Junior Recital: Nicolas Franz, jazz guitar

This recital is presented in partial fulfillment of requirements for the degree Bachelor of Music in Performance. Mr. Franz studies guitar with Trey Wright.https://digitalcommons.kennesaw.edu/musicprograms/1475/thumbnail.jp

Senior Recital: Nicolas Franz, jazz guitar

This recital is presented in partial fulfillment of requirements for the degree Bachelor of Music in Performance. Mr. Franz studies jazz guitar with Trey Wright.https://digitalcommons.kennesaw.edu/musicprograms/1505/thumbnail.jp

Direct generation of a multi-transverse mode non-classical state of light

Quantum computation and communication protocols require quantum resources which are in the continuous variable regime squeezed and/or quadrature entangled optical modes. To perform more and more complex and robust protocols, one needs sources that can produce in a controlled way highly multimode quantum states of light. One possibility is to mix different single mode quantum resources. Another is to directly use a multimode device, either in the spatial or in the frequency domain. We present here the first experimental demonstration of a device capable of producing simultanuously several squeezed transverse modes of the same frequency and which is potentially scalable. We show that this device, which is an Optical Parametric Oscillator using a self-imaging cavity, produces a multimode quantum resource made of three squeezed transverse modes

Connecting the Dots: Analyzing Synthetic Observations of Star-Forming Clumps in Molecular Clouds

In this paper, we investigate the extent to which observations of molecular clouds can correctly identify and measure star-forming clumps. We produced a synthetic column density map and a synthetic spectral-line data cube from the simulated collapse of a 5000 M$_{\odot}$ molecular cloud. By correlating the clumps found in the simulation to those found in the synthetic observations, clump masses derived from spectral-line data cubes were found to be quite close to the true physical properties of the clumps. We also find that the `observed' clump mass function derived from the column density map is shifted by a factor of ~ 3 higher than the true clump mass function, due to projection of low-density material along the line of sight. Alves et al. (2007) first proposed that a shift of a clump mass function to higher masses by a factor of 3 can be attributed to a star formation efficiency of 30 %. Our results indicate that this finding may instead be due to an overestimate of clump masses determined from column density observations.Comment: 8 pages, 7 figures, Accepted for publication in the Astrophysical Journa

Multiprong control of glioblastoma multiforme invasiveness: blockade of pro-inflammatory signaling, anti-angiogenesis, and homeostasis restoration

Glioblastoma multiforme (GBM) is the most invasive type of glial tumor with poor overall survival, despite advances in surgical resection, chemotherapy, and radiation. One of the main challenges in treating GBM is related to the tumor’s location, complex and heterogeneous biology, and high invasiveness. To meet the demand for oxygen and nutrients, growing tumors induce new blood vessels growth. Antibodies directed against vascular endothelial growth factor (VEGF), which promotes angiogenesis, have been developed to limit tumor growth. Bevacizumab (Avastin), an anti-VEGF monoclonal antibody, is the first approved angiogenesis inhibitor with therapeutic promise. However, it has limited efficacy, likely due to adaptive mutations in GBM, leading to overall survival compared to the standard of care in GBM patients. Molecular connections between angiogenesis, inflammation, oxidative stress pathways, and the development of gliomas have been recognized. Improvement in treatment outcomes for patients with GBM requires a multifaceted approach due to the converging dysregulation of signaling pathways. While most GBM clinical trials focus on “anti-angiogenic” modalities, stimulating inflammation resolution is a novel host-centric therapeutic avenue. The selective therapeutic possibilities for targeting the tumor microenvironment, specifically angiogenic and inflammatory pathways expand. So, a combination of agents aiming to interfere with several mechanisms might be beneficial to improve outcomes. Our approach might also be combined with other therapies to enhance sustained effectiveness. Here, we discuss Suramab (anti-angiogenic), LAU-0901 (a platelet-activating factor receptor antagonist), Elovanoid (ELV; a novel lipid mediator), and their combination as potential alternatives to contain GBM growth and invasiveness.Fil: Bazan, Nicolas G.. State University of Louisiana; Estados UnidosFil: Reid, Madigan M.. State University of Louisiana; Estados UnidosFil: Cruz Flores, Valerie A.. State University of Louisiana; Estados UnidosFil: Gallo, Juan Eduardo Maria. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; ArgentinaFil: Lewis, William. State University of Louisiana; Estados UnidosFil: Belayev, Ludmila. State University of Louisiana; Estados Unido

Prognostic relevance of CCDC88C (Daple) transcripts in the peripheral blood of patients with cutaneous melanoma

A loss of balance between G protein activation and deactivation has been implicated in the initiation of melanomas, and non-canonical Wnt signaling via the Wnt5A/Frizzled (FZD) pathway has been shown to be critical for the switch to an invasive phenotype. Daple [CCDC88C], a cytosolic guanine nucleotide exchange modulator (GEM) which enhances non-canonical Wnt5A/FZD signaling via activation of trimeric G protein, Gαi, has been shown to serve opposing roles-as an inducer of EMT and invasiveness and a potent tumor suppressor-via two isoforms, V1 (full-length) and V2 (short spliced isoform), respectively. Here we report that the relative abundance of these isoforms in the peripheral circulation, presumably largely from circulating tumor cells (CTCs), is a prognostic marker of cutaneous melanomas. Expression of V1 is increased in both the early and late clinical stages (p \u3c 0.001, p = 0.002, respectively); V2 is decreased exclusively in the late clinical stage (p = 0.003). The two isoforms have opposing prognostic effects: high expression of V2 increases relapse-free survival (RFS; p = 0.014), whereas high expression of V1 tends to decrease RFS (p = 0.051). Furthermore, these effects are additive, in that melanoma patients with a low V2-high V1 signature carry the highest risk of metastatic disease. We conclude that detection of Daple transcripts in the peripheral blood (i.e., liquid biopsies) of patients with melanoma may serve as a prognostic marker and an effective strategy for non-invasive long-term follow-up of patients with melanoma

Cosmological quantum entanglement

We review recent literature on the connection between quantum entanglement and cosmology, with an emphasis on the context of expanding universes. We discuss recent theoretical results reporting on the production of entanglement in quantum fields due to the expansion of the underlying spacetime. We explore how these results are affected by the statistics of the field (bosonic or fermionic), the type of expansion (de Sitter or asymptotically stationary), and the coupling to spacetime curvature (conformal or minimal). We then consider the extraction of entanglement from a quantum field by coupling to local detectors and how this procedure can be used to distinguish curvature from heating by their entanglement signature. We review the role played by quantum fluctuations in the early universe in nucleating the formation of galaxies and other cosmic structures through their conversion into classical density anisotropies during and after inflation. We report on current literature attempting to account for this transition in a rigorous way and discuss the importance of entanglement and decoherence in this process. We conclude with some prospects for further theoretical and experimental research in this area. These include extensions of current theoretical efforts, possible future observational pursuits, and experimental analogues that emulate these cosmic effects in a laboratory setting.Comment: 23 pages, 2 figures. v2 Added journal reference and minor changes to match the published versio