of informal caregivers (ICs) are as complex and severely rated as people with cancer, yet MYCaW has only been used to represent cancer patientsâ concerns and wellbeing. This paper reports on the development of a new qualitative coding framework for MYCaW to capture the concerns of ICs, to better understand the needs of this group.
Methods: This multicentred study involved collection of data from ICs receiving support from two UK cancer support charities (Penny Brohn UK and Cavendish Cancer Care). Qualitative codes were developed through a detailed thematic analysis of ICsâ stated concerns.
Results: Thematic analysis of IC questionnaire data identified key themes which were translated into a coding framework with two overarching sections; 1. âinformal caregiver concerns for selfâ and 2. âinformal caregiver concerns for the person with cancerâ. Supercategories with specific accompanying codes were developed for each section. Two further rounds of framework testing across different cohorts allowed for iterative development and refinement of the framework content.
Conclusions: This is the first person-centred tool specifically designed for capturing ICâs concerns through their own words. This coding framework will allow for IC data to be analysed using a rigorous and reproducible method, and therefore reported in a standardised way. This may also be of interest to those exploring the needs of ICs of people in other situations
Prospective Home-use Study on Non-invasive Neuromodulation Therapy for Essential Tremor.
Highlights: This prospective study is one of the largest clinical trials in essential tremor to date. Study findings suggest that individualized non-invasive neuromodulation therapy used repeatedly at home over three months results in safe and effective hand tremor reduction and improves quality of life for many essential tremor patients.
Background: Two previous randomized, controlled, single-session trials demonstrated efficacy of non-invasive neuromodulation therapy targeting the median and radial nerves for reducing hand tremor. This current study evaluated efficacy and safety of the therapy over three months of repeated home use.
Methods: This was a prospective, open-label, post-clearance, single-arm study with 263 patients enrolled across 26 sites. Patients were instructed to use the therapy twice daily for three months. Pre-specified co-primary endpoints were improvements on clinician-rated Tremor Research Group Essential Tremor Rating Assessment Scale (TETRAS) and patient-rated Bain & Findley Activities of Daily Living (BF-ADL) dominant hand scores. Other endpoints included improvement in the tremor power detected by an accelerometer on the therapeutic device, Clinical and Patient Global Impression scores (CGI-I, PGI-I), and Quality of Life in Essential Tremor (QUEST) survey.
Results: 205 patients completed the study. The co-primary endpoints were met (pâȘ0.0001), with 62% (TETRAS) and 68% (BF-ADL) of \u27severe\u27 or \u27moderate\u27 patients improving to \u27mild\u27 or \u27slight\u27. Clinicians (CGI-I) reported improvement in 68% of patients, 60% (PGI-I) of patients reported improvement, and QUEST improved (p = 0.0019). Wrist-worn accelerometer recordings before and after 21,806 therapy sessions showed that 92% of patients improved, and 54% of patients experienced â„50% improvement in tremor power. Device-related adverse events (e.g., wrist discomfort, skin irritation, pain) occurred in 18% of patients. No device-related serious adverse events were reported.
Discussion: This study suggests that non-invasive neuromodulation therapy used repeatedly at home over three months results in safe and effective hand tremor reduction in many essential tremor patients
DNA G-quadruplex and i-motif structure formation is interdependent in human cells
Guanine- and cytosine-rich nucleic acid sequences have the potential to form secondary structures such as G-quadruplexes and i-motifs, respectively. We show that stabilization of G-quadruplexes using small molecules destabilizes the i-motifs, and vice versa, indicating these gene regulatory controllers are interdependent in human cells. This has important implications as these structures are predominately considered as isolated structural targets for therapy, but their interdependency highlights the interplay of both structures as an important gene regulatory switch
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