Genetic effects on gene expression across human tissues

Characterization of the molecular function of the human genome and its variation across individuals is essential for identifying the cellular mechanisms that underlie human genetic traits and diseases. The Genotype-Tissue Expression (GTEx) project aims to characterize variation in gene expression levels across individuals and diverse tissues of the human body, many of which are not easily accessible. Here we describe genetic effects on gene expression levels across 44 human tissues. We find that local genetic variation affects gene expression levels for the majority of genes, and we further identify inter-chromosomal genetic effects for 93 genes and 112 loci. On the basis of the identified genetic effects, we characterize patterns of tissue specificity, compare local and distal effects, and evaluate the functional properties of the genetic effects. We also demonstrate that multi-tissue, multi-individual data can be used to identify genes and pathways affected by human disease-associated variation, enabling a mechanistic interpretation of gene regulation and the genetic basis of diseas

Genetic effects on gene expression across human tissues

Characterization of the molecular function of the human genome and its variation across individuals is essential for identifying the cellular mechanisms that underlie human genetic traits and diseases. The Genotype-Tissue Expression (GTEx) project aims to characterize variation in gene expression levels across individuals and diverse tissues of the human body, many of which are not easily accessible. Here we describe genetic effects on gene expression levels across 44 human tissues. We find that local genetic variation affects gene expression levels for the majority of genes, and we further identify inter-chromosomal genetic effects for 93 genes and 112 loci. On the basis of the identified genetic effects, we characterize patterns of tissue specificity, compare local and distal effects, and evaluate the functional properties of the genetic effects. We also demonstrate that multi-tissue, multi-individual data can be used to identify genes and pathways affected by human disease-associated variation, enabling a mechanistic interpretation of gene regulation and the genetic basis of disease

Geophysics Integrated Studies in the Sun Earth System: A Cooperative Project of Vietnam, Europe, and Africa

The Hanoi Institute of Geophysics (Vietnam) will participate to international Heliophysical Year. This paper presents Vietnam‘s participation into this International cooperative project : the Vietnamese network of magnetometers, meteorological stations, ionosondes and GPS receivers involved in campaigns of measurements, the research field selected for the training of young Vietnamese scientists, and the Institutes involve in this training. This paper also presents some particularities of geophysical parameters in Vietnam : the strong amplitude of the equatorial electrojet observed by satellite data and confirmed by magnetic observations at the ground level presented for the first time to the international community, the monsoon signature etc. Finally the differences between the Asian sector and the African sector lead to the development of comparative studies between Asia and Africa

Sun-Earth System Interaction studies over Vietnam: an international cooperative project

International audienceDuring many past decades, scientists from various countries have studied separately the atmospheric motions in the lower atmosphere, in the Earth's magnetic field, in the magnetospheric currents, etc. All of these separate studies lead today to the global study of the Sun and Earth connections, and as a consequence, new scientific programs (IHY- International Heliophysical Year, CAWSES- Climate and Weather in the Sun-Earth System) are defined, in order to assume this new challenge. In the past, many scientists did not have the possibility to collect data at the same time in the various latitude and longitude sectors. Now, with the progress of geophysical sciences in many developing countries, it is possible to have access to worldwide data sets. This paper presents the particularities of geophysical parameters measured by the Vietnamese instrument networks. It introduces a cooperative Vietnamese-IGRGEA (International Geophysical Research Group Europe Africa) project, and presents, for the first time, to the international community, the geophysical context of Vietnam. Concerning the ionosphere: since 1963, during four solar cycles, the ionosonde at Phu Thuy (North Vietnam) was operating. The Phu Thuy data exhibits the common features for the ionospheric parameters, previously observed in other longitude and latitude sectors. The critical frequencies of the E, F1 and F2 ionospheric layers follow the variation of the sunspot cycle. F2 and E critical frequencies also exhibit an annual variation. The first maps of TEC made with data from GPS receivers recently installed in Vietnam illustrate the regional equatorial pattern, i.e. two maxima of electronic density at 15 N and 15 S from the magnetic equator and a trough of density at the magnetic equator. These features illustrate the equatorial fountain effect. Concerning the Earth's magnetic field: a strong amplitude of the equatorial electrojet was first observed by the CHAMP satellite at the height of 400 km in the Vietnamese longitude sector. In this paper we compare the ground magnetic observations of the Indian and Vietnamese magnetometer networks. This comparison highlights the regional structure of the amplitude of the equatorial electrojet, which is stronger in Vietnam than in India. Concerning the monsoon: Vietnam exhibits a strong monsoon and has mainly one rainy season peaking in August, hence associated with the southwest monsoon flow. But some monsoon variability from one place to another is related to the orography. In the mountainous northern regions of Vietnam, there is an "early" monsoon peaking in July. In the coastal regions between 12 N and 19 N the monsoon season is centered on October. Concerning lightning: Vietnam is a country of strong atmospheric storms with some areas of very intense lightning in North Vietnam (22,5 N, 105 E) and in South Vietnam (11 N, 107 E). In North Vietnam strong lightning is associated with the most intense rainy region. Keywords. Ionosphere (Electric fields and currents) - Meteorology and dynamics (Tropical meteorology) - Geomagnetism and paleomagnetism (Time variations, diurnal to secular