Dolo eventuale ed imputazione soggettiva dell'evento del reato

La ricerca mira a verificare la compatibilità della figura del dolo eventuale con i riferimenti normativi vigenti in tema di imputazione soggettiva dell'evento del reato

Acoustic Attenuation of COVID-19 Face Masks: Correlation to Fibrous Material Porosity, Mask Breathability and Bacterial Filtration Efficiency

none7openMartarelli, Milena; Montalto, Luigi; Chiariotti, Paolo; Simoni, Serena; Castellini, Paolo; Battista, Gianmarco; Paone, NicolaMartarelli, Milena; Montalto, Luigi; Chiariotti, Paolo; Simoni, Serena; Castellini, Paolo; Battista, Gianmarco; Paone, Nicol

A Discrete-Continuous Method for Predicting Thermochemical Phenomena in a Cement Kiln and Supporting Indirect Monitoring

Thermochemical phenomena involved in cement kilns are still not well understood because of their complexity, besides technical difficulties in achieving direct measurements of critical process variables. This article addresses the problem of their comprehensive numerical prediction. The presented numerical model exploits Computational Fluid Dynamics and Finite Difference Method approaches for solving the gas domain and the rotating wall, respectively. The description of the thermochemical conversion and movement of the powder particles is addressed with a Lagrangian approach. Coupling between gas, particles and the rotating wall includes momentum, heat and mass transfer. Three-dimensional numerical predictions for a full-size cement kiln are presented and they show agreement with experimental data and benchmark literature. The quality and detail of the results are believed to provide a new insight into the functioning of a cement kiln. Attention is paid to the computational burden of the model and a methodology is presented for reducing the time-to-solution and paving the way for its exploitation in quasi-real-time, indirect monitoring

Research on Experiential Marketing from the Qingdao International Beer Festival

近年来，“体验”一词成为营销界出现频率越来越高的词汇。在学术界，早在上世纪70年代就有学者提出，但较为集中和富有成果的研究基本都在2000以后才出现，并且长期以来都以约瑟夫·派恩、詹姆斯·吉尔摩和伯德·施密特博士的研究为奠基之作；在业界，体验营销作为一种新型的营销方式，在国外的很多企业，尤其是很多跨国企业中已经得到了很成熟的应用，并且取得了很好的效果，而在国内，由于多种原因，只在小部分企业当中得以应用，普及程度并不高。不管未来如何，现如今体验式营销作为一种为消费者带来个性化消费体验的营销手段，已经逐渐开始流行并被商家所接受和采用，研究体验营销及其应用，对国内产品品牌建设方面有很高的借鉴价值。 ...In recent years, the word “experiencing” appears more and more frequently in the marketing area. As a matter of fact,the concept of experiential marketing had been mentioned during the 1970s. As a new way of marketing, experiential marketing has already been widely used in foreign enterprises, especially in the transnational enterprises. Howerer, in china, as a result of several things, experienti...学位：文学硕士院系专业：新闻传播学院广告学系_传播学学号：1052006115025

Towards the integration of process and quality control using multi-agent technology

The paper introduces a vision on the design of distributed manufacturing control systems using the multi-agent principles to enhance the integration of the production and quality control processes. It is highlighted how agent technology may enforce interaction of manufacturing execution system and distributed control system, enhancing the exploitation of the available information at the quality control and process control levels. A specific focus is made on a suitable engineering methodology for the design and realization of such concept. Innovation is also presented at the level of adaptive process control and self-optimizing quality control, with examples related to a home appliance production line

Immunohistochemical analysis of chromatin remodeler DAXX in high grade urothelial carcinoma

Background/Aims: The chromatin remodeler DAXX, a predominantly nuclear protein, regulates the status of chromatin organization. The aim of this exploratory immunohistochemical study was to evaluate DAXX protein expression in high grade invasive urothelial carcinoma (UC) of the bladder as a biological regulator of aggressiveness. Methods: Quantitative analysis was made on DAXX immunostained nuclei in tissue sections from 5 cases of bladder normal urothelium (NU) and 5 cases of bladder pT1 UC. Carcinoma in situ (CIS) and high grade papillary carcinoma (HGPCa) were identified in 2 out of 5 UC cases. Results: The nuclei in UC show an open configuration of the chromatin composed of granules varying in size and distribution and a mean nuclear area 1.7 times greater than that in NU (UC: mean and SD 24.4 ± 11.4 square microns; NU: 14.8 6.5 square microns. The differences are statistically significant). 70% of the NU nuclei are immunostained, whereas 90% of UC nuclei are positive. The mean gray level value in UC, related to the intensity of nuclear immunostaining, is lower than in NU by a factor of 0.94 (UC: mean and SD 100 ± 15; NU: 106 ± 15. The differences are statistically significant). In particular, the value in the nuclei adjacent to the stroma in UC is slightly lower than in the intermediate cell layers by factor of 0.98, whereas in NU it is slightly greater by a factor 1.02 and 1.04 compared to the intermediate and superficial cell layers. The values in CIS and HGPCa are similar to those in UC. Conclusions: The quantitative immunohistochemical analysis shows an altered protein expression of chromatin remodeler DAXX in UC and in its preinvasive phases, when compared to NU. DAXX evaluation, if associated with markers related to global DNA methylation and histone acetylation, could be used in clinical practice as a marker of aggressiveness. Virtual slides: The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/139845729710237

XDEM for Tuning Lumped Models of Thermochemical Processes Involving Materials in the Powder State

Processes involving materials in gaseous and powder states cannot be modelled without coupling interactions between the two states. XDEM (Extended Discrete Element Method) is a valid tool for tackling this issue, since it allows a coupled CFD- DEM simulation to be run. Such strength, however, mainly finds in long computational times its main drawback. This aspect is indeed critical in several applications, since a long computational time is in contrast with the increasing demand for predictive tools that can provide fast and accurate results in order to be used in new monitoring and control strategies. This paper focuses on the use of the XDEM framework as a tool for fine tuning a lumped representation of the non-isothermal decarbonation of a CaCO3 sample in powder state. The tuning of the lumped model is performed exploiting the multi-objective optimization capability of genetic algorithms. Results demonstrate that such approach makes it possible to estimate fast and accurate models to be used, for instance, in the fields of virtual sensing and predictive control

A New Method for the Experimental Assessment of Finger Haemodynamic Effects Induced by a Hydraulic Breaker in Operative Conditions

Abstract: A New Method for the Experimental Assessment of Finger Haemodynamic Effects Induced by a Hydraulic Breaker in Operative Conditions: Matteo VALENTINO, et al

MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer

MicroRNA deregulation is frequent in human colorectal cancers (CRCs), but little is known as to whether it represents a bystander event or actually drives tumor progression in vivo. We show that miR-135b overexpression is triggered in mice and humans by APC loss, PTEN/PI3K pathway deregulation, and SRC overexpression and promotes tumor transformation and progression. We show that miR-135b upregulation is common in sporadic and inflammatory bowel disease-associated human CRCs and correlates with tumor stage and poor clinical outcome. Inhibition of miR-135b in CRC mouse models reduces tumor growth by controlling genes involved in proliferation, invasion, and apoptosis. We identify miR-135b as a key downsteam effector of oncogenic pathways and a potential target for CRC treatment