Supermembranes and M(atrix) Theory

In these lectures, we review the D=11 supermembrane and supersymmetric matrix models at an introductory level. We also discuss some more recent developments in connection with non-perturbative string theory.Comment: 46 pages, 4 figures, Lectures given by H. Nicolai at the Trieste Spring School on Non-Perturbative Aspects of String Theory and Supersymmetric Gauge Theories, 23 - 31 March 199

Target- and Maturation-Specific Membrane-Associated Molecules Determine the Ingrowth of Entorhinal Fibers into the Hippocampus

AbstractIn this study the role of membrane-associated molecules involved in entorhinohippocampal pathfinding was examined. First outgrowth preferences of entorhinal neurites were analyzed on membrane carpets obtained from their proper target area, the hippocampus, and compared to preferences on control membranes from brain regions which do not receive afferent connections from the entorhinal cortex. On a substrate consisting of alternating lanes of hippocampal and control membranes, entorhinal neurites exhibited a strong tendency to grow on lanes of hippocampal membrane. These tissue-specific outgrowth preferences were maintained even on membrane preparations from adult brain tissue devoid of myelin. To determine the possible maturation dependence of these membranes, we examined guidance preferences of entorhinal neurites on hippocampal membranes of different developmental stages ranging from embryonic to postnatal and adult. Given a choice between alternating lanes of embryonic (E15–E16) and neonatal (P0–P1) hippocampal membranes, entorhinal neurites preferred to extend on neonatal membranes. No outgrowth preferences were observed on membranes obtained between E19 and P10. From P10 onward there was a reoccurrence of a preference for postnatal membrane lanes when neurites were presented with a choice between P15, P30, and adult membranes (>P60). This choice behavior of entorhinal neurites temporally correlates with the ingrowth of the perforant path into the hippocampus and with the stabilization of this brain area in vivo. Experiments in which postnatal and adult hippocampal membranes were heat inactivated or treated to remove molecules sensitive to phosphatidylinositol-specific phospholipase C demonstrated that entorhinal fiber preferences were controlled in this assay by attractive guidance cues and were independent of phosphatidylinositol-sensitive linked molecules. Moreover, entorhinal neurites displayed a positive discrimination for membrane-associated guidance cues of their target field, thus preferring to grow on membranes from the molecular layer of the dentate gyrus compared with CA3 or hilus membranes. Heat-inactivation experiments indicated that preferential growth of entorhinal axons is due to a specific attractivity of the molecular layer substrate. The data presented demonstrate that outgrowth of entorhinal fibers on hippocampal membranes is target and maturation dependent

The Ursinus Weekly, October 31, 1960

Second Forum to feature speaker on Bill of Rights • Pre-medders hear Dean of Jefferson • Conference on careers to be held in Phila. • Mr. Jones attends colloquium on college admissions in N.Y. • Sixty-one girls get sorority bids • Debating Club to hold meet on Tues., Nov. 1 • National Teacher Exams to be given on Feb. 11 • Big Little Sister party to be held Tuesday, Nov. 1 in college woods • Young Democrats hear Kennedy in Norristown on Sat. • YM-YW to sponsor formal political debate on Nov. 2 • New Lantern staff policy includes planned criticism • Newman Club to discuss All Saint\u27s Day at meeting • Young Republicans poll campus to determine student political leanings • APO initiates 17 new pledges • Chemistry society tours research laboratory • Society Hill Playhouse launches inaugural season • Frosh elect officers; Dave Kohr is president • Senior class to receive annuals • Spanish Club hears Dave Williams on October 17 • Editorial: A proposal • Letters to the editor • Hurrah! Brave new world • Point of interest • Reflections • Customs program called beneficial • Bears lose two games in soccer • Ursinus trackman sets AAU record • Wagner defeats Bears; Allebach is standout • Lassies divide during past week • Intramural corner • 1,350 fellowships offered by N.C.S. • Presidential humor • Y hears speaker on social work • Phila. Museum of Art to open new wing • Russian film premieres at Franklin Institute • Phila. art directors to have exhibition • Romance language teachers to attend dinner at Temple • Captain Dinneen of U.S. Army to visit Ursinus • Business Administration Club to hear Mr. King speak Weds.https://digitalcommons.ursinus.edu/weekly/1325/thumbnail.jp

