Observational limits on type 1 active galactic nucleus rate in COSMOS

We present black hole masses and accretion rates for 182 Type 1 active galactic nuclei (AGNs) in COSMOS. We estimate masses using the scaling relations for the broad H β, Mg ii, and C iv emission lines in the redshift ranges 0.16 < z < 0.88, 1 < z < 2.4, and 2.7 < z < 4.9. We estimate the accretion rate using an Eddington ratio LI/L_(Edd) estimated from optical and X-ray data.We find that very few Type 1 AGNs accrete below LI/L_(Edd) ∼ 0.01, despite simulations of synthetic spectra which show that the survey is sensitive to such Type 1 AGNs. At lower accretion rates the broad-line region may become obscured, diluted, or nonexistent. We find evidence that Type 1 AGNs at higher accretion rates have higher optical luminosities, as more of their emission comes from the cool (optical) accretion disk with respect to shorter wavelengths. We measure a larger range in accretion rate than previous works, suggesting that COSMOS is more efficient at finding low accretion rate Type 1 AGNs. However, the measured range in accretion rate is still comparable to the intrinsic scatter from the scaling relations, suggesting that Type 1 AGNs accrete at a narrow range of Eddington ratio, with LI/L_(Edd) ∼ 0.1

L-type voltage-gated calcium channel regulation of in vitro human cortical neuronal networks

The combination of in vitro multi-electrode arrays (MEAs) and the neuronal differentiation of stem cells offers the capability to study human neuronal networks from patient or engineered human cell lines. Here, we use MEA-based assays to probe synaptic function and network interactions of hiPSC-derived neurons. Neuronal network behaviour first emerges at approximately 30 days of culture and is driven by glutamate neurotransmission. Over a further 30 days, inhibitory GABAergic signalling shapes network behaviour into a synchronous regular pattern of burst firing activity and low activity periods. Gene mutations in L-type voltage gated calcium channel subunit genes are strongly implicated as genetic risk factors for the development of schizophrenia and bipolar disorder. We find that, although basal neuronal firing rate is unaffected, there is a dose-dependent effect of L-type voltage gated calcium channel inhibitors on synchronous firing patterns of our hiPSC-derived neural networks. This demonstrates that MEA assays have sufficient sensitivity to detect changes in patterns of neuronal interaction that may arise from hypo-function of psychiatric risk genes. Our study highlights the utility of in vitro MEA based platforms for the study of hiPSC neural network activity and their potential use in novel compound screening

Site‐specific inhibition of the thalamic reticular nucleus induces distinct modulations in sleep architecture

The thalamic reticular nucleus (TRN) is crucial for the modulation of sleep-related oscillations. The caudal and rostral subpopulations of the TRN exert diverse activities, which arise from their interconnectivity with all thalamic nuclei, as well as other brain regions. Despite the recent characterization of the functional and genetic heterogeneity of the TRN, the implications of this heterogeneity for sleep regulation have not been assessed. Here, using a combination of optogenetics and electrophysiology in C57BL/6 mice, we demonstrate that caudal and rostral TRN modulations are associated with changes in cortical alpha and delta oscillations, and have distinct effects on sleep stability. Tonic silencing of the rostral TRN elongates sleep episodes, while tonic silencing of the caudal TRN fragments sleep. Overall, we show evidence of distinct roles exerted by the rostral and caudal TRN in sleep regulation and oscillatory activity

The effect of functional roles on perceived group efficiency during computer-supported collaborative learning

In this article, the effect of functional roles on group performance and collaboration during computer-supported collaborative learning (CSCL) is investigated. Especially the need for triangulating multiple methods is emphasised: Likert-scale evaluation questions, quantitative content analysis of e-mail communication and qualitative analysis of open-ended questions were used. A comparison of fourty-one questionnaire observations, distributed over thirteen groups in two research conditions – groups with prescribed functional roles (n = 7, N = 18) and nonrole groups (n = 6, N = 23) – revealed no main effect for performance (grade). Principal axis factoring of the Likert-scales revealed a latent variable that was interpreted as perceived group efficiency (PGE). Multilevel modelling (MLM) yielded a positive marginal effect of PGE. Most groups in the role condition report a higher degree of PGE than nonrole groups. Content analysis of e-mail communication of all groups in both conditions (role n = 7, N = 25; nonrole n = 6, N = 26) revealed that students in role groups contribute more ‘coordination’ focussed statements. Finally, results from cross case matrices of student responses to open-ended questions support the observed marginal effect that most role groups report a higher degree of perceived group efficiency than nonrole groups

