Influence of Annealing Conditions on Structure and Critical Parameters of Ni50Mn37Sn13 Magnetocaloric Material

In this paper, we present the influence of annealing conditions on structure and magnetic behavior of Ni$_{50}$Mn$_{37}$Sn$_{13}$ magnetocaloric alloy prepared by arc-melting technique. The results show that the almost single phase of the full Heusler structure of Ni$_{2}$MnSn could be achieved by appropriate annealing. The transformation between martensite and austenite phases, and multi-magnetic phase behavior are observed more clearly with higher fraction of Ni$_{2}$MnSn phase. By using Arrott-Noaks method, critical parameters were determined to be $\beta   0.464 \pm  0.021$, $\gamma  = 1.117 \pm  0.073$ and $\delta  = 3.41$, which lay between mean-field model ($\beta  = 0.5$ and $\gamma = 1$, $\delta  = 3$) with long-range ferromagnetic orders and 3D Heisenberg model ($\beta  = 0.365$, $\gamma = 1.336$, $\delta {\rm g}= 4.66$) with short-range ferromagnetic orders. The calculated results are in good accordance with the experimentally observed coexistence of weak-ferromagnetic martensite and strong-ferromagnetic austenite phases

Magnetic Properties and Giant Magnetocaloric Effect In Mn-based Heusler Compounds

Magnetic properties and giant magnetocaloric effect (GMCE) of Mn-based Heusler compounds such as Co-Mn-Si, Ni-Mn-Sn, Ni-Mn-Sb have been investigated. The results show that the structure strongly influences on magnetic properties and GMCE of these alloys. The coexistence of ferromagnetic (FM) and antiferromagnetic (AFM) orders is observed. The magnetic phase transitions can be controlled by changing composition and annealing condition of the alloys. GMCEs with large magnitude and wide working temperature range have been obtained on these alloys showing their application potential for magnetic refrigeration technology

Assessment of impacts of utilization on water resources in the basin of trans-boundary Red river system

The Red river system is the large trans-boundary river system, there has been no united system of hydrology stations as well as integrated plan for the water use and management in the whole basin. The trend of water resources change in the Red river system basin has been assessed on the basic of statistic analyses of data observed during the studies, especially in the time when the exploitation of water resources has been intensified for the multisectoral development. This paper shows some of the results from considerations of the water use in the highlands that is influential in water resources in the Red river system basin and the planned reservoirs which are built in the basin of Red river system. The results include the assessment of the state and trend of water resources in the Red river system basin, the trend of water level lowering in the lowlands and its impacts

Evaluation Of Agronomic Traits And Adaptation Of Some Promising Salt Tolerant Rice Lines/Varieties Growing In The Coastal Areas In Thanh Hoa Province, Vietnam

Rice (Oryza sativa L.) is the main food in Vietnam and plays an important role in economic activity in this country. However, rice yield and growing areas are adversely influenced by the threats of the devastation caused by the rise of sea level. This study aimed to evaluate the salt effects in field experiments of 19 promising salt tolerance rice lines/varieties carrying QTL/Saltol, which were selected from the BC2F5 breeding combination between FL479 and Bac Thom 7 (BC7). The field experiments were conducted in two consecutive seasons at three saline-affected rice growing areas, including Nga Son, Hoang Hoa and Quang Xuong districts, Thanh Hoa province. The results showed that among those promising rice lines, the HL15 line had the best yield components in all experimented sites, and good agronomic traits with short plant height and shorter growth duration than the BC7 variety (115-117 days) in the spring season and 102-103 days in the summer season, respectively. All tested had the same level of pest resistance/infection as the control variety BT7 under production conditions using pesticides including HL1, HL13 and HL15, which were mildly infected with the bacterial leaf blight, while HL15 variety showed high resistance to pests and diseases. Moreover, the HL2, HL15 and HL19 lines had scored 3, equivalent to FL478 (tolerant), and the survival rate was over 85% compared with the control variety. Overall, our findings showed that the promising purebred variety HL15 had a range of good agronomic characteristics, resistance to major pests and diseases, high yield potential and salinity tolerance of 6‰. The HL15 variety was renamed as SHPT15 and continued to conduct procedures to recognize it as a new rice variety

Climate change and health in Southeast Asia – defining research priorities and the role of the Wellcome Trust Africa Asia Programmes

This article summarises a recent virtual meeting organised by the Oxford University Clinical Research Unit in Vietnam on the topic of climate change and health, bringing local partners, faculty and external collaborators together from across the Wellcome and Oxford networks. Attendees included invited local and global climate scientists, clinicians, modelers, epidemiologists and community engagement practitioners, with a view to setting priorities, identifying synergies and fostering collaborations to help define the regional climate and health research agenda. In this summary paper, we outline the major themes and topics that were identified and what will be needed to take forward this research for the next decade. We aim to take a broad, collaborative approach to including climate science in our current portfolio where it touches on infectious diseases now, and more broadly in our future research directions. We will focus on strengthening our research portfolio on climate-sensitive diseases, and supplement this with high quality data obtained from internal studies and external collaborations, obtained by multiple methods, ranging from traditional epidemiology to innovative technology and artificial intelligence and community-led research. Through timely agenda setting and involvement of local stakeholders, we aim to help support and shape research into global heating and health in the region

Climate change and health in Southeast Asia – defining research priorities and the role of the Wellcome Trust Africa Asia Programmes

This article summarises a recent virtual meeting organised by the Oxford University Clinical Research Unit in Vietnam on the topic of climate change and health, bringing local partners, faculty and external collaborators together from across the Wellcome and Oxford networks. Attendees included invited local and global climate scientists, clinicians, modelers, epidemiologists and community engagement practitioners, with a view to setting priorities, identifying synergies and fostering collaborations to help define the regional climate and health research agenda. In this summary paper, we outline the major themes and topics that were identified and what will be needed to take forward this research for the next decade. We aim to take a broad, collaborative approach to including climate science in our current portfolio where it touches on infectious diseases now, and more broadly in our future research directions. We will focus on strengthening our research portfolio on climate-sensitive diseases, and supplement this with high quality data obtained from internal studies and external collaborations, obtained by multiple methods, ranging from traditional epidemiology to innovative technology and artificial intelligence and community-led research. Through timely agenda setting and involvement of local stakeholders, we aim to help support and shape research into global heating and health in the region.</ns4:p

Climate change and health in Southeast Asia – defining research priorities and the role of the Wellcome Trust Africa Asia Programmes

This article summarises a recent virtual meeting organised by the Oxford University Clinical Research Unit in Vietnam on the topic of climate change and health, bringing local partners, faculty and external collaborators together from across the Wellcome and Oxford networks. Attendees included invited local and global climate scientists, clinicians, modelers, epidemiologists and community engagement practitioners, with a view to setting priorities, identifying synergies and fostering collaborations to help define the regional climate and health research agenda. In this summary paper, we outline the major themes and topics that were identified and what will be needed to take forward this research for the next decade. We aim to take a broad, collaborative approach to including climate science in our current portfolio where it touches on infectious diseases now, and more broadly in our future research directions. We will focus on strengthening our research portfolio on climate-sensitive diseases, and supplement this with high quality data obtained from internal studies and external collaborations, obtained by multiple methods, ranging from traditional epidemiology to innovative technology and artificial intelligence and community-led research. Through timely agenda setting and involvement of local stakeholders, we aim to help support and shape research into global heating and health in the region

SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types

Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial

Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049

A first update on mapping the human genetic architecture of COVID-19

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