First record of Vallonia costata (O. F. Müller, 1774) (Gastropoda, Eupulmonata, Valloniidae) from British Columbia, Canada, confirmed by partial-COI gene sequence

The minute terrestrial snail Vallonia costata (O. F. Müller, 1774) is reported for the first time from the province of British Columbia, Canada. The identification was based on shell morphology and confirmed by COI gene data. This species is presumed to be introduced to the province

Lumped Parameter Model for Silicon Crystal Growth from Granulate Crucible

In the present paper, a lumped parameter model for the novel Silicon Granulate Crucible (SiGC) method is proposed, which is the basis for a future model-based control system for the process. The model is analytically deduced based on the hydromechanical, geometrical, and thermal conditions of the process. Experiments are conducted to identify unknown model parameters and to validate the model. The physical consistency of the model is verified using simulation studies and a prediction error of below 2% is reached. © 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinhei

Avian Immunome DB: an example of a user-friendly interface for extracting genetic information

BackgroundGenomic and genetic studies often require a target list of genes before conducting any hypothesis testing or experimental verification. With the ever-growing number of sequenced genomes and a variety of different annotation strategies, comes the potential for ambiguous gene symbols, making it cumbersome to capture the “correct” set of genes. In this article, we present and describe the Avian Immunome DB (Avimm) for easy gene property extraction as exemplified by avian immune genes. The avian immune system is characterised by a cascade of complex biological processes underlaid by more than 1000 different genes. It is a vital trait to study particularly in birds considering that they are a significant driver in spreading zoonotic diseases. With the completion of phase II of the B10K (“Bird 10,000 Genomes”) consortium’s whole-genome sequencing effort, we have included 363 annotated bird genomes in addition to other publicly available bird genome data which serve as a valuable foundation for Avimm.Construction and contentA relational database with avian immune gene evidence from Gene Ontology, Ensembl, UniProt and the B10K consortium has been designed and set up. The foundation stone or the “seed” for the initial set of avian immune genes is based on the well-studied model organism chicken (Gallus gallus). Gene annotations, different transcript isoforms, nucleotide sequences and protein information, including amino acid sequences, are included. Ambiguous gene names (symbols) are resolved within the database and linked to their canonical gene symbol. Avimm is supplemented by a command-line interface and a web front-end to query the database.Utility and discussionThe internal mapping of unique gene symbol identifiers to canonical gene symbols allows for an ambiguous gene property search. The database is organised within core and feature tables, which makes it straightforward to extend for future purposes. The database design is ready to be applied to other taxa or biological processes. Currently, the database contains 1170 distinct avian immune genes with canonical gene symbols and 612 synonyms across 363 bird species. While the command-line interface readily integrates into bioinformatics pipelines, the intuitive web front-end with download functionality offers sophisticated search functionalities and tracks the origin for each record. Avimm is publicly accessible at https://avimm.ab.mpg.de.publishe

The Ursinus Weekly, January 16, 1961

ISC tentatively plans new rushing program: New program is planned to eliminate tense rushing pressures of women\u27s sophomore year • Ursinus students saddened by the death of Mr. Lutz • APO seeks to aid others\u27 projects • Placement Office announces listing of job interviews • Magazine sponsors religion contest • Senate rule restricts slacks and Bermudas at home sports events • National Teacher Exams to be given on Feb. 11 • Students sought for world tour • Seelye, contributor to Hispania, elected to Pa. AATSP Council • Announcement of annual Finnegan Awards made • Museum presents Festival of Italy • Delta Pi Sigma holds father-son banquet, party • Frosh Curtain Clubbers elect Judith Habeck as representative • Chi Alpha hears Dr. Baker talk on future missionary trends • Three more Ursinus students engaged at Christmas time • WAA discusses ski trip, intramurals on Monday • Mrs. Gorwich, of Philadelphia Museum, talks to Spanish Club • Dr. Zucker addresses Friends-fellowship forum in Reading • Editorial: Status seeking only? • Letters to the editor • Review: Minor birds • On the faults of the marking system • College of critics • I\u27m an individual; Are you? • Mermaids organize for season with 10 returnees • Girls\u27 badminton prepare for winning season • Varsity losing skein continues to six straight • Stronger teams for a stronger college • Grapplers divide; Abele clinches win for Bears • Book review: The Choice • The quiet noisemakers • Lutheran Club to hold pre-Lenten serviceshttps://digitalcommons.ursinus.edu/weekly/1331/thumbnail.jp