Observational Limits on Type 1 AGN Accretion Rate in COSMOS

We present black hole masses and accretion rates for 182 Type 1 AGN in COSMOS. We estimate masses using the scaling relations for the broad Hb, MgII, and CIV emission lines in the redshift ranges 0.16<z<0.88, 1<z<2.4, and 2.7<z<4.9. We estimate the accretion rate using an Eddington ratio L_I/L_Edd estimated from optical and X-ray data. We find that very few Type 1 AGN accrete below L_I/L_Edd ~ 0.01, despite simulations of synthetic spectra which show that the survey is sensitive to such Type 1 AGN. At lower accretion rates the BLR may become obscured, diluted or nonexistent. We find evidence that Type 1 AGN at higher accretion rates have higher optical luminosities, as more of their emission comes from the cool (optical) accretion disk with respect to shorter wavelengths. We measure a larger range in accretion rate than previous works, suggesting that COSMOS is more efficient at finding low accretion rate Type 1 AGN. However the measured range in accretion rate is still comparable to the intrinsic scatter from the scaling relations, suggesting that Type 1 AGN accrete at a narrow range of Eddington ratio, with L_I/L_Edd ~ 0.1.Comment: Accepted for pulication in ApJ. 7 pages, 5 figures, table 1 available on reques

The Nature of Optically Dull Active Galactic Nuclei in COSMOS

We present infrared, optical, and X-ray data of 48 X-ray bright, optically dull AGNs in the COSMOS field. These objects exhibit the X-ray luminosity of an active galactic nucleus (AGN) but lack broad and narrow emission lines in their optical spectrum. We show that despite the lack of optical emission lines, most of these optically dull AGNs are not well-described by a typical passive red galaxy spectrum: instead they exhibit weak but significant blue emission like an unobscured AGN. Photometric observations over several years additionally show significant variability in the blue emission of four optically dull AGNs. The nature of the blue and infrared emission suggest that the optically inactive appearance of these AGNs cannot be caused by obscuration intrinsic to the AGNs. Instead, up to ~70% of optically dull AGNs are diluted by their hosts, with bright or simply edge-on hosts lying preferentially within the spectroscopic aperture. The remaining ~30% of optically dull AGNs have anomalously high f_x/f_o ratios and are intrinsically weak, not obscured, in the optical. These optically dull AGNs are best described as a weakly accreting AGN with a truncated accretion disk from a radiatively inefficient accretion flow.Comment: 12 pages, 10 figures. Accepted for publication in the Ap

The COSMOS AGN Spectroscopic Survey I: XMM Counterparts

We present optical spectroscopy for an X-ray and optical flux-limited sample of 677 XMM-Newton selected targets covering the 2 deg^2 COSMOS field, with a yield of 485 high-confidence redshifts. The majority of the spectra were obtained over three seasons (2005-2007) with the IMACS instrument on the Magellan (Baade) telescope. We also include in the sample previously published Sloan Digital Sky Survey spectra and supplemental observations with MMT/Hectospec. We detail the observations and classification analyses. The survey is 90% complete to flux limits of f_{0.5-10 keV}>8 x 10^-16 erg cm^-2 s^-1 and i_AB+<22, where over 90% of targets have high-confidence redshifts. Making simple corrections for incompleteness due to redshift and spectral type allows for a description of the complete population to $i_AB+<23. The corrected sample includes 57% broad emission line (Type 1, unobscured) AGN at 0.13<z<4.26, 25% narrow emission line (Type 2, obscured) AGN at 0.07<z<1.29, and 18% absorption line (host-dominated, obscured) AGN at 0<z<1.22 (excluding the stars that made up 4% of the X-ray targets). We show that the survey's limits in X-ray and optical flux include nearly all X-ray AGN (defined by L_{0.5-10 keV}>3 x 10^42 erg s^-1) to z<1, of both optically obscured and unobscured types. We find statistically significant evidence that the obscured to unobscured AGN ratio at z<1 increases with redshift and decreases with luminosity.Comment: Accepted for publication in the ApJ. 31 pages, 17 figures. Table 2 is available on reques

Concert recording 2017-04-23b

[Track 1]. Slowing down. I. Rotations in an emergency [Track 2]. II. Under the city [Track 3]. III. Forfeit [Track 4]. IV. Something comfortable to fall into / Jeremiah Flannery